Article
Obstetrics & Gynecology
Jian Zhang, Chenfeng Zhu, Li Yan, Yang Wang, Qian Zhu, Chuqing He, Xiaoqing He, Sifan Ji, Yuan Tian, Li Xie, Yan Liang, Wei Xia, Ben W. Mol, Judith A. F. Huirne
Summary: This study compared the effectiveness of a 52-mg levonorgestrel intrauterine system with hysteroscopic niche resection in reducing niche-related postmenstrual spotting. The results showed that the levonorgestrel intrauterine system was not more effective than hysteroscopic niche resection in reducing spotting days by at least 50% at 6 months, but it was superior in reducing spotting from 9 months onward.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Sener Gezer, Emre Kole, Lale Aksoy
Summary: This study compared the efficacy of vaginal micronized progesterone (VMP) with the levonorgestrel-releasing intrauterine system (LNG-IUS) in patients with non-atypical endometrial hyperplasia. The Menorrhagia Impact Questionnaire (MIQ) was used to assess quality of life. The results showed that there was no significant difference in regression rate between the two groups after 3 months of treatment, but the VMP group had better scores in terms of perception of blood loss.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Lueder M. Fels, Dustin Costescu, Carolina S. Vieira, Jeffrey F. Peipert, Eeva Lukkari-Lax, Birte M. Hofmann, Isabel Reinecke, Stefan Klein, Katrin Wiesinger, Bernhard Lindenthal, Runa Speer
Summary: This study aimed to evaluate the efficacy of adding indomethacin to the levonorgestrel-releasing intrauterine system in reducing the number of bleeding and spotting days during the first 90 days of use. The results showed that all three doses of indomethacin significantly reduced the number of bleeding and spotting days compared to the unmodified system. The lowest dose group achieved the highest reduction rate of 32%. Additionally, adding indomethacin did not affect the safety profile.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Sara Hogmark, Karin Lichtenstein Liljeblad, Niklas Envall, Kristina Gemzell-Danielsson, Helena Kopp Kallner
Summary: This study aimed to investigate if placement of an intrauterine device within 48 hours of completed medical abortion at up to 63 days' gestation leads to higher user rates at 6 months after the abortion compared with placement at 2 to 4 weeks after abortion. The results showed that there was no significant difference in usage rates between the intervention group and the control group. Furthermore, early placement of intrauterine devices seems to be safe, preferred by patients, and associated with lower pain scores.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Medicine, General & Internal
Paola Bianchi, Sun-Wei Guo, Marwan Habiba, Giuseppe Benagiano
Summary: This literature review examines the use of levonorgestrel-releasing intrauterine devices for heavy menstrual bleeding and/or dysmenorrhea. The review highlights that the insertion of a levonorgestrel-releasing intrauterine system is a useful option for long-term treatment, improving the quality of life and reducing menstrual blood loss and dysmenorrhea symptoms. Its ability to induce amenorrhea is considered to be the most important mechanism of action.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Kristen A. Matteson, Josie Valcin, Christina A. Raker, Melissa A. Clark
Summary: This study compared the effectiveness of the levonorgestrel intrauterine system and combined oral contraceptives in improving quality of life for individuals with heavy menstrual bleeding, and found no significant differences between the two treatments.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Tamara J. Oderkerk, Pleun Beelen, Peggy M. A. J. Geomini, Malou C. Herman, Jaklien C. Leemans, Ruben G. Duijnhoven, Judith E. Bosmans, Justine N. Pannekoek, Thomas J. Clark, Ben Willem J. Mol, Marlies Y. Bongers
Summary: This study aims to evaluate whether the combination of endometrial ablation and LNG-IUS is superior to endometrial ablation alone in reducing the need for hysterectomy due to ongoing bleeding and/or pain symptoms. The multicentre randomised controlled trial will assess participants' satisfaction, complications, side effects, and compare the rates of hysterectomy between the two groups at 24 months.
