Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds

On-target Inhibition of Tumor Fermentative Glycolysis as Visualized by Hyperpolarized Pyruvate

(2015) Pankaj Seth et al.   NEOPLASIA

Fragment Growing and Linking Lead to Novel Nanomolar Lactate Dehydrogenase Inhibitors

(2013) Anna Kohlmann et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anticancer Agents That Counteract Tumor Glycolysis

(2012) Carlotta Granchi et al.   ChemMedChem

Knockdown of lactate dehydrogenase A suppresses tumor growth and metastasis of human hepatocellular carcinoma

(2012) Shi L. Sheng et al.   FEBS Journal

MM/GBSA Binding Energy Prediction on the PDBbind Data Set: Successes, Failures, and Directions for Further Improvement

(2012) Paulette A. Greenidge et al.   Journal of Chemical Information and Modeling

2-(3-Oxo-1,3-diphenylpropyl)malonic Acids as Potent Allosteric Ligands of the PIF Pocket of Phosphoinositide-Dependent Kinase-1: Development and Prodrug Concept

(2012) Adriana Wilhelm et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design and Synthesis of Novel Lactate Dehydrogenase A Inhibitors by Fragment-Based Lead Generation

(2012) Richard A. Ward et al.   JOURNAL OF MEDICINAL CHEMISTRY

LDHA is necessary for the tumorigenicity of esophageal squamous cell carcinoma

(2012) Feng Yao et al.   TUMOR BIOLOGY

Galloflavin (CAS 568-80-9): A Novel Inhibitor of Lactate Dehydrogenase

(2011) Marcella Manerba et al.   ChemMedChem

Discovery ofN-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against Cancer Cells

(2011) Carlotta Granchi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

(2010) A. Le et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA