Article
Gastroenterology & Hepatology
Xuezhen Zeng, Guanrui Liao, Shumin Li, Haining Liu, Xiao Zhao, Shuang Li, Kai Lei, Shenghua Zhu, Zhihang Chen, Yi Zhao, Xuxin Ren, Tianhong Su, Alfred Sze-Lok Cheng, Sui Peng, Shuibin Lin, Ji Wang, Shuling Chen, Ming Kuang
Summary: METTL1 plays a role in shaping the immunosuppressive tumor microenvironment after insufficient RFA, influencing tumor recurrence and treatment efficacy.
Review
Oncology
Chun Wai Mui, Wai Nok Chan, Bonan Chen, Alvin Ho-Kwan Cheung, Jun Yu, Kwok Wai Lo, Huixing Ke, Wei Kang, Ka Fai To
Summary: This review summarizes the dysregulation of the Hippo-YAP1 pathway in lung carcinoma and discusses therapeutic strategies, while also providing research directions for future investigation.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Oncology
Alvin Ho-Kwan Cheung, Chris Ho-Lam Hui, Kit Yee Wong, Xiaoli Liu, Bonan Chen, Wei Kang, Ka Fai To
Summary: The use of cell cycle inhibitors in tumor biology has highlighted the importance of understanding the cell cycle for optimizing therapeutic approaches. Cell cycle aberrations in cancers have been found to have oncogenic effects beyond cell proliferation alone, impacting cancer metabolism, immunity, and metastasis. This review comprehensively summarizes recent findings and advances in these interrelated processes, emphasizing knowledge gaps, therapeutic approaches, and challenges in targeted therapy resistance. Understanding how the cell cycle modulates diverse aspects of cancer biology is crucial for identifying new molecular targets.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Biotechnology & Applied Microbiology
Xiaoyu Liu, Jingying Zhou, Haoran Wu, Shufen Chen, Lingyun Zhang, Wenshu Tang, Liang Duan, Ying Wang, Eleanor McCabe, Mengying Hu, Zhuo Yu, Hanzhuang Liu, Chung Hang Jonathan Choi, Joseph Jao-yiu Sung, Leaf Huang, Rihe Liu, Alfred Sze-lok Cheng
Summary: The local microenvironment where tumors develop can affect cancer progression and treatment outcomes. In hepatocellular carcinoma (HCC), which often develops in a liver fibrotic environment, nanodelivery of a PD-L1 trap gene shows superior efficacy compared to conventional monoclonal antibodies in treating fibrosis-associated HCC.
Article
Pathology
Alvin Ho-Kwan Cheung, Kit-Yee Wong, Cho-Han Chiang, Xiaoli Liu, Yihan Zhang, Chris Ho-Lam Hui, Bonan Chen, Yifei Wang, Chit Chow, Wei Kang, Ka-Fai To
Summary: The study analyzed 170 plasma EGFR mutation tests and conducted a systematic review and meta-analysis to identify clinical and imaging features that correlate with plasma EGFR mutation test sensitivity. The results showed that patients with stage IV disease had a significantly lower false-negative rate than those with stage I through III disease. Additionally, patients with distant metastases and more suspicious lymph nodes on imaging findings were associated with a low false-negative rate.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Alfred Sze-Lok Cheng
Article
Gastroenterology & Hepatology
Zhiwu Tan, Mei Sum Chiu, Xinxiang Yang, Ming Yue, Tan To Cheung, Dongyan Zhou, Yuewen Wang, Anthony Wing-Hung Chan, Chi Wing Yan, Ka Yi Kwan, Yik Chun Wong, Xin Li, Jingying Zhou, Ka Fai To, Jiye Zhu, Chung Mau Lo, Alfred Sze-Lok Cheng, Stephen Lam Chan, Li Liu, You-Qiang Song, Kwan Man, Zhiwei Chen
Summary: A PD-1 isoform called Delta 42PD-1 plays an important role in the development and resistance to nivolumab immune checkpoint blockade (ICB) in hepatocellular carcinoma (HCC). We investigated the role of Delta 42PD-1 in HCC patients and found that Delta 42PD-1(+) T cells accounted for up to 71% of cytotoxic T lymphocytes in untreated HCC patients and were associated with HCC severity. These Delta 42PD-1(+) T cells were more exhausted than PD-1(+) T cells. HCC patients treated with anti-PD-1 ICB showed increased frequencies of Delta 42PD-1(+) T cells over time, especially in patients with progressive disease. Delta 42PD-1(+) T cells sustained HCC through toll-like receptor 4 signaling. An anti-Delta 42PD-1 antibody inhibited tumor growth in murine HCC models.
