Article
Obstetrics & Gynecology
Kristen A. Matteson, Josie Valcin, Christina A. Raker, Melissa A. Clark
Summary: This study compared the effectiveness of the levonorgestrel intrauterine system and combined oral contraceptives in improving quality of life for individuals with heavy menstrual bleeding, and found no significant differences between the two treatments.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Medicine, General & Internal
Sijing Chen, Jianhong Liu, Shiyi Peng, Ying Zheng
Summary: This study compared the efficacy and safety of the levonorgestrel-releasing intrauterine system (LNG-IUS) with medical treatments for women with heavy menstrual bleeding. The results showed that LNG-IUS was superior to medical treatments in terms of short-term and medium-term clinical responses, blood loss control, compliance, and satisfaction.
FRONTIERS IN MEDICINE
(2022)
Article
Obstetrics & Gynecology
Pleun Beelen, Marleen G. A. M. van der Velde, Malou C. Herman, Peggy M. Geomini, Marian J. van den Brink, Ruben G. Duijnhoven, Marlies Y. Bongers
Summary: This study aimed to compare the reintervention rates of women choosing different treatments and found that women receiving LNG-IUS were more likely to undergo additional interventions. There were no significant differences in reintervention rates between women in the observational cohort and those in the randomized controlled trial.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Review
Obstetrics & Gynecology
Tamara J. Oderkerk, Majorie M. A. van de Kar, Carlijn H. M. van Der Zanden, Peggy M. A. J. Geomini, Malou C. Herman, Marlies Y. Bongers
Summary: Immediately inserting a levonorgestrel-intrauterine system (LNG-IUS) after endometrial ablation/resection seems to reduce the need for re-intervention and hysterectomy rates, and improve patient satisfaction. However, limited observational studies with low methodological quality are currently available, highlighting the need for higher quality research to confirm these findings.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Obstetrics & Gynecology
Rebeca M. Furlani, Elaine Garcia, Sara Castro, Helymar C. Machado, Luis Bahamondes, Ilza Monteiro
Summary: The study compared the expulsion rates of the levonorgestrel intrauterine system among women with heavy menstrual bleeding and those using it solely for contraception. Results showed similar expulsion rates between the two groups, with previous cesarean delivery identified as a risk factor for expulsion. The study recommends placement of the LNG IUS after the cessation of bleeding or a reduction of menstrual flow among women with heavy menstrual bleeding.
Article
Obstetrics & Gynecology
Hong Yang, Shengtan Wang, Xiaoyan Fu, Ruihong Lan, Humin Gong
Summary: The modified LNG-IUS is a safe and cost-effective method for reducing downward movement and expulsion rates in patients with adenomyosis and heavy menstrual bleeding.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Psychology, Developmental
Misha Khalighi, Allison P. Wheeler, Oluyemisi A. Adeyemi-Fowode, Peter A. Kouides, Ramon A. Durazo-Arvizu, Kristina Haley, Candice M. Dersch, Angela C. Weyand, Maureen K. Baldwin, Claudia Borzutzky
Summary: This study compared patient outcomes in adolescents with and without inherited bleeding disorders (BD) who underwent treatment for heavy menstrual bleeding (HMB) using the 52-mg levonorgestrel-releasing intrauterine system (52-LNG-IUS) within 12 months of insertion. The findings showed that both groups experienced improvement in bleeding outcomes and had similar rates of spontaneous expulsion.
JOURNAL OF ADOLESCENT HEALTH
(2022)
Article
Medicine, Research & Experimental
Mikio Momoeda, Shigeo Akira, Tasuku Harada, Jo Kitawaki, Nagamasa Maeda, Ikuko Ota, Keisuke Yoshihara, Noriko Takahashi
Summary: This study aimed to evaluate the quality of life of Japanese women using LNG-IUS and found that LNG-IUS improves the quality of life for women with dysmenorrhea and heavy menstrual bleeding, regardless of patient background characteristics.
ADVANCES IN THERAPY
(2022)
Article
Obstetrics & Gynecology
Tasuku Harada, Ikuko Ota, Jo Kitawaki, Mikio Momoeda, Nagamasa Maeda, Shigeo Akira, Mikiko Umeyama, Toshiyuki Sunaya, Kazufumi Hirano
Summary: This study examined the safety and clinical outcomes of the levonorgestrel-releasing intrauterine system (LNG-IUS) for heavy menstrual bleeding and dysmenorrhea. The results showed that LNG-IUS effectively reduced dysmenorrhea and chronic pelvic pain, but patients with underlying organic disease should be monitored for the risk of expulsion.
