A novel bispecific EGFR/Met antibody blocks tumor-promoting phenotypic effects induced by resistance to EGFR inhibition and has potent antitumor activity

Protein Kinase B/AKT and Focal Adhesion Kinase: Two Close Signaling Partners in Cancer

(2012) Shouye Wang et al.   Anti-Cancer Agents in Medicinal Chemistry

Development of tetravalent IgG1 dual targeting IGF-1R–EGFR antibodies with potent tumor inhibition

(2012) Rebecca Croasdale et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Targeting the Epidermal Growth Factor Receptor in Solid Tumor Malignancies

(2012) Mette K. Nedergaard et al.   BIODRUGS

Acquisition of EMT phenotype in the gefitinib-resistant cells of a head and neck squamous cell carcinoma cell line through Akt/GSK-3β/snail signalling pathway

(2012) S Maseki et al.   BRITISH JOURNAL OF CANCER

Lack of AKT activation in lung cancer cells with EGFR mutation is a novel marker of cetuximab sensitivity

(2012) Miyako Takata et al.   CANCER BIOLOGY & THERAPY

Cyclin G-associated kinase regulates protein phosphatase 2A by phosphorylation of its B'γ subunit

(2012) Yoko Naito et al.   CELL CYCLE

Dual Blockade of EGFR and c-Met Abrogates Redundant Signaling and Proliferation in Head and Neck Carcinoma Cells

(2011) H. Xu et al.   CLINICAL CANCER RESEARCH

HGF/c-MET Targeted Therapeutics: Novel Strategies for Cancer Medicine

(2011) Timothy A. Yap et al.   CURRENT DRUG TARGETS

Role of MetMAb (OA-5D5) in c-MET active lung malignancies

(2011) Mosmi Surati et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Hepatocyte Growth Factor Induces Resistance to Anti-Epidermal Growth Factor Receptor Antibody in Lung Cancer

(2011) Tadaaki Yamada et al.   Journal of Thoracic Oncology

A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity

(2011) Jianying Dong et al.   mAbs

Bispecific digoxigenin-binding antibodies for targeted payload delivery

(2011) S. Metz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer invasion and resistance: interconnected processes of disease progression and therapy failure

(2011) Stephanie Alexander et al.   TRENDS IN MOLECULAR MEDICINE

Src/FAK-mediated regulation of E-cadherin as a mechanism for controlling collective cell movement

(2011) Alan Serrels et al.   Cell Adhesion & Migration

MET Kinase Inhibitor SGX523 Synergizes with Epidermal Growth Factor Receptor Inhibitor Erlotinib in a Hepatocyte Growth Factor-Dependent Fashion to Suppress Carcinoma Growth

(2010) Y.-W. Zhang et al.   CANCER RESEARCH

HGF Rescues Colorectal Cancer Cells from EGFR Inhibition via MET Activation

(2010) D. Liska et al.   CLINICAL CANCER RESEARCH

Growth Factors and their receptors in cancer metastases

(2010) Shi Yu Yang   Frontiers in Bioscience-Landmark

Quantitative Analysis of HGF and EGF-Dependent Phosphotyrosine Signaling Networks

(2010) Dean E. Hammond et al.   JOURNAL OF PROTEOME RESEARCH

Activation of HER family members in gastric carcinoma cells mediates resistance to MET inhibition

(2010) Simona Corso et al.   Molecular Cancer

MET signalling: principles and functions in development, organ regeneration and cancer

(2010) Livio Trusolino et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Combined inhibition of MET and EGFR suppresses proliferation of malignant mesothelioma cells

(2009) Koji Kawaguchi et al.   CARCINOGENESIS

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non–Small-Cell Lung Cancers Dependent on the Epidermal Growth Factor Receptor Pathway

(2009) Kim-Son H. Nguyen et al.   Clinical Lung Cancer

Targeting MET as a strategy to overcome crosstalk-related resistance to EGFR inhibitors

(2009) Michalis V Karamouzis et al.   LANCET ONCOLOGY

Hepatocyte Growth Factor Induces Gefitinib Resistance of Lung Adenocarcinoma with Epidermal Growth Factor Receptor-Activating Mutations

(2008) S. Yano et al.   CANCER RESEARCH

HER kinase activation confers resistance to MET tyrosine kinase inhibition in MET oncogene-addicted gastric cancer cells

(2008) T. Bachleitner-Hofmann et al.   MOLECULAR CANCER THERAPEUTICS

Signaling networks assembled by oncogenic EGFR and c-Met

(2008) A. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA