Review
Ophthalmology
Xinyuan Zhang, Connie Zhi Fong Lim, Jay Chhablani, Yew Meng Wong
Summary: Central serous chorioretinopathy (CSCR) is a disease characterized by serous detachment of the neural retina and/or retinal pigment epithelium (RPE) in the posterior pole. Recent studies have proposed venous overload choroidopathy as a potential cause of CSCR, with specific morphological and pathological characteristics. Genetic variants play a role in the pathophysiology of CSCR. Various imaging platforms have been used for diagnosis and management of CSCR. Half-dose photodynamic therapy (PDT) is the main treatment, but the use of oral eplerenone remains controversial. The underlying pathogenesis of CSCR is still not fully understood. Investigations suggest a possible link between CSCR and polypoidal choroidal vasculopathy (PCV). This review provides an overview of the pathogenesis, diagnosis, imaging features, and management strategies for CSCR, highlighting recent findings.
Article
Ophthalmology
Maciej Gawecki, Andrzej Grzybowski, Anna Swiech
Summary: Central serous chorioretinopathy (CSCR) is a common disease that can cause visual impairment. This study aimed to identify characteristic biometric parameters for CSCR. The results showed that CSCR patients had increased choroidal thickness, and longer disease duration was associated with decreased retinal thickness.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Chemistry, Medicinal
Manuel Vilela, Carolina Mengue
Summary: Currently, there is no universally adopted classification system for central serous chorioretinopathy due to unknown aspects related to pathogenesis and clinical spectrum and evolution. The best option may be to aggregate multimodal pieces of information alongside temporal and phenotypic characteristics.
Article
Ophthalmology
Sumit Randhir Singh, Claudio Iovino, Dinah Zur, Dua Masarwa, Matias Iglicki, Ramkailash Gujar, Marco Lupidi, Dmitrii S. Maltsev, Elodie Bousquet, Mehdi Bencheqroun, Francesca Amoroso, Luiz H. Lima, Srikanta Kumar Padhy, Vishal Govindahari, Khushboo Chandra, Eric H. Souied, Francisco J. Rodriguez, Laura A. Daza, Hernan A. Rios, Carlo Cagini, Enrico Peiretti, Francine Behar-Cohen, Jay Chhablani
Summary: This study aimed to identify the factors predicting the visual and anatomical outcomes in eyes with central serous chorioretinopathy (CSCR). The results showed that factors such as central macular thickness (CMT), subfoveal choroidal thickness (SFCT), linear extent of ellipsoid zone (EZ), and interdigitation zone damage on optical coherence tomography (OCT) were predictive of anatomical and visual outcomes in CSCR eyes.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Ophthalmology
Adrian T. T. Fung, Yi Yang, Andrew W. W. Kam
Summary: Central serous chorioretinopathy (CSC) is a common non-surgical retinopathy associated with fluid leakage. The exact cause is not fully understood, but changes in the choroid, sclera, and RPE have been observed. CSC can be divided into acute, chronic, and recurrent subtypes, and recent classifications include simple and complex based on RPE changes. Multimodal imaging is useful in the diagnosis and management of CSC and its complications. Treatment options include laser, medications, intravitreal therapy, and surgery, with argon laser and photodynamic therapy having the strongest evidence.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Medicine, General & Internal
Takeshi Kimura, Takashi Araki, Yuki Komuku, Hisashi Iwami, Fumi Gomi
Summary: The study found that some CSC patients had lower blood serotonin concentrations, which were associated with increased fluorescein leakage points, recurrence of subretinal fluids, and failure to significantly improve BCVA during follow-up.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
N. A. O. Y. A. Imanaga, N. O. B. U. H. I. R. O. Terao, S. H. O. T. A. Sawaguchi, T. A. M. A. K. Tamashiro, S. O. R. A. K. O. Wakugawa, Y. U. K. I. H. I. D. E. Yamauchi, H. I. D. E. K. I. Koizumi
Summary: This retrospective, cross-sectional study aimed to investigate the clinical factors related to the presence of loculation of fluid (LOF) in central serous chorioretinopathy (CSC). The study found that a thicker choroid and thicker sclera were associated with the presence of LOF in CSC. Age, sex, subfoveal choroidal thickness (SCT), and scleral thickness were also found to be related to LOF.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Endocrinology & Metabolism
Shanshan Yu, Kaixuan Cui, Peiqi Wu, Benjuan Wu, Xi Lu, Rong Huang, Xiaoyu Tang, Jianqiang Lin, Boyu Yang, Jinfeng Zhao, Qingjing He, Xiaoling Liang, Yue Xu
Summary: This study suggests that melatonin could be a promising and safe therapeutic strategy for central serous chorioretinopathy (CSC) patients. Melatonin administration inhibited choroidal thickening, vasodilation, and inflammation in an experimental CSC rat model.
