Article
Nanoscience & Nanotechnology
Wenjuan Chen, Mingming Zhang, Chun Wang, Qiqing Zhang
Summary: This study successfully captured tumor antigens and enhanced tumor-specific immune response by developing multifunctional nanoparticles. The combination of polyethylenimine and indocyanine green promoted immunogenic cell death, while the positively charged polyethylenimine segment exhibited the best antigen-capturing ability and stimulated antitumor immune responses. Additionally, the covalent bonding of pyridyl disulfide groups played a significant role in suppressing distant tumor growth.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Gastroenterology & Hepatology
Yung-Tsung Li, Chun-Jen Liu, Jia-Horng Kao, Li-Feng Lin, Hui-Chu Tu, Chih-Chiang Wang, Po-Hsi Huang, Huei-Ru Cheng, Pei-Jer Chen, Ding-Shinn Chen, Hui-Lin Wu
Summary: MTA1 is a generic RNA-binding protein that regulates gene expression posttranscriptionally by binding to MYC in the cytoplasm, and its interaction with MYC is associated with early recurrence in patients with HBV-HCC.
Article
Multidisciplinary Sciences
Carolyn Marquis, Cindy L. Fonseca, Katelyn A. Queen, Lisa Wood, Sarah E. Vandal, Heidi L. H. Malaby, Joseph E. Clayton, Jason Stumpff
Summary: Chromosomal instability (CIN) is a hallmark of tumor cells, caused by changes in microtubule dynamics and control compromising the mitotic spindle. Inhibition of KIF18A results in mitotic delays, multipolar spindles, and increased cell death in CIN tumor cells. Sensitivity to KIF18A knockdown is strongly correlated with centrosome fragmentation, providing a potential target to reduce proliferative capacity of CIN cells.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Benjamin L. Oyler, Jeferson A. Valencia-Davila, Eirini Moysi, Adam Molyvdas, Kalliopi Ioannidou, Kylie March, David Ambrozak, Laurence De Leval, Giulia Fabozzi, Amina S. Woods, Richard A. Koup, Constantinos Petrovas
Summary: The secondary immune reactions in human lymphoid tissues require a highly coordinated and compartmentalized environment. Through a combination of flow cytometry, imaging, and mass spectrometry techniques, researchers have identified a compartmentalized organization at the cellular and molecular levels in human tonsils. This organization is characterized by the uneven distribution of specialized immune cell subsets, soluble mediators, and lipids across different anatomical areas of the tonsillar tissue. The application of these experimental approaches could lead to the discovery of novel in situ interactions and molecular targets for manipulating lymphoid organ immune reactions, particularly in the germinal center.
Review
Immunology
Chaoying Hu, Jianyang Liu, Feiran Cheng, Yu Bai, Qunying Mao, Miao Xu, Zhenglun Liang
Summary: This review summarizes the research progress of amplifying mRNA vaccines and provides an outlook on their prospects and future directions in cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Jie Wang, Kaichen Zhou, Huihuang Zhu, Fukun Wei, Sai Ma, Yi Kan, Bingheng Li, Lijun Mao
Summary: Currently, common treatments for prostate cancer include surgery, radiation therapy, chemotherapy, and hormone therapy. However, patients often experience high recurrence rates and may develop castration-resistant prostate cancer. Tumor vaccines, which utilize tumor-specific antigens (TSA) and tumor-associated antigens (TAA), aim to activate a specific immune response against cancer cells in the body. Different types of prostate cancer vaccines, such as cellular vaccines, extracellular-based anti-tumor vaccines, polypeptide vaccines, and nucleic acid vaccines, have been developed with the advancement of tumor vaccine technology. This review provides a summary of the current status and progress in the development of prostate cancer vaccines.
Article
Oncology
Karoline Kielbassa, Marco V. Haselager, Danique J. C. Bax, Bianca F. van Driel, Julie Dubois, Mark-David Levin, Sabina Kersting, Rebecka Svanberg, Carsten U. Niemann, Arnon P. Kater, Eric Eldering
Summary: Chronic lymphocytic leukemia (CLL) cells upregulate Bcl-2 proteins in the lymph node (LN) microenvironment, reducing sensitivity to the BCL-2 inhibitor venetoclax through signaling pathways involving B-cell receptor, Toll-like receptors, and CD40. A study analyzing samples from the HOVON141/VISION clinical trial found that two cycles of lead-in ibrutinib treatment decreased Bcl-2 protein expression and attenuated CD40-induced venetoclax resistance. Additionally, TLR9 stimulation reversed the effects of ibrutinib on venetoclax sensitivity by increasing CD40 expression and protein translation. These findings suggest that ibrutinib interrupts TLR9-induced CD40 upregulation, potentially inhibiting CLL cell priming for venetoclax resistance in the LN microenvironment.
Article
Oncology
Mary K. McKenna, Ada Ozcan, Daniel Brenner, Norihiro Watanabe, Maureen Legendre, Dafydd G. Thomas, Christopher Ashwood, Richard D. Cummings, Challice Bonifant, David M. Markovitz, Malcolm K. Brenner
Summary: Researchers have developed a novel chimeric antigen receptor (CAR) based on plant lectins, which can recognize abnormal sugar residues on malignant cells and associated stromal cells. The CAR showed promising antitumor effects in models of pancreatic ductal adenocarcinoma (PDAC).
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Cell Biology
Dan Wang, Jianfei Chen, Bohan Li, Qingling Jiang, Ling Liu, Ziyi Xia, Qiusheng Zheng, Minjing Li, Defang Li
Summary: Emerging evidence suggests that lncRNA-Gm31932 is significantly decreased in ATRA and PB-4-induced mouse melanoma B16 cells. Silencing lncRNA-Gm31932 inhibits cell proliferation, induces cell cycle arrest and differentiation, and affects the expression of cell cycle-related proteins through the miR-344d-3-5p/Prc1 (and Nuf2) axis.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Rui-Min Chang, Yao Fu, Jun Zeng, Xiao-Yan Zhu, Yang Gao
Summary: This study reveals that cancer-derived exosomal miR-197-3p promotes angiogenesis and migration in lung adenocarcinoma (LUAD) metastasis by targeting TIMP2 and TIMP3.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Minli Yang, Yujiao Zhou, Haijun Deng, Hongzhong Zhou, Shengtao Cheng, Dapeng Zhang, Xin He, Li Mai, Yao Chen, Juan Chen
Summary: The study identified RPL23 as a driver of tumor metastasis in HCC, with its depletion inhibiting cell proliferation, migration, invasion, and distant metastasis. Mechanistically, RPL23 positively regulated MMP9 expression by directly associating with its 3'UTR, suggesting it may be a potential therapeutic target for HCC tumorigenesis and metastasis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Peixiang Ma, Ping Ren, Chuyue Zhang, Jiaxing Tang, Zheng Yu, Xuekai Zhu, Kun Fan, Guanglei Li, Wei Zhu, Wei Sang, Chenyu Min, Wenzhang Chen, Xingxu Huang, Guang Yang, Richard A. Lerner
Summary: A novel approach using CAR-T cells with an avidity-based selection method has been proposed by scientists, achieving specific recognition of tumor cells with reduced off-tumor effects and retained antitumor efficacy.
Article
Oncology
Anh Nguyen, Gary Johanning, Yihui Shi
Summary: CAR-T cell therapy, through combination with small molecule drugs and other immunotherapy, is emerging as a promising approach to overcome challenges in targeting solid tumors and improve treatment outcomes.
