Article
Multidisciplinary Sciences
Adele M. Alchahin, Shenglin Mei, Ioanna Tsea, Taghreed Hirz, Youmna Kfoury, Douglas Dahl, Chin-Lee Wu, Alexander O. Subtelny, Shulin Wu, David T. Scadden, John H. Shin, Philip J. Saylor, David B. Sykes, Peter V. Kharchenko, Ninib Baryawno
Summary: By analyzing ccRCC patient samples using single-cell transcriptomics, a distinct transcriptional signature predictive of metastatic potential and patient survival was identified. Potential therapeutic targets including the CXCL9/CXCL10-CXCR3 axis and the CD70-CD27 axis were highlighted.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Wenqing Lu, Xiaofang Che, Xiujuan Qu, Chunlei Zheng, Xianghong Yang, Bowen Bao, Zhi Li, Duo Wang, Yue Jin, Yizhe Wang, Jiawen Xiao, Jianfei Qi, Yunpeng Liu
Summary: This study comprehensively analyzed the role of succinylation regulators in ccRCC and suggested their specific and critical impact on tumor prognosis. By clustering patients based on the expression patterns of regulators, distinct clusters with different survival outcomes and clinicopathological features were identified, indicating their potential mechanisms in promoting malignant progression. The study provided new insights into the understanding of succinylation modification and its clinical implications in ccRCC treatments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Hanyu Rao, Xiaoxue Li, Min Liu, Jing Liu, Wenxin Feng, Huayuan Tang, Jin Xu, Wei-Qiang Gao, Li Li
Summary: This study reveals that SETD2 inhibits beta-catenin activity during the transition from polycystic kidney disease (PKD) to renal cell carcinoma (RCC) by competing with beta-catenin for binding promoters of target genes, ultimately enhancing Wnt/beta-catenin signaling and promoting epithelial-to-mesenchymal transition and tumorigenesis.
Article
Cell Biology
Wenzhong Zheng, Shiqiang Zhang, Huan Guo, Xiaobao Chen, Zhangcheng Huang, Shaoqin Jiang, Mengqiang Li
Summary: This study analyzed tumor angiogenesis subtypes and potential epigenetic regulation mechanisms in KIRC patients, indicating that evaluating the angiogenesis subtypes of KIRC based on an angiogenesis signature with 183 genes may help develop more targeted treatments for KIRC patients.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Oncology
Lei Yang, Haoli Yin, Yi Chen, Chun Pan, Hexing Hang, Yanwen Lu, Wenliang Ma, Xin Li, Weidong Gan, Hongqian Guo, Dongmei Li
Summary: PEBP1P2 inhibits ccRCC metastasis formation and regulates both PEBP1 and KLF13. Therefore, molecular therapies targeting PEBP1P2 might be an effective treatment strategy against ccRCC and other cancers with low PEBP1P2 levels.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Waleed Ali, Daniel Jacobs, Simon Zhen, Alan M. Diamond, Andre Kajdacsy-Balla
Summary: The study investigates the association between RNA levels of SELENO proteins and ccRCC, and reveals that higher mRNA expression of Selenoprotein I, T, and P is associated with better overall survival outcomes and differential expression of other selenoproteins based on tumor stage. The study also finds relative hypomethylation among selenoproteins in primary ccRCC tumor samples compared to normal tissue. Network and enrichment analysis identifies multiple genes through which selenoproteins may modulate cancer progression and outcomes.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Review
Endocrinology & Metabolism
Haiyan Zhu, Xin Wang, Shihao Lu, Kongbo Ou
Summary: Clear cell renal cell carcinoma (ccRCC) is a malignancy characterized by metabolic reprogramming, which provides potential targets for therapeutic interventions. This review summarizes recent discoveries of metabolic alterations in ccRCC, including changes in glucose, lipid, and amino acid metabolism. It also discusses the development of metabolic drugs targeting these pathways and proposes future trends in drug development. Overall, this review highlights the potential for developing new treatments for ccRCC based on metabolic alterations.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Corina Daniela Ene, Mircea Nicolae Penescu, Simona Roxana Georgescu, Mircea Tampa, Ilinca Nicolae
Summary: Summary of the translated text
Article
Multidisciplinary Sciences
Sumeyye Su, Shaya Akbarinejad, Leili Shahriyari
Summary: This study utilized digital cytometry to estimate the percentage of different immune cell types in 526 renal tumors, revealing that the most common immune cell types in clear cell renal cell carcinomas (ccRCC) tumors are CD8+ T-cells, macrophages, and CD4+ T-cells. Furthermore, unsupervised clustering analysis identified four distinct groups of ccRCC tumors based on the relative numbers of immune cells.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Jacek Rysz, Beata Franczyk, Janusz Lawinski, Anna Gluba-Brzozka