Article
Public, Environmental & Occupational Health
Tamara J. Oderkerk, Pleun Beelen, Peggy M. A. J. Geomini, Malou C. Herman, Jaklien C. Leemans, Ruben G. Duijnhoven, Judith E. Bosmans, Justine N. Pannekoek, Thomas J. Clark, Ben Willem J. Mol, Marlies Y. Bongers
Summary: This study aims to evaluate whether the combination of endometrial ablation and LNG-IUS is superior to endometrial ablation alone in reducing the need for hysterectomy due to ongoing bleeding and/or pain symptoms. The multicentre randomised controlled trial will assess participants' satisfaction, complications, side effects, and compare the rates of hysterectomy between the two groups at 24 months.
Article
Obstetrics & Gynecology
Hanifi Sahin, Arif Gungoren, Burak Sezgin, Burak Un, Eda Adeviye Sahin, Kenan Dolapcioglu, Rahime Nida Bayik
Summary: The study evaluated the effects of a levonorgestrel-releasing intrauterine device (LNG-IUD) on patients with idiopathic heavy menstrual bleeding. The results showed a significant increase in resistance indices of intra-myometrial arteries in LNG-IUD users one year after insertion, indicating a possible mechanism for reducing menstrual blood flow. This suggests further studies on the vascular effects of LNG-IUD and supports clinicians in managing heavy menstrual bleeding.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Obstetrics & Gynecology
Maarten D. H. Vink, France R. M. Portrait, Tim C. van Wezep, Xander Koolman, Ben W. Mol, Marlies Y. Bongers, Eric J. E. van der Hijden
Summary: Considerable practice variation exists among Dutch hospitals in the stepped care approach to idiopathic HMB. Improving adherence to this approach could improve quality of care and reduce costs.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Review
Medicine, General & Internal
Paola Bianchi, Sun-Wei Guo, Marwan Habiba, Giuseppe Benagiano
Summary: This literature review examines the use of levonorgestrel-releasing intrauterine devices for heavy menstrual bleeding and/or dysmenorrhea. The review highlights that the insertion of a levonorgestrel-releasing intrauterine system is a useful option for long-term treatment, improving the quality of life and reducing menstrual blood loss and dysmenorrhea symptoms. Its ability to induce amenorrhea is considered to be the most important mechanism of action.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
M. Wilde, G. Moyer, P. S. Huguelet
Summary: This case report describes the successful use of a levonorgestrel intrauterine device (LNG-IUD) in a 16-year-old female with vascular Ehlers-Danlos syndrome (EDS) and heavy menstrual bleeding (HMB). The device was placed under ultrasound guidance in the operating room. At the 6-month follow-up, the patient reported significant improvement in bleeding and high satisfaction. This case demonstrates that LNG-IUD may be a safe and effective treatment option for menstrual management in individuals with vascular EDS.
JOURNAL OF PEDIATRIC AND ADOLESCENT GYNECOLOGY
(2023)
Editorial Material
Obstetrics & Gynecology
Julia Pakey, Janelle S. Nassim, Rachel Reynolds
Summary: Counseling patients about the risk of acne associated with hormonal intrauterine devices is crucial in shared decision making for contraception methods.
OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Pleun Beelen, Marian J. van den Brink, Malou C. Herman, Peggy M. A. J. Geomini, Janny H. Dekker, Ruben G. Duijnhoven, Nienke Mak, Hannah S. van Meurs, Sjors F. Coppus, Jan Willem van der Steeg, Heleen P. Eising, Diana S. Massop-Helmink, Ellen R. Klinkert, Theodoor E. Nieboer, Anne Timmermans, Lucet F. van der Voet, Sebastiaan Veersema, Nicol A. C. Smeets, Joke M. Schutte, Marchien van Baal, Patrick M. Bossuyt, Ben Willem J. Mol, Marjolein Y. Berger, Marlies Y. Bongers
Summary: This study compared the effectiveness of the levonorgestrel-releasing intrauterine system with endometrial ablation in women with heavy menstrual bleeding. Both treatments led to a significant decrease in menstrual blood loss and similar quality of life scores post-treatment, but endometrial ablation showed a significant advantage in reducing menstrual blood loss.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Johannes J. Duvekot, Ruben G. Duijnhoven, Eva van Horen, Caroline J. Bax, Kitty W. Bloemenkamp, Ingrid A. Brusse, Peter H. Dijk, Maureen T. Franssen, Arie Franx, Martijn A. Oudijk, Martina M. Porath, Hubertina C. Scheepers, Aleid G. van Wassenaer-Leemhuis, Joris van Drongelen, Ben W. Mol, Wessel Ganzevoort
Summary: Despite the premature termination of the trial, it was observed that temporizing management resulted in a modest prolongation of pregnancy without significant changes in perinatal and maternal outcomes. Conducting a randomized study for this important research question was not feasible due to slow recruitment.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Obstetrics & Gynecology
Albertine J. Vroom, Luca Aerts, Marlies Y. Bongers, Arianne C. Lim, Bart J. Pielkenrood, Peggy M. A. J. Geomini, Nehalennia van Hanegem
