Article
Radiology, Nuclear Medicine & Medical Imaging
Charbel Saade, Lina Karout, Khalil El Asmar, Lena Naffaa, Fadi El Merhi, Rida Salman, Alain S. Abi-Ghanem
Summary: The purpose of this study was to investigate the impact of iodine quantification on image reconstruction using a vascular-specific contrast media phantom. The results showed that there were slight differences in the performance of different iodine media for image reconstruction under different tube voltage and current, with higher visual grading characteristic in one group than the other. In qualitative image analysis, no difference was found in Cohen's kappa analysis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Todd C. Soesbe, Yin Xi, Khaled Nasr, John R. Leyendecker, Robert E. Lenkinski, Matthew A. Lewis
Summary: The study aimed to develop a dual-energy CT method for differentiating and quantifying high-Z contrast elements, evaluating the limitations based on element concentration and atomic number. Results showed that dual-energy CT can effectively differentiate and quantify high-Z elements with high accuracy. Differentiation between elements was proportional to the isoattenuating HU values.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ralf Gutjahr, Robbert C. Bakker, Feiko Tiessens, Sebastiaan A. van Nimwegen, Bernhard Schmidt, Johannes Frank Wilhelmus Nijsen
Summary: The study evaluated the feasibility of dual-energy CT-based material decomposition to detect and quantify holmium microspheres in phantoms and rabbits. Results showed that spectral material decomposition using different tube voltage combinations allowed accurate quantifications for concentrations down to 0.125 mg/mL holmium.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Leening P. Liu, Nadav Shapira, Andrew A. Chen, Russell T. Shinohara, Pooyan Sahbaee, Mitchell Schnall, Harold Litt, Peter B. Noel
Summary: This study compared the image characteristics of a first-generation dual-source photon-counting computed tomography (PCCT) and a dual-source dual-energy CT (DECT) scanner at ultra-low radiation dose levels. The results showed that PCCT had high precision in Hounsfield unit (HU) measurements at various radiation dose levels, outperforming DECT at low doses and significantly reducing electronic background noise.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dominik Deniffel, Andreas Sauter, Alexander Fingerle, Ernst J. Rummeny, Marcus R. Makowski, Daniela Pfeiffer
Summary: The study suggests that DE-CT-derived IC and Z(eff) in addition to conventional HU values can be clinically useful for discriminating between primary lung cancer and pulmonary metastases. Combining these imaging parameters may improve the accuracy of differentiation between the two types of tumors.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Josua A. A. Decker, Jim O'Doherty, U. Joseph Schoepf, Thomas M. M. Todoran, Gilberto J. J. Aquino, Verena Brandt, Dhiraj Baruah, Nicola Fink, Emese Zsarnoczay, Thomas Flohr, Bernhard Schmidt, Thomas Allmendinger, Franka Risch, Akos Varga-Szemes, Tilman Emrich
Summary: This study assessed the impact of scan modes and reconstruction kernels using a novel dual-source photon-counting detector CT (PCD-CT) on the lumen visibility and sharpness of different stent sizes. The results showed that the UHR acquisition mode and sharp reconstruction kernels significantly improved the in-stent lumen visibility and sharpness, especially for smaller stent sizes.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Simon Lennartz, Anushri Parakh, Jinjin Cao, David Zopfs, Nils Grosse Hokamp, Avinash Kambadakone
Summary: The study investigates the inter-scan and inter-scanner variation of iodine concentration and attenuation in different DECT scanners, finding that the iodine concentration shows higher variation compared to attenuation values. This variation depends on the scanner pairs and organs assessed, highlighting the importance of acknowledging these differences in clinical and scientific DECT applications.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Cristobal Martinez, Claudia de Molina, Manuel Desco, Monica Abella
Summary: This study optimized the calibration protocol through simulations and evaluated the placement effects of the calibration phantom's materials and sizes in the system. The proposed method, based on a simple and cost-effective phantom, provides appropriate separation of the spine and identification of nodules as small as 6 mm in size.
