Article
Immunology
Mohammed J. S. Al-Ghabban, Nagham Y. Al-Bayati, Qasim S. Al-Mayah, Hisham Y. Al-Matubsi
Summary: The GG genotype of CTLA-4+49G/A polymorphism was found to be significantly less common in CL patients, with the G allele being more common in controls. Newly diagnosed CL patients had significantly higher serum sCTLA-4 levels, which may serve as an additional diagnostic tool.
MICROBIAL PATHOGENESIS
(2021)
Review
Oncology
Navid Sobhani, Dana Rae Tardiel-Cyril, Aram Davtyan, Daniele Generali, Raheleh Roudi, Yong Li
Summary: Immunotherapies have shown promise in cancer treatment but face challenges. Understanding the molecular mechanisms of immune checkpoint inhibitors and the role of regulatory T cells is crucial for improving cancer therapies.
Article
Immunology
Catalina Lee-Chang, Jason Miska, David Hou, Aida Rashidi, Peng Zhang, Rachel A. Burga, Ignacio Jusue-Torres, Ting Xiao, Victor A. Arrieta, Daniel Y. Zhang, Aurora Lopez-Rosas, Yu Han, Adam M. Sonabend, Craig M. Horbinski, Roger Stupp, Irina V. Balyasnikova, Maciej S. Lesniak
Summary: The B-Vax vaccine developed in this study showed significant effects in activating autologous CD8(+) T cells and killing GBM cells, achieving an 80% tumor eradication rate in experimental animals.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Immunology
Maria Zagorulya, Leon Yim, Duncan M. Morgan, Austin Edwards, Elen Torres-Mejia, Noor Momin, Chloe V. McCreery, Izabella L. Zamora, Brendan L. Horton, James G. Fox, K. Dane Wittrup, J. Christopher Love, Stefani Spranger
Summary: This study reveals that regulatory T (Treg) cells suppress the function of type 1 conventional dendritic cells (DC1s) through close contact, driving poor responses to immunotherapy in lung cancer patients. The interaction between Treg cells and DC1s is mediated by IFN-g in the tumor-draining lymph nodes (LNs), leading to the differentiation of Treg cells into Th1-like effector Treg cells.
Article
Immunology
Adele Friot, Sophia Djebali, Severine Valsesia, Peggy Parroche, Maxence Dubois, Jessica Baude, Francois Vandenesch, Jacqueline Marvel, Yann Leverrier
Summary: Staphylococcus aureus is a pathogen associated with various diseases and the emergence of antibiotic-resistant strains has raised concerns. Developing vaccines may help overcome these resistant strains, but the ability of S. aureus to internalize into cells poses a challenge. This study explores the potential of CD8(+) T cells to recognize and kill S. aureus-infected dendritic cells, paving the way for CD8(+) T cell-based therapies against S. aureus.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Joseph A. Pereira, Zachary Lanzar, Joseph T. Clark, Andrew P. Hart, Bonnie B. Douglas, Lindsey Shallberg, Keenan O'Dea, David A. Christian, Christopher A. Hunter
Summary: At homeostasis, a significant proportion of activated Foxp3(+) T regulatory cells (T-regs), called eT(regs), co-express higher levels of PD-1 and CTLA-4. Short term blockade of PD-1 or CTLA-4 pathways increases eT(reg) populations, while combined blockade of both pathways has an additive effect. Mechanistically, combined blockade decreases suppressive phospho-SHP2 Y580 in eT(reg) cells, leading to increased proliferation, enhanced IL-10 production, and reduced expression of CD80 and MHC-II in dendritic cells and macrophages. Therefore, targeting PD-1 and CTLA-4 pathways in T-reg cells can be useful in modulating inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Gil-Ran Kim, Je-Min Choi
Summary: CTLA-4, an immune checkpoint molecule, plays a crucial role in T-cell activation and immune regulation. Its signaling is independent of ligand interaction and relies on tyrosine and lysine motifs. This review summarizes the biology and molecular signaling events of CTLA-4 and discusses strategies to target its signaling for immune modulation and disease therapy.
