Article
Chemistry, Medicinal
Wenchao Lu, Mengyang Fan, Wenzhi Ji, Jason Tse, Inchul You, Scott B. Ficarro, Isidoro Tavares, Jianwei Che, Audrey Y. Kim, Xijun Zhu, Andrew Boghossian, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Stephen M. Hinshaw, Behnam Nabet, Steven M. Corsello, Nicholas Kwiatkowski, Jarrod A. Marto, Tinghu Zhang, Nathanael S. Gray
Summary: TEAD proteins, along with their coactivators YAP and TAZ, are important regulators of gene expression in the Hippo pathway. Aberrant TEAD/YAP signaling has been implicated in various cancers. Recent research has identified TEADs as being palmitoylated, suggesting a new avenue for developing anticancer drugs targeting TEAD.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Xu Li, Shu Zhuo, Yong Suk Cho, Yuchen Liu, Yingzi Yang, Jian Zhu, Jin Jiang
Summary: Hippo signaling inhibits the oncogenic potential of YAP/TAZ-TEAD transcriptional complex, restricting tumor growth. In AR-positive prostate cancer, YAP acts as a tumor suppressor by counteracting TEAD-mediated AR signaling. YAP competes with AR for TEAD binding, disrupting AR-TEAD interaction and preventing TEAD from promoting AR signaling. Targeting the Hippo signaling pathway may provide a therapeutic opportunity to treat therapy resistant AR variants-driven prostate cancer.
Review
Biochemistry & Molecular Biology
Boon Chin Heng, Xuehui Zhang, Dominique Aubel, Yunyang Bai, Xiaochan Li, Yan Wei, Martin Fussenegger, Xuliang Deng
Summary: YAP and TAZ are crucial proteins involved in maintaining tissue/organ size and have diverse roles in various biological processes, including cell proliferation, tissue regeneration, cell fate determination, tumorigenesis, and mechanosensing.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cell Biology
Jing Cai, Kyungsuk Choi, Hongde Li, Katiuska Daniela Pulgar Prieto, Yonggang Zheng, Duojia Pan
Summary: This study reveals that the essential role of YAP in liver and lung development can be bypassed by inactivation of the TEAD corepressor VGLL4, indicating that YAP's major physiological function is to antagonize VGLL4. The findings highlight the central importance of VGLL4-mediated transcriptional repression in regulating the Hippo pathway and provide insights into potential strategies for modulating Hippo signaling in cancer and regenerative medicine.
GENES & DEVELOPMENT
(2022)
Article
Biology
Rachel Warren, Handeng Lyu, Kylie Klinkhammer, Stijn P. De Langhe
Summary: Idiopathic pulmonary fibrosis (IPF) is characterized by fibrotic alveolar remodeling and progressive loss of pulmonary function. Chronic alveolar injury and failure to repair the respiratory epithelium are intrinsic to IPF pathogenesis. Loss or dysfunction of alveolar type 2 (AT2) stem cells can trigger pulmonary fibrosis. Increased YAP activity in respiratory epithelial cells in IPF lungs may promote pulmonary fibrosis. However, recent research also shows that YAP and Taz are important for AT1 cell maintenance and alveolar epithelial regeneration. Targeting YAP may help promote AT1 cell regeneration and treat pulmonary fibrosis.
Article
Biochemistry & Molecular Biology
Xigan He, Jinggui Chen, Jiamin Zhou, Anrong Mao, Weiqi Xu, Hongxu Zhu, Qi Pan, Yiming Zhao, Ning Zhang, Longrong Wang, Miao Wang, Zeyang Liu, Weiping Zhu, Lu Wang
Summary: This study identified a newly found lncRNA, EWSAT1, which plays a crucial role in hepatocellular carcinoma (HCC) metastasis. EWSAT1 is significantly upregulated in HCC and is associated with an aggressive phenotype and low patient survival. It promotes proliferation and metastasis of HCC cells by activating the transcription of cancer-related genes through the Hippo-YAP signaling pathway.
Article
Cell Biology
Samar Sayedyahossein, Louise Thines, David B. Sacks
Summary: The Hippo signaling pathway regulates various cellular processes, including cell proliferation, differentiation, migration, and mechanosensation. Calcium ion (Ca2+) has been found to influence core components of the Hippo pathway. However, the crosstalk between Ca2+ signaling and the Hippo pathway is not fully understood.
CELLULAR SIGNALLING
(2023)
Article
Pharmacology & Pharmacy
Wanyun Zuo, Na Liu, Yunhong Zeng, Zhenghui Xiao, Keke Wu, Fan Yang, Biao Li, Qingqing Song, Yunbin Xiao, Qiming Liu
Summary: In this study, luteolin was found to have a beneficial effect on pulmonary arterial hypertension, possibly through inhibiting the HIPPO-YAP/PI3K/AKT signaling pathway. Therefore, luteolin may become a promising candidate for the treatment of PAH.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Masum M. Mia, Manvendra K. Singh
Summary: Fibrosis is a defective wound healing process often seen after chronic injury and/or inflammation in various organs. The Hippo signaling pathway plays a crucial role in the pathophysiology of fibrotic diseases, regulating cell proliferation, apoptosis, cell fate decisions, and contributing to the development of organ fibrosis.
Review
Oncology
Hewen Shi, Ying Zou, Weiwei Zhong, Zhaoying Li, Xiaoxue Wang, Yancun Yin, Defang Li, Ying Liu, Minjing Li
Summary: This review summarizes the important roles of Yap/Taz in activating the Hippo pathway in liver cancer, and discusses the crosstalks between the Hippo pathway and other cancer associated pathways and molecules.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Dermatology
Yao Yuan, Natalia Salinas Parra, Qianming Chen, Ramiro Iglesias-Bartolome
Summary: In this study, the transcriptional targeting of YAP1 and TAZ in basal cell carcinoma was investigated using a TEAD inhibitor, showing reduced proliferation and increased differentiation of cancer cells. The findings also revealed YAP1/TAZ.TEAD-independent effects impacting STAT3 and NF-kappa B pathways in cancer cells.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Oncology
Tianxing Zhou, Xueyang Li, Jing Liu, Jihui Hao
Summary: Despite improvements in cancer survival, the mechanisms of cancer metastasis remain poorly understood. Metastasis involves a series of events such as epithelial-to-mesenchymal transition, invasion, angiogenesis, intravasation, survival in circulation, extravasation, mesenchymal-to-epithelial transition, colonization, and adaptation. Furthermore, cancer cells can remodel the tumor microenvironment and evade immune surveillance. The Hippo signaling pathway has been identified as a key regulator of cancer metastasis, offering potential as a therapeutic target.
CANCER BIOLOGY & MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yannick Mesrouze, Fedir Bokhovchuk, Marco Meyerhofer, Catherine Zimmermann, Patrizia Fontana, Dirk Erdmann, Patrick Chene
Summary: The Hippo signaling pathway is crucial for controlling organ size in animals and the binding interface between TEAD and YAP is essential for the development and survival of organisms. The conservation of the YAP:TEAD complex suggests an early evolutionary appearance in metazoans. Some Actinopterygii species have YAP variants with different TEAD-binding domains, but they still bind to TEAD with similar affinity. The YAP homolog in Caenorhabditis elegans does not contain the TEAD-binding domain found in other metazoans. A TEAD-binding domain, as seen in metazoan YAP, and WW domain(s) are not found in non-metazoan species.
Correction
Biochemistry & Molecular Biology
Xiao Zheng, Lujun Chen, You Zhou, Qi Wang, Zhuojun Zheng, Bin Xu, Chen Wu, Qi Zhou, Wenwei Hu, Changping Wu, Jingting Jiang
Summary: The paper has published an amendment which can be accessed through the original article.
