Mechanisms by which maternal obesity programs offspring for obesity: evidence from animal studies

Interventions to prevent adverse fetal programming due to maternal obesity during pregnancy

(2013) Peter W Nathanielsz et al.   NUTRITION REVIEWS

Growth and insulin dynamics in two generations of female offspring of mothers receiving a single course of synthetic glucocorticoids

(2012) Nathan M. Long et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Multigenerational effects of fetal dexamethasone exposure on the hypothalamic–pituitary–adrenal axis of first- and second-generation female offspring

(2012) Nathan M. Long et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Aerobic exercise reduces oxidative stress and improves vascular changes of small mesenteric and coronary arteries in hypertension

(2012) Fernanda R Roque et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sexually Dimorphic Effects of Maternal Nutrient Reduction on Expression of Genes Regulating Cortisol Metabolism in Fetal Baboon Adipose and Liver Tissues

(2012) C. Guo et al.   DIABETES

Maternal obesity in the rat programs male offspring exploratory, learning and motivation behavior: prevention by dietary intervention pre-gestation or in gestation

(2012) J.S. Rodriguez et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Maternal obesity downregulates microRNA let-7g expression, a possible mechanism for enhanced adipogenesis during ovine fetal skeletal muscle development

(2012) X Yan et al.   INTERNATIONAL JOURNAL OF OBESITY

Maternal obesity, lipotoxicity and cardiovascular diseases in offspring

(2012) Maolong Dong et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Maternal High-Fat Diet Modulates the Fetal Thyroid Axis and Thyroid Gene Expression in a Nonhuman Primate Model

(2012) Melissa A. Suter et al.   MOLECULAR ENDOCRINOLOGY

Heterogeneity of income and lifestyle determinants of body weight among adult women in Mexico, 2006

(2012) M.A. Colchero et al.   SOCIAL SCIENCE & MEDICINE

Emergence of insulin resistance in juvenile baboon offspring of mothers exposed to moderate maternal nutrient reduction

(2011) Jaehyek Choi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The forgotten face of regular physical exercise: a ‘natural’ anti-atherogenic activity

(2011) Justyna Szostak et al.   CLINICAL SCIENCE

Maternal obesity eliminates the neonatal lamb plasma leptin peak

(2011) Nathan M. Long et al.   JOURNAL OF PHYSIOLOGY-LONDON

A common cause for a common phenotype: The gatekeeper hypothesis in fetal programming

(2011) S. McMullen et al.   MEDICAL HYPOTHESES

Prenatal Factors for Childhood Blood Pressure Mediated by Intrauterine and/or Childhood Growth?

(2011) X. Wen et al.   PEDIATRICS

Review: The placenta and developmental programming: Balancing fetal nutrient demands with maternal resource allocation

(2011) G.J. Burton et al.   PLACENTA

Maternal High Fat Diet Is Associated with Decreased Plasma n–3 Fatty Acids and Fetal Hepatic Apoptosis in Nonhuman Primates

(2011) Wilmon F. Grant et al.   PLoS One

Maternal obesity induces fibrosis in fetal myocardium of sheep

(2010) Yan Huang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Maternal obesity and overnutrition alter fetal growth rate and cotyledonary vascularity and angiogenic factor expression in the ewe

(2010) Yan Ma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Maternal Antioxidant Supplementation Prevents Adiposity in the Offspring of Western Diet-Fed Rats

(2010) S. Sen et al.   DIABETES

Maternal obesity in ewes results in reduced fetal pancreatic β-cell numbers in late gestation and decreased circulating insulin concentration at term

(2010) L. Zhang et al.   DOMESTIC ANIMAL ENDOCRINOLOGY

Early Overnutrition Results in Early-Onset Arcuate Leptin Resistance and Increased Sensitivity to High-Fat Diet

(2010) Maria M. Glavas et al.   ENDOCRINOLOGY

A Maternal “Junk Food” Diet in Pregnancy and Lactation Promotes Nonalcoholic Fatty Liver Disease in Rat Offspring

(2010) Stéphanie A. Bayol et al.   ENDOCRINOLOGY

Overnutrition and maternal obesity in sheep pregnancy alter the JNK-IRS-1 signaling cascades and cardiac function in the fetal heart

(2010) Jingying Wang et al.   FASEB JOURNAL

Epigenomics: maternal high-fat diet exposure in utero disrupts peripheral circadian gene expression in nonhuman primates

(2010) Melissa Suter et al.   FASEB JOURNAL

Prevalence and Trends in Obesity Among US Adults, 1999-2008

(2010) Katherine M. Flegal   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Prenatal synthetic glucocorticoid exposure alters hypothalamic-pituitary-adrenal regulation and pregnancy outcomes in mature female guinea pigs

