Article
Biochemical Research Methods
Yuya Cheng, Peize Wu, Ying Kan, Ming Li, Hongmei Li
Summary: In this study, liquid chromatography-high-resolution mass spectrometry methods were used to comprehensively characterize and quantify thymalfasin-related impurities. The results showed that there are various impurities in thymalfasin standard and commercial materials, with over half of them related to the C-terminal Asn residue. Therefore, it is proposed to modify or replace the C-terminal Asn residue of thymalfasin for new drug research and development.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Yuhe Shen, Rongxin Su, Dongzhao Hao, Xiaojian Xu, Meital Reches, Jiwei Min, Heng Chang, Tao Yu, Qing Li, Xiaoyu Zhang, Yuefei Wang, Yuefei Wang, Wei Qi
Summary: The authors investigated the effect of the molecular chirality of (L)-3,4-dihydroxyphenylalanine on the improved structural and thermal stability of self-assembled films by tyrosinase-induced oxidative polymerization. The pure enantiomers showed altered kinetics and morphology upon co-assembly, allowing the fabrication of layer-to-layer stacked nanostructures and films with enhanced properties. The (L+D)-racemic mixtures exhibited different molecular arrangements and self-assembly mechanisms, resulting in stronger intermolecular forces and increased elastic modulus.
NATURE COMMUNICATIONS
(2023)
Article
Engineering, Biomedical
Ross Burdis, Xavier Barcelo Gallostra, Daniel J. Kelly
Summary: Scaffold-free tissue engineering can generate more hyaline-like cartilage tissue compared to single-cell scaffold-free approaches. Temporal enzymatic treatment can enhance microtissue fusion and tissue remodeling, leading to the formation of a denser and more biomimetic zonal collagen network. This study demonstrates that using biological building blocks can be improved by using temporal enzymatic treatment during graft development.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Lucy A. Harwood, Luet L. Wong, Jeremy Robertson
Summary: Kinetic resolution using biocatalysis is an excellent complementary technique to traditional asymmetric catalysis, producing valuable oxygenated structures for synthetic route development. Enzymes catalyzing the insertion of an oxygen atom into the substrate, such as the Baeyer-Villiger rearrangement, epoxidation, and hydroxylation, play a key role in oxidative kinetic resolution. These key enantiomer-enriched intermediates have important applications in natural product synthesis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Biochemistry & Molecular Biology
Ana Sofia Almeida, Barbara Silva, Paula Guedes de Pinho, Fernando Remiao, Carla Fernandes
Summary: New psychoactive substances, such as synthetic cathinones, pose a public health threat as they are easily accessible online and often sold as legal alternatives to illicit drugs. Synthetic cathinones are widely abused due to their stimulating and hallucinogenic effects. However, their chemical and toxicological properties remain unknown, as new derivatives continue to emerge on the drug market. This review focuses on the recent developments in synthetic cathinones, including over 50 derivatives since 2014, and highlights the importance of enantioselectivity studies and enantioseparation analysis in understanding their biological and toxicological activities.
Article
Biochemical Research Methods
Ming Li, Ralf D. Josephs, Adeline Daireaux, Tiphaine Choteau, Steven Westwood, Gustavo Martos, Robert I. Wielgosz, Hongmei Li
Summary: Oxytocin is a crucial peptide used for labor induction and postpartum bleeding control, but also shows potential as a biomarker for emotions and cancer diagnosis. Accurate purity characterization through various methods is essential, considering the unique analytical challenge posed by the presence of disulfide bonds in Oxytocin. Newly developed LC-hrMS method has been effective in identifying and quantifying structurally related impurities in synthetic OXT materials.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Organic
Ani Ozcelik, Raquel Pereira-Cameselle, Angeles Pena-Gallego, J. Lorenzo Alonso-Gomez
Summary: This study reports the synthesis and characterization of the first TCBD-SBF compound and provides information on its chiral configuration and potential energy surface through experiments and calculations. The calculated first hyperpolarizability suggests that this compound has potential nonlinear optical properties suitable for NLO applications.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Damiano Verardo, Beatrice Adelizzi, Daniel A. Rodriguez-Pinzon, Nicolas Moghaddam, Emma Thomee, Tessa Loman, Xavier Godron, Adrian Horgan
Summary: Enzymatic DNA synthesis is a promising method that utilizes mild aqueous conditions and enzymes instead of solvents and phosphoramidites. This study demonstrates a cycle of site-specific dispensing of terminal deoxynucleotidyl transferase enzyme and 3' blocked nucleotide, followed by bulk slide washing, to achieve microscale control of nucleic acid sequence and length.
