Article
Biochemistry & Molecular Biology
Xu Li, Shu Zhuo, Yong Suk Cho, Yuchen Liu, Yingzi Yang, Jian Zhu, Jin Jiang
Summary: Hippo signaling inhibits the oncogenic potential of YAP/TAZ-TEAD transcriptional complex, restricting tumor growth. In AR-positive prostate cancer, YAP acts as a tumor suppressor by counteracting TEAD-mediated AR signaling. YAP competes with AR for TEAD binding, disrupting AR-TEAD interaction and preventing TEAD from promoting AR signaling. Targeting the Hippo signaling pathway may provide a therapeutic opportunity to treat therapy resistant AR variants-driven prostate cancer.
Article
Biochemistry & Molecular Biology
Lingquan Wang, Wei Xu, Yu Mei, Xufeng Wang, Wentao Liu, Zhenggang Zhu, Zhentian Ni
Summary: This study found that CHRDL2 is abnormally upregulated in gastric cancer and is associated with tumor progression and poor patient prognosis. CHRDL2 overexpression promotes proliferation and cell cycle transition of gastric cancer cells, and it plays a key role by activating the YAP/TAZ pathway.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Oncology
Yuanke Liang, Xiaoling Zhou, Qin Xie, Hexing Sun, Kaiyuan Huang, Huan Chen, Wende Wang, Benqing Zhou, Xiaolong Wei, De Zeng, Haoyu Lin
Summary: Radiotherapy is an essential treatment for breast cancer, but the resistance of tumors to radiation compromises its efficacy. This study demonstrates that CD146, highly expressed in triple-negative breast cancer, is induced by radiation and promotes tumor cell radioresistance both in vitro and in vivo. The underlying mechanism involves CD146 activating YAP protein and promoting its abnormal nuclear localization, inducing EMT and stemness, and enhancing DNA damage repair. Additionally, CD146 forms a co-receptor complex with integrin beta 1, further contributing to radiation resistance. Dual inhibition of CD146 and integrin beta 1 activity shows potential for overcoming radiotherapeutic resistance in breast cancer.
Article
Dermatology
Yao Yuan, Natalia Salinas Parra, Qianming Chen, Ramiro Iglesias-Bartolome
Summary: In this study, the transcriptional targeting of YAP1 and TAZ in basal cell carcinoma was investigated using a TEAD inhibitor, showing reduced proliferation and increased differentiation of cancer cells. The findings also revealed YAP1/TAZ.TEAD-independent effects impacting STAT3 and NF-kappa B pathways in cancer cells.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Multidisciplinary Sciences
Yan Gu, Yanrong Chen, Lai Wei, Shuang Wu, Kaicheng Shen, Chengxiang Liu, Yan Dong, Yang Zhao, Yue Zhang, Chi Zhang, Wenling Zheng, Jiangyi He, Yunlong Wang, Yifei Li, Xiaoxin Zhao, Hongwei Wang, Jun Tan, Liting Wang, Qi Zhou, Ganfeng Xie, Houjie Liang, Juanjuan Ou
Summary: Loss of ABHD5 promotes the activation of c-Met via a non-canonical pathway, sustaining the stemness of colorectal cancer cells.
NATURE COMMUNICATIONS
(2021)
Review
Medicine, Research & Experimental
Javeria Qadir, Feiya Li, Burton B. Yang
Summary: This review examines the interplay between the Hippo signaling pathway and circular RNAs (circRNAs) in various forms of cancer. It discusses how circRNAs can function as either tumor suppressors or oncogenes in cancer by interacting with miRNAs or proteins. The review also highlights the limitations and constraints in studying circRNA mechanisms, and raises questions about the role of circRNAs associated with the Hippo-YAP pathway in cancer. Finally, it explores the potential of circRNAs as diagnostic and prognostic biomarkers, as well as molecular targets for cancer therapy.
Article
Oncology
Tianxing Zhou, Xueyang Li, Jing Liu, Jihui Hao
Summary: Despite improvements in cancer survival, the mechanisms of cancer metastasis remain poorly understood. Metastasis involves a series of events such as epithelial-to-mesenchymal transition, invasion, angiogenesis, intravasation, survival in circulation, extravasation, mesenchymal-to-epithelial transition, colonization, and adaptation. Furthermore, cancer cells can remodel the tumor microenvironment and evade immune surveillance. The Hippo signaling pathway has been identified as a key regulator of cancer metastasis, offering potential as a therapeutic target.
