Targeting RNA polymerase I to treat MYC-driven cancer

Chromatin states at ribosomal DNA loci

(2013) Stephan Hamperl et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Targeting RNA polymerase I transcription and the nucleolus for cancer therapy

(2013) Ross D Hannan et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice

(2013) L. Soucek et al.   GENES & DEVELOPMENT

Disruption of the MYC-miRNA-EZH2 loop to suppress aggressive B-cell lymphoma survival and clonogenicity

(2013) X Zhao et al.   LEUKEMIA

Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers

(2013) M. Pourdehnad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The nucleolus: an emerging target for cancer therapy

(2013) Nadine Hein et al.   TRENDS IN MOLECULAR MEDICINE

A subset of Drosophila Myc sites remain associated with mitotic chromosomes colocalized with insulator proteins

(2013) Jingping Yang et al.   Nature Communications

Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition

(2013) Alexandre Puissant et al.   Cancer Discovery

Coordinated Silencing of MYC-Mediated miR-29 by HDAC3 and EZH2 as a Therapeutic Target of Histone Modification in Aggressive B-Cell Lymphomas

(2012) Xinwei Zhang et al.   CANCER CELL

Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53

(2012) Megan J. Bywater et al.   CANCER CELL

A new PICTure of nucleolar stress

(2012) Akira Suzuki et al.   CANCER SCIENCE

Cancer Epigenetics: From Mechanism to Therapy

(2012) Mark A. Dawson et al.   CELL

All Things to All People

(2012) Trevor D. Littlewood et al.   CELL

c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells

(2012) Zuqin Nie et al.   CELL

Transcriptional Amplification in Tumor Cells with Elevated c-Myc

(2012) Charles Y. Lin et al.   CELL

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

Suprainduction of p53 by disruption of 40S and 60S ribosome biogenesis leads to the activation of a novel G2/M checkpoint

(2012) S. Fumagalli et al.   GENES & DEVELOPMENT

Translational control in cellular and developmental processes

(2012) Jian Kong et al.   NATURE REVIEWS GENETICS

STAT1:DNA sequence-dependent binding modulation by phosphorylation, protein:protein interactions and small-molecule inhibition

(2012) Andrew J. Bonham et al.   NUCLEIC ACIDS RESEARCH

Functional genomics identifies therapeutic targets for MYC-driven cancer

(2012) M. Toyoshima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Revisiting the Nucleolus: From Marker to Dynamic Integrator of Cancer Signaling

(2012) D. Ruggero   Science Signaling

The mTORC1 Inhibitor Everolimus Prevents and Treats Eμ- Myc Lymphoma by Restoring Oncogene-Induced Senescence

(2012) Meaghan Wall et al.   Cancer Discovery

MicroRNA miR-308 regulates dMyc through a negative feedback loop in Drosophila

(2012) K. Daneshvar et al.   Biology Open

Polyamine pathway inhibition as a novel therapeutic approach to treating neuroblastoma

(2012) Laura D. Gamble et al.   Frontiers in Oncology

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Endogenous Myc maintains the tumor microenvironment

(2011) N. M. Sodir et al.   GENES & DEVELOPMENT

Cell-type specific and combinatorial usage of diverse transcription factors revealed by genome-wide binding studies in multiple human cells

(2011) B.-K. Lee et al.   GENOME RESEARCH

Demonstration that Drug-targeted Down-regulation of MYC in Non-Hodgkins Lymphoma Is Directly Mediated through the Promoter G-quadruplex

(2011) Robert V. Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Solution Structure of a 2:1 Quindoline–c-MYC G-Quadruplex: Insights into G-Quadruplex-Interactive Small Molecule Drug Design

(2011) Jixun Dai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genomic c-Myc Quadruplex DNA Selectively Kills Leukemia

(2011) K. C. Sedoris et al.   MOLECULAR CANCER THERAPEUTICS

A Critical Role for Noncoding 5S rRNA in Regulating Mdmx Stability

(2011) Muyang Li et al.   MOLECULAR CELL

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

(2011) Johannes Zuber et al.   NATURE

Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11

(2011) Masato Sasaki et al.   NATURE MEDICINE

Heterogeneity in MYC-induced mammary tumors contributes to escape from oncogene dependence

(2011) J Y Leung et al.   ONCOGENE

Genome-wide mapping of Myc binding and gene regulation in serum-stimulated fibroblasts

(2011) D Perna et al.   ONCOGENE

The Action Mechanism of the Myc Inhibitor Termed Omomyc May Give Clues on How to Target Myc for Cancer Therapy

(2011) Mauro Savino et al.   PLoS One

Cell-Type Independent MYC Target Genes Reveal a Primordial Signature Involved in Biomass Accumulation

(2011) Hongkai Ji et al.   PLoS One

Deep Sequencing of MYC DNA-Binding Sites in Burkitt Lymphoma

(2011) Volkhard Seitz et al.   PLoS One

Targeting MYC dependence in cancer by inhibiting BET bromodomains

(2011) J. A. Mertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Guarding the ‘translation apparatus’: defective ribosome biogenesis and the p53 signaling pathway

(2011) Anirban Chakraborty et al.   Wiley Interdisciplinary Reviews-RNA

The RNA Polymerase I Transcription Machinery: An Emerging Target for the Treatment of Cancer

(2010) Denis Drygin et al.   Annual Review of Pharmacology and Toxicology

Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth

(2010) Denis Drygin et al.   CANCER RESEARCH

A Myc Network Accounts for Similarities between Embryonic Stem and Cancer Cell Transcription Programs