MOLECULES AND CELLS
(2022)
Article
Multidisciplinary Sciences
Noriko Sato, Richard N. Bamford, Bonita R. Bryant, Yutaka Tagaya, Thomas A. Waldmann
Summary: When purified, naive T cells and regulatory T cells could not proliferate to the γC-cytokines IL-2, IL-7, or IL-15, despite expressing the cognate cytokine receptors. However, dendritic cells enabled their proliferation through cell-to-cell contact, independent of T cell receptor stimulation. This preconditioning effect activated specific cellular pathways and facilitated cytokine-mediated proliferation of T cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Satoshi Kubo, Rhea Kataria, Yikun Yao, Justin Q. Gabrielski, Lixin Zheng, Tovah E. Markowitz, Waipan Chan, Jian Song, Arun K. Boddapati, Keita Saeki, Bjoern Haupl, Ann Y. Park, Yan H. Cheng, Jing Cui, Thomas Oellerich, Michael J. Lenardo
Summary: Apoptosis is a genetically regulated program of cell death that plays a key role in immune disease processes. The transcription factor EBF4 was identified as a regulator of T cell death and cytotoxic immune function in humans, suggesting its importance in immune responses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Katsiaryna Marhelava, Anna Burdzinska, Angelika Muchowicz, Agnieszka Goral, Andriy Zhylko, Karolina Soroczynska, Kuba Retecki, Marta Krawczyk, Marta Klopotowska, Zofia Pilch, Leszek Paczek, Karl-Johan Malmberg, Sebastien Walchli, Magdalena Winiarska, Radoslaw Zagozdzon
Summary: This study provides new information on the efficacy of PD-L1-targeted CAR against PD-L1(low) targets. The results show that PD-L1-CAR cells have strong reactivity and cytotoxicity against both PD-L1(high) and PD-L1(low) target cells. Additionally, PD-L1-CAR cells also exhibit potent cytotoxic effects against non-malignant cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Cell Biology
Priyanka Chauhan, Shuxian Hu, Wen S. Sheng, James R. Lokensgard
Summary: Regulatory T-cells (Tregs) play critical roles in controlling cytotoxic T-cell responses against microglial cells and suppressing the production of tumor necrosis factor and interferon. Tregs can also reduce MHC-1 expression on microglial cells and decrease the production of interleukin-6.
Review
Immunology
Ilse Gille, Frans H. J. Claas, Geert W. Haasnoot, Mirjam H. M. Heemskerk, Sebastiaan Heidt
Summary: Solid organ transplantation is an effective treatment for end-stage diseases, but the need for immunosuppression can lead to serious side effects. CAR Treg therapy, specifically with HLA-A2 CAR Tregs, shows potential in promoting transplantation tolerance and improving graft survival.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Farid Ghorbaninezhad, Javad Masoumi, Mohammad Bakhshivand, Amir Baghbanzadeh, Ahad Mokhtarzadeh, Tohid Kazemi, Leili Aghebati-Maleki, Siamak Sandoghchian Shotorbani, Mahdi Jafarlou, Oronzo Brunetti, Mariacarmela Santarpia, Behzad Baradaran, Nicola Silvestris
Summary: DC-based immunotherapy has gained interest in anti-cancer immunotherapies. However, the immunosuppressive mechanisms in the tumor environment, such as inhibitory immune checkpoint molecules, can reduce the efficacy of DC-mediated anti-tumoral immune responses. In this study, we found that blocking CTLA-4 expression on DCs promoted their stimulatory properties and resulted in increased T cell proliferation and cytokine production.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Ippei Date, Terutsugu Koya, Takuya Sakamoto, Misa Togi, Haruhiko Kawaguchi, Asuka Watanabe, Tomohisa Kato, Shigetaka Shimodaira
Summary: This study demonstrates that human platelet lysate (HPL) can enhance the viability, yield, and purity of interferon-alpha-induced dendritic cells (IFN-DCs), leading to increased antigen-specific cytotoxic T lymphocytes (CTLs) production. Additionally, HPL-induced IFN-DCs show elevated cytokine production and improved endocytic and proteolytic activities, suggesting a novel approach for dendritic cell-based immunotherapies.
Review
Immunology
Min Hu, Natasha M. Rogers, Jennifer Li, Geoff Y. Zhang, Yuan Min Wang, Karli Shaw, Philip J. O'Connell, Stephen Alexander
Summary: Tregs play a crucial role in kidney transplantation by limiting immune activation and potentially reducing the need for immunosuppression. Studies have shown their importance in improving allo-specific Treg function in both animal and human models.
FRONTIERS IN IMMUNOLOGY
(2021)