(2010) Elizabeth Dunn et al.   JOURNAL OF PHYSIOLOGY-LONDON

Epigenetic modification of fetal baboon hepatic phosphoenolpyruvate carboxykinase following exposure to moderately reduced nutrient availability

(2010) Mark J. Nijland et al.   JOURNAL OF PHYSIOLOGY-LONDON

RAPID REPORT: Dietary intervention prior to pregnancy reverses metabolic programming in male offspring of obese rats

(2010) E. Zambrano et al.   JOURNAL OF PHYSIOLOGY-LONDON

Hepatic and very low-density lipoprotein fatty acids in obese offspring of overfed dams

(2010) Samira Bouanane et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Placental Amino Acid Transport and Placental Leptin Resistance in Pregnancies Complicated by Maternal Obesity☆

(2010) D.M. Farley et al.   PLACENTA

Maternal Diet-Induced Obesity Alters Mitochondrial Activity and Redox Status in Mouse Oocytes and Zygotes

(2010) Natalia Igosheva et al.   PLoS One

Maternal dexamethasone administration and the maturation of perirenal adipose tissue of the neonatal sheep

(2010) M.G. Gnanalingham et al.   Organogenesis

Maternal obesity downregulates myogenesis and β-catenin signaling in fetal skeletal muscle

(2009) Jun F. Tong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Altered skeletal muscle insulin signaling and mitochondrial complex II-III linked activity in adult offspring of obese mice

(2009) Piran Shelley et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Acetyl-CoA carboxylases 1 and 2 show distinct expression patterns in rats and humans and alterations in obesity and diabetes

(2009) Sebastian Kreuz et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Up-Regulation of Toll-Like Receptor 4/Nuclear Factor-κB Signaling Is Associated with Enhanced Adipogenesis and Insulin Resistance in Fetal Skeletal Muscle of Obese Sheep at Late Gestation

(2009) Xu Yan et al.   ENDOCRINOLOGY

Obesity and Enhanced Diabetes and Cardiovascular Risk in Adult Rats due to Early Postnatal Overfeeding

(2009) A. Plagemann et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Evidence for Sympathetic Origins of Hypertension in Juvenile Offspring of Obese Rats

(2009) Anne-Maj Samuelsson et al.   HYPERTENSION

Nationally Representative Surveys Show Recent Increases in the Prevalence of Overweight and Obesity among Women of Reproductive Age in Bangladesh, Nepal, and India

(2009) Yarlini Balarajan et al.   JOURNAL OF NUTRITION

Feto-placental Adaptations to Maternal Obesity in the Baboon

(2009) D. Farley et al.   PLACENTA

Maternal Obesity Induced by Diet in Rats Permanently Influences Central Processes Regulating Food Intake in Offspring

(2009) Shona L. Kirk et al.   PLoS One

Hypothalamic Neuroendocrine Circuitry is Programmed by Maternal Obesity: Interaction with Postnatal Nutritional Environment

(2009) Hui Chen et al.   PLoS One

The extremely slow and variable activity of dihydrofolate reductase in human liver and its implications for high folic acid intake

(2009) S. W. Bailey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of energy balance regulatory genes in the developing ovine fetal hypothalamus at midgestation and the influence of hyperglycemia

(2008) Clare L. Adam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Molecular mechanisms for hyperinsulinaemia induced by overproduction of selenium-dependent glutathione peroxidase-1 in mice

(2008) X. D. Wang et al.   DIABETOLOGIA

High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice

(2008) Helen N. Jones et al.   FASEB JOURNAL

Established maternal obesity in the rat reprograms hypothalamic appetite regulators and leptin signaling at birth

(2008) M J Morris et al.   INTERNATIONAL JOURNAL OF OBESITY

Early overweight and pubertal maturation—pathways of association with young adults’ overweight: a longitudinal study

(2008) A A Mamun et al.   INTERNATIONAL JOURNAL OF OBESITY

Methyl donor supplementation prevents transgenerational amplification of obesity

(2008) R A Waterland et al.   INTERNATIONAL JOURNAL OF OBESITY

Hypothalamic alterations in fetuses of high fat diet-fed obese female rats

(2008) Anshu Gupta et al.   JOURNAL OF ENDOCRINOLOGY

AMP-activated protein kinase signalling pathways are down regulated and skeletal muscle development impaired in fetuses of obese, over-nourished sheep

(2008) Mei J. Zhu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Obesity in Pregnancy Stimulates Macrophage Accumulation and Inflammation in the Placenta

(2008) J.C. Challier et al.   PLACENTA

Diet-Induced Obesity in Female Mice Leads to Offspring Hyperphagia, Adiposity, Hypertension, and Insulin Resistance

(2007) Anne-Maj Samuelsson et al.   HYPERTENSION