Article
Ophthalmology
Zhi Wei Lim, Miao-Li Chee, Sing Hui Lim, Sahil Thakur, Shivani Majithia, Zhi Da Soh, Zhen Ling Teo, Tyler Hyungtaek Rim, Charumathi Sabanayagam, Yih-Chung Tham, Ching-Yu Cheng
Summary: This study evaluated the normative profiles for neuroretinal rim area in a multiethnic Asian population. The results showed that Indian eyes had significantly smaller neuroretinal rim areas compared to Chinese and Malays, and these differences were associated with age, gender, and axial length.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Sooyeon Choe, Mirinae Jang, Young Kook Kim, Ki Ho Park, Jin Wook Jeoung
Summary: This study investigated the diagnostic utility of three-dimensional neuroretinal rim thickness (3D-NRRT) in distinguishing patients with superior segmental optic nerve hypoplasia (SSOH) from normal-tension glaucoma (NTG). The results showed that 3D-NRRT can be useful in differentiating SSOH from NTG, particularly in certain clock-hour sectors. However, retinal nerve fiber layer thickness (RNFLT) may be more appropriate for distinguishing the two conditions in other sectors.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Ji-Ah Kim, Eun Ji Lee, Tae-Woo Kim, Se Joon Woo
Summary: This study found differences in the topographic morphology of the optic nerve head between eyes with normal-tension glaucoma and central retinal artery occlusion, suggesting different mechanisms of optic nerve head damage in these two conditions.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Andrew K. C. Lam, H. C. Lai, Y. K. Sung, W. H. Lam, C. M. Tiu
Summary: This study investigated the success rate of NRR segmentation in myopic eyes using Cirrus built-in software and determined the number of acquisitions required to identify NRR thinning. The results showed that there were segmentation errors in some scans, and these errors occurred more frequently in the inferior-temporal and superior meridians. Manual inspection of Cirrus segmentation lines is necessary for accurate NRR thickness measurement.
SCIENTIFIC REPORTS
(2023)
Article
Ophthalmology
Nimesh B. Patel, Louvenia Carter-Dawson, Laura J. Frishman
Summary: This study found that the optic nerve head's response to transient changes in intraocular pressure is associated with features of the optic nerve head and surrounding tissues. The neural rim properties at baseline and the extent of axial elongation are associated with the severity of glaucomatous loss in the nonhuman primate model.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Xiaolin Xie, Binyao Chen, Jianling Yang, Chukai Huang, Kunliang Qiu, Ce Zheng, Mingzhi Zhang
Summary: This study provided normative SD-OCT data on the pRNFL grayscale value profile in nonglaucomatous eyes. Lower average pRNFL grayscale value was independently correlated to older age, longer axial length, lower RPE grayscale value, and lower ImageQ. These determinants should be considered when interpreting pRNFL grayscale value in glaucoma assessment.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Ya-Hui Wei, Yu Cai, Bonnie N. K. Choy, Bai-Bing Li, Ruo-Shi Li, Chen Xing, Xia Wang, Tian Tian, Yuan Fang, Mei Li, Ying-Zi Pan
Summary: NTG patients showed higher DCR values compared to controls, with some DCRs being negatively correlated with CCT and IOP, while others were positively correlated with these factors. The cornea was more deformable in NTG compared to HTG or controls, indicating a potential biomechanical mechanism underlying glaucomatous optic neuropathy in NTG patients.
CHINESE MEDICAL JOURNAL
(2021)
Article
Engineering, Biomedical
Ambika Sharma, Monika Agrawal, Sumantra Dutta Roy, Vivek Gupta, Praveen Vashisht, Talvir Sidhu
Summary: This study proposes a fusion method combining deep features and clinically significant statistical features to detect Peripapillary Atrophy, showing promising results with average sensitivity, specificity, and accuracy values of 95.83%. The method outperforms existing techniques and achieves the best accuracy reported in the literature on large and varied datasets.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2021)
Article
Ophthalmology
Alessandro A. Jammal, Felipe A. Medeiros
Summary: This study evaluated the impact of corneal hysteresis (CH) on progressive neuroretinal rim loss in glaucoma. The findings indicated that lower CH measurements were associated with faster loss of the neuroretinal rim.
