DPP4 inhibition attenuates filtration barrier injury and oxidant stress in the zucker obese rat

Advanced glycation end products evoke endothelial cell damage by stimulating soluble dipeptidyl peptidase-4 production and its interaction with mannose 6-phosphate/insulin-like growth factor II receptor

(2013) Yuji Ishibashi et al.   Cardiovascular Diabetology

Dipeptidylpeptidase Inhibition Is Associated with Improvement in Blood Pressure and Diastolic Function in Insulin-Resistant Male Zucker Obese Rats

(2013) Annayya R. Aroor et al.   ENDOCRINOLOGY

DPP4 Deficiency Exerts Protective Effect against H2O2 Induced Oxidative Stress in Isolated Cardiomyocytes

(2013) Hui-Chun Ku et al.   PLoS One

DPP-4 Inhibitors as Therapeutic Modulators of Immune Cell Function and Associated Cardiovascular and Renal Insulin Resistance in Obesity and Diabetes

(2013) Annayya Aroor et al.   CardioRenal Medicine

The novel DPP-4 inhibitors linagliptin and BI 14361 reduce infarct size after myocardial ischemia/reperfusion in rats

(2012) Berthold Hocher et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

DPP-4 Inhibition on Top of Angiotensin Receptor Blockade Offers a New Therapeutic Approach for Diabetic Nephropathy

(2012) Markus L. Alter et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Renal and Cardiac Effects of DPP-4 Inhibitors – from Preclinical Development to Clinical Research

(2012) Berthold Hocher et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Attenuation of Renovascular Damage in Zucker Diabetic Fatty Rat by NWT-03, an Egg Protein Hydrolysate with ACE- and DPP4-Inhibitory Activity

(2012) Yumei Wang et al.   PLoS One

Combination of direct renin inhibition with angiotensin type 1 receptor blockade improves aldosterone but does not improve kidney injury in the transgenic Ren2 rat

(2012) Adam Whaley-Connell et al.   REGULATORY PEPTIDES

Dipeptidyl Peptidase 4 Is a Novel Adipokine Potentially Linking Obesity to the Metabolic Syndrome

(2011) D. Lamers et al.   DIABETES

Glucagon-like peptide-1 receptor agonist ameliorates renal injury through its anti-inflammatory action without lowering blood glucose level in a rat model of type 1 diabetes

(2011) R. Kodera et al.   DIABETOLOGIA

The Role of Overweight and Obesity in the Cardiorenal Syndrome

(2011) James R. Sowers et al.   CardioRenal Medicine

The Oral Dipeptidyl Peptidase-4 Inhibitor Sitagliptin Increases Circulating Endothelial Progenitor Cells in Patients With Type 2 Diabetes: Possible role of stromal-derived factor-1 

(2010) G. P. Fadini et al.   DIABETES CARE

Oxidized high-density lipoprotein enhances inflammatory activity in rat mesangial cells

(2010) Miao Zhang et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Prevalence and Trends in Obesity Among US Adults, 1999-2008

(2010) Katherine M. Flegal   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

PRAS40 acts as a nodal regulator of high glucose-induced TORC1 activation in glomerular mesangial cell hypertrophy

(2010) Nirmalya Dey et al.   JOURNAL OF CELLULAR PHYSIOLOGY

OBESITY INDUCED RENAL OXIDATIVE STRESS CONTRIBUTES TO RENAL INJURY IN SALT-SENSITIVE HYPERTENSION

(2009) Jeffrey E Quigley et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

The Role of the Mammalian Target Of Rapamycin (mTOR) in Renal Disease

(2009) W. Lieberthal et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Nck Proteins Maintain the Adult Glomerular Filtration Barrier

(2009) N. Jones et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Renal Activity of Akt Kinase in Obese Zucker Rats

(2008) Jana Ždychová et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Oral Doses of BI 1356, an Inhibitor of Dipeptidyl Peptidase 4, in Healthy Male Volunteers

(2008) S. Hüttner et al.   JOURNAL OF CLINICAL PHARMACOLOGY

(R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a Novel Xanthine-Based Dipeptidyl Peptidase 4 Inhibitor, Has a Superior Potency and Longer Duration of Action Compared with Other Dipeptidyl Peptidase-4 Inhibitors

(2008) L. Thomas et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS