Journal
OPTICS COMMUNICATIONS
Volume 283, Issue 9, Pages 1987-1992Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.optcom.2009.12.046
Keywords
Integrated optics; Flow cytometry; Optical losses; Collimation of light
Categories
Funding
- RMST [EP/E016774/1]
- EPSRC [EP/E016774/1] Funding Source: UKRI
- NERC [noc010003, noc010013] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/E016774/1] Funding Source: researchfish
- Natural Environment Research Council [noc010013, noc010003] Funding Source: researchfish
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Flow cytometry is widely used for analyzing micro-particles such as cells and bacteria. Microfabricated flow cytometers promise reduced instrument size and cost with increased robustness and have application in medicine, life sciences and environmental metrology. Further miniaturisation and robustness can be achieved if integrated optics are used instead of traditional free space optics. We present designs simulation and experimental characterisation of integrated optics for a microfabricated cytometer made from SU-8 resin on a glass substrate. The optics constructed from combinations of optical fibres (positioned with microgrooves), waveguides, and microlenses enable analysis of scattered light and fluorescence from particles positioned near the centre of a microchannel using one dimensional sheath flow. Four different methods for directing the incident light onto the particles are examined and the optimum design discussed. (C) 2009 Elsevier B.V. All rights reserved.
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