Mice engineered for an obligatory Mdm4 exon skipping express higher levels of the Mdm4-S isoform but exhibit increased p53 activity

A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression

(2014) N. Okada et al.   GENES & DEVELOPMENT

Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery

(2013) M. Bezzi et al.   GENES & DEVELOPMENT

Mdm4 loss in mice expressing a p53 hypomorph alters tumor spectrum without improving survival

(2013) M Fang et al.   ONCOGENE

MDMX contains an autoinhibitory sequence element

(2013) M. Bista et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutant Mice Lacking the p53 C-Terminal Domain Model Telomere Syndromes

(2013) Iva Simeonova et al.   Cell Reports

Alternate Splicing of the p53 Inhibitor HDMX Offers a Superior Prognostic Biomarker than p53 Mutation in Human Cancer

(2012) Kristiaan Lenos et al.   CANCER RESEARCH

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

MDM4 is a key therapeutic target in cutaneous melanoma

(2012) Agnieszka Gembarska et al.   NATURE MEDICINE

Fuzzy Tandem Repeats Containing p53 Response Elements May Define Species-Specific p53 Target Genes

(2012) Iva Simeonova et al.   PLoS Genetics

Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity

(2011) Y. V. Wang et al.   GENES & DEVELOPMENT

Validation of MdmX as a therapeutic target for reactivating p53 in tumors

(2011) D. Garcia et al.   GENES & DEVELOPMENT

Functions of MDMX in the Modulation of the p53-Response

(2011) Kristiaan Lenos et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability

(2011) V. Pant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo

(2011) L. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Stapled p53 Helix Overcomes HDMX-Mediated Suppression of p53

(2010) Federico Bernal et al.   CANCER CELL

HDMX-L Is Expressed from a Functional p53-responsive Promoter in the First Intron of theHDMXGene and Participates in an Autoregulatory Feedback Loop to Control p53 Activity

(2010) Anna Phillips et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Radioresistance and Accelerated B Cell Lymphomas in Mice with Mdmx Mutations that Prevent Modifications by DNA-Damage-Activated Kinases

(2009) Yunyuan V. Wang et al.   CANCER CELL

MDM4 (MDMX) and its Transcript Variants

(2009) F. Mancini et al.   CURRENT GENOMICS

Analysis of human MDM4 variants in papillary thyroid carcinomas reveals new potential markers of cancer properties

(2008) Andrea Prodosmo et al.   JOURNAL OF MOLECULAR MEDICINE-JMM