Summary: Renal cell carcinoma is a group of malignant tumors of the renal cortex. Clear cell papillary renal cell carcinoma, a specific subtype, shares morphologic and genetic features with other subtypes but also has distinct clinical behavior. Differentiating clear cell papillary renal cell carcinoma from other subtypes is crucial for appropriate management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Haofei Wang, Juping Zhao, Xin Xie, Jun Dai, Danfeng Xu, Xin Huang
Summary: This study reveals that ZNF692 promotes tumorigenesis in clear cell renal carcinoma (ccRCC) by suppressing the transcription of essential genes. Through ChIP-seq analysis, ZNF692 was found to regulate genes associated with cell growth, Wnt signaling, and immune response in ccRCC. Luciferase reporter assays demonstrated that ZNF692 transcriptionally represses the expression of IRF4 and FLT4 in a ZNF692 binding motif-dependent manner. Furthermore, MYC was observed to bind to the promoter regions of ZNF692, specifically driving its overexpression in ccRCC. Overall, this study provides valuable insights into the functional significance of ZNF692 in ccRCC and its potential as a therapeutic target in cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Oncology
Javier C. Angulo, Claudia Manini, Jose I. Lopez, Angel Pueyo, Begona Colas, Santiago Ropero
Summary: This review examines the accumulated evidence on the role of epigenetic markers in prognosis and treatments for clear cell renal cell carcinoma (ccRCC). Several epigenetic markers show promise for clinical use but require further validation. The development of epigenetic therapies, either alone or in combination with other treatments, is still in early stages and holds potential for improving the diagnosis and treatment of ccRCC.
Article
Oncology
S. C. Joosten, S. N. O. Odeh, A. Koch, N. Buekers, M. J. B. Aarts, M. M. L. L. Baldewijns, L. Van Neste, S. van Kuijk, L. J. Schouten, P. A. van den Brandt, V. C. Tjan-Heijnen, M. van Engeland, K. M. Smits
Summary: This study compared potential prognostic methylation markers for ccRCC and identified five methylation markers that potentially show prognostic value in addition to currently known clinicopathological factors. The prognostic biomarker model performed better than the clinical model in predicting outcomes, but had limited added value in a separate patient cohort.
CLINICAL EPIGENETICS
(2021)
Review
Oncology
Arti M. M. Raghubar, Matthew J. J. Roberts, Simon Wood, Helen G. G. Healy, Andrew J. J. Kassianos, Andrew J. J. Mallett
Summary: This review examines recent single-cell transcriptomics studies of ccRCC to clarify the transition of PTEC in ccRCC development and the immune cell types, states, and interactions that may limit the response to targeted immune therapy. It suggests stromal cells as key drivers in recurrent and locally invasive ccRCC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
W. Liang, S. H. Chen, G. L. Yang, J. Y. Feng, Q. Ling, B. Wu, H. B. Yan, J. W. Cheng
Summary: This study demonstrates that zinc-finger protein 677 (ZNF677) acts as a tumor suppressor gene in clear cell renal cell carcinoma (ccRCC), inhibiting tumor cell proliferation and invasion, inducing apoptosis. Low expression of ZNF677 is associated with shorter overall survival. High expression of ZNF677 can be considered as a favorable prognostic indicator for ccRCC.
Meeting Abstract
Oncology
Hope Elizabeth Uronis, Christel Rushing, Gerard C. Blobe, Shiaowen David Hsu, Niharika B. Mettu, James Leroy Wells, Donna Niedzwiecki, Leighanne Hartman, Ashley Moyer, Herbert Hurwitz, John H. Strickler
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Oncology
John H. Strickler, Christel N. Rushing, Hope E. Uronis, Michael A. Morse, Donna Niedzwiecki, Gerard C. Blobe, Ashley N. Moyer, Emily Bolch, Renee Webb, Sherri Haley, Ace J. Hatch, Ivy P. Altomare, Gary B. Sherrill, David Z. Chang, James L. Wells, S. David Hsu, Jingquan Jia, S. Yousuf Zafar, Andrew B. Nixon, Herbert I. Hurwitz
Summary: The combination of cabozantinib and panitumumab has shown activity in patients with metastatic colorectal cancer, with dose modifications of cabozantinib improving tolerability. Further study is warranted to identify biomarkers for patient populations most likely to benefit.