Article
Chemistry, Physical
Kochunnoonny Manoj, Hiroki Takahashi, Sekai Iwama, G. Rajesh Gonnade, Hirohito Tsue, Rui Tamura
Summary: Two new hydrate cocrystals, (RS)-arginine-fumaric acid-H2O (2) and (S)-arginine-2 fumaric acid-H2O (3), obtained from the slow evaporation of saturated aqueous ethanol solution, play a crucial role in the enrichment of arginine in the mother liquor due to their unstable formation.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Multidisciplinary Sciences
Erdem D. Tabdanov, Nelson J. Rodriguez-Merced, Alexander X. Cartagena-Rivera, Vikram V. Puram, Mackenzie K. Callaway, Ethan A. Ensminger, Emily J. Pomeroy, Kenta Yamamoto, Walker S. Lahr, Beau R. Webber, Branden S. Moriarity, Alexander S. Zhovmer, Paolo P. Provenzano
Summary: The authors utilize nanotextured elastic platforms to enhance T cell migration in complex tumor microenvironments by manipulating the balance between microtubule stability and force generation. They demonstrate that rational manipulation of the microtubule-contractility axis results in engineered T cells that more effectively navigate 3D matrix and tumor volumes, potentially enhancing the efficacy of immune therapeutics.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Katerina Skordi, Antonis Anastassiades, Adeline D. Fournet, Rahul Kumar, Michael Schulze, Wolfgang Wernsdorfer, George Christou, Vassilios Nastopoulos, Spyros P. Perlepes, Constantina Papatriantafyllopoulou, Anastasios J. Tasiopoulos
Summary: Simultaneous employment of 1,3-propanediol and di-2-pyridyl ketone in Mn carboxylate chemistry has led to the synthesis of three new, structurally-related [Mn-24] and [Mn-23] clusters, based on nanosized supertetrahedal T4 Mn/O structural cores exhibiting slow relaxation of magnetization below 3.5 K.
CHEMICAL COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Chong-Chih Tsai, Wei-Kuang Liang
Summary: The study introduces an intrinsic ERP (iERP) method to overcome the drawbacks and retain the advantages of event-related mode analysis. This method can effectively reveal multiple ERP components and cluster statistical effects by using a tailored definition of each mode's neighbors.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Physical
Tobias M. Milzarek, Sebastian Schuler, Anke Matura, Tobias A. M. Gulder
Summary: This study systematically investigated the effects of structural changes to the natural substrate sorbicillin on its activity, providing important insights into its promiscuity and facilitating the efficient preparation of unnatural sorbicillinoids. Additionally, the total syntheses of several natural and unnatural sorbicillinoids were reported.
Article
Chemistry, Multidisciplinary
Aziza R. Alrafiah, Mohammed M. Abu-Illah, Rania M. Magadmi, Aqeel Aqeel, Abdulmuttaleb Najmi, Sattam Jaddoh
Summary: Amphetamine addiction is prevalent worldwide despite its severe physical and mental consequences. This study reveals elevated levels of inflammatory biomarkers in the serum of amphetamine addicts and establishes a correlation between liver function enzymes and predictive biomarkers for Alzheimer's disease.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Tong Wang, Johanna M. Fowler, Laura Liu, Christian E. Loo, Meiqi Luo, Emily K. Schutsky, Kiara N. Berrios, Jamie E. DeNizio, Ashley Dvorak, Nick Downey, Saira Montermoso, Bianca Y. Pingul, MacLean Nasrallah, Walraj S. Gosal, Hao Wu, Rahul M. Kohli
Summary: DM-Seq is a non-destructive and direct method for profiling 5mC at single-base resolution. It employs two key DNA-modifying enzymes and enables accurate detection of 5mC. Compared to the TET-assisted pyridine borane sequencing approach, DM-Seq shows no PCR-related underdetection bias and can differentiate 5mC from 5-hydroxymethylcytosine in clinical tumor samples.