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexander Hertel, Hishan Tharmaseelan, Lukas T. Rotkopf, Dominik Noerenberg, Philipp Riffel, Konstantin Nikolaou, Jakob Weiss, Fabian Bamberg, Stefan O. Schoenberg, Matthias F. Froelich, Isabelle Ayx
Summary: This study aims to evaluate the stability of radiomics analysis using photon-counting detector CT (PCCT) on phantom scans. PCCT scans were performed on organic phantoms consisting of apples, kiwis, limes, and onions to extract radiomics parameters. Statistical analysis showed that most parameters have good stability, and identified important features for the application of radiomics analysis in clinical practice.
EUROPEAN RADIOLOGY
(2023)
Article
Physics, Multidisciplinary
Zhi-Li Wang, Rui-Cheng Zhou, Li-Ming Zhao, Kun Ren, Wen Xu, Bo Liu, Heng Chen
Summary: This study conducts a coherence analysis to investigate the influence of the source grating on fringe visibility in dual phase grating interferometry. The results can serve as general guidelines for designing and optimizing dual phase grating x-ray interferometers.
Article
Radiology, Nuclear Medicine & Medical Imaging
David Zopfs, Josefine Graffe, Robert Peter Reimer, Sebastian Schaefer, Thorsten Persigehl, David Maintz, Jan Borggrefe, Stefan Haneder, Simon Lennartz, Nils Grosse Hokamp
Summary: Dual-energy computed tomography allows accurate quantification of iodine, and this study provides guidance on iodine concentration in abdominal organs and anatomical landmarks based on a large cohort without radiological tumor burden.
EUROPEAN RADIOLOGY
(2021)
Article
Multidisciplinary Sciences
Guibin Zan, Sheraz Gul, Jin Zhang, Wei Zhao, Sylvia Lewis, David J. Vine, Yijin Liu, Piero Pianetta, Wenbing Yun
Summary: The study developed a TLI system with MAAST source, offering high-resolution and tri-contrast X-ray imaging for biomedical applications. Tomography of Drum fish tooth revealed valuable complementary structural information using this method.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andre Euler, Tristan Nowak, Brian Bucher, Matthias Eberhard, Bernhard Schmidt, Thomas G. Flohr, Diana Frey, Oliver Distler, Hatem Alkadhi
Summary: The study assessed the accuracy and impact of different sizes and tube voltages on bone mineral density (BMD) using a photon-counting detector CT system in an ex vivo animal spine. Results showed that neither size nor tube voltage had significant effect on BMD measurements.
INVESTIGATIVE RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Torsten Diekhoff, Michael Scheel, Wiebke Kress, Bernd Hamm, Paul Jahnke
Summary: This study aimed to determine optimal tube current settings for dual-energy computed tomography (DECT) imaging of the neck. Results showed that optimal DECT scanning parameters can achieve 120% of the radiation exposure with around 80% of the image quality, but optimal tube current settings depend on the desired reconstruction.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yannick Scharll, Sofia Letrari, Gregor Laimer, Peter Schullian, Reto Bale
Summary: This study evaluated the targeting accuracy of stereotactic punctures using a hybrid robotic device and optical tracking. The results demonstrated that this method achieved high accuracy and feasibility in puncturing a phantom.
EUROPEAN RADIOLOGY
(2022)
Article
Computer Science, Interdisciplinary Applications
Thorsten Sellerer, Korbinian Mechlem, Ruizhi Tang, Kirsten Alexandra Taphorn, Franz Pfeiffer, Julia Herzen
Summary: Dual-energy X-ray imaging and X-ray dark-field imaging are both promising techniques in the field of medical imaging, with the former providing material-specific information and the latter facing challenges in microstructure decomposition. By applying the dual-energy concept to X-ray dark-field imaging, it is possible to address the issue of microstructure decomposition more effectively.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2021)
Article
Multidisciplinary Sciences
Marios Georgiadis, Aileen Schroeter, Zirui Gao, Manuel Guizar-Sicairos, Marianne Liebi, Christoph Leuze, Jennifer A. McNab, Aleezah Balolia, Jelle Veraart, Benjamin Ades-Aron, Sunglyoung Kim, Timothy Shepherd, Choong H. Lee, Piotr Walczak, Shirish Chodankar, Phillip DiGiacomo, Gergely David, Mark Augath, Valerio Zerbi, Stefan Sommer, Ivan Rajkovic, Thomas Weiss, Oliver Bunk, Lin Yang, Jiangyang Zhang, Dmitry S. Novikov, Michael Zeineh, Els Fieremans, Markus Rudin
Summary: This study demonstrates the use of small-angle X-ray scattering tensor tomography (SAXS-TT) to quantify myelin levels, nanostructural integrity, and axon orientations in nervous tissue. The method was successfully applied to whole mouse brain, mouse spinal cord, and human white and gray matter samples, showcasing its potential in studying myelination in development, aging, disease, and treatment.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Cinzia Giannini, Liberato De Caro, Alberta Terzi, Luca Fusaro, Davide Altamura, Ana Diaz, Rocco Lassandro, Francesca Boccafoschi, Oliver Bunk
Summary: Diseases like diabetes can lead to high sugar concentrations in the body, promoting the formation of glycoconjugates such as glycated collagen. Glucose and galactose produce similar changes in collagen, while ribose is faster in glycation and has qualitatively different effects on collagen structure.
Article
Nanoscience & Nanotechnology
Thomas Mortelmans, Dimitrios Kazazis, Celestino Padeste, Philipp Berger, Xiaodan Li, Yasin Ekinci
Summary: The development of a three-dimensional nanofluidic device for rapid and multiplexed detection of viral antibodies is presented. The device is made from poly(methyl methacrylate) and utilizes nanoscale topography variations for particle immobilization and trapping. It can be used for specific and sensitive multiplexed detection of serological antibodies against different viral proteins. The device's applications can be extended to detect various diseases simultaneously.
ACS APPLIED NANO MATERIALS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Robert C. Power, Amanda G. Henry, Julian Moosmann, Felix Beckmann, Heiko Temming, Anthony Roberts, Adeline Le Cabec
Summary: Research on dental calculus can provide insights into diet, health, and environmental pollution. The use of PPC-SR-mu CT technique allows for non-destructive examination of its internal organization, revealing important features and the high heterogeneity and variability within calculus.
JOURNAL OF MEDICAL IMAGING
(2022)
Article
Chemistry, Multidisciplinary
Kirsten Taphorn, Madleen Busse, Johannes Brantl, Benedikt Guenther, Ana Diaz, Mirko Holler, Martin Dierolf, Doris Mayr, Franz Pfeiffer, Julia Herzen
Summary: Quantitative near-field ptychographic X-ray computed tomography is used to assess the location of X-ray stains within cells and identify intracellular structures. The method can be applied to study the distribution of different X-ray stains and compare them to unstained samples. The nanoscopic stain concentrations obtained quantitatively correspond well with dual-energy micro computed tomography measurements.
Article
Materials Science, Multidisciplinary
Kilian Maria Arthur Mueller, Andreas Unterrainer, Diana Marcela Rojas-Gonzalez, Elena De-Juan-Pardo, Marian Sebastian Willner, Julia Herzen, Petra Mela
Summary: Melt electrowriting (MEW) enables precise digital fabrication of scaffold architectures by creating micron-sized fibers. However, charge accumulation and fiber bridging disrupt the desired pattern and make controlled printing difficult. To address this, a design strategy is developed to introduce controlled microporosity directly in MEW scaffolds by creating bridging-free parallel fibers that are angularly shifted from layer to layer and starting at a random point. This allows for the decoupling of pore size from fiber diameter and enables customization of mechanical properties.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Instruments & Instrumentation
Tilman Donath, Dubravka Sisak Jung, Max Burian, Valeria Radicci, Pietro Zambon, Andrew N. Fitch, Catherine Dejoie, Bingbing Zhang, Marie Ruat, Michael Hanfland, Cameron M. Kewish, Grant A. van Riessen, Denys Naumenko, Heinz Amenitsch, Gleb Bourenkov, Gerard Bricogne, Ashwin Chari, Clemens Schulze-Briese
Summary: This paper facilitates the optimal use of EIGER2 detectors by providing theory and practical advice on their design, technical specifications, operating modes, and new acquisition features. It also presents examples of their implementation and application at several synchrotron sources, demonstrating their advantages in high-throughput data collection, X-ray diffraction, and optical experiments.
