Article
Pharmacology & Pharmacy
Huan Shen, Changquan Calvin Sun, Lichun Kang, Xiaoyue Tan, Peng Shi, Lingyu Wang, Ergang Liu, Junbo Gong
Summary: The study demonstrates that low-dose salinomycin can induce M1-type macrophage polarization, leading to decreased CD206 cells and increased CD86 cells in tumors, resulting in significant inhibition of tumor growth and metastasis.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Cell Biology
Jiaqi Fang, Qian Ou, Boheng Wu, Sisi Li, Mian Wu, Jialing Qiu, Nuo Cen, Kaixin Hu, Yangfei Che, Yuan Ma, Jianping Pan
Summary: This study investigated the influence of TcpC, a virulence factor of Uropathogenic Escherichia coli (UPEC), on the polarization of macrophages into M1 and M2 subsets and the potential mechanisms involved. The results showed that TcpC inhibits M1 macrophage polarization through down-regulation of p38, ERK/NF-κB signaling pathways, while promoting M2 macrophage polarization through up-regulation of the Akt/STAT6 signaling pathway. These findings not only shed light on the regulatory effects of TcpC on macrophage polarization and signaling pathways, but also provide a novel mechanism for TcpC-mediated evasion of macrophage-mediated innate immunity.
Article
Immunology
Zhaiyi Liu, Zhiyue Bao, Bo Yu, Lihong Chen, Guangrui Yang
Summary: This study demonstrates that Pemetrexed (PEM) effectively alleviates immune-mediated hepatic injuries by inhibiting M1 macrophage activation through the NF-kappa B signaling pathways. It significantly improves mouse survival rates and reduces serum transaminase levels. Additionally, PEM also mitigates oxidative stress, reduces histopathological liver damage, and decreases hepatocyte apoptosis. Furthermore, PEM decreases the expression of proinflammatory cytokines and genes associated with M1 macrophages in the liver.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Xiaojiang Yang, Hong Qian, Jia Meng, Hui Jiang, Tao Yuan, Shaoqiang Yang, Yibin Luo, Ninrong Bao, Jianning Zhao, Dongsheng Wang
Summary: The aim of this study was to evaluate the anti-rheumatoid arthritis (RA) effect of Lonicerin (LON), a safe compound with anti-inflammatory and immunomodulatory properties. LON treatment attenuated the disease progression of CIA mice with lower paw swelling, clinical score, mobility, and inflammatory response. Mechanistically, LON regulated the polarization of M1/M2 macrophages, especially by inhibiting macrophage polarization toward M1, and inhibited NF-kappa B signaling pathway and NLRP3 inflammasome activation.
PHYTOTHERAPY RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Liu-Gen Li, Xing-Chun Peng, Ting-Ting Yu, Hua-Zhen Xu, Ning Han, Xiao-Xin Yang, Qi-Rui Li, Jun Hu, Bin Liu, Zi-Yi Yang, Xiang Xu, Xiao Chen, Mei-Fang Wang, Tong-Fei Li
Summary: This study demonstrates that Dihydroartemisinin (DHA) can remodel tumor-associated macrophages (TAMs) into an anti-tumor phenotype and induce ferroptosis and DNA damage response in TAMs. The study also shows that ferroptosis and DNA damage response in TAMs regulate the phenotypic remodeling induced by DHA. This provides a novel strategy and therapeutic target for anti-lung cancer immunotherapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Xiaoran Ma, Shuang Wang, Chenglin Li, Xihui Jia, Tiantian Wang, Zhe Leng, Ran Lu, Xiaowen Kong, Jinyu Zhang, Ling Li
Summary: Baicalein (BAI), a natural flavonoid, has been found to alleviate clinical symptoms, demyelination, and inflammatory response in EAE mice. It inhibits M1 microglia/macrophage activation, decreases the expression of proinflammatory cytokines, and targets STAT1 to inhibit polarization. These findings suggest the potential use of BAI in the treatment of MS.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Sahar S. Abd-Elhalem, Mohamed H. Al-Doori, Marwa T. Hassen
Summary: This study aimed to explore the potential mechanisms of curcumin on macrophage polarization, expression, activation, and cytokine secretion in adjuvant-induced arthritis and its role in enhancing the therapeutic action of methotrexate while minimizing side effects. The results showed that treating arthritic rats with curcumin, either alone or in combination with methotrexate, resulted in improvement in paw inflammation, growth rate, spleen weights, and hematological analyses. Curcumin may have a promising role in regulating macrophage expression, activation, cytokine secretion, and polarization.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Engineering, Biomedical
Gowri Rangaswamy Gunassekaran, Sri Murugan Poongkavithai Vadevoo, Moon-Chang Baek, Byungheon Lee
Summary: In this study, M1 macrophage-derived exosomes were engineered to reprogram TAMs into M1-like macrophages for inhibiting tumor growth. The results showed that systemic administration of these exosomes increased anti-tumor immunity more efficiently than untargeted and control peptide-labeled exosomes.