(2010) Jonghwan Kim et al.   CELL

c-Myc Regulates Transcriptional Pause Release

(2010) Peter B. Rahl et al.   CELL

The role of UBF in regulating the structure and dynamics of transcriptionally active rDNA chromatin

(2010) Elaine Sanij et al.   Epigenetics

The Yin and Yang functions of the Myc oncoprotein in cancer development and as targets for therapy

(2010) Lars-Gunnar Larsson et al.   EXPERIMENTAL CELL RESEARCH

Chemotherapeutic Drugs Inhibit Ribosome Biogenesis at Various Levels

(2010) Kaspar Burger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In Vitro Cytotoxicity and In Vivo Efficacy, Pharmacokinetics, and Metabolism of 10074-G5, a Novel Small-Molecule Inhibitor of c-Myc/Max Dimerization

(2010) D. M. Clausen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The Nucleolus under Stress

(2010) Séverine Boulon et al.   MOLECULAR CELL

c-MYC coordinately regulates ribosomal gene chromatin remodeling and Pol I availability during granulocyte differentiation

(2010) Gretchen Poortinga et al.   NUCLEIC ACIDS RESEARCH

Myc proteins as therapeutic targets

(2010) W C Gustafson et al.   ONCOGENE

Ribosome biogenesis surveillance: probing the ribosomal protein-Mdm2-p53 pathway

(2010) C Deisenroth et al.   ONCOGENE

MYCN-regulated microRNAs repress estrogen receptor-  (ESR1) expression and neuronal differentiation in human neuroblastoma

(2010) J. Loven et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling to p53: Ribosomal Proteins Find Their Way

(2009) Yanping Zhang et al.   CANCER CELL

Acting Locally and Globally: Myc's Ever-Expanding Roles on Chromatin

(2009) N. V. Varlakhanova et al.   CANCER RESEARCH

Targeting Ornithine Decarboxylase Impairs Development of MYCN-Amplified Neuroblastoma

(2009) R. J. Rounbehler et al.   CANCER RESEARCH

Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model

(2009) Janaiah Kota et al.   CELL

MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities

(2009) C. V. Dang et al.   CLINICAL CANCER RESEARCH

Myc's other life: stem cells and beyond

(2009) Elisa Laurenti et al.   CURRENT OPINION IN CELL BIOLOGY

Regulation of nucleolar signalling to p53 through NEDDylation of L11

(2009) Anders Sundqvist et al.   EMBO REPORTS

The Importance of Negative Superhelicity in Inducing the Formation of G-Quadruplex and i-Motif Structures in the c-Myc Promoter: Implications for Drug Targeting and Control of Gene Expression

(2009) Daekyu Sun et al.   JOURNAL OF MEDICINAL CHEMISTRY

Multiple Independent Binding Sites for Small-Molecule Inhibitors on the Oncoprotein c-Myc

(2009) Dalia I. Hammoudeh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ribosomal Protein S7 Is Both a Regulator and a Substrate of MDM2

(2009) Yan Zhu et al.   MOLECULAR CELL

Absence of nucleolar disruption after impairment of 40S ribosome biogenesis reveals an rpL11-translation-dependent mechanism of p53 induction

(2009) Stefano Fumagalli et al.   NATURE CELL BIOLOGY

c-Myc induces changes in higher order rDNA structure on stimulation of quiescent cells

(2009) C-N Shiue et al.   ONCOGENE

Regression of murine lung tumors by the let-7 microRNA

(2009) P Trang et al.   ONCOGENE

Silencing c-MYCExpression by Targeting Quadruplex in P1 Promoter Using Locked Nucleic Acid Trap†

(2008) Niti Kumar et al.   BIOCHEMISTRY

Evolution of the holozoan ribosome biogenesis regulon

(2008) Seth J Brown et al.   BMC GENOMICS

Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc–Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice

(2008) Jianxia Guo et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

N-Myc Regulates a Widespread Euchromatic Program in the Human Genome Partially Independent of Its Role as a Classical Transcription Factor

(2008) R. Cotterman et al.   CANCER RESEARCH

ODC1 Is a Critical Determinant of MYCN Oncogenesis and a Therapeutic Target in Neuroblastoma

(2008) M. D. Hogarty et al.   CANCER RESEARCH

Hematopoietic Stem Cell Function and Survival Depend on c-Myc and N-Myc Activity

(2008) Elisa Laurenti et al.   Cell Stem Cell

Epigenetic regulation of TTF-I-mediated promoter–terminator interactions of rRNA genes

(2008) Attila Németh et al.   EMBO JOURNAL

Myc's broad reach

(2008) M. Eilers et al.   GENES & DEVELOPMENT

UBF levels determine the number of active ribosomal RNA genes in mammals

(2008) Elaine Sanij et al.   JOURNAL OF CELL BIOLOGY

Crosstalk between c-Myc and ribosome in ribosomal biogenesis and cancer

(2008) Mu-Shui Dai et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Mdm2 Regulates p53 mRNA Translation through Inhibitory Interactions with Ribosomal Protein L26

(2008) Yaara Ofir-Rosenfeld et al.   MOLECULAR CELL

Modelling Myc inhibition as a cancer therapy

(2008) Laura Soucek et al.   NATURE

Suppression of Myc oncogenic activity by ribosomal protein haploinsufficiency

(2008) Maria Barna et al.   NATURE

Analysis of Myc-Induced Histone Modifications on Target Chromatin

(2008) Francesca Martinato et al.   PLoS One

Combined Analysis of Murine and Human Microarrays and ChIP Analysis Reveals Genes Associated with the Ability of MYC To Maintain Tumorigenesis

(2008) Chi-Hwa Wu et al.   PLoS Genetics