Article
Agriculture, Dairy & Animal Science
Isaac Hyeladi Malgwi, Veronika Halas, Petra Grunvald, Stefano Schiavon, Ildiko Jocsak
Summary: Intramuscular fat (IMF) is an important indicator of pork sensory quality, influenced by dietary nutrients, genes, and metabolic pathways in pigs. Nutrigenetics and nutrigenomics provide a powerful tool for estimating nutrient requirements and programming dietary nutrient supply based on individual pig's genetic make-up. Understanding the mechanisms of fat metabolism and IMF deposition is crucial for improving swine production and economically important traits.
Review
Nutrition & Dietetics
Anto Cordelia T. A. Dhanapal, Ramatu Wuni, Eduard F. F. Ventura, Teh Kuan Chiet, Eddy S. G. Cheah, Annaletchumy Loganathan, Phoon Lee Quen, Mahenderan Appukutty, Mohd F. M. Noh, Ian Givens, Karani Santhanakrishnan Vimaleswaran
Summary: This study aims to address malnutrition in Malaysia and proposes a conceptual framework for implementing precision nutrition strategies. The framework includes research in the fields of genetics, genomics, transcriptomics, and more, as well as training and resource development for stakeholders.
Review
Environmental Sciences
Shambhavi Srivastava, Ankit Kumar Dubey, Reecha Madaan, Rajni Bala, Yugam Gupta, Bahadur Singh Dhiman, Suresh Kumar
Summary: This article discusses the characteristics of cancer and the development of tumors, as well as the relationship between nutrition and genes. Nutrients can influence gene expression and cancer risk. Altering dietary habits can potentially reduce individual cancer risk.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Nutrition & Dietetics
Sangeetha Shyam, Ke Xin Lee, Angeline Shu Wei Tan, Tien An Khoo, Shivani Harikrishnan, Shehzeen Alnoor Lalani, Amutha Ramadas
Summary: Personalized nutrition is an approach that tailors nutrition advice based on individuals' genetic information. Despite interest among scholars, the impact of this approach on lifestyle habits and health has not been adequately explored. A systematic review of randomized trials suggests that there is limited evidence supporting the consistent benefits of personalized nutrition in improving dietary, behavioral, or health outcomes. Future trials should focus on improving methodological quality and expanding the generalizability of the results.
Review
Nutrition & Dietetics
Lynnette Ferguson, Matthew Barnett
Summary: Nutrigenomics New Zealand (NuNZ) was a collaborative research programme established by three organizations with the aim of studying the application of nutrigenomics in New Zealand and exploring its potential benefits in the plant food and agricultural sectors. The programme divided nutrigenomics into personalized nutrition and nutrigenomics, utilizing various science laboratories for comprehensive analysis to understand the impact of food products and diets on health.
Article
Medicine, Research & Experimental
Sandra Caramujo-Balseiro, Carlos Faro, Lina Carvalho
Summary: This study discusses the link between dietary habits, genes, and colorectal cancer occurrence, proposing four fundamental metabolic pathways and analyzing related gene polymorphisms. It also highlights the association between diet and genes, as well as the importance in CRC prevention or treatment.
MEDICAL HYPOTHESES
(2021)
Review
Agriculture, Dairy & Animal Science
Xiaohan Liu, Yifan Tang, Jiajin Wu, Jian-Xin Liu, Hui-Zeng Sun
Summary: Increasing the efficiency and sustainability of cattle production is crucial for meeting the protein needs of a growing human population. Genetics and nutrition play key roles in selecting and improving cattle with beneficial traits. Feedomics, a combination of omic techniques, provides insights into the relationships between genes and nutrition/nutrients at different molecular levels, optimizing cattle production. This review summarizes the applications of feedomics techniques to understand the impact of genetic elements on nutrition response and how nutrients affect the functional genome of cattle, highlighting the role of rumen microbiome in the interaction between host genes and nutrition.
Review
Food Science & Technology
Fabio Caradonna, Ilenia Cruciata, Claudio Luparello
Summary: The intake of alcoholic beverages may have negative effects on genetic and epigenetic regulation, leading to different risks of cancer in populations based on genotypes. This review summarizes selected studies on the impact of low-dose alcohol consumption on tumorigenic pathways, including the relationship between dietary compounds and alcohol, the effects of other components in alcoholic drinks on oncogenes and oncosuppressors, and the role of alcohol within specific dietary regimens.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Nutrition & Dietetics
Daianna Lima da Mata, Alexandre Siqueira Guedes Coelho, Dulcineia Saes Parra Abdala, Maria Aderuza Horst, Cristiane Cominetti
Summary: Genetic scores based on SNPs related to lipid metabolism were found to be significantly associated with unfavorable outcomes in circulating lipid profile biomarkers of adolescents. Each point increase in the genetic scores was associated with changes in specific lipid profile biomarkers, suggesting potential clinical applications to target interventions for reducing cardiovascular disease risk.
Article
Health Care Sciences & Services
Sapna Batheja, Emma M. Schopp, Samantha Pappas, Siri Ravuri, Susan Persky
Summary: This study aims to characterize the landscape of precision nutrition content on Twitter, focusing on nutrigenetics and nutrigenomics. Tweet authors, content types, and the presence of misinformation were examined.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Genetics & Heredity
Phoebe Yam, Jody Albright, Melissa VerHague, Erik R. Gertz, Fernando Pardo-Manuel de Villena, Brian J. Bennett
Summary: This study analyzed the effects of different macronutrient diets on body composition and obesity-related traits in a genetically diverse mouse population, showing significant variation in phenotypic responses among different genetic strains. The findings underscore the importance of considering genetic diversity when making dietary recommendations for weight management.
FRONTIERS IN GENETICS
(2021)
Review
Agriculture, Dairy & Animal Science
M. Alagawany, Shaaban S. Elnesr, Mayada R. Farag, Karima El-Naggar, M. Madkour
Summary: This review discusses the definition of nutrigenomics and nutrigenetics in poultry nutrition and their impact on production efficiency and meat quality.
WORLDS POULTRY SCIENCE JOURNAL
(2022)
Review
Nutrition & Dietetics
Varsha Singh
Summary: Nutrigenetics and nutrigenomics, combined with omics technologies, are important for personalizing nutrition-based care and understanding individual responses to therapy. These approaches provide new insights into cell regulation and can be used for the development of precision nutrition.
Review
Biochemistry & Molecular Biology
Anna Vesnina, Alexander Prosekov, Victor Atuchin, Varvara Minina, Anastasia Ponasenko
Summary: Personalized nutrition is an effective preventive measure against atherosclerosis by considering genetic characteristics, microbiota status, and environmental factors. Selecting the appropriate diet based on individual traits can help prevent atherosclerosis. Challenges such as lack of strong evidence on the impact of certain genetic features, high cost, and result interpretation difficulties hinder the active use of personalized nutrition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Justine Keathley, Veronique Garneau, Valerie Marcil, David M. Mutch, Julie Robitaille, Iwona Rudkowska, Gabriela Sofian, Sophie Desroches, Marie-Claude Vohl
Summary: The study found that most gene-diet associations lack sufficient scientific and clinical evidence for implementation in practice, but two gene-diet associations with strong evidence can be considered in certain cases. The first CPGs in nutrigenetics offer guidance on genetic testing for evaluating responsiveness to dietary/supplemental omega-3 and their impact on plasma lipids/lipoproteins/apolipoproteins, emphasizing two associations with strong scientific validity.
FRONTIERS IN NUTRITION
(2022)
Article
Multidisciplinary Sciences
Ankit Shukla, Thu H. M. Nguyen, Sarat B. Moka, Jonathan J. Ellis, John P. Grady, Harald Oey, Alexandre S. Cristino, Kum Kum Khanna, Dirk P. Kroese, Lutz Krause, Eloise Dray, J. Lynn Fink, Pascal H. G. Duijf
NATURE COMMUNICATIONS
(2020)
Article
Nutrition & Dietetics
Stephanie Andraos, Beatrix Jones, Clare Wall, Eric Thorstensen, Martin Kussmann, David Cameron-Smith, Katherine Lange, Susan Clifford, Richard Saffery, David Burgner, Melissa Wake, Justin O'Sullivan
Summary: The study reveals that family, age, and sex contribute to variations in the concentrations of plasma B vitamers in Australian children and adults. Concordance in B vitamer levels was found between parent-child pairs, with different generations showing specificity in their vitamer concentrations.