Article
Oncology
Aliva Prity Minz, Biswajit Das, Debasish Mohapatra, Voddu Suresh, Swayambara Mishra, Shantibhusan Senapati
Summary: In patients with pancreatic cancer, the peritoneal cavity is a common site of metastasis. Peritoneal macrophages play a significant role in peritoneal metastases of different cancers. This study investigates the effect of Gemcitabine (GEM), a chemotherapy drug, on the polarization of macrophages and its potential clinical implications in pancreatic cancer. The results show that GEM induces a M1-like polarization of macrophages, resulting in cytotoxicity towards pancreatic cancer cells and delayed disease progression in a mouse model.
CLINICAL & EXPERIMENTAL METASTASIS
(2022)
Article
Rheumatology
Xiuhua Wu, Zhimian Wang, Jing Shi, Xin Yu, Chaoran Li, Jinjing Liu, Fengchun Zhang, Hua Chen, Wenjie Zheng
Summary: This study investigated the effect of BD serum on the phenotypes and functions of macrophage polarization. The findings revealed that BD serum promoted macrophage polarization towards a proinflammatory M1-like phenotype through NF-kappa B signaling. This may contribute to inflammation in BD. The study suggests that M1 polarized macrophages could be a potential therapeutic target for BD.
ARTHRITIS RESEARCH & THERAPY
(2022)
Article
Integrative & Complementary Medicine
Wenyu Jia, Siwan Luo, Gena Lai, Shiqi Li, Shuai Huo, Meifang Li, Xing Zeng
Summary: This study found that Polyporus polysaccharide can inhibit the proliferation and migration of bladder cancer cells by activating macrophages, while promoting their apoptosis. The JAK2/NF-κB pathway plays an important role in this process.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2021)
Article
Biochemistry & Molecular Biology
Hyun-Jun Park, Eun-Hye Seo, Liyun Piao, Sang-Tae Park, Min-Ki Lee, Seong-Eun Koh, Seung-Hyun Lee, Seong-Hyop Kim
Summary: The study showed that the CD39 inhibitor POM-1 increased apoptosis of colon cancer cells, limited tumor growth in mice, and elevated the expression of M1-tumor phenotypes from TAMs in the tumor tissue.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Kejun Peng, Nianhua Deng, Yao Meng, Qianchuan He, Hao Meng, Ting Luo, Yanru Wei, Yue Kang, Xiaodong Zhou, Fubing Shen
Summary: Alpha-MMC can regulate the immune system by inhibiting the expression of inflammatory cytokines without affecting anti-inflammatory cytokines. The findings suggest that Alpha-MMC may be a potential treatment for severe inflammation and autoimmune diseases characterized by cytokine storms.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Pediatrics
Shenghua Yu, ZhiBao Lv, Zhimei Gao, Jingyi Shi, Qingfeng Sheng, Lulu Zheng, Junmei Zhou, Xueli Wang
Summary: The study found that hydrogen attenuated the severity of NEC by inhibiting the expression of NF-κB p65 and promoting the conversion of M1 macrophages.
FRONTIERS IN PEDIATRICS
(2021)
Article
Biochemistry & Molecular Biology
Lingyun Lai, Yi Li, Jianjun Liu, Lei Luo, Jianguo Tang, Jun Xue, Te Liu
Summary: The study shows that abnormalities in Klotho expression can lead to kidney injury and chronic kidney disease, potentially due to immune activation and chronic inflammation induced by gut microbiota imbalance.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Serika D. Naicker, Claire L. Feerick, Kevin Lynch, Dawn Swan, Cian McEllistrim, Robert Henderson, Niamh A. Leonard, Oliver Treacy, Alessandro Natoni, Athina Rigalou, Joana Cabral, Christopher Chiu, Kate Sasser, Thomas Ritter, Michael O'Dwyer, Aideen E. Ryan
Summary: Multiple Myeloma (MM) is a malignant disorder of plasma cells that remains incurable despite significant advances in treatment. Daratumumab, the first CD38-directed monoclonal antibody, has pleiotropic mechanisms of activity, including enhancing natural killer (NK) cell and macrophage-mediated antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis (ADCP). The combination of daratumumab with cyclophosphamide (CTX) enhances macrophage-mediated clearance of MM cells by altering the tumor microenvironment and promoting a pro-inflammatory phenotype, supporting the potential addition of cyclophosphamide to MM treatment regimens containing monoclonal antibodies.
