Article
Medicine, Research & Experimental
Liwen Li, Fan Sun, Lei Han, Xujie Liu, Yadong Xiao, Alyssa D. Gregory, Steven D. Shapiro, Gutian Xiao, Zhaoxia Qu
Summary: The tumor suppressor gene PDLIM2 plays a crucial role in lung tumor suppression, regulated by the ROS/BACH1 pathway, affecting the polarization and differentiation of AMs to promote lung cancer.
Article
Chemistry, Multidisciplinary
Ran Liu, Zheng Liu, Mohan Chen, Hang Xing, Penghui Zhang, Jingjing Zhang
Summary: This study reports a new archetype of PROTAC (PS-ApTCs) that can selectively degrade NSPs by introducing an aptamer to a CRBN ligand. PS-ApTCs effectively degrade nucleolin in the cell membrane and cytoplasm, while avoiding degradation in the nucleus. Furthermore, PS-ApTCs exhibits superior antitumor activity and synergistic effects with aptamer-drug conjugate-based chemotherapy.
Article
Pharmacology & Pharmacy
Sibusiso B. Maseko, Yasmine Brammerloo, Inge Van Molle, Adria Sogues, Charlotte Martin, Christoph Gorgulla, Estelle Plant, Julien Olivet, Jeremy Blavier, Thandokuhle Ntombela, Frank Delvigne, Haribabu Arthanari, Hiba El Hajj, Ali Bazarbachi, Carine Van Lint, Kourosh Salehi-Ashtiani, Han Remaut, Steven Ballet, Alexander N. Volkov, Jean-Claude Twizere
Summary: Human T-cell leukemia virus type-1 (HTLV-1) is the first pathogenic retrovirus discovered in human. The interactions involving Tax-1 PDZ-domains are amenable to small molecule inhibition, which provides a framework for the design of targeted therapies for HTLV-1-induced diseases. Our work demonstrates that one specific compound can inhibit the Tax-1hDLG1 interaction and HTLV-1 cell-to-cell transmission, highlighting the potential of small molecules as a strategy to target Tax-1 functions.
ANTIVIRAL RESEARCH
(2023)
Article
Microbiology
Maria Gisele Goncalves, Lucila Okuyama Fukasawa, Karoline Rodrigues Campos, Fabio Takenori Higa, Adele Caterino-de-Araujo
Summary: Brazil currently has the highest number of individuals infected with human T-lymphotropic virus 1- and 2- (HTLV-1 and HTLV-2) globally. Molecular protocols and commercial assays for HTLV-1/-2 diagnosis are not available or validated by the Brazilian regulatory agency. In this study, two in-house multiplex quantitative real-time PCR assays were developed and validated for HTLV-1/-2 diagnosis. The assays showed high sensitivity and specificity and could resolve issues with indeterminate and untyped results in HTLV western blotting.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Virology
Hengbo Li, Feng Zou, Jie Zhang, Shengyu Zhu, Kaifei Chu, Xu Zhang, Tiejun Zhao
Summary: This study reveals the negative regulatory role of Yes-associated protein (YAP) in Tax activation of HTLV-1 transcription. YAP interacts with Tax and prevents the association between Tax and p300, resulting in the inhibition of HTLV-1 transcription. This finding is important for understanding the mechanisms underlying the persistent infection and latency of HTLV-1 in host cells.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Tiejun Zhao, Zhilong Wang, Jinyong Fang, Wenzhao Cheng, Yiling Zhang, Jinhua Huang, Lingling Xu, Hongwei Gou, Linghui Zeng, Zhigang Jin, Masao Matsuoka
Summary: In this study, it was found that YAP activation is associated with HTLV-1 infection in adult T-cell leukemia/lymphoma (ATL), and this activation is mediated by the NF-kappa B/p65 pathway. YAP activation plays a critical role in the pathogenesis of ATL, suggesting YAP as a potential therapeutic target for ATL treatment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Susan Smith, Jaideep Seth, Amanda Midkiff, Rachel Stahl, Yu-Ci Syu, Nikoloz Shkriabai, Mamuka Kvaratskhelia, Karin Musier-Forsyth, Pooja Jain, Patrick L. Green, Amanda R. Panfil
Summary: In this study, YBX1 was found to interact with the viral gene HBZ of HTLV-1 and enhance transcription activity from the 5 & PRIME; LTR promoter. The interaction between YBX1 and Tax or HBZ affected the transcription and protein abundance of both genes. Overall, YBX1 positively influences HTLV-1 gene expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jing Liu, Collin Tokheim, Jonathan D. Lee, Wenjian Gan, Brian J. North, X. Shirley Liu, Pier Paolo Pandolfi, Wenyi Wei