OPHTHALMOLOGY GLAUCOMA
(2022)
Article
Ophthalmology
Poemen PuiMan Chan, Ruyue Shen, Carol Y. Cheung, Anni Ling, Marco Yu, Chi-Pui Pang, Clement C. Tham
Summary: This study compared the rates of peripapillary vessel density (pVD) loss and retinal nerve fibre layer (RNFL) thinning in normal tension glaucoma (NTG) and primary angle closure glaucoma (PACG). The results showed that NTG eyes had more extensive and faster pVD loss compared to PACG eyes, while the rates of RNFL thinning did not differ significantly between the two groups. Baseline global pVD and mean deviation (MD) were independently associated with the rate of pVD loss in NTG.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Yong Woo Kim, Glen P. Sharpe, Donna M. Hutchison, Paul E. Rafuse, Lesya M. Shuba, Marcelo T. Nicolela, Jayme R. Vianna, Balwantray C. Chauhan
Summary: The impact of glaucoma severity on the rates of change in minimum rim width (MRW), peripapillary retinal nerve fiber layer (RNFL), and macular ganglion cell layer (GCL) thickness was studied. The study found that glaucoma patients had a faster rate of change in GCL thickness compared to healthy subjects, while there were no significant differences in the rates of change in MRW and RNFL. Age and visual field mean deviation (MD) also had some impact on the rates of change.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Eun Jung Lee, Hyun Joo Kee, Kyung-Ah Park, Jong Chul Han, Changwon Kee
Summary: The study identified the presence of choroidal microvascular dropout (MvD) in both nonarteritic anterior ischemic optic neuropathy (NAION) and open-angle glaucoma (OAG) eyes, with a higher frequency in NAION eyes and larger areas of MvD and RNFL defects. The distribution of MvD showed a strong correspondence to superimposition areas of beta PPA and RNFL defects, highlighting a potential mechanistic relationship between these factors.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Ali Riza Cenk Celebi, Elli A. Park, Alice Chandra Verticchio Vercellin, Edem Tsikata, Ramon Lee, Eric Shieh, Hussein Antar, Madeline Freeman, Jing Zhang, Christian Que, Huseyin Simavli, Michael McClurkin, Rong Guo, Tobias Elze, Johannes F. de Boer, Teresa C. Chen
Summary: This study evaluated the structure-function relationship in glaucoma using HVF perimetry and a three-dimensional neuroretinal rim parameter derived from SD-OCT volume scans. The results showed that MDB neuroretinal rim thickness has a strong correlation with visual function, highlighting the potential for improving in vivo imaging in glaucoma using 3D OCT algorithms.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Abinaya Priya Venkataraman, Josefine Andersson, Lina Fivelsdal, Maria Nilsson, Alberto Dominguez-Vicent
Summary: The repeatability of peripapillary retinal nerve fiber layer measurements in healthy eyes varied depending on scan direction and sectors, with vertical scans providing more homogeneous repeatability across sectors. Horizontal sectors showed better repeatability with 512 A-scans x 96 B-scans and 512 A-scans x 128 B-scans, while vertical sectors had better repeatability with 512 A-scans x 96 B-scans and 512 A-scans x 128 B-scans, showing more symmetric repeatability among sectors.
Article
Multidisciplinary Sciences
Jihei Sara Lee, Sungeun Park, Sung Sik Kim, Chan Yun Kim, Wungrak Choi, Sang Yeop Lee, Hyoung Won Bae
Summary: This study aimed to investigate the presence of peripapillary choroidal microvasculature dropout (MvD) in eyes with optic neuritis and its association with longitudinal changes in retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIP) thicknesses. Optical coherence tomography angiography (OCTA) was used to evaluate 48 eyes with optic neuritis, and MvD was found in 41.7% of the eyes. MvD was most commonly found in the temporal quadrant, and eyes with MvD had significantly lower peripapillary retinal vessel density in the temporal quadrant. At 6 months follow-up, eyes with MvD showed thinner GCIP in multiple sectors. The presence of MvD was significantly associated with thinner global GCIP thickness at 6 months follow-up.
Article
Ophthalmology
Balwantray C. Chauhan, Jayme R. Vianna, Glen P. Sharpe, Shaban Demirel, Christopher A. Girkin, Christian Y. Mardin, Alexander F. Scheuerle, Claude F. Burgoyne
Article
Ophthalmology
Hongli Yang, Haomin Luo, Christy Hardin, Yaxing Wang, Jin Wook Jeoung, Cindy Albert, Jayme R. Vianna, Glen P. Sharpe, Juan Reynaud, Shaban Demirel, Steven L. Mansberger, Brad Fortune, Marcelo Nicolela, Stuart K. Gardiner, Balwantray C. Chauhan, Claude F. Burgoyne
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Corey A. Smith, Michael E. West, Glen P. Sharpe, Donna M. Hutchison, Lesya M. Shuba, Paul E. Rafuse, Marcelo T. Nicolela, Balwantray C. Chauhan
BRITISH JOURNAL OF OPHTHALMOLOGY
(2020)
Review
Ophthalmology
Jayant Iyer, Jayme R. Vianna, Balwantray C. Chauhan, Harry A. Quigley
CURRENT OPINION IN OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Inas F. Aboobakar, Jiangxia Wang, Balwantray C. Chauhan, Michael Boland, David S. Friedman, Pradeep Y. Ramulu, Jithin Yohannan
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2020)
Article
Ophthalmology
Ya Xing Wang, Hongli Yang, Haomin Luo, Seung Woo Hong, Stuart K. Gardiner, Jin Wook Jeoung, Christy Hardin, Glen P. Sharpe, Kouros Nouri-Mahdavi, Joseph Caprioli, Shaban Demirel, Christopher A. Girkin, Jeffrey M. Liebmann, Christian Y. Mardin, Harry A. Quigley, Alexander F. Scheuerle, Brad Fortune, Balwantray C. Chauhan, Claude F. Burgoyne
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Jin Wook Jeoung, Hongli Yang, Stuart Gardiner, Ya Xing Wang, Seungwoo Hong, Brad Fortune, Michael J. A. Girard, Christy Hardin, Ping Wei, Marcelo Nicolela, Jayme R. Vianna, Balwantray C. Chauhan, Claude F. Burgoyne
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Kazunori Hirasawa, Corey A. Smith, Michael E. West, Glen P. Sharpe, Lesya M. Shuba, Paul E. Rafuse, Marcelo T. Nicolela, Jayme R. Vianna, Balwantray C. Chauhan
Summary: This study aimed to identify characteristics of patients with early open-angle glaucoma showing greater macular perfusion density (PD) loss compared to macular ganglion cell layer (GCL) thickness loss. Results indicated that patients with more PD loss were associated with lower signal strength in OCT and OCT angiography, thicker retinal nerve fiber layer thickness, and female sex. Less than one-third of patients with early glaucoma experienced more perfusion loss compared to conventional structural loss in the macula.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Takeshi Yabana, Michele L. Hooper, Spring R. Farrell, Balwantray C. Chauhan
Summary: The study evaluated the specificity of genetically encoded calcium sensor GCaMP3 expression in retinal ganglion cells (RGCs) of transgenic mice. It was found that the numbers of GCaMP3+ and RBPMS+ cells decreased significantly after optic nerve transection (ONT), while the number of ChAT+ cells remained unchanged.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Ophthalmology
Michael E. West, Glen P. Sharpe, Donna M. Hutchison, Paul E. Rafuse, Lesya M. Shuba, Marcelo T. Nicolela, Jayme R. Vianna, Balwantray C. Chauhan
Summary: In the study comparing the 24-2 and 10-2 tests in glaucoma patients with early damage, it was found that the AUC values were not significantly different between the two tests, but the sensitivity of the 24-2 test was higher at matched specificity. The repeatability of test results during follow-up ranged from 55% to 70%.
Article
Ophthalmology
Yong Woo Kim, Glen P. Sharpe, Donna M. Hutchison, Paul E. Rafuse, Lesya M. Shuba, Marcelo T. Nicolela, Jayme R. Vianna, Balwantray C. Chauhan
Summary: The impact of glaucoma severity on the rates of change in minimum rim width (MRW), peripapillary retinal nerve fiber layer (RNFL), and macular ganglion cell layer (GCL) thickness was studied. The study found that glaucoma patients had a faster rate of change in GCL thickness compared to healthy subjects, while there were no significant differences in the rates of change in MRW and RNFL. Age and visual field mean deviation (MD) also had some impact on the rates of change.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Ophthalmology
Johnny Di Pierdomenico, Delaney C. M. Henderson, Sara Giammaria, Victoria L. Smith, Alienor J. Jamet, Corey A. Smith, Michele L. Hooper, Balwantray C. Chauhan
Summary: Age and intraocular pressure (IOP) are the two most important risk factors for the development and progression of open-angle glaucoma. This paper provides a review on the evaluation of retinal ganglion cell loss in experimental glaucoma (EG) using serial in vivo imaging. The study compares the effects of elevated IOP on ganglion cell complex thickness and individual RGC dendritic morphology changes in adult and old mice, highlighting the potential of single RGC imaging for understanding RGC loss.
PROGRESS IN RETINAL AND EYE RESEARCH
(2022)
Article
Ophthalmology
Rami Darwich, Faisal Jarrar, Mustafa Syed, Glen P. Sharpe, Balwantray C. Chauhan
Summary: Both spectral-domain (SD) and swept-source (SS) optical coherence tomography (OCT) showed similar visualization of optic nerve head (ONH) structures, with a tendency for higher visualization rates with SS-OCT.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Letter
Ophthalmology
Brooklyn Rawlyk, Balwantray C. Chauhan
CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE
(2021)
Article
Ophthalmology
Dong An, Philip House, Christopher Barry, Andrew Turpin, Allison M. McKendrick, Balwantray C. Chauhan, Siobhan Manners, Stuart Graham, Dao-Yi Yu, William H. Morgan
OPHTHALMOLOGY GLAUCOMA
(2020)