Article
Cell Biology
Scott M. Emrich, Ryan E. Yoast, Ping Xin, Vikas Arige, Larry E. Wagner, Nadine Hempel, Donald L. Gill, James Sneyd, David Yule, Mohamed Trebak
Summary: The study reveals the non-redundant functions of STIM1/2 and Orai1/2/3 proteins in ensuring the graded diversity of mammalian Ca2+ signaling. Additionally, it shows that the unactivated STIM1/2 inhibit IP3R-evoked Ca2+ release, with the inhibition gradually relieved as agonist intensity and STIM1/2 activation increase.
Review
Anatomy & Morphology
John B. Pawlak, Gerard C. Blobe
Summary: TGF-beta superfamily signaling is often modified by co-receptors, leading to dynamic effects on SMAD-mediated pathways. The release of soluble forms of these co-receptors can further modulate signaling, potentially antagonizing membrane-bound receptors.
DEVELOPMENTAL DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Ryan E. Yoast, Scott M. Emrich, Xuexin Zhang, Ping Xin, Vikas Arige, Trayambak Pathak, J. Cory Benson, Martin T. Johnson, Ahmed Emam Abdelnaby, Natalia Lakomski, Nadine Hempel, Jung Min Han, Genevieve Dupont, David Yule, James Sneyd, Mohamed Trebak
Summary: The study demonstrates that MCU is a universal regulator of intracellular Ca2+ signaling across mammalian cell types, affecting Ca2+ signal transduction and nuclear translocation through multiple mechanisms.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Oncology
Xiuchao Wang, Yunzhan Li, Zekun Li, Shengchen Lin, Hongwei Wang, Jianwei Sun, Chungen Lan, Liangliang Wu, Dongxiao Sun, Chongbiao Huang, Pankaj K. Singh, Nadine Hempel, Mohamed Trebak, Gina M. DeNicola, Jihui Hao, Shengyu Yang
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease with few effective treatments. Activating the Keap1-Nrf2 antioxidant program promotes migration, invasion, metastasis, and metabolic stress resistance in PDAC. The cystine transporter SLC7A11 is identified as a druggable target downstream of the MCU-Nrf2 axis.
Article
Biology
Ben Horst, Shrikant Pradhan, Roohi Chaudhary, Eduardo Listik, Liz Quintero-Macias, Alex Seok Choi, Michael Southard, Yingmiao Liu, Regina Whitaker, Nadine Hempel, Andrew Berchuck, Andrew B. Nixon, Nam Y. Lee, Yoav Henis, Karthikeyan Mythreye
Summary: Hypoxia increases the levels of inhibin in ovarian cancer, which promotes tumor growth, endothelial cell invasion, and permeability. Inhibin is regulated primarily through HIF-1, and targeting inhibin can reduce permeability and alter the balance of pro and anti-angiogenic mechanisms, leading to vascular normalization. This study provides new insights into the therapeutic significance of inhibins in normalizing tumor vasculature in ovarian cancer.
COMMUNICATIONS BIOLOGY
(2022)
Article
Cell Biology
Zainab Shonibare, Mehri Monavarian, Kathleen O'Connell, Diego Altomare, Abigail Shelton, Shubham Mehta, Renata Jaskula-Sztul, Rebecca Phaeton, Mark D. Starr, Regina Whitaker, Andrew Berchuck, Andrew B. Nixon, Rebecca C. Arend, Nam Y. Lee, C. Ryan Miller, Nadine Hempel, Karthikeyan Mythreye
Summary: Growth factors in tumor environments, specifically the TGF-0 superfamily growth factors BMP and TGF-0/activin, play a crucial role in regulating cell survival and metastasis. This study uncovers the opposing effects of BMPs and TGF-0/activin on the expression of SOX2, a key signaling node, impacting anchorage-independent cell survival in ovarian cancers. Repression of SOX2 by BMPs leads to reduced tumor burden and improved survival, while TGF-0 and activin A promote SOX2 expression and anchorage-independent survival.
