Article
Cell Biology
Mengling Ye, Lu Zhao, Lu Zhang, Siyi Wu, Zhao Li, Yi Qin, Fei Lin, Linghui Pan
Summary: Colorectal cancer is a common tumor worldwide, and long non-coding RNAs play important roles in its development. This study reveals that NALT1 promotes the proliferation and migration of colorectal cancer cells by competitively regulating the expression of miRNA-574-5p and PEG10. These findings suggest the potential of NALT1 as a biomarker and therapeutic target for colorectal cancer.
CELL DEATH & DISEASE
(2022)
Article
Biotechnology & Applied Microbiology
Heng Zhang, Shao-Qiang Wang, Jie-Bo Zhu, Li-Na Wang, Hang Lin, Lin-Feng Li, Yuan-Da Cheng, Chao-Jun Duan, Chun-Fang Zhang
Summary: CALML3-AS1 is upregulated while BTNL9 is downregulated in NSCLC. Depletion of CALML3-AS1 inhibits malignant phenotypes, tumor growth, and liver metastasis in NSCLC. Mechanistically, ALKBH5 enhances the stability of CALML3-AS1 through m6A demethylation, while YTHDC2 destabilizes CALML3-AS1. Additionally, CALML3-AS1 represses BTNL9 transcription and expression through the recruitment of EZH2. Downregulation of BTNL9 counteracts the antitumor effects mediated by CALML3-AS1 in NSCLC.
CANCER GENE THERAPY
(2023)
Article
Oncology
Mohammad Heiat, Ehsan Rezaei, Javad Gharechahi, Masoumeh Abbasi, Javad Behroozi, Mohammad Ali Abyazi, Behzad Baradaran
Summary: Silencing SIX4 inhibits the survival, migration, and invasion ability of pancreatic cancer cells, increases apoptosis and autophagy rates, and reduces mitochondrial membrane potential. Furthermore, knockdown of SIX4 affects the expression of genes related to apoptosis and metastasis. Overall, SIX4 plays a critical role in the development of pancreatic cancer.
Article
Cell Biology
Jing Shen, Guiling Liu, Hongyan Qi, Xueping Xiang, Jimin Shao
Summary: The study found that JMJD5 can cooperate with HUWE1 to degrade EGFR, thereby inhibiting the growth of NSCLC and enhancing the sensitivity of TKI. Additionally, JMJD5 can be transported into recipient cells via extracellular vesicles, thus inhibiting NSCLC growth.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Mackenzie L. Davenport, John B. Echols, Austin D. Silva, Joshua C. Anderson, Philip Owens, Clayton Yates, Qing Wei, Shuko Harada, Douglas R. Hurst, Mick D. Edmonds
Summary: miR-31 demonstrates oncogenic properties in specific subtypes of lung cancer, highlighting its potential as a therapeutic target in these subtypes.
Article
Pharmacology & Pharmacy
Mai Hazekawa, Takuya Nishinakagawa, Masato Hosokawa, Daisuke Ishibashi
Summary: This study aimed to deliver therapeutic siRNAs for melanoma lung metastases using autologous serum-derived exosomes. The results showed that siRNA-loaded exosomes prepared with autologous serum-derived exosomes significantly decreased the number of metastatic lung colonies. Autologous serum-derived exosomes, which have high organ accumulation, could potentially be used as efficient carriers of therapeutic siRNAs for melanoma patients with lung metastases.