NATURE CHEMICAL BIOLOGY
(2023)
Article
Behavioral Sciences
J. L. Liu, H. L. Chen, X. Y. Chen, R. K. Cui, A. Guerrero, X. N. Zeng
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
(2017)
Article
Chemistry, Organic
Marc Puigmarti, Maria Pilar Bosch, Josep Coll, Angel Guerrero
SYNTHESIS-STUTTGART
(2017)
Review
Biochemistry & Molecular Biology
Angel Guerrero
CURRENT MEDICINAL CHEMISTRY
(2018)
Article
Gastroenterology & Hepatology
Francisco Espin Alvarez, Anna M. Rodriguez Rivero, Jordi Navines Lopez, Elena Diaz Celorio, Jordi Tarasco Palomares, Luis Felipe del Castillo Riestra, Iva Borisova, Jaime Fernandez-Llamazares, Pau Turon Dols, Joan Francesc Julian Ibanez
JOURNAL OF GASTROINTESTINAL SURGERY
(2019)
Article
Materials Science, Biomaterials
Manuel Rivas, Luis J. del Valle, Anna M. Rodriguez-Rivero, Pau Turon, Jordi Puiggali, Carlos Aleman
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2018)
Article
Agriculture, Multidisciplinary
Angel Guerrero, Victoria Elena Ramos, Sergio Lopez, Jose Maria Alvarez, Aroa Dominguez, Maria Milagro Coca-Abia, Maria Pilar Bosch, Carmen Quero
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2019)
Article
Chemistry, Multidisciplinary
Guillem Revilla-Lopez, Anna M. Rodriguez-Rivero, Luis J. del Valle, Jordi Puiggali, Pau Turon, Carlos Aleman
Article
Entomology
Aroa Dominguez, Sergio Lopez, Ana Bernabe, Angel Guerrero, Carmen Quero
Article
Biochemical Research Methods
Maria Ricart-Ortega, Alice E. Berizzi, Juanlo Catena, Fanny Malhaire, Lourdes Munoz, Carmen Serra, Guillaume Lebon, Cyril Goudet, Amadeu Llebaria
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2020)
Article
Multidisciplinary Sciences
Sergio Lopez, Aroa Dominguez, Angel Guerrero, Carmen Quero
Summary: Plant essential oils, especially thyme oil and its major constituent thymol, were evaluated for their potential as disruptants of pheromone-mediated communication and mating behavior in major pest moths. Results showed that both thyme oil and thymol altered antennal response in males and interrupted pheromone-mediated attraction, indicating their potential as pest control tools. Further research is needed to explore the specific mechanisms and effects of thyme oil and thymol on mating disruption in these species.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Monica Marro, Anna M. Rodriguez-Rivero, Cuauhtemoc Araujo-Andrade, Maria Teresa Fernandez-Figueras, Laia Perez-Roca, Eva Castella, Jordi Navines, Antonio Mariscal, Joan Francesc Julian, Pau Turon, Pablo Loza-Alvarez
Summary: In this study, the biochemical composition of breast cancer microcalcifications was investigated, revealing the natural adsorption and encapsulation of DNA within hydroxyapatite formations in breast cancer tissue. Other relevant biomolecules such as lipids, proteins, cytochrome C, and polysaccharides were also found to be encapsulated in these calcifications, representing an important breakthrough in understanding the role of hydroxyapatite in malignant tissues.
Review
Entomology
Syed Arif Hussain Rizvi, Justin George, Gadi V. P. Reddy, Xinnian Zeng, Angel Guerrero
Summary: Insect pheromones, particularly sex pheromones, have been highly successful in controlling low density pest populations and reducing pest populations with minimal impact on their natural enemies. Mass trapping and mating disruption strategies using sex pheromones have significantly decreased the use of conventional insecticides, providing sustainable and eco-friendly pest management in agricultural crops. Recent interdisciplinary research has greatly advanced our understanding of pheromone perception mechanisms and their practical applications in agricultural pest management.