Article
Medicine, General & Internal
Sarah Averbach, Gennifer Kully, Erica Hinz, Arnab Dey, Holly Berkley, Marisa Hildebrand, Florin Vaida, Sadia Haider, Lisa G. Hofler
Summary: This study compared the rates of expulsion for intrauterine devices (IUDs) placed early postpartum (2-4 weeks after birth) with those placed at the standard interval (6-8 weeks postpartum). The study found that at the 6-month follow-up, the complete expulsion rate for the early placement group was 2.0%, while it was 0% for the interval placement group. The partial expulsion rate was 9.4% for the early placement group and 7.6% for the interval placement group. Therefore, understanding the expulsion risk at these time points can help patients and clinicians make informed decisions about the timing of IUD placement.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Obstetrics & Gynecology
Jennifer E. Kaiser, David K. Turok, Alexandra Gero, Lori M. Gawron, Rebecca G. Simmons, Jessica N. Sanders
Summary: This study compared 1-year pregnancy and intrauterine device continuation rates among emergency contraception users. The results showed similar rates between levonorgestrel 52-mg intrauterine device and copper intrauterine device groups.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Marcos Marangoni, Montas Laporte, Fernanda Surita, Maria B. Kraft, Luis Bahamondes, Cassia R. T. Juliato
Summary: The 1-year follow-up study on post-placental insertion of TCu380A-IUD and LNG-IUS found that device expulsion was more common among users of TCu380A-IUD and women who had vaginal delivery.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Obstetrics & Gynecology
Pleun Beelen, Marleen G. A. M. van der Velde, Malou C. Herman, Peggy M. Geomini, Marian J. van den Brink, Ruben G. Duijnhoven, Marlies Y. Bongers
Summary: This study aimed to compare the reintervention rates of women choosing different treatments and found that women receiving LNG-IUS were more likely to undergo additional interventions. There were no significant differences in reintervention rates between women in the observational cohort and those in the randomized controlled trial.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Pleun Beelen, Marian J. van den Brink, Malou C. Herman, Peggy M. Geomini, Ruben G. Duijnhoven, Marlies Y. Bongers
Summary: This study identified factors associated with failure of treatment using LNG-IUS in women with heavy menstrual bleeding, with younger age and severe dysmenorrhea found to be risk factors for discontinuation of treatment. High discontinuation rates were observed in this group of women.
Article
Gastroenterology & Hepatology
Dennis M. Jensen, Thomas Kovacs, Kevin A. Ghassemi, Marc Kaneshiro, Jeffrey Gornbein
Summary: This study aimed to compare the outcomes of using large OTSC versus standard hemostasis in the treatment of NVUGIB. Results showed that OTSC significantly reduced rates of rebleeding, severe complications, and post-randomization red cell transfusions, especially beneficial for patients with major stigmata of hemorrhage.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Pharmacology & Pharmacy
A. Buhur, O. Unal
Summary: This study evaluated the efficacy of the levonorgestrel-releasing intrauterine device in treating menorrhagia using a pictorial blood assessment chart. The results showed that 91.4% of the patients experienced a significant reduction in menstrual bleeding after device insertion, and there was also a significant decrease in the pictorial blood assessment chart scores at 6 months postoperatively. This indicates that the levonorgestrel-releasing intrauterine device is a safe and effective treatment option for abnormal uterine bleeding, and the pictorial blood assessment chart is a reliable tool for evaluating menstrual blood loss in women.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Obstetrics & Gynecology
Brooke Andrews, Kristen Quick, Erin MacLeod, Kayce Edwards, Bryan K. Rone
Summary: The use of an atraumatic Allis clamp during intrauterine device (IUD) placement results in less bleeding compared to the standard single-tooth tenaculum, with no difference in insertion success rates.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
C. Gerlinger, K. Gude, T. Schmelter, M. Schaefers, J. Endrikat
Article
