Review
Endocrinology & Metabolism
Ruping Pan, Yong Chen
Summary: Obesity is characterized by the overaccumulation of white adipose tissue in the body, leading to various metabolic disorders. Targeting human thermogenic adipose tissues shows promise in combating obesity.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Alana Deutsch, Kosaku Shinoda
Summary: Studies have shown that prolonged exposure to cold can increase the thermogenic capacity of brown adipose tissue through the recruitment of new brown adipocytes. Shamsi et al. and Angueira et al. have identified novel cellular origins of cold-induced brown adipocytes and elucidated the molecular mechanism regulating the expansion of brown adipose tissue.
Review
Cell Biology
Helaina Von Bank, Charlie Kirsh, Judith Simcox
Summary: Adipose tissue plays diverse roles in maintaining energy balance, including storing lipids in excess energy states and releasing fatty acids in energy-depleted conditions. Aging of adipose tissue leads to changes in cellular composition and function, increasing the risk of metabolic diseases in aged populations.
AGEING RESEARCH REVIEWS
(2021)
Article
Engineering, Biomedical
So Young Chun, Jun Nyung Lee, Yun-Sok Ha, Bo Hyun Yoon, Eun Hye Lee, Bo Mi Kim, Haejung Gil, Man-Hoon Han, Woo Seok Oh, Tae Gyun Kwon, Tae-Hwan Kim, Bum Soo Kim
Summary: Human adipose tissue, particularly perirenal fat tissue, is a valuable source of extracellular matrix (ECM) for regenerative medicine. By optimizing the extraction process and comparing different methods, it has been shown that fine homogenization and drying with acetone followed by decellularization with Triton X-100 can yield high-quality ECM with potential applications in tissue engineering and regenerative medicine.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Hideyuki Okuma, Kentaro Mori, Suguru Nakamura, Tetsuo Sekine, Yoshihiro Ogawa, Kyoichiro Tsuchiya
Summary: SGLT2 inhibitor ipragliflozin (Ipra) reduces urinary albumin excretion and glomerular hypertrophy in high-fat diet (HFD)-fed mice. The expansion of perirenal fat (PRAT) induced by Ipra may play an important role in improving diabetic nephropathy (DN) in HFD-fed mice by reducing leptin levels and inhibiting glomerular endothelial cells (GECs) proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Safaa H. Hammoud, Ibrahim AlZaim, Yusra Al-Dhaheri, Ali H. Eid, Ahmed F. El-Yazbi
Summary: Healthy adipose tissue is crucial for human wellbeing, contributing to energy balance and internal organ insulation, and playing a role in synthesizing and secreting adipokines affecting glucose and lipid balance. Inflammation induced by obesity in adipose tissue is linked to insulin resistance, metabolic syndrome, type 2 diabetes, as well as cardiovascular diseases, while alterations in perirenal adipose tissue have implications for renal and cardiovascular function. This suggests potential avenues for future pharmacological therapies targeting adipose tissue immunometabolism in the treatment of chronic kidney disease and cardiovascular disorders.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Engineering, Biomedical
So Young Chun, Yun-Sok Ha, Bo Hyun Yoon, Eun Hye Lee, Bo Mi Kim, Haejung Gil, Man-Hoon Han, Tae Gyun Kwon, Bum Soo Kim, Jun Nyung Lee
Summary: This study found that acetone treatment of human perirenal adipose tissue can achieve optimal delipidation efficiency and ECM extraction, with lower DNA content and the highest residual collagen concentration.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Editorial Material
Endocrinology & Metabolism
Imke L. Lemmer, Alexander Bartelt
Summary: An elegant quantitative analysis of brown fat and skeletal muscle metabolite flux reveals that brown fat predominantly uses glucose and lactate and acts as a nitrogen scavenger during thermogenesis.
