Review
Oncology
Xiao-Ru Liang, Yan-Fei Liu, Feng Chen, Zhi-Xia Zhou, Li-Jie Zhang, Zhi-Juan Lin
Summary: Long non-coding RNAs (lncRNAs) are involved in various biological processes and regulate key proteins in the cell cycle of cancer cells. Understanding their role in cell cycle regulation can lead to new therapeutic strategies for cancer treatment. This review article summarizes recent studies on lncRNA control of cell cycle-related proteins and discusses their emerging role in cancer diagnosis and therapy.
CANCER MANAGEMENT AND RESEARCH
(2023)
Article
Oncology
Debora Bencivenga, Emanuela Stampone, Arianna Aulitto, Annunziata Tramontano, Clementina Barone, Aide Negri, Domenico Roberti, Silverio Perrotta, Fulvio Della Ragione, Adriana Borriello
Summary: CDKN1B haploinsufficiency is associated with the development of several human cancers, while missense mutations in CDKN1B may facilitate carcinogenesis. A study on the cancer-associated G9R-p27(Kip1) variant revealed that it lacks major tumor suppressor activities of p27(Kip1) and may lose function due to S12 phosphorylation. This study suggests that haploinsufficiency could be caused by unpredictable post-translational modifications resulting from cancer-associated missense mutations generating novel consensus sequences.
MOLECULAR ONCOLOGY
(2021)
Review
Oncology
Mitra Zabihi, Ramin Lotfi, Amir-Mohammad Yousefi, Davood Bashash
Summary: CDKs, cyclins, and CKIs play important roles in the cell cycle regulatory machinery, and dysregulation of their expression or function can contribute to tumorigenesis. While designing CDK inhibitors to target tumor cells shows promise, the non-canonical functions of CDKs pose challenges in their application. This review aims to explore the biology of CDKs and their contribution to tumorigenesis, and discuss the pros and cons of CDK inhibition in the treatment of human cancers.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Toshiya Fujisaki, Ken Saito, Toshiaki Kikuchi, Eisaku Kondo
Summary: OGFOD1 is an important factor that regulates the transcription and stabilization of cell cycle-related genes, and plays a role in maintaining the function of specific cell cycle regulators during cancer cell proliferation.
Article
Nutrition & Dietetics
Jochen Rutz, Sebastian Maxeiner, Eva Juengel, Felix K. -H. Chun, Igor Tsaur, Roman A. Blaheta
Summary: This study found that polyphenol-rich olive mill wastewater (OMWW) has a profound inhibitory effect on chemo-sensitive as well as gemcitabine- and cisplatin-resistant bladder cancer cells. It may block cell proliferation by manipulating the cell cycle and deactivating signaling pathways.
Review
Oncology
Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Peixin Dong, Nikolaus Gassler, Mohammad Taheri, Aria Baniahmad, Nader Akbari Dilmaghani
Summary: This article summarizes the important role of Cyclin-dependent kinases (CDK) in cancer, emphasizing the significance of understanding CDK function and mechanisms for future cancer therapies targeting these kinases.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Zhangjie Wang, Na Shen, Ziao Wang, Lei Yu, Song Yang, Yang Wang, Yu Liu, Gaohua Han, Qi Zhang
Summary: This study reveals that TRIM3 functions as a tumor suppressor in non-small cell lung cancer (NSCLC) by promoting cell death and inhibiting tumorigenesis. TRIM3 directly interacts with SLC7A11/xCT, leading to its degradation and inhibition of NSCLC development. Low TRIM3 expression is associated with a worse prognosis in NSCLC.
CELL DEATH AND DIFFERENTIATION
(2023)
Review
Cell Biology
Yi Xiao, Jixin Dong
Summary: This article discusses the role and therapeutic potential of Cyclin K in cancer. Studies have shown that Cyclin K plays important roles in various biological processes and is critical in cancer cell growth and therapeutic resistance. Additionally, the druggability of Cyclin K has been demonstrated, providing novel opportunities for cancer treatment.
Article
Biochemistry & Molecular Biology
Tetsuo Niwa, Yasunori Akaike, Kaichi Watanabe, Taku Chibazakura
Summary: This study demonstrates that the loss of two redundant pathways, cyclin degradation and CDK inhibitors, leads to hyperactivation of cyclin A-CDK, inducing rapid tetraploidization. Tetraploidization is not caused by chromosome endoreduplication but by mitotic failure. Hyperactive cyclin A-CDK promotes excessive duplication of centrosomes during S phase, leading to mitotic slippage and subsequent tetraploidization.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Kailing Zhou, Yu Sun, Dan Dong, Chenghai Zhao, Wei Wang
Summary: EMP3 acts as a potential tumor suppressor in breast cancer by inhibiting cell cycle progression, DNA repair, and stem-like properties, leading to enhanced sensitivity of breast cancer cells to DNA-damaging agents.
CELL DEATH & DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Da Young Lee, Jung Nyeo Chun, Minsoo Cho, Insuk So, Ju-Hong Jeon
Summary: E2F8 is a multifaceted transcription factor that is involved in various aspects of cancer development and progression. It has the ability to promote cancer cell proliferation and survival while also exhibiting tumor-suppressing activity. This review highlights the recent progress in understanding the role of E2F8 in human cancers and its implications for developing therapeutic strategies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Multidisciplinary Sciences
Asmita Bhattacharya, Juncheng Wei, Wenxin Song, Beixue Gao, Chunyan Tian, Shuangcheng Alivia Wu, Jian Wang, Ligong Chen, Deyu Fang, Ling Qi
Summary: The SEL1L-HRD1 ERAD plays a key role in suppressing hepatocyte proliferation and liver cancer by degrading misfolded WNT5A, thereby inhibiting hepatocyte proliferation.
Article
Oncology
Maryam Rasouli, Sara Khakshournia, Omid Vakili, Sanaz Dastghaib, Atefeh Seghatoleslam, Sayed Mohammad Shafiee
Summary: Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths worldwide. UBE2Q1, a newly identified ubiquitin-conjugating enzyme, is significantly expressed in colorectal tumors. The study suggests that UBE2Q1 may contribute to CRC progression by modulating the levels of p53 protein. Experimental results show that transfection of UBE2Q1 leads to a significant decrease in p53 protein levels in SW480 cells, while the change in p53 protein levels is not significant in LS180 cells. This indicates that UBE2Q1 may promote CRC progression by interacting with and degrading p53 protein.
Review
Biochemistry & Molecular Biology
Manlio Tolomeo, Antonio Cascio
Summary: STAT3 is a complex regulator of transcription, with constitutive activation reported in many tumors but less frequent somatic mutations in cancer. Oncogenic targets of STAT3 have been identified, and inhibitors have been developed for cancer prevention and treatment. However, data suggest that STAT3 functions are multifaceted and its cellular role is determined by various signals and factors, making targeted therapies tailored to specific tumor types important.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Johannes Tobias Thiel, Adrien Daigeler, Jonas Kolbenschlag, Katarzyna Rachunek, Sebastian Hoffmann
Summary: Soft tissue sarcomas (STSs) are rare malignant conditions that are difficult to treat. Recent research indicates that dysregulation of cyclin-dependent kinase (CDK) signaling pathways can be a strong driver of sarcogenesis. This review discusses the role of CDK signaling in STS development and its implications for targeted treatment.