Obstetrics & Gynecology
Gerard G. Nahum, Andrew M. Kaunitz, Kimberly Rosen, Thomas Schmelter, Richard Lynen
Article
Oncology
Luis Paz-Ares, Vera Hirsh, Li Zhang, Filippo de Marinis, James Chih-Hsin Yang, Heather A. Wakelee, Takashi Seto, Yi-Long Wu, Silvia Novello, Erszebet Juhasz, Osvaldo Aren, Yan Sun, Thomas Schmelter, Teng Jin Ong, Carol Pena, Egbert F. Smit, Tony S. Mok
JOURNAL OF THORACIC ONCOLOGY
(2015)
Article
Ophthalmology
Jeffrey S. Heier, Jean-Franois Korobelnik, David M. Brown, Ursula Schmidt-Erfurth, Diana V. Do, Edoardo Midena, David S. Boyer, Hiroko Terasaki, Peter K. Kaiser, Dennis M. Marcus, Quan D. Nguyen, Glenn J. Jaffe, Jason S. Slakter, Christian Simader, Yuhwen Soo, Thomas Schmelter, Robert Vitti, Alyson J. Berliner, Oliver Zeitz, Carola Metzig, Frank G. Holz
Article
Obstetrics & Gynecology
Kristina Gemzell-Danielsson, Dan Apter, Sylvia Dermout, Thomas Faustmann, Kimberly Rosen, Thomas Schmelter, Martin Merz, Anita Nelson
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2017)
Article
Ophthalmology
Charles C. Wykoff, Dennis M. Marcus, Edoardo Midena, Jean-Francois Korobelnik, Namrata Saroj, Andrea Gibson, Robert Vitti, Alyson J. Berliner, Zinaria Williams Liu, Oliver Zeitz, Carola Metzig, Thomas Schmelter, Jeffrey S. Heier
JAMA OPHTHALMOLOGY
(2017)
Article
Ophthalmology
Hiroko Terasaki, Kunihiko Shiraki, Masahito Ohji, Carola Metzig, Thomas Schmelter, Oliver Zeitz, Olaf Sowade, Masato Kobayashi, Robert Vitti, Alyson Berliner, Fumio Shiraga
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2019)
Article
Pharmacology & Pharmacy
Antonia M. Joussen, Sebastian Wolf, Peter K. Kaiser, David Boyer, Thomas Schmelter, Rupert Sandbrink, Oliver Zeitz, Gesa Deeg, Annett Richter, Torsten Zimmermann, Joachim Hoechel, Ulf Buetehorn, Walter Schmitt, Brigitte Stemper, Michael K. Boettger
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2019)
Correction
Obstetrics & Gynecology
Kristina Gemzell-Danielsson, Dan Apter, Sylvia Dermout, Thomas Faustmann, Kimberly Rosen, Thomas Schmelter, Martin Merz, Anita Nelson
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2019)
Article
Ophthalmology
Jeffrey S. Heier, Charles C. Wykoff, Nadia K. Waheed, John W. Kitchens, Sunil S. Patel, Robert Vitti, Lorah Perlee, Karen W. Chu, Sergio Leal, Friedrich Asmus, Vladimir Son, Thomas Schmelter, David M. Brown
Article
Medical Informatics
Christoph Muysers, Alex Dmitrienko, Hermann Kulmann, Bodo Kirsch, Susanne Lippert, Thomas Schmelter, Anke Schulz, Nicole Mentenich, Heinz Schmitz, Matthias Schaefers, Gerold Meinhardt, Thomas Keil, Stephanie Roll
THERAPEUTIC INNOVATION & REGULATORY SCIENCE
(2020)
Article
Ophthalmology
Yuichiro Ogura, Tomohiro Iida, Won Ki Lee, Chui Ming Gemmy Cheung, Paul Mitchell, Sergio Leal, Thomas Schmelter, Tatsuro Ishibashi
Summary: IVT-AFL monotherapy was effective for Japanese patients with PCV, and the addition of rescue PDT did not provide additional benefits. Most patients showed good outcomes at week 96, but a subset of patients required rescue photodynamic therapy.
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Jean-Francois Korobelnik, Michael Larsen, Nicole Eter, Clare Bailey, Sebastian Wolf, Thomas Schmelter, Helmut Allmeier, Varun Chaudhary
Summary: The study evaluated the efficacy and safety of IVT-AFL treat-and-extend dosing in patients with macular edema secondary to CRVO. Significant improvements in functional and anatomic outcomes were achieved, with most patients extending treatment intervals successfully. The safety profile of IVT-AFL was consistent with previous studies.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Paul Mitchell, Frank G. Holz, Philip Hykin, Edoardo Midena, Eric Souied, Helmut Allmeier, George Lambrou, Thomas Schmelter, Sebastian Wolf
Summary: The study compared the efficacy of early-start vs. late-start intravitreal aflibercept treat-and-extend (T&E) regimens in patients with neovascular age-related macular degeneration. The outcomes showed similar visual and anatomical results between the two groups over a two-year period, with only one injection difference.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Ophthalmology
Justus G. Garweg, Jana Stefanickova, Carel Hoyng, Thomas Schmelter, Tobias Niesen, Olaf Sowade, Sobha Sivaprasad
OPHTHALMOLOGY RETINA
(2019)