Article
Nutrition & Dietetics
Brit H. Boehmer, Stephanie R. Wesolowski, Laura D. Brown, Paul J. Rozance
Summary: The study aimed to investigate whether a 9-day leucine infusion could enhance insulin secretion and increase pancreatic islet size, beta-cells, and vascularity in intrauterine fetal growth restriction (IUGR) fetal sheep. However, the results showed that IUGR fetal sheep islets were not responsive to leucine infusion in terms of insulin secretion or any histologic features measured, unlike normally growing fetuses.
JOURNAL OF NUTRITION
(2021)
Article
Genetics & Heredity
Yang Liu, Qiyue Ding, Steven J. Halderson, Sebastian I. Arriola Apelo, Amanda K. Jones, Sambhu M. Pillai, Maria L. Hoffman, Sarah Reed, Kristen E. Govoni, Steven A. Zinn, Wei Guo
Summary: Overfeeding during gestation can have long-lasting effects on offspring autophagy signaling, especially in later developmental stages and female offspring. Targeting autophagy pathways may be a strategy to mitigate the adverse effects in offspring of over-fed ewes.
FRONTIERS IN GENETICS
(2022)
Article
Endocrinology & Metabolism
Eileen I. Chang, Byron Hetrick, Stephanie R. Wesolowski, Carrie E. McCurdy, Paul J. Rozance, Laura D. Brown
Summary: The study found that a two-week insulin infusion in IUGR fetal sheep can promote myoblast proliferation, but does not increase fiber or myonuclear number. Additionally, intrinsic defects in IUGR fetuses may limit their ability to restore fiber number.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Paul J. Rozance, Brit H. Boehmer, Eileen I. Chang, Stephanie R. Wesolowski, Laura D. Brown
Summary: This study found that chronic leucine infusion in late gestation fetal sheep increased leucine oxidation rates but did not increase protein synthesis rates. Increasing leucine concentrations stimulated amino acid transporter expression and primed protein synthesis pathways in skeletal muscle.
JOURNAL OF NUTRITION
(2023)
Article
Multidisciplinary Sciences
Kevin Yu, Michelle Rodriguez, Zubin Paul, Elizabeth Gordon, Tongjun Gu, Kelly Rice, Eric W. Triplett, Maureen Keller-Wood, Charles E. Wood
Summary: Recent evidence suggests bacterial DNA and protein can enter the fetus from the maternal bloodstream, and now the importance of bacterial transmission from the maternal mouth to the fetus has been discovered. Through inoculating maternal sheep using three different methods, it was found that the oral route is effective for transmitting bacterial cellular components to the fetus.
SCIENTIFIC REPORTS
(2021)
Article
Obstetrics & Gynecology
Laura D. Brown, Claire Palmer, Lucas Teynor, Brit H. Boehmer, Jane Stremming, Eileen Chang, Alicia White, Amanda K. Jones, Sarah N. Cilvik, Stephanie R. Wesolowski, Paul J. Rozance
Summary: The study found that fetal sex does not have a widespread impact on experimental insults, with most outcomes showing no gender-based differences. The only exceptions were higher hormone concentrations in female fetuses.
REPRODUCTIVE SCIENCES
(2022)
Article
Endocrinology & Metabolism
Alicia White, Jane Stremming, Brit H. Boehmer, Eileen I. Chang, Sonnet S. Jonker, Stephanie R. Wesolowski, Laura D. Brown, Paul. J. Rozance
Summary: After a 1-week infusion of IGF-1 LR3, late gestation fetal sheep showed lower plasma insulin and glucose concentrations, reduced fetal glucose-stimulated insulin secretion, and decreased fractional insulin secretion from isolated fetal islets without changes in pancreatic insulin content.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Developmental Biology
Linkai Zhu, Nicole Tillquist, Giovanna Scatolin, Rachael Gately, Mia Kawaida, Amanda Reiter, Sarah Reed, Steven Zinn, Kristen Govoni, Zongliang Jiang
Summary: Studies have shown that inadequate or excessive maternal nutrition during gestation does not affect semen characteristics in male sheep offspring, but it does result in significant changes in the composition and expression of small noncoding RNAs in sperm, as well as alterations in DNA methylation at specific genomic loci.
Article
Multidisciplinary Sciences
Jack R. T. Darby, Song Zhang, Stacey L. Holman, Beverly S. Muhlhausler, Caroline McMillen, Janna L. Morrison
Summary: The effects of fetal glucose infusion on cardiac growth and metabolism signaling molecules were evaluated. Results showed that despite increased fetal plasma glucose and insulin concentrations, there were no significant changes in mRNA expression and protein abundance of these molecules.
Article
Genetics & Heredity
Mingna Li, Weiwei Liang, Caiye Zhu, Shizhen Qin
Summary: The study demonstrates the significant roles of Bmf and Smad4 in the apoptosis of sheep granulosa cells (GCs), shedding light on the regulatory pathway between Smad4 and Bmf.
Article
Cell Biology
Xiaowei Qin, Wenqing Dang, Xiaofeng Yang, Kai Wang, Ermias Kebreab, Lihua Lyu
Summary: The inactivation of protein neddylation has been found to play an important role in regulating the proliferation of sheep follicular granulosa cells. Inhibition of neddylation significantly attenuated cell proliferation and induced apoptosis in sheep follicular granulosa cells. Furthermore, neddylation inactivation affected multiple signaling pathways and mitochondrial functions, leading to changes in cell physiology.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Maria Peterson, Mary Gauvin, Sambhu Pillai, Amanda Jones, Katelyn McFadden, Katelynn Cameron, Sarah Reed, Steven Zinn, Kristen Govoni
Summary: Maternal under- and over-nutrition during gestation were found to alter offspring pancreas structure, causing reductions in islet size and number. The changes in DNA methylation patterns were diet-specific and sex-dependent, indicating a potential mechanism for the effects of fetal programming on pancreas development.
Article
Agriculture, Dairy & Animal Science
Maria Grazia Cappai, Petra Wolf, Annette Liesegang, Giovanni Paolo Biggio, Andrea Podda, Antonio Varcasia, Claudia Tamponi, Fiammetta Berlinguer, Ignazio Cossu, Walter Pinna, Raffaele Cherchi
Summary: Monitoring serum protein fraction (SPF) levels, including metabolic profiling, in pregnant jennies can provide insights into the overall health status of the mother. Adequate dietary nutrient supplementation during mid-gestation is crucial to prevent homeostasis perturbation of jennies.
Article
Medicine, General & Internal
Siyuan He, Xiaoqian Yu, Daxin Cui, Yin Liu, Shanshan Yang, Hongmei Zhang, Wanxin Hu, Zhiguang Su
Summary: Pancreatic NF-Y might play an essential role in regulating b-cell compensation under metabolic stress caused by insulin resistance in obesity. NF-Y deletion in b-cells worsened glucose intolerance and b-cell dysfunction, leading to increased apoptosis and reactive oxygen species production. This study provides insights into the mechanism of b-cell compensation in obesity-related type 2 diabetes.
CHINESE MEDICAL JOURNAL
(2023)
Article
Cell Biology
Rui Wang, Wenchao Hu
Summary: The study demonstrated that asprosin induces apoptosis in beta-cells by inhibiting autophagy. High glucose and asprosin both lead to increased apoptosis and altered expression of certain proteins in MIN6 cells, affecting the AMPK-mTOR signaling pathway. Activation of the AMPK pathway by AICAR partially reverses the effects of asprosin on autophagy and apoptosis in beta-cells.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Obstetrics & Gynecology
Hillary F. Huber, Anderson H. Kuo, Cun Li, Susan L. Jenkins, Kenneth G. Gerow, Geoffrey D. Clarke, Peter W. Nathanielsz
REPRODUCTIVE SCIENCES
(2019)
Article
Veterinary Sciences
Natalia Schlabritz-Loutsevitch, Maira Carrillo, Cun Li, Peter Nathanielsz, Christopher Maguire, James Maher, Edward Dick, Gene Hubbard, Jerzy Stanek
JOURNAL OF MEDICAL PRIMATOLOGY
(2019)
Article
Endocrinology & Metabolism
Eugenia Mata-Greenwood, Hillary F. Huber, Cun Li, Peter W. Nathanielsz
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2019)
Editorial Material
Neurosciences
Peter W. Nathanielsz
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Review
Behavioral Sciences
Katja Franke, Bea R. H. Van den Bergh, Susanne R. de Rooij, Nasim Kroegel, Peter W. Nathanielsz, Florian Rakers, Tessa J. Roseboom, Otto W. Witte, Matthias Schwab
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2020)
Article
Geriatrics & Gerontology
Elena Zambrano, Luis A. Reyes-Castro, Guadalupe L. Rodriguez-Gonzalez, Roberto Chavira, Peter W. Nathanielsz
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2020)
Article
Medicine, General & Internal
Teresa L. Serafim, Teresa Cunha-Oliveira, Claudia M. Deus, Vilma A. Sardao, Ines M. Cardoso, Shanshan Yang, John F. Odhiambo, Adel B. Ghnenis, Ashley M. Smith, Junfei Li, Peter W. Nathanielsz, Stephen P. Ford, Paulo J. Oliveira
Summary: Maternal obesity impacts foetal liver mitochondrial oxidative capacity and total mitochondrial phospholipid content, as well as the regulation of foetal liver redox pathways, revealing metabolic adaptations to a higher foetal lipid environment. In utero programming of foetal hepatic metabolism may persist and compromise mitochondrial bioenergetics in later life, increasing susceptibility to metabolic diseases.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Diana C. Castro-Rodriguez, Carlos A. Ibanez, Jorge Uribe, Marta Menjivar, Maria de los Angeles Granados-Silvestre, Kenneth G. Gerow, Peter W. Nathanielsz, Elena Zambrano
INTERNATIONAL JOURNAL OF OBESITY
(2020)
Article
Toxicology
Luis F. Grilo, Joao D. Martins, Chiara H. Cavallaro, Peter W. Nathanielsz, Paulo J. Oliveira, Susana P. Pereira
TOXICOLOGY IN VITRO
(2020)
Article
Behavioral Sciences
C. Akos Szabo, Melissa De La Garza, Robert Shade, Alexander M. Papanastassiou, Peter Nathanielsz
Summary: This study demonstrated the efficacy of cortical responsive neurostimulation (CRN) in a male baboon with genetic generalized epilepsy (GGE), showing a 38% median reduction in generalized tonic-clonic seizures (GTCS) under treatment. The ictal patterns and circadian distribution of GTCS were also altered by the RNS therapy, shifting gradually from night to daytime.
EPILEPSY & BEHAVIOR
(2021)
Editorial Material
Medicine, General & Internal
Peter W. Nathanielsz
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Medicine, General & Internal
Elena Zambrano, Peter W. Nathanielsz, Guadalupe L. Rodriguez-Gonzalez
Summary: Developmental programming can predispose offspring to metabolic, behavioral, and reproductive dysfunction in adult life, with evidence showing a connection between aging phenotype and longevity. Maternal nutrition during development can have effects on the male reproductive system's aging, impacting factors like hormone production, oxidative stress, and sperm quality. Understanding these developmental programming aging interactions can improve male health, longevity, and future generations' health.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Medicine, General & Internal
Elena Zambrano, Consuelo Lomas-Soria, Peter W. Nathanielsz
Summary: Compelling evidence suggests that developmental programming influences ageing, affecting organ phenotype and predisposing to diseases that shorten lifespan. Studies demonstrate effects of maternal under- and overnutrition on offspring's pancreatic islets, adipose tissue, and oxidative stress, impacting ageing.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Geriatrics & Gerontology
Daniel A. Adekunbi, Cun Li, Peter W. Nathanielsz, Adam B. Salmon
Summary: The study found that the resilience of cells in responding to homeostatic challenges varies based on the chronological age and sex of the donor, using baboon primary fibroblasts as a model.
Article
Biology
Consuelo Lomas-Soria, Guadalupe L. Rodriguez-Gonzalez, Carlos A. Ibanez, Luis A. Reyes-Castro, Peter W. Nathanielsz, Elena Zambrano
Summary: The present study explored the impact of maternal obesity on hepatic mitochondrial function in male and female offspring at different ages. The findings suggest that maternal obesity accelerates the age-related down-regulation of electron transport chain (ETC) gene expression, leading to oxidative stress, premature aging, and metabolic dysfunction in male offspring. These effects were not observed in female offspring until later in life. The study highlights the importance of mitochondria in the development of fatty liver and provides insights into the mechanisms underlying sexual dimorphism in aging.
Article
Agriculture, Dairy & Animal Science
Mehak Nisar, Shafayat Ahmad Beigh, Abdul Qayoom Mir, Syed Ashaq Hussain, Aijaz Ahmad Dar, Iqbal Yatoo, Adil Mehraj Khan
Summary: This study aimed to evaluate the role of vitamin D in redox balance, insulin resistance, and its predicting value for subclinical pregnancy toxemia (SPT) in pregnant ewes. The results showed that ewes with insufficient vitamin D had significantly lower total antioxidant capacity (TAC) compared to ewes with sufficient vitamin D, and there were significant differences in metabolite concentrations between the two groups. Additionally, vitamin D was positively correlated with fructosamine, calcium, and TAC, and negatively correlated with non-esterified fatty acid (NEFA) and total oxidant status (TOS). Ewes with insufficient vitamin D had a higher risk of developing SPT two weeks prior to lambing and at lambing.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2024)
Article
Agriculture, Dairy & Animal Science
L. G. Gonzalez-Arostegui, A. Munoz-Prieto, C. P. Rubio, J. J. Ceron, L. Bernal, I. Rubic, V. Mrljak, J. C. Gonzalez-Sanchezc, A. Tvarijonaviciute
Summary: This study investigated changes in the saliva and serum proteome of dogs with hypothyroidism using TMT labelling and LC-MS/MS. The findings showed that this disease induces alterations in the saliva and serum proteome, reflecting physiological and pathological changes in the immune system, metabolism, skin, and coagulation. The downregulation of LDH in saliva may serve as a potential biomarker for canine hypothyroidism.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2024)
Article
Agriculture, Dairy & Animal Science
Camila R. C. Brito, Agatha D. Cordeiro, Pricila Baldessar, Carolini Schultz, Monike Quirino, Rafael R. Ulguim, Paulo B. D. Goncalves, Thomaz Lucia Jr, Ivan Bianchi, Bernardo G. Gasperin
Summary: This study tested synchronization protocols without progestogens during the luteal phase in gilts. The results showed that the protocols based on PGF and hCG were effective in reducing the interval between estrus in gilts. Additionally, the hCG2 protocol had negative effects on the number of piglets born alive and total litter size.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2024)
Article
Agriculture, Dairy & Animal Science
F. Frers, J. Delarocque, K. Feige, K. Huber, T. Warnken
Summary: This study aimed to investigate the relationship between insulin dysregulation and the expression and phosphorylation of key proteins in the insulin signaling cascade in different tissues of horses. The results showed enhanced phosphorylation of the insulin receptor and protein kinase B in response to stimulation, while phosphorylation of adenosine monophosphate protein kinase alpha decreased after glucose administration. Interestingly, horses with insulin dysregulation had significantly higher phosphorylation of mechanistic target of rapamycin in muscle tissue. These findings suggest that insulin signaling is maintained in horses, but post-receptor alterations may occur.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2024)
Article
Agriculture, Dairy & Animal Science
Patrice Dufour, Vincent Frisee, Goulven Rigaux, Flore Brutinel, Sophie Egyptien, Philippe Bossaert, Jessica Deleersnyder, Stefan Deleuze, Stephanie Peeters, Caroline Le Goff, Jerome Ponthier, Etienne Cavalier
Summary: This report describes the method of measuring progesterone and estrone-sulfate using Liquid Chromatography coupled with Mass Spectrometry in American Bison feces. This method provides an alternative to serum assay for studying the pregnancy-related evolution of these hormones in American Bison.
DOMESTIC ANIMAL ENDOCRINOLOGY
(2024)