Review
Medicine, Research & Experimental
Javeria Qadir, Feiya Li, Burton B. Yang
Summary: This review examines the interplay between the Hippo signaling pathway and circular RNAs (circRNAs) in various forms of cancer. It discusses how circRNAs can function as either tumor suppressors or oncogenes in cancer by interacting with miRNAs or proteins. The review also highlights the limitations and constraints in studying circRNA mechanisms, and raises questions about the role of circRNAs associated with the Hippo-YAP pathway in cancer. Finally, it explores the potential of circRNAs as diagnostic and prognostic biomarkers, as well as molecular targets for cancer therapy.
Review
Cell Biology
Alexander D. Fulford, Helen McNeill
CURRENT OPINION IN CELL BIOLOGY
(2020)
Article
Cell Biology
Abilasha Rao-Bhatia, Min Zhu, Wen-Chi Yin, Sabrina Coquenlorge, Xiaoyun Zhang, Janghee Woo, Yu Sun, Charlotte H. Dean, Aimin Liu, Chi-Chung Hui, Ramesh A. Shivdasani, Helen McNeill, Sevan Hopyan, Tae-Hee Kim
DEVELOPMENTAL CELL
(2020)
Article
Medicine, Research & Experimental
Kelly L. Betterman, Drew L. Sutton, Genevieve A. Secker, Jan Kazenwadel, Anna Oszmiana, Lillian Lim, Naoyuki Miura, Lydia Sorokin, Benjamin M. Hogan, Mark L. Kahn, Helen McNeill, Natasha L. Harvey
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Multidisciplinary Sciences
Maria Brooun, Alexander Klimovich, Mikhail Bashkurov, Bret J. Pearson, Robert E. Steele, Helen McNeill
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Yonit Tsatskis, Robyn Rosenfeld, Joel D. Pearson, Curtis Boswell, Yi Qu, Kyunga Kim, Lacramioara Fabian, Ariz Mohammad, Xian Wang, Michael Robson, Karen Krchma, Jun Wu, Joao Goncalves, Didier Hodzic, Shu Wu, Daniel Potter, Laurence Pelletier, Wade H. Dunham, Anne-Claude Gingras, Yu Sun, Jin Meng, Dorothea Godt, Tim Schedl, Brian Ciruna, Kyunghee Choi, John R. B. Perry, Rod Bremner, Eric C. Schirmer, Julie A. Brill, Andrea Jurisicova, Helen McNeill
Article
Gastroenterology & Hepatology
Elisabeth Verboven, Ivan M. Moya, Leticia Sansores-Garcia, Jun Xie, Hanne Hillen, Weronika Kowalczyk, Gerlanda Vella, Stefaan Verhulst, Stephanie A. Castaldo, Ana Alguero-Nadal, Lucia Romanelli, Cristina Mercader-Celma, Natalia A. Souza, Soheil Soheily, Leen Van Huffel, Thomas Van Brussel, Diether Lambrechts, Tania Roskams, Frederic P. Lemaigre, Gabrielle Bergers, Leo A. van Grunsven, Georg Halder
Summary: YAP/TAZ are not essential for liver development and regeneration in hepatocytes, but they indirectly contribute to liver regeneration by maintaining bile duct integrity and ensuring immune cell recruitment and function.
Article
Gastroenterology & Hepatology
Mickael Di-Luoffo, Sophie Pirenne, Thoueiba Saandi, Axelle Loriot, Claude Gerard, Nicolas Dauguet, Fatima Manzano-Nunez, Natalia Alves Souza Carvalhais, Florence Lamoline, Sabine Cordi, Katarzyna Konobrocka, Vitaline De Greef, Mina Komuta, Georg Halder, Patrick Jacquemin, Frederic P. Lemaigre
Summary: A mouse model combining Kras(G12D) expression in cholangiocytes with DDC diet-induced inflammation accurately mimics the development of iCCA, showing similar histological features to human IPNBs and activating signaling pathways seen in human iCCA. TNS4, stimulated by KRAS(G12D), plays a crucial role in promoting tumor progression in this model.