Article
Endocrinology & Metabolism
Cheryl Cero, Weiguo Shu, Amy L. Reese, Diana Douglas, Michael Maddox, Ajeet P. Singh, Sahara L. Ali, Alexander R. Zhu, Jacqueline M. Katz, Anne E. Pierce, Kelly T. Long, Naris Nilubol, Raymond H. Cypess, Jonathan L. Jacobs, Fang Tian, Aaron M. Cypess
Summary: In this study, we generated and characterized a pair of immortalized human brown and white adipocytes. These cells exhibited similar characteristics to primary adipocytes, including adrenergic signaling, lipolysis, and thermogenesis. The brown adipocytes showed distinct metabolic features compared to the white adipocytes, providing mechanistic insights into the association between obesity and brown adipose tissue dysfunction.
Article
Cell & Tissue Engineering
Stefania Carobbio, Anne-Claire Guenantin, Myriam Bahri, Sonia Rodriguez-Fdez, Floris Honig, Ioannis Kamzolas, Isabella Samuelson, Kathleen Long, Sherine Awad, Dunja Lukovic, Slaven Erceg, Andrew Bassett, Sasha Mendjan, Ludovic Vallier, Barry S. Rosen, Davide Chiarugi, Antonio Vidal-Puig
Summary: The research team has developed a new chemically defined protocol for differentiating human pluripotent stem cells into brown adipocytes, overcoming limitations in BAT research. The obtained brown adipocytes express markers and respond to stimuli.
Article
Medicine, Research & Experimental
Jian Yu, Xin Chen, Yuanjin Zhang, Xiangdi Cui, Zhe Zhang, Wenxiu Guo, Dongmei Wang, Shengbo Huang, Yanru Chen, Yepeng Hu, Cheng Zhao, Jin Qiu, Yu Li, Meiyao Meng, Mingwei Guo, Fei Shen, Mengdi Zhang, Ben Zhou, Xuejiang Gu, Jiqiu Wang, Xin Wang, Xinran Ma, Lingyan Xu
Summary: This study demonstrates that azithromycin, a type of macrolide antibiotics, inhibits the functionality of brown and beige adipocytes. Azithromycin accumulates in adipose tissue of obese patients and is associated with BMI and body weight. The antibiotic impairs mitochondrial function in brown and beige adipocytes through inhibiting mitochondrial respiratory complex I and increasing ROS levels.
Review
Multidisciplinary Sciences
Prasanna Santhanam, Steven P. Rowe, Lilja B. Solnes, Brittany Quainoo, Rexford S. Ahima
Summary: BAT is predominantly found in the supraclavicular region, as well as mediastinal and paravertebral areas, and is mainly seen in young individuals. It is activated by cold temperature and the sympathetic nervous system. Various imaging techniques have been used to detect BAT in humans, including PET/CT, CT, MRI, and radiotracers for SPECT.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Review
Medicine, General & Internal
Angelo Alito, Angelo Quartarone, Giulia Leonardi, Adriana Tisano, Antongiulio Bruschetta, Francesca Cucinotta, Demetrio Milardi, Simona Portaro
Summary: This review aims to comprehensively evaluate the effects of cold on adipose tissue and biomarkers, and explore their potential applications in rehabilitation medicine. The results suggest that cold exposure can promote brown adipose tissue activation, but factors such as aging and body mass index may interfere with this activity.
Article
Cell Biology
Miriam A. Holzman, Abigail Ryckman, Tova M. Finkelstein, Kim Landry-Truchon, Kyra A. Schindler, Jenna M. Bergmann, Lucie Jeannotte, Jennifer H. Mansfield
Summary: Hoxa5 plays a critical role in embryonic BAT development and negatively regulates formation of epaxial muscle. The protein is expressed in embryonic adipocytes as early as day 12.5.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Nutrition & Dietetics
Karla J. Suchacki, Roland H. Stimson
Summary: The recent discovery of brown adipose tissue in adult humans offers a new strategy to treat obesity and associated metabolic diseases by increasing energy expenditure. Brown adipose tissue acts as a thermogenic organ that improves insulin sensitivity and lipid clearance, highlighting its beneficial role in metabolic health. Exercise, dietary macronutrients, and bioactive compounds can impact brown adipose tissue activity, and dietary interventions may represent a nonpharmacological means to enhance brown adipose tissue mass and activity for weight loss and improved metabolic health.
