Article
Oncology
Jian Xu, Wei Zhang
Summary: This study revealed that EZR accelerates the progression of pancreatic cancer through the FAK/AKT signaling pathway, promoting proliferation and migration of PC cells.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Xufeng Wang, Xinyu Chang, Changyu He, Zhiyuan Fan, Zhenjia Yu, Beiqin Yu, Xiongyan Wu, Junyi Hou, Jianfang Li, Liping Su, Bingya Liu, Zhenggang Zhu
Summary: ATP5B is highly expressed in tumor tissues of GC and is positively correlated with age, tumor size, TNM stage, lymph node metastasis, and poor prognosis. Overexpression of ATP5B in GC cells increases cellular ATP content and promotes migration, invasion, and proliferation through the FAK/AKT/MMP2 pathway.
Article
Biochemistry & Molecular Biology
Karina A. Miller, Seamus Degan, Yanqing Wang, Joseph Cohen, Sheng Yu Ku, David W. Goodrich, Irwin H. Gelman
Summary: PTEN loss is a common mutation in prostate cancer, driving disease progression through AKT activation. Different transgenic prostate cancer models with Akt activation and Rb loss exhibit different metastatic outcomes. PTEN deficiency is correlated with increased dependence on p110 beta and AKT2 for metastatic growth or motility, and downregulation of the metastasis suppressor SMAD4. On the other hand, PTEN expression is associated with greater dependence on p110 alpha and AKT1.
Article
Oncology
Xinxin Cheng, Jie Wang, Chunling Liu, Tianduo Jiang, Ningzhi Yang, Dan Liu, Huanhuan Zhao, Zhelong Xu
Summary: Zinc transporters have been found to be associated with the pathogenesis of various human diseases, including cancer. Among these, high expression of ZIP13 is an independent prognostic factor for poor survival in ovarian cancer patients. ZIP13 regulates intracellular zinc distribution, affecting gene expression related to extracellular matrix organization and cytokine-mediated signaling pathway, ultimately activating the Src/FAK pathway and promoting metastasis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Yang Yang, Yizhe Wang, Xiaofang Che, Kezuo Hou, Jie Wu, Chunlei Zheng, Yang Cheng, Yunpeng Liu, Xuejun Hu, Jingdong Zhang
Summary: The study revealed that the integrin alpha 5/FAK/STAT3/AKT signaling pathway promotes icotinib resistance and malignancy in NSCLC cells. Targeting this pathway may provide a promising strategy to overcome drug resistance.
Article
Oncology
Lei Jiang, Yan Chen, Guangtao Min, Jun Wang, Wei Chen, Hongpeng Wang, Xiangwen Wang, Nan Yao
Summary: BAG4 has been found to be overexpressed in gastric cancer tissues compared to normal tissues, and its elevated expression is associated with advanced tumor characteristics and poor patient outcomes. Mechanistically, BAG4 promotes invasion and metastasis of gastric cancer cells by activating the PI3K/AKT/NF-kappa B/ZEB1 axis to induce epithelial-mesenchymal transition.
Article
Oncology
Qing Han, Fei Xiao, Lili Ma, Jinmei Zhou, Lan Wang, Huang Cheng, Jingjing Zhu, Fuli Yao, Jianxin Lyu, Linyong DU
Summary: This study revealed that DDR1 is highly expressed in breast cancer and negatively correlated with the prognosis of breast cancer patients. DDR1 facilitates migration and invasion in breast cancer cells via activation of the Src-FAK signaling.
Article
Multidisciplinary Sciences
Dan Liao, Yanyan Liu, Cuifen Li, Bin He, Guanghui Zhou, Yejia Cui, Haohai Huang
Summary: This study investigated the effect of Arctigenin (ARG), a nature-derived component, on cervical cancer cells. The results showed that ARG could inhibit cell proliferation, invasion, and metastasis, and promote apoptosis, through the inhibition of the FAK/paxillin pathway.