Summary: The study assessed the quality of endometrial samples obtained by office endometrial aspiration before or after saline contrast sonohysterography (SCSH) in women with postmenopausal bleeding and a thickened endometrium. The results showed that SCSH did not affect the quality of endometrial samples, suggesting that both procedures can be performed in one outpatient visit for optimal diagnostic workup.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Obstetrics & Gynecology
Pleun Beelen, Marleen G. A. M. van der Velde, Malou C. Herman, Peggy M. Geomini, Marian J. van den Brink, Ruben G. Duijnhoven, Marlies Y. Bongers
Summary: This study aimed to compare the reintervention rates of women choosing different treatments and found that women receiving LNG-IUS were more likely to undergo additional interventions. There were no significant differences in reintervention rates between women in the observational cohort and those in the randomized controlled trial.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Robert Flynn, Kelly Plueschke, Chantal Quinten, Valerie Strassmann, Ruben G. Duijnhoven, Maria Gordillo-Maranon, Marcia Rueckbeil, Catherine Cohet, Xavier Kurz
Summary: The study found that RWE is widely used to support the evaluation of MAAs and EOIs submitted to the EMA, with registries and hospital data being the main sources. RWE is primarily used to support the safety and efficacy of drugs, with cohort studies being the most commonly used study design.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Obstetrics & Gynecology
Imke M. A. Reinders, Gaston R. Cremers, Stefanus J. van Rooijen, Jaklien C. Leemans, Christel W. Perquin, Peggy M. A. J. Geomini, Jacques W. M. Maas, Marlies Y. Bongers
Summary: Adding an informative 360-degree VR video to conventional information did not result in a reduction of anxiety prior to visiting the one-stop clinic. However, the majority of women who watched the video felt that it was of added value. Interestingly, women who reported higher anxiety at baseline seemed less willing to watch the video.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Surgery
Suzanne J. Dedden, Esther V. A. Bouwsma, Peggy M. A. J. Geomini, Marlies Y. Bongers, Judith A. F. Huirne
Summary: This study aimed to identify predictors of recovery following different approaches of hysterectomy. The study found that older age and same day removal of indwelling catheter were predictors of shorter duration until full return to work after hysterectomy.
Article
Public, Environmental & Occupational Health
Tamara J. Oderkerk, Pleun Beelen, Peggy M. A. J. Geomini, Malou C. Herman, Jaklien C. Leemans, Ruben G. Duijnhoven, Judith E. Bosmans, Justine N. Pannekoek, Thomas J. Clark, Ben Willem J. Mol, Marlies Y. Bongers
Summary: This study aims to evaluate whether the combination of endometrial ablation and LNG-IUS is superior to endometrial ablation alone in reducing the need for hysterectomy due to ongoing bleeding and/or pain symptoms. The multicentre randomised controlled trial will assess participants' satisfaction, complications, side effects, and compare the rates of hysterectomy between the two groups at 24 months.
Article
Obstetrics & Gynecology
J. Van Gemert, M. C. Herman, P. Beeien, P. M. Geomini, M. Y. Bongers
Summary: This study demonstrates that in the treatment of hysteroscopic transcervical resection of endometrial polyps, tissue removal device (TRD) is superior to the electrosurgical polyp snare (DPS) in complete polyp removal. TRD has a faster operation time and higher patient satisfaction. However, a serious adverse event occurred in the DPS group, indicating the need for safety precautions.
FACTS VIEWS AND VISION IN OBGYN
(2022)
Article
Obstetrics & Gynecology
Monique D. M. van Beukering, Marjo J. G. J. van Melick, Ruben G. Duijnhoven, Ewoud Schuit, Sophie L. Liem, Monique H. W. Frings-Dresen, Alouisa J. P. van de Wetering, Marc E. A. Spaanderman, Marjolein Kok, Ben W. Mol
Summary: This study aimed to determine whether certain working conditions up to 20 weeks of pregnancy increase the risk of preterm birth in multiple pregnancies. The results showed that working more than 28 hours was associated with very preterm birth, while irregular working times were associated with preterm birth. Additionally, nearly 60% of women with multiple pregnancies continued to work under circumstances that were not in accordance with the guidelines before 20 weeks of pregnancy.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Oncology
Tamara J. Oderkerk, Mileen R. D. van de Kar, Karlijn M. C. Cornel, Marlies Y. Bongers, Peggy M. A. J. Geomini
Summary: Previous endometrial ablation is not associated with the development and diagnosis of endometrial cancer. Most cases of endometrial cancer after ablation present with vaginal bleeding as the initial symptom. Diagnostic work-up is not impeded by previous endometrial ablation, and endometrial cancers after ablation are usually detected at early stages.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