Article
Radiology, Nuclear Medicine & Medical Imaging
Mats Andersson, Oscar Jalnefjord, Mikael Montelius, Magnus Rizell, Malin Sternby Eilard, Maria Ljungberg
Summary: This study evaluated the response to intratumoral injections with the immune primer, ilixadencel, in hepatocellular carcinoma (HCC) using diffusion-weighted magnetic resonance imaging (DW-MRI) and intravoxel incoherent motion (IVIM) with histogram analysis. The results showed significant reductions in the perfusion-related parameter D* after ilixadencel injections, as well as correlations between baseline D values and tumor size change at three months. Further research is needed to confirm these findings and explore the treatment effect on HCC.
Article
Biophysics
Alejandra N. Torres, Ludgero Tavares, Maria J. Pereira, Jan W. Eriksson, John G. Jones
Summary: This study characterized the fatty acid composition and positional distribution of triglycerides in human subcutaneous adipose tissue using C-13 NMR spectroscopy. The study found that the sn2 position of triglycerides is enriched with monounsaturated fatty acids, while the sn1,3 position is enriched with saturated fatty acids. Furthermore, the study revealed a significant positive correlation between palmitoleic acid levels and both BMI and insulin sensitivity.
NMR IN BIOMEDICINE
(2023)
Article
Medicine, General & Internal
Maria K. Svensson, Francesc Sorio Vilela, Margret Leosdottir, Jonas Banefelt, Maria Lindh, Alexander Rieem Dun, Anna Norhammar, Guillermo Villa
Summary: In recent years, there has been an increase in the proportion of post-myocardial infarction patients with high lipid-lowering treatment (LLT) intensity and adherence, with little change after transfer to primary care. The combination of LLT intensity and adherence is important for preventing future cardiovascular events.
UPSALA JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Jan Melin, Maria K. Svensson, Bo Albinsson, Ola Winqvist, Karlis Pauksens
Summary: This study investigated the immune response of hemodialysis (HD) patients to the second and third doses of the SARS-CoV-2 BNT162b2 mRNA vaccine and found that the third dose led to a robust and improved immunological response. However, a few patients did not develop any antibody response, highlighting the need to monitor vaccine response and provide appropriate antibodies or antiviral drugs for non-responding patients.
UPSALA JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Maria J. Pereira, Ayesha Azim, Susanne Hetty, Bipasha Nandi Jui, Joel Kullberg, Martin H. Lundqvist, Jan W. Eriksson
Summary: This study aims to investigate the expression of interleukin-33 (IL-33) in subcutaneous adipose tissue (SAT) of type 2 diabetes (T2D) subjects and its effects on human adipocyte glucose uptake. The results showed that T2D subjects had higher IL-33 gene and protein expression in SAT, which was associated with insulin resistance and reduced gene expression of markers related to lipid storage and adipogenesis. Additionally, IL-33 treatment reduced adipocyte glucose uptake.