Article
Multidisciplinary Sciences
Nima Sayyadi, Irene Justiniano, Yan Wang, Xianlin Zheng, Wei Zhang, Lianmei Jiang, Dmitry M. Polikarpov, Robert D. Willows, David Gillatt, Douglas Campbell, Bradley J. Walsh, Jingli Yuan, Yiqing Lu, Nicolle H. Packer, Yuling Wang, James A. Piper
Summary: Two molecular cytology approaches, TGiA and RiA, have been developed to detect prostate cancer cells. TGiA-OSAM showed single-cell PCa detection sensitivity, while RiA had a lower limit of detection. Both assays detected low abundance PCa cells in patient urine and showed correlation with clinical data.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Yanli Li, Enric Mateu, Ivan Diaz
Summary: This study examined the impact of freezing porcine PBMC on cell viability and functionality. After one month in liquid nitrogen, cell viability was above 89%, and PBMC response to mitogens showed similarities to fresh cells. However, frozen PBMC exhibited impaired antigen-specific responses, particularly in proliferation assays, suggesting a potential impact on effector/memory cells but not on naïve T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Carlos Rossa, Nisha J. D'Silva
Editorial Material
Biochemistry & Molecular Biology
Michelle Monje, Jeremy C. Borniger, Nisha J. D'Silva, Benjamin Deneen, Peter B. Dirks, Faranak Fattahi, Paul S. Frenette, Livia Garzia, David H. Gutmann, Douglas Hanahan, Shawn L. Hervey-Jumper, Hubert Hondermarck, Jonathan B. Hurov, Adam Kepecs, Sarah M. Knox, Alison C. Lloyd, Claire Magnon, Jami L. Saloman, Rosalind A. Segal, Erica K. Sloan, Xin Sun, Michael D. Taylor, Kevin J. Tracey, Lloyd C. Trotman, David A. Tuveson, Timothy C. Wang, Ruth A. White, Frank Winkler
Article
Otorhinolaryngology
Tingting Qin, Lada A. Koneva, Yidan Liu, Yanxiao Zhang, Anna E. Arthur, Katie R. Zarins Mph, Thomas E. Carey, Douglas Chepeha, Gregory T. Wolf, Laura S. Rozek, Maureen A. Sartor
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2020)
Article
Dentistry, Oral Surgery & Medicine
M. Liu, R. Banerjee, C. Rossa Jr, N. J. D'Silva
JOURNAL OF DENTAL RESEARCH
(2020)
Review
Biochemistry & Molecular Biology
Marsha-Kay N. D. Hutchinson, Michelle Mierzwa, Nisha J. D'Silva
Article
Otorhinolaryngology
Lisa M. Pinatti, Hana N. Sinha, Collin Brummel, Christine M. Goudsmit, Timothy J. Geddes, George D. Wilson, Jan A. Akervall, Chad J. Brenner, Heather M. Walline, Thomas E. Carey
Summary: This study found that HPV integration was positively correlated with E6/E7 expression, age at diagnosis, and patient survival. HPV integration may serve as a molecular marker of good prognosis.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2021)
Article
Oncology
Siyu Liu, Marcell Costa de Medeiros, Evan M. Fernandez, Katie R. Zarins, Raymond G. Cavalcante, Tingting Qin, Gregory T. Wolf, Maria E. Figueroa, Nisha J. D'Silva, Laura S. Rozek, Maureen A. Sartor
CLINICAL EPIGENETICS
(2020)
Article
Immunology
Priyanka Singh, Rajat Banerjee, Songlin Piao, Marcell Costa de Medeiros, Emily Bellile, Min Liu, Dilna Damodaran Puthiya Veettil, Ligia B. Schmitd, Nickole Russo, Erika Danella, Ronald C. Inglehart, Kyriel M. Pineault, Deneen M. Wellik, Greg Wolf, Nisha J. D'Silva
Summary: This study reveals a mechanism by which cancer cells subvert adjacent histologically normal epithelium to promote aggressive invasion and metastasis. It highlights the role of DMBT1 in this process and suggests new therapeutic strategies to reduce tumor recurrence.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Rajat Banerjee, Min Liu, Emily Bellile, Ligia B. Schmitd, Mitsuo Goto, Marsha-Kay N. D. Hutchinson, Priyanka Singh, Shuang Zhang, Dilna P. Damodaran, Mukesh K. Nyati, Matthew E. Spector, Brent Ward, Gregory Wolf, Keith Casper, Michelle Mierzwa, Nisha J. D'Silva
Summary: Radiation therapy, a common treatment for head and neck cancer, is not always effective due to the development of resistance. This study reveals that EGFR-mediated phosphorylation of TRIP13 at Y56 is a vital mechanism for radiation resistance and proposes TRIP13-pY56 as a predictive indicator for the response to radiation or cetuximab, and as a potential therapeutic target.
