Evi1 defines leukemia-initiating capacity and tyrosine kinase inhibitor resistance in chronic myeloid leukemia

The shortest isoform of C/EBP , liver inhibitory protein (LIP), collaborates with Evi1 to induce AML in a mouse BMT model

(2013) N. Watanabe-Okochi et al.   BLOOD

BCR-ABL1 tyrosine kinase sustained MECOM expression in chronic myeloid leukaemia

(2012) Swagata Roy et al.   BRITISH JOURNAL OF HAEMATOLOGY

Altered Microenvironmental Regulation of Leukemic and Normal Stem Cells in Chronic Myelogenous Leukemia

(2012) Bin Zhang et al.   CANCER CELL

The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells

(2012) Haojian Zhang et al.   NATURE GENETICS

Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins

(2011) A. Yoshimi et al.   BLOOD

Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival

(2011) A. Hamilton et al.   BLOOD

Persistence of leukemia stem cells in chronic myelogenous leukemia patients in prolonged remission with imatinib treatment

(2011) S. Chu et al.   BLOOD

Leukemic stem cell persistence in chronic myeloid leukemia patients with sustained undetectable molecular residual disease

(2011) J.-C. Chomel et al.   BLOOD

IL-6 Controls Leukemic Multipotent Progenitor Cell Fate and Contributes to Chronic Myelogenous Leukemia Development

(2011) Damien Reynaud et al.   CANCER CELL

Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity

(2011) Keisuke Kataoka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Stem cell gene expression programs influence clinical outcome in human leukemia

(2011) Kolja Eppert et al.   NATURE MEDICINE

Genomic and Proteomic Analysis of the Impact of Mitotic Quiescence on the Engraftment of Human CD34+ Cells

(2011) Brahmananda Reddy Chitteti et al.   PLoS One

Frequent EVI1 translocations in myeloid blast crisis CML that evolves through tyrosine kinase inhibitors

(2011) Ronald L. Paquette et al.   Cancer Genetics

Evi-1 is a transcriptional target of mixed-lineage leukemia oncoproteins in hematopoietic stem cells

(2010) S. Arai et al.   BLOOD

EVI-1 oncogene expression predicts survival in chronic-phase CML patients resistant to imatinib treated with second-generation tyrosine kinase inhibitors

(2010) M. Daghistani et al.   BLOOD

BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells

(2010) M. Schemionek et al.   BLOOD

Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity

(2010) Amie S. Corbin et al.   JOURNAL OF CLINICAL INVESTIGATION

HighEVI1Expression Predicts Outcome in Younger Adult Patients With Acute Myeloid Leukemia and Is Associated With Distinct Cytogenetic Abnormalities

(2010) Stefan Gröschel et al.   JOURNAL OF CLINICAL ONCOLOGY

EVI1 overexpression in distinct subtypes of pediatric acute myeloid leukemia

(2010) B V Balgobind et al.   LEUKEMIA

TGF-β–FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia

(2010) Kazuhito Naka et al.   NATURE

Molecular Signatures of Quiescent, Mobilized and Leukemia-Initiating Hematopoietic Stem Cells

(2010) E. Camilla Forsberg et al.   PLoS One

Enhanced expression of the EVI1 gene in NUP98/HOXA-expressing leukemia cells

(2009) Minenori Eguchi-Ishimae et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

EVI-1 interacts with histone methyltransferases SUV39H1 and G9a for transcriptional repression and bone marrow immortalization

(2009) S Goyama et al.   LEUKEMIA

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

(2009) Chen Zhao et al.   NATURE

Loss of the Alox5 gene impairs leukemia stem cells and prevents chronic myeloid leukemia

(2009) Yaoyu Chen et al.   NATURE GENETICS

Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells

(2009) M Shimabe et al.   ONCOGENE

BCR-ABL fusion transcript types and levels and their interaction with secondary genetic changes in determining the phenotype of Philadelphia chromosome-positive leukemias

(2008) D. Jones et al.   BLOOD

High EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated

(2008) S. Lugthart et al.   BLOOD

Evi-1 promotes para-aortic splanchnopleural hematopoiesis through up-regulation of GATA-2 and repression of TGF-b signaling

(2008) Tomohiko Sato et al.   CANCER SCIENCE

Evi-1 Is a Critical Regulator for Hematopoietic Stem Cells and Transformed Leukemic Cells

(2008) Susumu Goyama et al.   Cell Stem Cell