M1 macrophage exosomes engineered to foster M1 polarization and target the IL-4 receptor inhibit tumor growth by reprogramming tumor-associated macrophages into M1-like macrophages

Harnessing tumor-associated macrophages as aids for cancer immunotherapy

(2019) Xiaolei Li et al.   Molecular Cancer

Non-genetic engineering of cytotoxic T cells to target IL-4 receptor enhances tumor homing and therapeutic efficacy against melanoma

(2018) Gowri Rangaswamy Gunassekaran et al.   BIOMATERIALS

Exosomes as a Drug Delivery System in Cancer Therapy: Potential and Challenges

(2018) Golam Kibria et al.   MOLECULAR PHARMACEUTICS

Anchor peptide captures, targets, and loads exosomes of diverse origins for diagnostics and therapy

(2018) Xianjun Gao et al.   Science Translational Medicine

Efficient RNA drug delivery using red blood cell extracellular vesicles

(2018) Waqas Muhammad Usman et al.   Nature Communications

Internalization of Exosomes through Receptor-mediated Endocytosis

(2018) Amber Gonda et al.   MOLECULAR CANCER RESEARCH

IL4 Receptor–Targeted Proapoptotic Peptide Blocks Tumor Growth and Metastasis by Enhancing Antitumor Immunity

(2017) Sri Murugan Poongkavithai Vadevoo et al.   MOLECULAR CANCER THERAPEUTICS

Exosomes from M1-Polarized Macrophages Potentiate the Cancer Vaccine by Creating a Pro-inflammatory Microenvironment in the Lymph Node

(2017) Lifang Cheng et al.   MOLECULAR THERAPY

Tumour-associated macrophages as treatment targets in oncology

(2017) Alberto Mantovani et al.   Nature Reviews Clinical Oncology

Pancreatic Cancer Cell Exosome-Mediated Macrophage Reprogramming and the Role of MicroRNAs 155 and 125b2 Transfection using Nanoparticle Delivery Systems

(2016) Mei-Ju Su et al.   Scientific Reports

Reprogramming Tumor-Associated Macrophages by Antibody Targeting Inhibits Cancer Progression and Metastasis

(2016) Anna-Maria Georgoudaki et al.   Cell Reports

Peptide therapeutics: current status and future directions

(2015) Keld Fosgerau et al.   DRUG DISCOVERY TODAY

Enhanced delivery of liposomes to lung tumor through targeting interleukin-4 receptor on both tumor cells and tumor endothelial cells

(2015) Lianhua Chi et al.   JOURNAL OF CONTROLLED RELEASE

Induced PD-L1 Expression Mediates Acquired Resistance to Agonistic Anti-CD40 Treatment

(2015) A. Zippelius et al.   Cancer Immunology Research

T H 2-Polarized CD4 + T Cells and Macrophages Limit Efficacy of Radiotherapy

(2015) Stephen L. Shiao et al.   Cancer Immunology Research

Dynamic Biodistribution of Extracellular Vesicles in Vivo Using a Multimodal Imaging Reporter

(2014) Charles P. Lai et al.   ACS Nano

Tumour-associated macrophages targeted transfection with NF-κB decoy/mannose-modified bubble lipoplexes inhibits tumour growth in tumour-bearing mice

(2014) Yusuke Kono et al.   JOURNAL OF DRUG TARGETING

Plasticity of Macrophage Function during Tumor Progression: Regulation by Distinct Molecular Mechanisms

(2014) S. K. Biswas et al.   JOURNAL OF IMMUNOLOGY

Poly-cyclodextrin and poly-paclitaxel nano-assembly for anticancer therapy

(2014) Ran Namgung et al.   Nature Communications

Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection

(2013) Yuki Takahashi et al.   JOURNAL OF BIOTECHNOLOGY

Extracellular vesicles: biology and emerging therapeutic opportunities

(2013) Samir EL Andaloussi et al.   NATURE REVIEWS DRUG DISCOVERY

MicroRNA-mediated control of macrophages and its implications for cancer

(2013) Mario Leonardo Squadrito et al.   TRENDS IN IMMUNOLOGY

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes

(2012) Jessica Wahlgren et al.   NUCLEIC ACIDS RESEARCH

Differential macrophage programming in the tumor microenvironment

(2012) Brian Ruffell et al.   TRENDS IN IMMUNOLOGY

miR-511-3p Modulates Genetic Programs of Tumor-Associated Macrophages

(2012) Mario Leonardo Squadrito et al.   Cell Reports

Identification and manipulation of tumor associated macrophages in human cancers

(2011) Moniek Heusinkveld et al.   Journal of Translational Medicine

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

(2011) G. L. Beatty et al.   SCIENCE

Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes

(2010) K. Movahedi et al.   CANCER RESEARCH

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Macrophages, innate immunity and cancer: balance, tolerance, and diversity

(2010) Alberto Mantovani et al.   CURRENT OPINION IN IMMUNOLOGY

Rho-kinase 2 is frequently overexpressed in hepatocellular carcinoma and involved in tumor invasion

(2009) Carmen Chak-Lui Wong et al.   HEPATOLOGY

Significance of M2-Polarized Tumor-Associated Macrophage in Pancreatic Cancer

(2009) Hiroshi Kurahara et al.   JOURNAL OF SURGICAL RESEARCH

Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System

(2008) Sherry L. LaPorte et al.   CELL

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark