Article
Biochemistry & Molecular Biology
Armaghan Saeb, Sarah M. Grundmann, Denise K. Gessner, Sven Schuchardt, Erika Most, Gaiping Wen, Klaus Eder, Robert Ringseis
Summary: This study demonstrates that adding insect cuticles to the diet can improve hepatic lipid metabolism in obese rats, possibly by modulating the gut microbiome and affecting plasma metabolites.
Article
Immunology
Baosheng Zhou, Honglin Wang, Bo Zhang, Lianlian Zhang
Summary: The study demonstrated the neuroprotective effects of Lico B in MCAO rats, showing improvements in cerebral infarction, memory impairments, and neurological deficits, as well as a reduction in oxidative stress and inflammation levels. Additionally, Lico B attenuated neuronal injury and apoptosis by activating the Nrf2 pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Qinghe Meng, Derek M. Culnan, Tamer Ahmed, Mingjie Sun, Robert N. Cooney
Summary: Roux-en-Y gastric bypass (RYGB) has significant effects on intestinal GLP-1 release and glucose transport in obese rats, potentially improving glycemic control by increasing GRP119 and FFAR2/3.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Bo Xu, Jiaqi Fang, Jianguang Wang, Xuehan Jin, Shengfu Liu, Kaihang Song, Ping Wang, Junjian Liu, Shuhao Liu
Summary: This study investigated the protective effect of edaravone on blood spinal cord barrier (BSCB) disruption after spinal cord injury (SCI). The results showed that edaravone treatment promoted functional recovery, improved vascular damage, and up-regulated BSCB-associated proteins in rats with SCI. In vitro experiments also demonstrated that edaravone improved cell viability, restored intercellular junctions, and promoted angiogenic activities. The underlying mechanism may involve the improvement of autophagy and the phosphorylation of RIP1/RIP3/MLKL. Overall, edaravone can be a potential treatment option for SCI.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Surgery
Eun Jeong Ko, Yoo Jin Shin, Sheng Cui, Sun Woo Lim, Byung Ha Chung, Chul Woo Yang
Summary: This study evaluated the effects of SGLT2i and DPP4i in TAC-induced diabetes and nephrotoxicity. The results showed that the combination of SGLT2i and DPP4i was more effective in reducing blood glucose levels, improving pancreatic islet function, and enhancing renal function compared to using each drug alone. Additionally, the combination therapy significantly reduced oxidative stress.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Nutrition & Dietetics
Magdalena J. M. Marschall, Sarah M. Grundmann, Denise K. Gessner, Gaiping Wen, Erika Most, Klaus Eder, Robert Ringseis
Summary: This study aimed to investigate the potential of dietary insect meal from Hermetia illucens larvae to attenuate liver steatosis and hyperlipidemia in obese Zucker rats. The study conducted a 4-week trial with obese and lean Zucker rats, replacing a portion of casein protein in the diets of obese rats with protein from HI larvae meal. Results showed that the inclusion of HI larvae meal significantly reduced liver lipid accumulation and improved dyslipidemia markers in obese rats. These findings suggest the potential of HI larvae meal as a functional food for preventing obesity-related metabolic disorders.
Article
Microbiology
Michael S. Robeson, Kanishka Manna, Christopher Randolph, Stephanie Byrum, Reza Hakkak
Summary: Obesity is the leading cause of health-related diseases globally. This study investigated the effects of short-term metformin treatment on the gut microbiota profile in an obese rat model. The results showed that short-term metformin treatment altered the composition of the gut microbiota, particularly the Bacteroides species, in obese rats.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Pediatrics
Katarzyna Mackowiak-Lewandowicz, Danuta Ostalska-Nowicka, Katarzyna Zaorska, Elzbieta Kaczmarek, Jacek Zachwieja, Martin Witt, Michal Nowicki
Summary: By studying the expression pattern of lipid metabolism and kidney damage markers in obese adolescents, it is possible to predict the risk of developing CKD. Increased serum concentrations of cholesterol, triglycerides, and urine concentration of neutrophil gelatinase-associated lipocalin may serve as potential predictors for CKD development in obese adolescents.