Article
Biology
Jeannine A. Frei, Cheryl J. Brandenburg, Jonathan E. Nestor, Didier M. Hodzic, Celine Plachez, Helen McNeill, Derek M. Dykxhoorn, Michael W. Nestor, Gene J. Blatt, Yu-Chih Lin
Summary: Genetic studies have linked FAT1 with autism spectrum disorder, and it is expressed in postnatal mouse brains with a unique localization pattern. The decreased expression of FAT1 in neural precursor cells from individuals with ASD suggests a potential role in the disease etiology, particularly in cerebellum function, which is a vulnerable brain region in ASD.
Article
Cell Biology
Vincent De Smet, Nathalie Eysackers, Vincent Merens, Mina Kazemzadeh Dastjerd, Georg Halder, Stefaan Verhulst, Inge Mannaerts, Leo A. van Grunsven
Summary: Recent research has shown that both the initiation and activation transcriptional programs of hepatic stellate cells are active in mice and humans with chronic liver disease. This suggests that molecules involved in both phases are equally important in finding druggable targets for chronic liver disease.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Didier Hodzic, Jun Wu, Karen Krchma, Andrea Jurisicova, Yonit Tsatskis, Yijie Liu, Peng Ji, Kyunghee Choi, Helen McNeill
Summary: This study reveals for the first time the crucial role of nuclear envelope protein NEMP1 in erythropoiesis. The researchers found that NEMP1 plays an important regulatory role in nuclear envelope openings and enucleation process of red blood cells. The results provide a valuable mouse model for studying defective erythropoiesis.
Article
Multidisciplinary Sciences
W. Kowalczyk, L. Romanelli, M. Atkins, H. Hillen, C. Bravo Gonzalez-Blas, J. Jacobs, J. Xie, S. Soheily, E. Verboven, I. M. Moya, S. Verhulst, M. de Waegeneer, L. Sansores-Garcia, L. van Huffel, R. L. Johnson, L. A. van Grunsven, S. Aerts, G. Halder
Summary: The Hippo signaling pathway is not essential for normal organ growth, and the overgrowth phenotypes associated with its activation result from abnormal genetic programs. In addition, the transcriptional activity of Hippo pathway effectors is not correlated with cell proliferation. A functional screen in Drosophila identified several target genes of the Hippo pathway that are required for ectopic overgrowth but not normal growth.
Article
Biology
Swann Floc'hlay, Ramya Balaji, Dimitrije Stankovic, Valerie M. Christiaens, Carmen Bravo Gonzalez-Blas, Seppe De Winter, Gert J. Hulselmans, Maxime De Waegeneer, Xiaojiang Quan, Duygu Koldere, Mardelle Atkins, Georg Halder, Mirka Uhlirova, Anne-Kathrin Classen, Stein Aerts
Summary: This study provides important insights into the wound response and its relationship to malignancy. By using a systems biology approach, the authors demonstrate the dual use of regulatory sequences in achieving context dependence for wound repair and tumor growth. This research is valuable for researchers in the fields of gene regulation, developmental biology, and cancer research.
Meeting Abstract
Oncology
Adeela Kamal, Aurelie Candi, Matthias Versele, Bart Vanderhoydonck, Arnaud Marchand, Ron de Jong, Thuy Hoang, Georg Halder, Patrick Chaltin, Stephen L. Gwaltney, Mike Burgess
Meeting Abstract
Gastroenterology & Hepatology
Vincent De Smet, Stefaan Verhulst, Liza Dewyse, Mina Kazemzadeh Dastjerd, Hendrik Reynaert, Georg Halder, Inge Mannaerts, Leo A. van Grunsven
JOURNAL OF HEPATOLOGY
(2021)
Meeting Abstract
Gastroenterology & Hepatology
Mickael Di-Luoffo, Sophie Pirenne, Thoueiba Saandi, Axelle Loriot, Claude Gerard, Nicolas Dauguet, Fatima Manzano-Nunez, Natalia Alves Souza Carvalhais, Florence Lamoline, Sabine Cordi, Katarzyna Konobrocka, Vitaline De Greef, Mina Komuta, Georg Halder, Patrick Jacquemin, Frederic Lemaigre
JOURNAL OF HEPATOLOGY
(2021)