Review
Pharmacology & Pharmacy
Stefano Mastrangelo, Alberto Romano, Giorgio Attina, Palma Maurizi, Antonio Ruggiero
Summary: Despite intensive treatment, the prognosis for high-risk neuroblastoma is poor. Using 131-I-metaiodobenzylguanidine (131-I-MIBG) as a treatment for neuroblastoma, especially when combined with chemotherapy at diagnosis, has proven to be highly effective. Including 131-I-MIBG in all induction regimens improves early response rates and consequently long-term survival for patients.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Oncology
Kevin Campbell, Susan Groshen, Angela C. Evans, Stephen Wilson, Aimy Sebastian, Gabriela G. Loots, Araz Marachelian, Myriam Armant, Sharmistha Pal, Daphne A. Haas-Kogan, Julie R. Park, Meaghan Granger, Katherine K. Matthay, Matthew A. Coleman, Steven G. DuBois
Summary: This study evaluated the efficacy of I-131-MIBG in combination with different radiation sensitizers on patients with relapsed neuroblastoma. The results showed significant modulation of radiation-associated biomarkers after I-131-MIBG treatment, and the extent of modulation was affected by concomitant radiation sensitizers. Blood biomarkers were associated with treatment response and toxicity.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Winniberg Alvarez-Leon, Irasema Mendieta, Evangelina Delgado-Gonzalez, Brenda Anguiano, Carmen Aceves
Summary: The research shows that molecular iodine (I-2) and cyclophosphamide (CFF) have potential therapeutic effects on neuroblastoma, inhibiting cell proliferation and enhancing sensitivity to chemotherapy. Additionally, I-2 can reduce tumor formation and decrease the expression of malignant markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Francois Sevrin, Helene Kolesnikov-Gauthier, Olivier Cougnenc, Emilie Bogart, Gudrun Schleiermacher, Frederic Courbon, Marion Gambart, Anne-Laure Giraudet, Nadege Corradini, Jean-Noel Badel, Erwann Rault, Aurore Oudoux, Marie Cecile Le Deley, Dominique Valteau-Couanet, Anne-Sophie Defachelles
Summary: This study evaluated the tandem infusions of I-131-metaiodobenzylguanidine (mIBG) and topotecan in children with relapsed/refractory metastatic neuroblastoma (NBL). The results showed that MIITOP had acceptable tolerability in this heavily pretreated population and encouraging survival rates in VHR-NBL when followed by busulfan-melphalan.
PEDIATRIC BLOOD & CANCER
(2023)
Review
Oncology
Diogo Alpuim Costa, J. Guilherme Goncalves-Nobre, Mafalda Sampaio-Alves, Nuno Guerra, Joana Arana Ribeiro, Carla Espiney Amaro
Summary: Neuroblastoma is a common cancer in infants with diverse clinical presentations and prognostic factors. Multimodal therapy approaches include chemotherapy, radiotherapy, immunotherapy, and surgical resection. Hyperbaric oxygen therapy is used as a complementary measure to overcome tumor hypoxia.
FRONTIERS IN ONCOLOGY
(2023)
Review
Immunology
Qiongyu Duan, Tianyu Hu, Qiuxia Zhu, Xueying Jin, Feng Chi, Xiaodong Chen
Summary: mRNA drugs are a promising therapy with advantages in design simplicity, short development cycle, strong target specificity, wide therapeutic field, and long-lasting effect. Delivery system technology plays a crucial role in ensuring the efficacy and safety of mRNA drugs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Seyed Mohammad Javad Mortazavi, Saba Nowroozi, Masoud Haghani, Zinat Zarrini-Monfared, Farshid Gheisari, Lembit Sihver
Summary: This paper presents a clinical trial evaluating the effect of probiotics supplementation on reducing acute side effects of radioiodine therapy in patients with differentiated thyroid cancer (DTC). The study found that probiotics were effective in reducing dry mouth and taste loss or change when administered prior to radioiodine treatment. However, they did not show benefits for other radiation-induced complications. Further large-scale clinical trials are needed to enhance our knowledge in this field.
Review
Oncology
Lok Lam Ngai, Angele Kelder, Jeroen J. W. M. Janssen, Gert J. Ossenkoppele, Jacqueline Cloos
Summary: Acute myeloid leukemia is a heterogeneous disease with poor survival, and many patient- and leukemia-specific characteristics have been shown to be valuable prognostic factors, with measurable residual disease (MRD) playing a crucial role in prognostic assessment. Multiparameter flow cytometry (MFC) based MRD measurement is currently the most commonly used method, with combinations of different techniques showing promising results in improving its prognostic value.
FRONTIERS IN ONCOLOGY
(2021)
Review
Nutrition & Dietetics
Daniela Martini, Massimiliano Tucci, James Bradfield, Antonio Di Giorgio, Mirko Marino, Cristian Del Bo', Marisa Porrini, Patrizia Riso
Summary: The study found that current food-based dietary guidelines (FBDGs) have a strong focus on factors related to health outcomes, especially in the most recent guidelines. However, considerations for environmental impact and socio-cultural aspects of diet are less frequent, especially in older guidelines.
Article
Computer Science, Hardware & Architecture
Xiaomei Wang, Juan Xiao, Guiqin Jiang
Summary: Iodine is essential for thyroid function and is used in medical treatment and diagnosis. Embedded medical devices have various applications in the medical field.
MICROPROCESSORS AND MICROSYSTEMS
(2021)
Review
Cell Biology
Marzanna Lusiak-Szelachowska, Ryszard Miedzybrodzki, Zuzanna Drulis-Kawa, Kathryn Cater, Petar Knezevic, Cyprian Winogradow, Karolina Amaro, Ewa Jonczyk-Matysiak, Beata Weber-Dabrowska, Justyna Rekas, Andrzej Gorski
Summary: Combining phages with antibiotics can enhance bacterial clearance and reduce biofilm formation, demonstrating a synergistic effect. Some studies have also shown that antibiotics can induce the production of phages by bacteria. In clinical applications, simultaneous treatment with phages and antibiotics has been found to improve treatment outcomes.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Veterinary Sciences
Suzanne Busser, Valerie J. Poirier, Carolyn Liggins, Sharyn Bray
Summary: The study aimed to evaluate the variability in actual administered dose of preprepared I-131 single unit doses for the treatment of hyperthyroidism in cats. Results showed differences in actual administered dose and residual activity compared to the prescribed dose, which should be considered when treating cats.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Review
Chemistry, Medicinal
Daniel G. Oliveira, Raquel Faria, Tiago Torres
Summary: Psoriatic arthritis is a complex disease with potential significant disability which can be better managed with the use of dual inhibitor antibodies targeting two different cytokines simultaneously. Evidence suggests that the humanized monoclonal IgG1 antibody bimekizumab, which selectively neutralizes both IL-17A and IL-17F, has shown promising outcomes in the treatment of psoriatic arthritis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Pharmacology & Pharmacy
Adhimoolam Karthikeyan, Kim Na Young, Mohammad Moniruzzaman, Anteneh Marelign Beyene, Kyoungtag Do, Senthil Kalaiselvi, Taesun Min
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the small intestine and colon, including ulcerative colitis (UC) and Crohn's disease (CD), which are major factors for the development of colon cancer. Current treatments involve synthetic drugs and monoclonal antibodies with side effects and high relapse rates. Recent studies suggest that curcumin derived from turmeric may be a potential therapeutic agent for IBD, effectively reducing clinical relapse in patients.
Article
Clinical Neurology
Tianhua Li, Chengyu Song, David S. Liebeskind, Adam A. Dmytriw, Ran Xu, Xue Wang, Jie Wang, Hengxiao Zhao, Wenbo Cao, Haozhi Gong, Chao Zhang, Xuesong Bai, Liqun Jiao
Summary: This study analyzed the progress of randomized clinical trials (RCTs) in ischemic stroke and predicted future research directions. It found that a large number of RCTs related to ischemic stroke have been conducted in recent decades, and both the number of articles and their contribution to guidelines are increasing. The study also observed a shift in research topics and regional imbalances.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