PEDIATRIC NEPHROLOGY
(2022)
Article
Plant Sciences
Renshi Li, Ce Chen, Bei Liu, Wen Shi, Kuniyoshi Shimizu, Chaofeng Zhang
Summary: BDG effectively alleviated symptoms and damage in chronic ulcerative colitis mice by suppressing inflammation in the intestines and lungs. It protected the integrity of intestinal epithelial cells, contributing to the inhibition of colitis and lung injury.
Article
Biochemistry & Molecular Biology
Lionel Carneiro, Claire Fenech, Fabienne Lienard, Sylvie Grall, Besma Abed, Joulia Haydar, Camille Allard, Lucie Desmoulins, Romain Paccoud, Marie-Claude Brindisi, Thomas Mouillot, Laurent Brondel, Xavier Fioramonti, Luc Penicaud, Agnes Jacquin-Piques, Corinne Leloup
Summary: This study found that obese and insulin-resistant rats lacking ghrelin exhibited hypersensitivity to glucose and excessive insulin secretion, which could be reversed by ghrelin treatment. These findings suggest that ghrelin modulates glucose hypersensitivity and insulin secretion through regulating mitochondrial metabolism and reactive oxygen species signaling.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Medicine, Research & Experimental
Dan Song, Min Zhao, Liuxiang Feng, Pingyi Wang, Yimei Li, Wenhua Li
Summary: Salidroside attenuates acute lung injury by inhibiting inflammatory cytokine production, reducing LPS-induced pathological damage, and suppressing TNF-α and IL-6 secretion in the lung. This suggests that Salidroside may have a potential therapeutic effect in LPS-induced acute lung injury.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Lara S. F. Konijnenberg, Tom T. J. Luiken, Andor Veltien, Laween Uthman, Carolien T. A. Kuster, Laura Rodwell, Guus A. de Waard, Mariska Kea-te Lindert, Anat Akiva, Dick H. J. Thijssen, Robin Nijveldt, Niels van Royen
Summary: After acute myocardial infarction, reperfusion of blocked coronary artery may cause microvascular injury, leading to poor long-term prognosis. Imatinib, a tyrosine-kinase inhibitor, has shown potential in reducing vascular leakage in various organs. In this study, imatinib was found to attenuate microvascular injury and reduce myocardial infarct size in a rat model of myocardial reperfusion injury. These findings suggest that imatinib may have the potential to reduce reperfusion injury in patients with acute myocardial infarction.
BASIC RESEARCH IN CARDIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Stepan Melnyk, Reza Hakkak
Summary: Excessive weight and obesity are major risk factors for chronic diseases, including diabetes. Metformin, a medication commonly used for diabetes, has been found to significantly improve complications associated with the disease. In this study, metabolomics was used to analyze the effects of metformin on lean and obese Zucker rats, revealing both positive and negative impacts on different rat groups.
Article
Biochemistry & Molecular Biology
Yongquan Bai, Wenwen Wang, Li Wang, Lirong Ma, Dongsheng Zhai, Furong Wang, Rui Shi, Chaoyang Liu, Qing Xu, Guo Chen, Zifan Lu
Summary: Obacunone, extracted from Phellodendron chinense Schneid or Dictamnus dasycarpus Turcz plant, demonstrates potent ameliorative effects on liver fibrosis by inhibiting the TGF-beta/P-Smad pathway and EMT process, enhancing GPx-4 signal, and exerting antioxidant effects on reactive oxygen species.
Article
Neurosciences
Shunhui Wei, Bo Chen, See Wee Low, Charlene Priscilla Poore, Yahui Gao, Bernd Nilius, Ping Liao
Summary: Neuronal swelling is a pathological feature of stroke caused by aberrant accumulation of sodium and chloride ions inside neurons. SLC26A11 was identified as the major chloride entry pathway under hypoxia and blocking its activity could reduce chloride entry and attenuate hypoxia-induced neuronal swelling. Inhibition of SLC26A11 could be a novel therapeutic strategy for stroke.