Article
Biochemistry & Molecular Biology
Yeon Soo Kim, Priscilla W. Tang, Jaclyn E. Welles, Weihua Pan, Zaineb Javed, Amal Taher Elhaw, Karthikeyan Mythreye, Scot R. Kimball, Nadine Hempel
Summary: During metastasis, cancer cells need to adapt to loss of anchorage and resistance to anoikis. One important adaptation is the increase in antioxidant capacity and restoration of cellular redox balance. In ovarian cancer cells, an early response to detachment, a critical step in metastasis associated with increased oxidative stress, is the increase in mitochondrial superoxide dismutase SOD2 protein expression. This is achieved through the translational regulatory mechanism involving the cytosolic accumulation of the RNA binding protein HuR/ELAVL1 and the activation of mitogen-activated kinase p38.
Article
Biology
Kevin Tabury, Mehri Monavarian, Eduardo Listik, Abigail K. Shelton, Alex Seok Choi, Roel Quintens, Rebecca C. Arend, Nadine Hempel, C. Ryan Miller, Balazs Gyorrfy, Karthikeyan Mythreye
Summary: The study demonstrates the role of PVT1, a stress-induced long non-coding RNA, in ovarian cancer growth and metastasis. PVT1 is amplified and overexpressed in ovarian cancer, and its expression is regulated by tumor cells in response to cellular stress. High expression of PVT1 promotes tumor cell survival, growth, and migration, while reducing PVT1 levels effectively inhibits metastatic behavior and tumor cell dissemination. The findings suggest that PVT1 could be a promising therapeutic target to suppress metastasis and chemoresistance in ovarian cancer.
LIFE SCIENCE ALLIANCE
(2022)
Meeting Abstract
Oncology
D. J. George, E. Moore, G. C. Blobe, N. DeVito, B. A. Hanks, M. R. Harrison, C. J. Hoimes, J. Jia, M. Morse, P. Jayaprakasan, A. MacKelfresh, H. Mulder, K. Beauchamp, J. Michuda, M. C. Stumpe, E. Perakslis, T. Taxter
ANNALS OF ONCOLOGY
(2022)
Article
Oncology
Mark E. Sherman, Robert A. Vierkant, Matthew Masters, Derek C. Radisky, Stacey J. Winham, Amy C. Degnim, Celine M. Vachon, Alpa V. Patel, Lauren R. Teras
Summary: Nonsteroidal anti-inflammatory agents (NSAID) are inconsistently associated with modest reductions in breast cancer risk in the general population, but studies focusing on patients with benign breast disease (BBD) have shown a lower risk with NSAID use. As BBD includes fibroinflammatory lesions linked to elevated breast cancer risk, this study examined the association between NSAID use and breast cancer risk among patients with BBD.
CANCER PREVENTION RESEARCH
(2023)
Article
Oncology
Elle C. Moore, Gerard C. Blobe, Nicholas C. Devito, Brent A. Hanks, Michael R. Harrison, Christopher J. Hoimes, Jingquan Jia, Michael A. Morse, Parvathy Jayaprakasan, Andrew MacKelfresh, Hillary Mulder, Adam J. Hockenberry, Alia Zander, Martin C. Stumpe, Jackson Michuda, Kyle A. Beauchamp, Eric Perakslis, Timothy Taxter, Daniel J. George
Summary: This retrospective study evaluated the utility of a novel molecular diagnostic classifier in changing treatment recommendations for patients with cancer of uncertain origin. The results showed that the molecular diagnostic classifier altered treatment plans in the majority of patients, increasing confidence in selecting the most appropriate treatment regimen. Further studies are needed to determine if the use of molecular diagnostic classifiers improves clinical outcomes for patients with cancer of unknown primary.
Article
Biology
Zaineb Javed, Beth L. Worley, Coryn Stump, Sara S. Shimko, LaTaijah C. Crawford, Karthikeyan Mythreye, Nadine Hempel
Summary: Three-dimensional cell culture models, particularly the anchorage-independent spheroids derived by culturing cells in ultra-low attachment conditions, are important for tumor studies, especially in ovarian cancer research. This method allows for the assessment of mitochondrial function in a more relevant patho/physiological culture condition.
Article
Physiology
Beth L. Worley, Thomas Auen, Amy C. Arnold, Brett P. Monia, Nadine Hempel, Traci A. Czyzyk
Summary: The study showed that acute and peripherally restricted knockdown of Mpzl3 can alleviate negative metabolic effects induced by a high-fat and sucrose diet in mice. This knockdown led to reduced fat mass, circulating lipids, energy expenditure and food intake, as well as changes in gene expression related to lipid metabolism in various tissues. These findings suggest that inhibiting Mpzl3 could be a potential therapeutic approach for obesity and dyslipidemia.
PHYSIOLOGICAL REPORTS
(2021)