Article
Cell Biology
Milica Vranic, Fozia Ahmed, Susanne Hetty, Assel Sarsenbayeva, Vitor Ferreira, Giovanni Fanni, Angela M. Valverde, Jan W. Eriksson, Maria J. Pereira
Summary: We investigated the effects of second-generation antipsychotics (SGAs) on adipocyte differentiation and metabolism and found that aripiprazole (ARI) can impair adipocyte glucose uptake and increase fatty acid oxidation gene expression, while olanzapine (OLA) can increase leptin gene expression. These findings have important implications for understanding the metabolic effects of antipsychotic drugs and suggest that different SGAs may have different mechanisms of action.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Orthopedics
L. S. Lohmander, M. Peltonen, J. C. Andersson-Assarsson, C. Maglio, K. Sjoholm, M. Taube, P. Jacobson, P-A. Svensson, L. M. S. Carlsson, S. Ahlin
Summary: This study investigated the long-term effect of obesity and bariatric surgery on the incidences of osteoarthritis and arthroplasty of hip and knee. The results showed that the bariatric surgery group had a lower incidence of hip osteoarthritis but a higher incidence of knee arthroplasty compared to the control group.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Endocrinology & Metabolism
Lena M. S. Carlsson, Bjorn Carlsson, Peter Jacobson, Cecilia Karlsson, Johanna C. Andersson-Assarsson, Felipe M. Kristensson, Sofie Ahlin, Per-Arne Svensson, Magdalena Taube, Ingmar Naeslund, Kristjan Karason, Markku Peltonen, Kajsa Sjoholm
Summary: A study in Sweden found that bariatric surgery is associated with increased life expectancy and reduced overall mortality, regardless of whether patients had baseline type 2 diabetes (T2D) or not.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Endocrinology & Metabolism
Martin H. Lundqvist, Maria J. Pereira, Kristina Almby, Susanne Hetty, Jan W. Eriksson
Summary: Counter-regulatory hormonal responses to glucose variations differ in individuals with type 2 diabetes, prediabetes, and normoglycemia, and may contribute to the progression of the disease by promoting insulin resistance and dysglycemia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Per-Arne Svensson, Markku Peltonen, Johanna C. Andersson-Assarsson, Sofie Ahlin, Petra Brembeck, My Engstrom, Peter Jacobson, Magdalena Taube, Kajsa Sjoholm, Lena M. S. Carlsson
Summary: This study aimed to investigate the association between bariatric surgery and substance use disorder (SUD) with substances other than alcohol. The results showed that gastric bypass surgery was associated with an increased risk of non-alcohol SUD. This finding should be taken into consideration in long-term postoperative care.
Article
Endocrinology & Metabolism
Martin H. Lundqvist, Maria J. Pereira, Jan W. Eriksson
Summary: This study investigates whether inflammatory responses to glycemic and insulinemic variations are altered in obese individuals. The results show that hyperinsulinemia, hypoglycemia, and hyperglycemia lead to a decrease in multiple inflammatory markers, and the inflammatory response is more pronounced in obese individuals during hypoglycemia and hyperglycemia.
Article
Endocrinology & Metabolism
Fozia Ahmed, Milica Vranic, Susanne Hetty, Argyri Mathioudaki, Vagia Patsoukaki, Giovanni Fanni, Maria J. Pereira, Jan W. Eriksson
Summary: This study investigated the association of organic cation transporter 3 (OCT3) mRNA levels in subcutaneous adipose tissue with aging and markers of insulin resistance. The results showed that mRNA and protein levels of OCT3 increased with aging and were negatively associated with markers of insulin resistance. In addition, estradiol treatment resulted in a reduction in OCT3 mRNA levels.
Article
Endocrinology & Metabolism
Milica Vranic, Fozia Ahmed, Robin Kristofi, Susanne Hetty, Dariush Mokhtari, Maria K. Svensson, Jan W. Eriksson, Maria J. Pereira
Summary: This study evaluates the dopaminergic signaling in human adipose tissue in the context of obesity and type 2 diabetes (T2D) and its potential implications in adipose tissue metabolism. The results suggest that protein expression of DRD2 in subcutaneous adipose tissue is up-regulated with hyperglycemia and T2D, possibly as a compensatory mechanism. Additionally, dopamine receptor agonists inhibit adipocyte lipolysis and may have beneficial effects on lipid metabolism.
Article
Endocrinology & Metabolism
Kajsa Sjoholm, Lena M. S. Carlsson, Per-Arne Svensson, Johanna C. Andersson-Assarsson, Felipe Kristensson, Peter Jacobson, Markku Peltonen, Magdalena Taube
Summary: The study shows that bariatric surgery can prevent cancer in patients with obesity and diabetes, and long-term diabetes remission is associated with reduced cancer risk.