JOURNAL OF PINEAL RESEARCH
(2022)
Article
Ophthalmology
Felice Cardillo Piccolino, Daniela Fruttini, Chiara Eandi, Massimo Nicolo, Cesare Mariotti, Silvia Tito, Marco Lupidi
Summary: This study demonstrates a significant association between frequent vigorous physical activity and active central serous chorioretinopathy (CSCR), indicating it may be a risk factor for CSCR.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Young Ho Kim, Edward Kang, Jaeryung Oh
Summary: This study used en-face optical coherence tomography to investigate the location of pigment epithelial detachment (PED) in relation to various anatomical landmarks in the eye. The results suggest that the development of complicated PED with choroidal neovascularisation (CNV) can be attributed to both choroidal vascular abnormalities and retinal pigment epithelial insufficiency.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Ai Kido, Masahiro Miyake, Hiroshi Tamura, Shusuke Hiragi, Takeshi Kimura, Shosuke Ohtera, Ayako Takahashi, Sotaro Ooto, Koji Kawakami, Tomohiro Kuroda, Akitaka Tsujikawa
Summary: This study aimed to clarify the epidemiological background of central serous chorioretinopathy (CSC) using a nationwide health insurance claims database in Japan. Over an 8-year period, CSC was found to have a higher incidence rate in men, and most newly diagnosed patients did not receive major treatment. The results provide important population-based evidence for understanding the pathogenesis and mechanisms of CSC.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Joost Brinks, Femke M. van Haalen, Thomas J. van Rijssen, Nienke R. Biermasz, Onno C. Meijer, Alberto M. Pereira, Camiel J. F. Boon, Elon H. C. van Dijk
Summary: The study found that ocular abnormalities resembling (subclinical) central serous chorioretinopathy (CSC) are more common than previously thought in patients with active Cushing's syndrome (CS), and may even exist in patients without visual complaints. Early treatment may be necessary to prevent vision loss in these patients.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Yousif Subhi, Josefine Windfeld-Mathiasen, Anna Horwitz, Henrik Horwitz
Summary: This study explores the risk of central serous chorioretinopathy (CSC) in male androgen abusers and shows that they are not at an increased risk of CSC. It suggests that if androgens play a role in the pathophysiology of CSC, their role may be subtle.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Medicine, General & Internal
Leonie F. Keidel, Benedikt Schworm, Julian Langer, Nikolaus Luft, Tina Herold, Felix Hagenau, Julian E. Klaas, Siegfried G. Priglinger, Jakob Siedlecki
Summary: This study investigates the association between anterior scleral thickness (AST) and pachychoroid disorders. The results show that patients with central serous chorioretinopathy (CSC) and pachychoroid neovasculopathy (PNV) have a significantly thicker anterior sclera compared to the control group. This suggests that scleral thickness may contribute to the development of pachychoroid phenotypes by increasing venous overload.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
En-Zhong Jin, Tian-Qi Li, Chi Ren, Li Zhu, Wei Du, Jin-Feng Qu, Yu-Ou Yao, Xiao-Xin Li, Peng Zhou, Lv-Zhen Huang, Ming-Wei Zhao
Summary: This study identified a novel corticotropin-releasing hormone (CRH) gene variant associated with central serous chorioretinopathy (CSC). The variant was strongly associated with CSC in Chinese patients and decreased CRH gene expression. These findings implicate the hypothalamic-pituitary-adrenal stress response system in the pathogenesis of CSC and provide a new rationale for therapeutic intervention.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)