MOLECULAR NEUROBIOLOGY
(2023)
Editorial Material
Urology & Nephrology
C. John Sperati, Adam Whaley-Connell
ADVANCES IN CHRONIC KIDNEY DISEASE
(2015)
Article
Urology & Nephrology
Akhilesh Rao, Vishwam Pandya, Adam Whaley-Connell
ADVANCES IN CHRONIC KIDNEY DISEASE
(2015)
Article
Cardiac & Cardiovascular Systems
Shawn B. Bender, Jorge A. Castorena-Gonzalez, Mona Garro, Constantino C. Reyes-Aldasoro, James R. Sowers, Vincent G. DeMarco, Luis A. Martinez-Lemus
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2015)
Editorial Material
Peripheral Vascular Disease
Adam Whaley-Connell, James R. Sowers
JOURNAL OF CLINICAL HYPERTENSION
(2016)
Review
Endocrinology & Metabolism
Guanghong Jia, Vincent G. DeMarco, James R. Sowers
NATURE REVIEWS ENDOCRINOLOGY
(2016)
Article
Cardiac & Cardiovascular Systems
Camila Manrique, Javad Habibi, Annayya R. Aroor, James R. Sowers, Guanghong Jia, Melvin R. Hayden, Mona Garro, Luis A. Martinez-Lemus, Francisco I. Ramirez-Perez, Thomas Klein, Gerald A. Meininger, Vincent G. DeMarco
CARDIOVASCULAR DIABETOLOGY
(2016)
Article
Cardiac & Cardiovascular Systems
Guanghong Jia, Javad Habibi, Annayya R. Aroor, Luis A. Martinez-Lemus, Vincent G. DeMarco, Francisco I. Ramirez-Perez, Zhe Sun, Melvin R. Hayden, Gerald A. Meininger, Katelee Barrett Mueller, Iris Z. Jaffe, James R. Sowers
CIRCULATION RESEARCH
(2016)
Article
Endocrinology & Metabolism
Camila Manrique, Guido Lastra, Francisco I. Ramirez-Perez, Dominic Haertling, Vincent G. DeMarco, Annayya R. Aroor, Guanghong Jia, Dongqing Chen, Brady J. Barron, Mona Garro, Jaume Padilla, Luis A. Martinez-Lemus, James R. Sowers
Editorial Material
Peripheral Vascular Disease
Adam Whaley-Connell, James R. Sowers
Article
Peripheral Vascular Disease
Jaume Padilla, Francisco I. Ramirez-Perez, Javad Habibi, Brian Bostick, Annayya R. Aroor, Melvin R. Hayden, Guanghong Jia, Mona Garro, Vincent G. DeMarco, Camila Manrique, Frank W. Booth, Luis A. Martinez-Lemus, James R. Sowers
Article
Multidisciplinary Sciences
Agostinho G. Rocha, Antonietta Franco, Andrzej M. Krezel, Jeanne M. Rumsey, Justin M. Alberti, William C. Knight, Nikolaos Biris, Emmanouil Zacharioudakis, James W. Janetka, Robert H. Baloh, Richard N. Kitsis, Daria Mochly-Rosen, R. Reid Townsend, Evripidis Gavathiotis, Gerald W. Dorn
Article
Biochemistry & Molecular Biology
Huifangjie Li, Pengfei Yang, William Knight, Yingqiu Guo, Joel S. Perlmutter, Tammie L. S. Benzinger, John C. Morris, Jinbin Xu
JOURNAL OF NEUROCHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Huifangjie Li, William C. Knight, Pengfei Yang, Yingqiu Guo, Joel S. Perlmutter, John C. Morris, Randall J. Bateman, Tammie L. S. Benzinger, Jinbin Xu
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Clinical Neurology
Pengfei Yang, William C. Knight, Huifangjie Li, Yingqiu Guo, Joel S. Perlmutter, Tammie L. S. Benzinger, John C. Morris, Jinbin Xu
Summary: This study aimed to investigate the changes in dopamine receptors in Parkinson's disease patients, revealing a significant decrease in striatal D2 receptors in PD patients. Clinical manifestations correlated better with combined striatal D1R and D3R densities than with D1R or D3R alone.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Meeting Abstract
Clinical Neurology
H. Li, P. Yang, W. Knight, J. Xu
PARKINSONISM & RELATED DISORDERS
(2020)