CANCER BIOLOGY & MEDICINE
(2023)
Article
Oncology
Kana Hasegawa, Shinsuke Fujii, Shinji Matsumoto, Yudai Tajiri, Akira Kikuchi, Tamotsu Kiyoshima
Summary: The study demonstrates that the YAP signaling pathway promotes oral squamous cell carcinoma (OSCC) cell proliferation through the PIEZO1 channel, indicating a crucial role of YAP/PIEZO1 axis in tumorigenesis. These findings provide important insights into the understanding of cellular behavior changes during tumor growth.
JOURNAL OF PATHOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Zhifa Cao, Liwei An, Yi Han, Shi Jiao, Zhaocai Zhou
Summary: Gastric cancer is a highly aggressive disease without effective early diagnosis markers and targeted therapies, leading to high mortality rates worldwide. The Hippo signaling pathway, which is involved in organ size control and tissue homeostasis, has been found to play a crucial role in cancer development. This review provides a comprehensive overview of studies on the Hippo pathway in gastric cancer, including its role in tumor initiation, progression, metastasis, acquired drug resistance, and potential therapeutic strategies. The review aims to inspire further research and understanding of the Hippo signaling pathway in gastric cancer, as well as its translational implications for treatment.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Review
Oncology
Verena Hoffken, Anke Hermann, Hermann Pavenstadt, Joachim Kremerskothen
Summary: The conserved Hippo pathway plays a crucial role in regulating cell proliferation and apoptosis through various mechanisms, essential for organ size control and tumor prevention. WWC proteins, as components and upstream regulators of the Hippo pathway, are often overlooked in their role in cancer development.
Correction
Biochemistry & Molecular Biology
Xiao Zheng, Lujun Chen, You Zhou, Qi Wang, Zhuojun Zheng, Bin Xu, Chen Wu, Qi Zhou, Wenwei Hu, Changping Wu, Jingting Jiang
Summary: The paper has published an amendment which can be accessed through the original article.
Review
Cell Biology
Priyanka Samji, Manoj K. Rajendran, Vidya P. Warrier, Akshayaa Ganesh, Karunagaran Devarajan
Summary: Recent studies have shown that dysregulation of Hippo signaling, particularly the hyper activation of YAP/TAZ, can lead to uncontrolled cell proliferation and malignancy. Additionally, Hippo pathway may play a role in mediating chemotherapeutic resistance in cancer cells.
CELLULAR SIGNALLING
(2021)
Review
Biochemistry & Molecular Biology
Boon Chin Heng, Xuehui Zhang, Dominique Aubel, Yunyang Bai, Xiaochan Li, Yan Wei, Martin Fussenegger, Xuliang Deng
Summary: YAP and TAZ are crucial proteins involved in maintaining tissue/organ size and have diverse roles in various biological processes, including cell proliferation, tissue regeneration, cell fate determination, tumorigenesis, and mechanosensing.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cell Biology
Jing Cai, Kyungsuk Choi, Hongde Li, Katiuska Daniela Pulgar Prieto, Yonggang Zheng, Duojia Pan
Summary: This study reveals that the essential role of YAP in liver and lung development can be bypassed by inactivation of the TEAD corepressor VGLL4, indicating that YAP's major physiological function is to antagonize VGLL4. The findings highlight the central importance of VGLL4-mediated transcriptional repression in regulating the Hippo pathway and provide insights into potential strategies for modulating Hippo signaling in cancer and regenerative medicine.
GENES & DEVELOPMENT
(2022)
Article
Cell Biology
Yu-Tzu Chan, Ruey-Jen Lin, Ya-Hui Wang, Tsai-Hsien Hung, Yenlin Huang, John Yu, Jyh-Cherng Yu, Alice L. Yu
Summary: This study reveals the crucial role of YAP in breast cancer stem cells. Knockdown of YAP reduces the viability and stemness of BCSCs in vitro and tumor formation in vivo. IGF-1R and IGF-1 regulate the expression and localization of YAP, and YAP overexpression increases the expression of IGF-1. Clinical analysis shows that high levels of YAP and IGF-1 are associated with shorter overall survival in basal-like breast cancer patients. In conclusion, the interplay between YAP and the IGF-1/IGF-1R pathway is clinically relevant for sustaining the properties of BCSCs.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Cell Biology
Gayoung Seo, Han Han, Rebecca Elizabeth Vargas, Bing Yang, Xu Li, Wenqi Wang
Article
Biochemical Research Methods
Rebecca Elizabeth Kattan, Han Han, Gayoung Seo, Bing Yang, Yongqi Lin, Max Dotson, Stephanie Pham, Yahya Menely, Wenqi Wang
Summary: In this study, the protein interaction network of the human PLD family of enzymes and PA was defined using a proteomic approach. The study identified PJA2 as a novel E3 ubiquitin ligase for PLD1 and revealed the positive regulation of sphingosine kinase 1 by PA. The findings not only provide a rich resource for further characterization of the human PLD-PA lipid signaling, but also connect this important metabolic pathway with numerous biological processes.