Article
Oncology
Qinghua Wang, Zelin Liu, Guanzhong Zhai, Xi Yu, Shuai Ke, Haoren Shao, Jia Guo
Summary: This study found that GATA5 is downregulated in prostate cancer, and its downregulation is associated with tumor proliferation, migration, invasion, and the process of epithelial-mesenchymal transition (EMT). In addition, GATA5 can interact with PLAGL2 to regulate prostate cancer cell growth through the FAK/PI3K/AKT signaling pathway.
Article
Plant Sciences
Jen-Chih Tseng, Bi-Juan Wang, Ya-Pei Wang, Ying-Yu Kuo, Jen -Kun Chen, Tzyh-Chyuan Hour, Li-Kuo Kuo, Po-Jen Hsiao, Chien-Chih Yeh, Cheng-Li Kao, Li-Jane Shih, Chih-Pin Chuu
Summary: The study revealed that CAPE can simultaneously suppress EGFR and Akt signaling in PCa cells, leading to inhibition of cell migration and tumor growth. This highlights the potential of CAPE as a therapeutic agent for advanced PCa.
Article
Oncology
Ying Wang, Xia Luo, Nayiyuan Wu, Qianjin Liao, Jing Wang
Summary: The study aimed to investigate the role of the SRC-3/TRAF4/PI3K/AKT pathway in ovarian cancer development. It was found that SRC-3 and TRAF4 were upregulated in ovarian cancer cell lines. Silencing of SRC-3 or TRAF4 inhibited cell proliferation, migration, invasion, and stemness, as well as the activation of the PI3K/AKT signaling pathway. However, TRAF4 overexpression reversed the effect of SRC-3 silencing.
Article
Biochemistry & Molecular Biology
Jonas Weisse, Julia Rosemann, Lisa Muller, Matthias Kappler, Alexander W. Eckert, Markus Glass, Danny Misiak, Stefan Huttelmaier, Wolfgang G. Ballhausen, Mechthild Hatzfeld, Monika Haemmerle, Tony Gutschner
Summary: Cancer metastasis is the main cause of mortality, with the identification of new therapeutic targets being crucial for survival improvement. Through the study of intratumoral heterogeneity, Lymphocyte cell-specific protein-tyrosine kinase (LCK) was discovered as a significant regulator of motility in oral cancer cells, suggesting that inhibition of LCK could be a promising anti-metastasis therapy option for oral cancer patients.
Article
Biochemistry & Molecular Biology
Chan Wang, Jiaxin Chen, Yeye Kuang, Xiaoqing Cheng, Min Deng, Zhinong Jiang, Xiaotong Hu
Summary: The study found that TRPM4 is a novel methylated tumor suppressor gene that is downregulated in colorectal cancer. TRPM4 activates calpain-mediated cleavage of FAK through modulating the PI3K/Akt/mTOR signaling cascade, thereby impeding CRC migration and invasion.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Plant Sciences
Xiaoyi Qi, Yonglan Chen, Sha Liu, Li Liu, Zehui Yu, Ling Yin, Lu Fu, Mingming Deng, Sicheng Liang, Muhan Lu
Summary: This study revealed the antimetastatic effect of SAG on melanoma and identified the underlying molecular mechanisms through the inhibition of the PI3K-AKT signaling pathway. Results showed that SAG inhibited the proliferation, migration, and invasion of melanoma cells and effectively suppressed tumor growth in a xenograft model. These findings offer a theoretical foundation for the clinical application of SAG in antitumor therapy.
PHARMACEUTICAL BIOLOGY
(2023)
Article
Oncology
Shao Wenhua, Takaaki Tsunematsu, Masaaki Umeda, Hiroaki Tawara, Natsumi Fujiwara, Yasuhiro Mouri, Rieko Arakaki, Naozumi Ishimaru, Yasusei Kudo
Summary: Recently, it has been reported that the partial-epithelial-mesenchymal transition (p-EMT) program is associated with metastasis in head and neck squamous cell carcinoma (HNSCC). The study focused on the role of a novel cancer-specific POSTN isoform, Iso5, in HNSCC and found that Iso5 promoted invasion together with another isoform, Iso3. The researchers suggest that Iso5 can be a useful marker for detecting cancer cells undergoing p-EMT and a potential target for diagnosis and therapy in HNSCC.