Article
Biochemistry & Molecular Biology
Miguel Lopez de Heredia, Lourdes Munoz, Ciriaco Carru, Salvatore Sotgia, Angelo Zinellu, Carmen Serra, Amadeu Llebaria, Yukio Kato, Virginia Nunes
Summary: Cystinuria is a rare inherited disorder characterized by hyperexcretion of certain amino acids, leading to cystine stone formation in the urinary tract. Study analyzing levels of S-methyl-L-ergothioneine in urine showed potential as a biomarker for discriminating between different cystinuria phenotypes based on age, gender, and stone formation characteristics. Improved management of cystinuria patients could be achieved through monitoring this urinary biomarker.
Article
Multidisciplinary Sciences
Anna Duran-Corbera, Joan Font, Melissa Faria, Eva Prats, Marta Consegal, Juanlo Catena, Lourdes Munoz, Demetrio Raldua, Antonio Rodriguez-Sinovas, Amadeu Llebaria, Xavier Rovira
Summary: This study presents a new photopharmacological tool that allows the control of adrenoceptor activity through light-induced release. The tool effectively modulates various physiological systems, providing potential for the development of precise therapies in the future.
Article
Chemistry, Medicinal
Maria Ricart-Ortega, Alice E. Berizzi, Vanessa Pereira, Fanny Malhaire, Juanlo Catena, Joan Font, Xavier Gomez-Santacana, Lourdes Munoz, Charleine Zussy, Carmen Serra, Xavier Rovira, Cyril Goudet, Amadeu Llebaria
ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE
(2020)
Article
Chemistry, Organic
Faiza Diaba, Gisela Trenchs
Summary: The first violet light-mediated synthesis of gamma- and delta-lactams from N-alkenyl trichloroacetamides is reported in this paper. The reactions are conducted in tetrahydrofuran or 2-methyltetrahydrofuran as the sole solvent without catalysts or additives, under non-anhydrous conditions in an air atmosphere where the solvent serves as the radical initiator.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Feroze Hussain, Sajjad Ahmed, Ashiq Hussain Padder, Qazi Naveed Ahmed
Summary: This study reports a novel and efficient one-pot synthesis method for mixed phosphorotrithioates, which does not require supplementary additives and shows broad applicability.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Hyunjin Oh, Ikyon Kim
Summary: A new 1,2,4-triazole-pyrrolo[1,2-a]pyrazine hybrid system, 6-acylpyrrolo[1,2-a][1,2,4]triazolo[5,1-c]pyrazine, was synthesized using a catalyst-free method. This method involved sequential exposure of pyrrole-2-carbonitrile-derived substrates to DMF-DMA and acyl hydrazide, resulting in the formation of acylated pyrazine and 1,2,4-triazole rings, enabling the installation of various substituents at specific positions on the core skeleton.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Ming Yan, Si-fan Wang, Yong-po Zhang, Jin-zhong Zhao, Zhuo Tang, Guang-xun Li
Summary: Here we developed an efficient photocatalytic approach for the convenient preparation of sulfinamides. The reaction allows for the gram-scale preparation of sulfinamides and the one-pot synthesis of various sulfonyl amides.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Farzaneh Bandehali-Naeini, Zahra Tanbakouchian, Noushin Farajinia-Lehi, Nicolas Mayer, Morteza Shiri, Martin Breugst
Summary: Two tandem catalytic systems were developed for the synthesis of novel 3,4-disubstituted maleimides using the same Ugi adducts. Different maleimide structures can be synthesized using either Pd or Cu catalysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Article
Chemistry, Organic
Tanya Raghava, Anjan Chattopadhyay, Subhadeep Banerjee, Nivedita Sarkar
Summary: Amine substitution of two ortho fluorine atoms of tetrafluoroterephthalonitrile through SNAr chemistry is easily achievable. But further fluorine substitution is only possible under forcing conditions, yielding valuable fluorophores for bioimaging.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
Review
Chemistry, Organic
Anju Chadha, Santosh Kumar Padhi, Selvaraj Stella, Sowmyalakshmi Venkataraman, Thangavelu Saravanan
Summary: Alcohol dehydrogenases are enzymes that use cofactors for oxidation or reduction reactions of alcohols or carbonyl compounds. They are utilized in green chemistry and have applications in the production of pharmaceuticals. Recombinant enzymes have solved the challenge of producing purified enzymes in large quantities. Engineered alcohol dehydrogenases have been used in asymmetric synthesis in industry. Various methods have been established for regenerating expensive cofactors to make the enzymatic process more efficient and economically viable.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2024)