JOURNAL OF SYNCHROTRON RADIATION
(2023)
Article
Materials Science, Multidisciplinary
Luisa-Marie Heine, Andreas Heider, Roland Gauch, Mathias Schlett, Marc Hummel, Christoph Spurk, Felix Beckmann, Julian Moosmann
Summary: Laser beam welding is an important joining process for copper components in the electrical powertrain. However, welding copper with laser beams is challenging due to its high heat conductivity and low absorptivity. Recent research has shown that using blue lasers with a wavelength of 450 nm can improve the welding process and reduce weld defects. Additionally, investigations using a blue diode laser have provided insights into the material behavior during welding, particularly in relation to melt pool dynamics and capillary dynamics.
JOURNAL OF LASER APPLICATIONS
(2023)
Article
Chemistry, Physical
Alberta Terzi, Nunzia Gallo, Teresa Sibillano, Davide Altamura, Annalia Masi, Rocco Lassandro, Alessandro Sannino, Luca Salvatore, Oliver Bunk, Cinzia Giannini, Liberato De Caro
Summary: Type I collagen scaffold is widely used in tissue engineering and medical applications. The hierarchical structure and multiscale integrity of collagen from different animal sources were studied in relation to tissue-specific regeneration and scaffold design. The structural organization of collagen in tendons was investigated using X-ray scattering techniques and thermal and load-bearing tests.
Article
Chemistry, Multidisciplinary
Melissa Carrillo, Thomas J. Mason, Agnieszka Karpik, Isabelle Martiel, Michal W. Kepa, Katherine E. McAuley, John H. Beale, Celestino Padeste
Summary: Fixed targets are commonly used in serial crystallography, and a new polymer-based fixed target called MISP chip has been developed, which has precise cavities and fiducial markers. MISP chips have low X-ray background and optical transparency. They are best optimized for crystals around 25 μm in size, but can still collect high-quality data from crystals as small as 5 μm.
Letter
Oncology
Carlo Morasso, Renzo Vanna, Francesca Piccotti, Lidia Frizzi, Marta Truffi, Sara Albasini, Camelia Borca, Thomas Huthwelker, Laura Villani, Oliver Bunk, Cinzia Giannini, Fabio Corsi
CANCER COMMUNICATIONS
(2023)
Proceedings Paper
Optics
Mirko Riedel, Joerg U. Hammel, Julian P. Moosmann, Felix Beckmann, Florian L. Schwarzenberg, Paul Schuetz, Stephan Henne, Clemens Wulfing, Madleen Busse, Julia Herzen
Summary: Previously, we designed a new quantitative phase-contrast setup based on Talbot array illuminators, which can achieve a spatial resolution level comparable to propagation-based imaging. In this work, we focus on the progress of bringing this setup into user operation and collaborate with INI-Research to investigate the vascular system of mouse lymph nodes, demonstrating the stability and performance of the setup.
DEVELOPMENTS IN X-RAY TOMOGRAPHY XIV
(2022)
Proceedings Paper
Optics
Bashir Kazimi, Philipp Heuser, Frank Schluenzen, Hanna Cwieka, Diana Krueger, Berit Zeller-Plumhoff, Florian Wieland, Joerg U. Hammel, Felix Beckmann, Julian Moosmann
Summary: In this study, an active learning approach for semantic segmentation of tomography data using a guided and interactive framework is proposed, and different acquisition functions for selecting images to be annotated in the iterative process are evaluated.
DEVELOPMENTS IN X-RAY TOMOGRAPHY XIV
(2022)
Article
Environmental Sciences
Peter A. Alpert, Anthony Boucly, Shuo Yang, Huanyu Yang, Kevin Kilchhofer, Zhaochu Luo, Celestino Padeste, Simone Finizio, Markus Ammann, Benjamin Watts
Summary: Ice nucleation is a highly uncertain microphysical process that occurs in various ways on different types of particles. This study investigates the heterogeneous ice nucleation process and its relationship with different materials and environmental conditions.
ENVIRONMENTAL SCIENCE-ATMOSPHERES
(2022)