Review
Oncology
Eileen Reidy, Niamh A. Leonard, Oliver Treacy, Aideen E. Ryan
Summary: Colorectal cancer is a common solid tumor with many patients developing resistance to treatment. 3D models allow for studying interactions between cancer cells and other cells in the colon, aiding in understanding drug effects.
Review
Oncology
Thomas U. Marron, Aideen E. Ryan, Sangeetha M. Reddy, Sabina Kaczanowska, Rania H. Younis, Dipti Thakkar, Jiajia Zhang, Todd Bartkowiak, Rachel Howard, Kristin G. Anderson, Daniel Olson, Abdul Rafeh Naqash, Ravi B. Patel, Esha Sachdev, Maria E. Rodriguez-Ruiz, Michal Sheffer, Sarah Church, Christopher Fuhrman, Abigail Overacre-Delgoffe, Rosa Nguyen, Vaia Florou, Jessica E. Thaxton, David H. Aggen, Jennifer L. Guerriero
Summary: Although immune checkpoint inhibitors (ICIs) have improved overall survival for cancer patients, the optimal duration of therapy remains undefined and further research is needed. Early trials have shown that a significant percentage of patients have durable responses to ICIs, prompting the question of whether patients may be receiving too much treatment and if durable remissions can still be achieved with shorter courses. Designing well-controlled trials to identify biomarkers for predicting patients who would benefit from shorter courses of immunotherapy is crucial for future work in this area.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Cell & Tissue Engineering
Oliver Treacy, Kevin Lynch, Nick Murphy, Xizhe Chen, Ellen Donohoe, Aoife Canning, Paul Lohan, Georgina Shaw, Gerry Fahy, Aideen E. Ryan, Thomas Ritter
Summary: The study showed that low-dose subconjunctival injection of allogeneic MSCs effectively promoted corneal allograft survival, indicating a potential for improving future MSC immunotherapies for preventing corneal allograft rejection.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Christopher L. McGinity, Erika M. Palmieri, Veena Somasundaram, Dibyangana D. Bhattacharyya, Lisa A. Ridnour, Robert Y. S. Cheng, Aideen E. Ryan, Sharon A. Glynn, Douglas D. Thomas, Katrina M. Miranda, Stephen K. Anderson, Stephen J. Lockett, Daniel W. McVicar, David A. Wink
Summary: The metabolic requirements and functions of cancer and normal tissues differ significantly, with distorted vasculature and hypoxia-induced stress commonly observed in tumor microenvironments. Recent studies have shown that alterations in various metabolic pathways dictate tumor behavior and response to therapy, with metabolic heterogeneity within the tumor microenvironment playing a key role in promoting tumor behavior.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Meeting Abstract
Hematology
Claire L. Feerick, Kevin Lynch, Janusz Krawczyk, Michael O'Dwyer, Aideen Ryan
Meeting Abstract
Hematology
Dawn Swan, Michael E. O'Dwyer, Mary Cahill, Janusz Krawczyk, Vitaliy Mykytiv, John Quinn, Robert Henderson, Cian McEllistrim, Andres Hernando, Imelda Parker, Marc Nolan, Elizabeth Lenihan, Eva Szegezdi, Serika D. Naicker, Kevin Lynch, Alessandro Natoni, Aideen Ryan, Philip Murphy
Article
Gastroenterology & Hepatology
Shania M. Corry, Amy M. B. McCorry, Tamsin R. M. Lannagan, Niamh A. Leonard, Natalie C. Fisher, Ryan M. Byrne, Petros Tsantoulis, Xabier Cortes-Lavaud, Raheleh Amirkhah, Keara L. Redmond, Aoife J. McCooey, Sudhir B. Malla, Emily Rogan, Svetlana Sakhnevych, Michael A. Gillespie, Mark White, Susan D. Richman, Rene-Filip Jackstadt, Andrew D. Campbell, Sarah Maguire, Simon S. McDade, Daniel B. Longley, Maurice B. Loughrey, Helen G. Coleman, Emma M. Kerr, Sabine Tejpar, Timothy Maughan, Simon J. Leedham, Donna M. Small, Aideen E. Ryan, Owen J. Sansom, Mark Lawler, Philip D. Dunne
Summary: This study identifies and validates a HiFi-specific prognostic signature (HPS) based on STAT1-related signaling in the stroma-rich subtype of colon cancer. The HPS is associated with immune cell and antigen processing in stroma-rich colon cancer and treatment with the TLR3 agonist poly(I:C) can enhance the HPS signaling and reduce liver metastases.