Review
Oncology
Kang Hu, Chao Ma, Ruijie Ma, Qiming Zheng, Yepeng Wang, Nan Zhang, Zhigang Sun
Summary: Kruppel-like factor 6 splice variant 1 (KLF6-SV1) is an up-regulated splice variant in multiple malignancies, inhibiting KLF6 gene function and promoting tumor progression, which is associated with poor prognosis. The progress of KLF6-SV1 research in non-small cell lung cancer (NSCLC) reveals its important role in tumorigenesis, tumor development, and therapy resistance. Targeted silencing of KLF6-SV1 using small interfering RNA shows potential as a novel strategy for managing chemotherapy resistance in NSCLC patients.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Review
Oncology
Chao Ma, Kang Hu, Irfan Ullah, Qing-Kang Zheng, Nan Zhang, Zhi-Gang Sun
Summary: This article reviews the underlying molecular mechanisms of the hedgehog signaling pathway in promoting malignant biological behaviors in lung cancer, and explores the potential of inhibitors or natural compounds in clinical applications for lung cancer therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Beinuo Wang, Ruijie Zhang, Yao Wang, Hang Qian, Di Wu, Binfeng He, Hu Liao
Summary: Overcoming cisplatin-based drug resistance in lung cancer remains a challenge globally. Recent studies have shown that Rab GTPases play a role in multiple aspects of tumor progression, including drug resistance. In this study, a nanosystem was developed using Rab26 siRNA-loaded nanoparticles, which effectively transfected cisplatin-resistant lung cancer cells and induced apoptosis while inhibiting autophagy disruption. The combination therapy of siRab26 knockdown with cisplatin improved antitumor therapy in vitro and in vivo. These findings suggest that siRNP is an effective platform for lung cancer therapy in cases of drug resistance.
Review
Biochemistry & Molecular Biology
Amanda Kornel, Matteo Nadile, Evangelia Tsiani
Summary: This article discusses the leading cause of lung cancer in global deaths and the potential role of ursolic acid as a plant-derived chemical in the treatment of lung cancer, calling for more clinical studies to validate its efficacy.
Article
Medicine, Research & Experimental
Mumin Alper Erdogan, Erkan Yuca, Ahmed Ashour, Nilgun Gurbuz, Sevide Sencan, Bulent Ozpolat
Summary: This study investigated the role of the SCN5A gene encoding the NaV1.5 sodium channel in triple-negative breast cancer (TNBC). The overexpression of SCN5A was found to promote tumor growth, invasion, and metastasis in TNBC. Targeting NaV1.5 showed potential as a molecularly targeted strategy to control TNBC progression and enhance the efficacy of chemotherapy.
Review
Biochemistry & Molecular Biology
Fukang Jin, Zhiguang Yang, Jingbo Shao, Jianxin Tao, Christoph Reissfelder, Sonja Loges, Lei Zhu, Sebastian Schoelch
Summary: Mutations in the ARID1A gene are frequently found in various human cancers, including lung cancer. ARID1A loss is associated with poor prognosis and clinicopathological characteristics in lung cancer. Co-mutation of ARID1A and EGFR affects the efficacy of EGFR-TKIs but increases the clinical benefit of ICIs.
TRENDS IN MOLECULAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Agata Dutkowska, Bartosz Szmyd, Marcin Kaszkowiak, Daria Domanska-Senderowska, Dorota Pastuszak-Lewandoska, Ewa Brzezianska-Lasota, Jacek Kordiak, Adam Antczak
Summary: Tumours have the ability to avoid immune destruction and exhibit cancer-associated inflammation. The upregulation of interleukins IL-1 beta and IL-6 in non-small cell lung cancer (NSCLC) tissues suggests that inflammatory processes play a role in NSCLC, with a strong influence of smoking history on inflammation in tumourigenesis.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Xingyuan Shi, Xueping Luo, Ting Chen, Wei Guo, Chanjin Liang, Sihan Tang, Jianming Mo
Summary: Naringenin exhibits anti-proliferative and apoptosis effects in human lung cancer cells, as well as suppresses cell migration and reduces the expression of matrix metalloproteinases.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Correction
Oncology
Shu-Hui Xiao, Gong-Xiang Li, Lingli Quan
Summary: The study revealed that the lncRNA BX357664 is downregulated in clinical lung cancer tissues, and overexpression of BX357664 can inhibit proliferation and migration of lung cancer cells, thus suppressing the development of lung cancer.