Summary: Genetic fusions affecting degrons can alter protein stability and increase oncogene stability. Recurrent fusions such as BCR-ABL, CCDC6-RET, and PML-RARA disrupt protein stability by exchanging internal degrons. Additionally, fusions like EGFR or RAF1 can be stabilized by losing a C-terminal degron.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Aurelie Beauvois, Helene Gazona, Pradeep Singh Chauhan, Majeed Jamakhani, Jean-Rock Jacques, Marc Thiry, Emmanuel Dejardin, Emmanuel Di Valentin, Jean-Claude Twizere, Jean-Marie Peloponese, Makon-Sebastien Njock, Jun-Ichirou Yasunaga, Masao Matsuoka, Malik Hamaidia, Luc Willems
Summary: This study identified HLTF as a restriction factor against HTLV-1 by activating autophagic flux to inhibit viral replication. The viral protein Tax suppresses HLTF transcription and induces proteasomal degradation of HLTF protein. HLTF induction leads to dispersal of the Golgi apparatus and overproduction of secretory granules, resulting in an increase in defective viral particles.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Virology
Xiaorui Zuo, Ruoning Zhou, Sikai Yang, Guangyong Ma
Summary: HTLV-1 is an oncogenic retrovirus that mainly persists in the infected host cell as a provirus; it also causes a malignancy called adult T-cell leukemia/lymphoma (ATLL) in about 5% of infection. HTLV-1 replication is silent in vivo and relies on clonal proliferation of infected T cells for viral propagation. The mechanism of leukemic clone formation and ATLL onset during HTLV-1 infection is still unclear. This review summarizes the current understanding of HTLV-1 persistence and oncogenesis, incorporating recent cutting-edge discoveries obtained by high-throughput sequencing.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Immunology
Kazumi Nakano, Toshiki Watanabe
Summary: HTLV-1 is an oncovirus that causes ATL and other inflammatory diseases. Most infected individuals maintain a latent state, which may be an intrinsic characteristic acquired during HTLV-1's evolution. We compared the pathological aspects of HTLV-1 and HIV-1 and investigated the importance of viral replication regulators in infected T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Michi Miura, Tadasuke Naito, Mineki Saito
Summary: Human T-cell leukemia virus type 1 (HTLV-1) is a replication-competent human retrovirus that is associated with two types of diseases, adult T-cell leukemia-lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Although most infected individuals remain asymptomatic, a subpopulation develops these diseases. The complex virus-host interactions and the host immune response may regulate the development of HTLV-1-associated diseases.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Ronghui Zhu, Leah A. Santat, Joseph S. Markson, Nagarajan Nandagopal, Jan Gregrowicz, Michael B. Elowitz
Summary: Developing tissues form spatial patterns by establishing concentration gradients of morphogens. A synthetic, bottom-up approach compared the spatiotemporal dynamics of different extracellular circuits and found that three proteins successfully displaced gradients by shuttling ligands. A mathematical model explained the dynamics of these circuits, and combining components from mammalian and Drosophila systems suggests that shuttling is evolutionary conserved.
Article
Microbiology
Debora Glenda Lima de la-Roque, Elaine Vieira Santos, Evandra Strazza Rodrigues, Pericles Natan Mendes da Costa, Veronica Soares Brauer, Fausto Almeida, Tissiana Marques de Haes, Osvaldo Massaiti Takayanagui, Dimas Tadeu Covas, Simone Kashima
Summary: The expression of viral transcripts in serum-derived sEVs of HTLV-1 carriers is related to the PVL presented by the infected individual, and tax+ HBZ+ sEVs can induce the production of inflammatory cytokines.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xiaoming Jiang, Zhe Chu, Yang Cao, Ying Tang, Ying Shi, Xu Shi
Summary: Hepatocellular carcinoma (HCC) is a common and deadly malignancy worldwide. This study found that the downregulation of PDLIM2 in HCC is associated with poor prognosis, and overexpressed PDLIM2 can inhibit HCC cell proliferation, migration, invasion, and EMT by regulating beta-catenin, suggesting PDLIM2 as a promising therapeutic target for HCC.
CANCER GENE THERAPY
(2021)
Article
Chemistry, Medicinal
Hardik J. Patel, Pallav D. Patel, Stefan O. Ochiana, Pengrong Yan, Weilin Sun, Maulik R. Patel, Smit K. Shah, Elisa Tramentozzi, James Brooks, Alexander Bolaender, Liza Shrestha, Ralph Stephani, Paola Finotti, Cynthia Leifer, Zihai Li, Daniel T. Gewirth, Tony Taldone, Gabriela Chiosis
JOURNAL OF MEDICINAL CHEMISTRY
(2015)
Article
Medicine, Research & Experimental
Jing Fu, Shirong Li, Rentian Feng, Huihui Ma, Farideh Sabeh, G. David Roodman, Ji Wang, Samuel Robinson, X. Edward Guo, Thomas Lund, Daniel Normolle, Markus Y. Mapara, Stephen J. Weiss, Suzanne Lentzsch
JOURNAL OF CLINICAL INVESTIGATION
(2016)
Article
Oncology
Shirong Li, Jing Fu, Caisheng Lu, Markus Y. Mapara, Shahzad Raza, Ulrich Hengst, Suzanne Lentzsch
MOLECULAR CANCER THERAPEUTICS
(2016)
Article
Hematology
Ailing Liu, shirong Li, Vera Donnenberg, Jing Fu, Susanne M. Gollin, Huihui Ma, Caisheng Lu, Donna B. Stolz, Markus Y. Mapara, Sara A. Monaghan, Suzanne Lentzsch
Article
Hematology
Ailing Liu, shirong Li, Vera Donnenberg, Jing Fu, Susanne M. Gollin, Huihui Ma, Caisheng Lu, Donna B. Stolz, Markus Y. Mapara, Sara A. Monaghan, Suzanne Lentzsch
Article
Biochemistry & Molecular Biology
Anna Rodina, Tony Taldone, Yanlong Kang, Pallav D. Patel, John Koren, Pengrong Yan, Erica M. DaGama Gomes, Chenghua Yang, Maulik R. Patel, Liza Shrestha, Stefan O. Ochiana, Cristina Santarossa, Ronnie Maharaj, Alexander Gozman, Marc B. Cox, Hediye Erdjument-Bromage, Ronald C. Hendrickson, Leandro Cerchietti, Ari Melnick, Monica L. Guzman, Gabriela Chiosis
ACS CHEMICAL BIOLOGY
(2014)
Meeting Abstract
Oncology
Pengrong Yan, Hardik Patel, Chenghua Yang, Tony Taldone, Gabriela Chiosis
Article
Biochemistry & Molecular Biology
Anna Rodina, Pallav D. Patel, Yanlong Kang, Yogita Patel, Imad Baaklini, Michael J. H. Wong, Tony Taldone, Pengrong Yan, Chenghua Yang, Ronnie Maharaj, Alexander Gozman, Maulik R. Patel, Hardik J. Patel, William Chirico, Hediye Erdjument-Bromage, Tanaji T. Talele, Jason C. Young, Gabriela Chiosis
CHEMISTRY & BIOLOGY
(2013)
Letter
Oncology
S. Li, J. Fu, H. Ma, M. Y. Mapara, S. Lentzsch
Article
Biochemistry & Molecular Biology
Pallav D. Patel, Pengrong Yan, Paul M. Seidler, Hardik J. Patel, Weilin Sun, Chenghua Yang, Nanette S. Que, Tony Taldone, Paola Finotti, Ralph A. Stephani, Daniel T. Gewirth, Gabriela Chiosis
NATURE CHEMICAL BIOLOGY
(2013)
Article
Multidisciplinary Sciences
Azadeh Arabi, Karim Ullah, Rui M. M. Branca, Johan Johansson, Daniel Bandarra, Moritz Haneklaus, Jing Fu, Ingrid Aries, Peter Nilsson, Monique L. Den Boer, Katja Pokrovskaja, Dan Grander, Gutian Xiao, Sonia Rocha, Janne Lehtio, Olle Sangfelt
NATURE COMMUNICATIONS
(2012)
Article
Endocrinology & Metabolism
E. M. Stein, A. Dash, M. Bucovsky, S. Agarwal, J. Fu, S. Lentzsch, E. Shane
OSTEOPOROSIS INTERNATIONAL
(2019)
Article
Hematology
Shirong Li, Jing Fu, Christopher J. Walker, Jun Yang, Divaya Bhutani, Rajshekhar Chakraborty, Niha Mamillapalli, Markus Y. Mapara, Yosef Landesman, Suzanne Lentzsch
Summary: Selinexor is an inhibitor of XPO1 and reduces the levels of eIF4E, IKZF1, and c-MYC proteins in multiple myeloma cells. Combination treatment of Selinexor with pharmacologic inhibitors of protein translation shows synergistic effects in vitro.
Article
Multidisciplinary Sciences
Jing Fu, Shirong Li, Huihui Ma, Jun Yang, Gabriel M. Pagnotti, Lewis M. Brown, Stephen J. Weiss, Markus Y. Mapara, Suzanne Lentzsch
Summary: PD-1H functions as a potential MMP-13 receptor on osteoclasts, mediating MMP-13 induced cytoskeleton reorganization, fusogenesis and bone resorption, and further regulating osteolytic lesions.
NATURE COMMUNICATIONS
(2023)
Article
Hematology
Shirong Li, Jing Fu, Hui Wang, Huihui Ma, Xiaoming Xu, Yong-Guang Yang, Shixian Deng, Markus Y. Mapara, Suzanne Lentzsch