Article
Oncology
D. Swan, R. Henderson, C. McEllistrim, S. D. Naicker, J. Quinn, M. R. Cahill, V. Mykytiv, E. Lenihan, E. Mulvaney, M. Nolan, I. Parker, A. Natoni, K. Lynch, A. E. Ryan, E. Szegezdi, J. Krawczyk, P. Murphy, M. O'Dwyer
Summary: The study investigated the combination of Daratumumab with cyclophosphamide, bortezomib, and dexamethasone for newly diagnosed multiple myeloma patients. The results showed high rates of complete response and a favorable progression-free survival rate, indicating the effectiveness of the treatment regimen.
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2022)
Article
Cell Biology
Hannah Egan, Oliver Treacy, Kevin Lynch, Niamh A. Leonard, Grace O'Malley, Eileen Reidy, Aoise O'Neill, Shania M. Corry, Kim De Veirman, Karin Vanderkerken, Laurence J. Egan, Thomas Ritter, Aisling M. Hogan, Keara Redmond, Li Peng, Jenny Che, Wayne Gatlin, Pushpa Jayaraman, Margaret Sheehan, Aoife Canney, Sean O. Hynes, Emma M. Kerr, Philip D. Dunne, Michael E. O'Dwyer, Aideen E. Ryan
Summary: Immunosuppressive tumor microenvironments (TMEs) in cancer reduce immune responses, and mesenchymal stromal cells (MSCs) promote tumor progression through enhancing immune cell suppression in colorectal cancer (CRC). The hyper-sialylation of glycans promotes immune evasion by binding sialic acids to Siglecs receptors on immune cells, resulting in inhibition of their functions. However, the role of sialylation in MSC/CAF immunosuppression in the TME is not well characterized.
Article
Immunology
Jiemin Wang, Ellen Donohoe, Aoife Canning, Seyedmohammad Moosavizadeh, Fiona Buckley, Meadhbh A. Brennan, Aideen E. Ryan, Thomas Ritter
Summary: The study found that IFN-gamma and IFN-gamma/TGF-beta 1-licensed MSCs exhibited enhanced immunomodulatory effects on T cell proliferation, while TGF-beta 1 and IFN-gamma licensing strengthened the immunomodulatory effects of MSCs on reducing TNF-alpha and IL-1 beta expression in M1 macrophage-like THP-1 cells. Additionally, the study discovered an immunomodulatory effect mediated by MSC-derived apoptotic bodies (ABs).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Meeting Abstract
Oncology
Aideen Ryan, Oliver Treacy, Kevin Lynch, Kim De Veirman, Karin Vanderkerken, Laurence Egan, Thomas Ritter, Aisling Hogan, Keara Redmond, Sean Hynes, Emma Kerr, Michael O'Dwyer, Philip Dunne, Niamh Leonard, Hannah Egan
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Meeting Abstract
Immunology
Hannah Egan, Oliver Treacy, Niamh Leonard, Kevin Lynch, Amir Nader, Sean Hynes, Margaret Sheehan, Laurence J. Egan, Thomas Ritter, John Daly, Aisling M. Hogan, Michael O'Dwyer, Aideen E. Ryan
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Meeting Abstract
Immunology
Niamh A. Leonard, Oliver Treacy, Kevin Lynch, Grace O'Malley, Hannah Egan, Eileen Reidy, Thomas Ritter, Daniela Loessner, Laurance J. Egan, Aideen E. Ryan
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Meeting Abstract
Biotechnology & Applied Microbiology
Thomas Ritter, Kevin Lynch, Nick Murphy, Xizhe Chen, Aoife Canning, Ellen Donohoe, Paul Lohan, Georgina Shaw, Gerry Fahy, Aideen Ryan, Oliver Treacy