MOLECULAR & CELLULAR PROTEOMICS
(2022)
Article
Cell Biology
Han Han, Hiroki J. Nakaoka, Line Hofmann, Jeff Jiajing Zhou, Clinton Yu, Lisha Zeng, Junyu Nan, Gayoung Seo, Rebecca Elizabeth Vargas, Bing Yang, Ruxi Qi, Lee Bardwell, Dmitry A. Fishman, Ken W. Y. Cho, Lan Huang, Ray Luo, Rahul Warrior, Wenqi Wang
Summary: The Hippo pathway was found to regulate heavy metal homeostasis by phosphorylating and inhibiting MTF1, thus attenuating the transcription of heavy metal response genes and protecting cells from heavy metal-induced toxicity. The activity of the Hippo pathway kinase LATS is also inhibited by heavy metal treatment, suggesting an interplay between heavy metals and the Hippo pathway.
NATURE CELL BIOLOGY
(2022)
News Item
Biochemistry & Molecular Biology
Gayoung Seo, Wenqi Wang
NATURE CHEMICAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Ibtissem Nabti, Babu J. N. Reddy, Rachid Rezgui, Wenqi Wang, Steven P. Gross, George T. Shubeita
Summary: This study demonstrates that phosphorylated MAP4 can bias organelle transport towards the microtubule minus-ends by impairing the force generation of kinesin-1.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Hua Jiang, Weixiang Bian, Yue Sui, Huanle Li, Han Zhao, Wenqi Wang, Xu Li
Summary: Using a proteomic approach, this study identified FBXO42 as a previously unknown interactor of RBPJ. FBXO42 promotes RBPJ polyubiquitination and enhances its association with chromatin remodeling complexes, leading to global chromatin relaxation. Depletion of FBXO42 or inhibition of its activity attenuates leukemia development related to Notch signaling.
Review
Biochemical Research Methods
Rebecca Elizabeth Kattan, Deena Ayesh, Wenqi Wang
Summary: During intracellular signal transduction, protein-protein interactions (PPIs) play a critical role in regulating protein localization and function. Mass spectrometry-based interactome analysis has become a popular method for studying PPI networks, but the analysis of large datasets can be challenging. In this review, we discuss the methods and resources commonly used for analyzing large interactome-related proteomic data and propose a guideline for identifying novel interacting proteins.
BRIEFINGS IN BIOINFORMATICS
(2023)
Editorial Material
Biochemistry & Molecular Biology
Han Han, Wenqi Wang
Summary: In a recent study published in The EMBO Journal, Qi et al (2023) propose a new model for the Hippo kinase cascade, shedding light on the long-standing question of its precise organization.
Review
Biochemistry & Molecular Biology
Vijaykumar S. Meli, Praveen Krishna Veerasubramanian, Timothy L. Downing, Wenqi Wang, Wendy F. Liu
Summary: Innate immune cells are crucial for eliminating foreign agents and cellular debris. Their ability to perceive and respond to biochemical and mechanical cues from the microenvironment plays a significant role in determining their behavior. Recent studies have shown the involvement of mechanosensitive proteins YAP and TAZ in inflammation and immunity, and this review focuses on understanding their role and therapeutic potential in inflammatory diseases.
Article
Biology
Jeff Jiajing Zhou, Jin Sun Cho, Han Han, Ira L. Blitz, Wenqi Wang, Ken W. Y. Cho
Summary: Histone acetylation is a crucial epigenetic modification that regulates gene expression. Histone deacetylase 1 (Hdac1) binds to the zygotic genome during early embryogenesis and plays a dual role in both repressing and maintaining gene expression through histone acetylation-deacetylation cycles.
Article
Oncology
Han Han, Alisa Mahieu, Lucas Dantas de Paula, Wenqi Wang
Summary: Emerging studies have highlighted the importance of the Hippo pathway in controlling organ size, maintaining tissue homeostasis, promoting regeneration, and influencing development and diseases. However, our understanding of its functions and regulations is still incomplete. Recent research has revealed a functional interplay between the Hippo pathway and heavy metals, providing valuable insights into this crucial signaling pathway.
MOLECULAR & CELLULAR ONCOLOGY
(2022)
Meeting Abstract
Oncology
Gayoung Seo, Han Han, Bing Yang, Rebecca Vargas, Yuxuan Chen, Wenqi Wang
MOLECULAR CANCER RESEARCH
(2020)