Article
Anatomy & Morphology
Thankam S. Nair, Bala Naveen Kakaraparthi, Lucy Yang, Lillian Lu, Trey B. Thomas, Anna C. Morris, Pavan Kommareddi, Ariane Kanicki, Thomas E. Carey
Summary: The presence of Slc44a2 is associated with the expression and localization of cell adhesion proteins, and cells with Slc44a2 knockout demonstrate lower adhesion and faster proliferation. Additionally, there are significant alterations in the distribution of CD9 and CD81 in KO cells.
Article
Oncology
Clifford M. Chang, Michelle M. Chen, Emily L. Bellile, Laura S. Rozek, Thomas E. Carey, Matthew E. Spector, Gregory T. Wolf, Jeremy M. G. Taylor, Steven B. Chinn
Summary: The impact of nodal metastasis on survival in HPV-negative oropharyngeal squamous cell carcinoma (OPSCC) is reduced, independent of HPV status. This offers a novel area of study.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Oncology
Ligia B. Schmitd, Cindy Perez-Pacheco, Emily L. Bellile, Weisheng Wu, Keith Casper, Michelle Mierzwa, Laura S. Rozek, Gregory T. Wolf, Jeremy M. G. Taylor, Nisha J. D'Silva
Summary: This study investigates the spatial and transcriptomic profiles of nerves in relation to perineural invasion (PNI) in oral squamous cell carcinomas. The findings show that PNI is an independent predictor of poor prognosis and that the distance between nerves and tumor plays a role in patient outcomes. Transcriptomic analysis reveals changes in stress and growth responses in nerves close to cancer. These findings highlight the importance of nerve-cancer interactions and suggest a need to reclassify PNI based on the distance between nerves and tumors.
CLINICAL CANCER RESEARCH
(2022)
Review
Materials Science, Biomaterials
Nisha J. D'Silva, Cindy Perez-Pacheco, Ligia B. Schmitd
Summary: This article discusses the translational significance of neural phenotypes in oral squamous cell carcinoma, highlighting the importance of re-evaluating the concept of perineural invasion and identifying other neural phenotypes for treatment selection and prognosis.
Review
Biochemistry & Molecular Biology
Erika B. Danella, Marcell Costa de Medeiros, Nisha J. D'Silva
Summary: The oral mucosa plays a crucial role in protecting against physical, microbial, and chemical damage. When compromised, the wound healing response is activated, which involves processes such as immune infiltration, re-epithelialization, and stroma remodeling, all controlled by cytokines that promote cellular migration, invasion, and proliferation. These same cytokines are also implicated in cancer dissemination. Therefore, studying the cytokines involved in oral wound healing can provide insights into the cytokines exploited by oral squamous cell carcinoma (SCC) to promote tumor development and progression.
Review
Biochemistry & Molecular Biology
Ligia B. Schmitd, Cindy Perez-Pacheco, Nisha J. D'Silva
Summary: Nerve density in cancer is emerging as a relevant clinical parameter for patient survival, with nerves in the tumor microenvironment associated with poor survival and recurrence. Mechanistic studies have shown that nerve-secreted factors promote tumor growth and invasion, making tumors more aggressive. The overall number of nerves in the tumor microenvironment is more representative of the biological interaction with the tumor compared to perineural invasion.