Article
Gastroenterology & Hepatology
Yi Bao, Jianning Zhai, Huarong Chen, Chi Chun Wong, Cong Liang, Yanqiang Ding, Dan Huang, Hongyan Gou, Danyu Chen, Yasi Pan, Wei Kang, Ka Fai To, Jun Yu
Summary: YTHDF1 plays a crucial role in the tumour immune microenvironment of colorectal cancer by regulating the m(6)A-p65-CXCL1/CXCR2 pathway, affecting anti-tumour immune response, and serving as a potential target for immune checkpoint blockade therapy.
Article
Gastroenterology & Hepatology
Minako Nagai, Michael J. Wright, Ding Ding, Elizabeth D. Thompson, Ammar A. Javed, Matthew J. Weiss, Ralph H. Hruban, Jun Yu, Richard A. Burkhart, Jin He, John L. Cameron, Christopher L. Wolfgang, William R. Burns
Summary: Patients with pancreatic ductal adenocarcinoma (PDAC) and liver metastasis usually undergo palliative chemotherapy, while those with metastatic colorectal cancer are often considered for aggressive surgery. This study found that in select patients, curative-intent surgery for isolated liver metastasis in PDAC can result in meaningful survival, especially in those who received induction chemotherapy.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Endocrinology & Metabolism
Ping Gu, Kai Ding, Lei Lu, Yu Zhang, Wei Wang, Qingyu Guo, Yannian Liao, Bingjie Yang, Tiantian Wang, Changsheng Zhou, Bin Lu, Alice P. S. Kong, Alfred S. Cheng, Hannah Xiaoyan Hui, Jiaqing Shao
Summary: This study investigated the expressions of major brown adipose markers in white adipose tissue (WAT) of different ages and their associations with metabolic parameters and key adipokines. The findings suggest that UCP1 and PRDM16 have differential clinical correlations with metabolic features in human WAT in an age-dependent manner. UCP1 and PRDM16 may participate in the pathogenesis of ageing-related metabolic diseases with distinct mechanisms.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Rashid N. Lui, Sunny H. Wong, Nik Sheng Ding, Masau Sekiguchi, Jun Yu, Tiing-Leong Ang, Khay-Guan Yeoh, Han-Mo Chiu, Joseph J. Y. Sung
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yinnan Chen, Quanpeng Qiu, Junjun She, Jun Yu
Summary: Extrachromosomal circular DNA (ecDNA) is highly prevalent in various cancers, including colorectal cancer (CRC), and plays a critical role in regulating oncogene expression and resistance to therapy. Understanding the mechanisms and features of ecDNA in CRC provides insights into its pathogenesis and potential diagnostic and therapeutic implications. This review discusses the biogenesis, distinct features, and functional roles of ecDNA in CRC, including its involvement in oncogene overexpression, gene regulation, and topological interactions with active chromatin.
Article
Biochemistry & Molecular Biology
Xin-yue Zhang, Ze-xian Liu, Yi-fan Zhang, Li-xia Xu, Meng-ke Chen, Yu-feng Zhou, Jun Yu, Xiao-xing Li, Ning Zhang
Summary: Crotonylation plays a role in regulating HCC metastasis and invasion. Crotonylated SEPT2-K74-P85 alpha-AKT pathway facilitates cell invasion. High SEPT2-K74 crotonylation predicts poor prognosis and high recurrence rate in HCC patients.
CELL AND BIOSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Yanqiang Ding, Liuyang Zhao, Guoping Wang, Yu Shi, Gang Guo, Changan Liu, Zigui Chen, Olabisi Oluwabukola Coker, Junjun She, Jun Yu
Summary: This study used PacBio sequencing to reveal the DNA methylation landscape of gut phages. The research found that methylation plays an important role in the taxonomy and interaction with hosts of phages, and also discovered the presence of restriction-modification systems in some phage genomes, which aid in evading clearance by the host.
NUCLEIC ACIDS RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Yang Lyu, Fuda Xie, Bonan Chen, Wing Sum Shin, Wei Chen, Yulong He, Kam Tong Leung, Gary M. K. Tse, Jun Yu, Ka Fai To, Wei Kang
Summary: This review focuses on the complex interaction between the nervous system and gastrointestinal (GI) cancer, exploring the mechanisms of GI cancer development. It discusses the intricate relationship between the nervous system and GI tract development and tumor progression, as well as the feedback regulation of tumor cells on the nervous system. The review also highlights the influence of various components within the tumor microenvironment on GI cancer occurrence and progression. Furthermore, it emphasizes the transformation relationship between non-neuronal cells and neuronal cells, inspiring the development of nervous system-guided anti-tumor drugs.