Investigation of the Noncovalent Binding Mode of Covalent Proteasome Inhibitors around the Transition State by Combined Use of Cyclopropylic Strain-Based Conformational Restriction and Computational Modeling

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Title
Investigation of the Noncovalent Binding Mode of Covalent Proteasome Inhibitors around the Transition State by Combined Use of Cyclopropylic Strain-Based Conformational Restriction and Computational Modeling
Authors
Keywords
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Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 56, Issue 14, Pages 5829-5842
Publisher
American Chemical Society (ACS)
Online
2013-06-26
DOI
10.1021/jm400542h

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