Article
Endocrinology & Metabolism
Zainab Khudhair, Rafid Alhallaf, Ramon M. Eichenberger, Jen Whan, Andreas Kupz, Matt Field, Lutz Krause, David T. Wilson, Norelle L. Daly, Paul Giacomin, Javier Sotillo, Alex Loukas
Summary: The study shows that prophylactic and therapeutic infection of mice with the parasitic hookworm-like nematode Nippostrongylus brasiliensis significantly reduces fasting blood glucose and body weight gain in two different diet-induced mouse models of Type 2 diabetes. The infection is associated with elevated type 2 immune responses, increased eosinophil numbers, and changes in gut microbiota composition. These findings suggest that carefully controlled therapeutic hookworm infection could be a novel approach for treating metabolic syndrome and preventing Type 2 diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Microbiology
Donovan H. Parks, Fabio Rigato, Patricia Vera-Wolf, Lutz Krause, Philip Hugenholtz, Gene W. Tyson, David L. A. Wood
Summary: A fundamental goal of microbial ecology is to accurately determine species composition in microbial ecosystems. Microba Community Profiler (MCP) was found to generate accurate relative abundance estimates and fewer false positive predictions compared to other classifiers, establishing it as the best-in-class tool for comprehensive and accurate species profiling of human gastrointestinal samples. Using the Microba Genome Database significantly increases the accuracy of species classification.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chloe X. Yap, Anjali K. Henders, Gail A. Alvares, David L. A. Wood, Lutz Krause, Gene W. Tyson, Restuadi Restuadi, Leanne Wallace, Tiana McLaren, Narelle K. Hansell, Dominique Cleary, Rachel Grove, Claire Hafekost, Alexis Harun, Helen Holdsworth, Rachel Jellett, Feroza Khan, Lauren P. Lawson, Jodie Leslie, Mira Levis Frenk, Anne Masi, Nisha E. Mathew, Melanie Muniandy, Michaela Nothard, Jessica L. Miller, Lorelle Nunn, Gerald Holtmann, Lachlan T. Strike, Greig I. de Zubicaray, Paul M. Thompson, Katie L. McMahon, Margaret J. Wright, Peter M. Visscher, Paul A. Dawson, Cheryl Dissanayake, Valsamma Eapen, Helen S. Heussler, Allan F. McRae, Andrew J. O. Whitehouse, Naomi R. Wray, Jacob Gratten
Summary: The study found negligible direct associations between ASD diagnosis and the gut microbiome, but suggested that ASD-related restricted interests may be linked to diet, microbial taxonomic diversity, and stool consistency. The dataset was well powered to detect microbiome associations with traits such as age, dietary intake, and stool consistency, cautioning against claims that the microbiome has a driving role in ASD.
Article
Nutrition & Dietetics
Paloma K. Barrera-Reyes, Josue Cortes-Fernandez de Lara, Laure Poquet, Karine Redeuil, Martin Kussmann, Irma Silva-Zolezzi, Elizabeth M. Tejero
Summary: This study found that the concentrations of cocoa polyphenols were higher after sustained intake, with sulfate conjugates showing higher levels in females. Epicatechin-3'-glucuronide and epicatechin-3'-sulfate were the most abundant metabolites in all subjects.
Review
Genetics & Heredity
Aoife Doherty, Audrey Wall, Nora Khaldi, Martin Kussmann
Summary: Scientific research shows that diseases can be delayed, treated, or prevented through health-promoting functional food ingredients (FFIs) to maintain health. Consumers are increasingly seeking information on food, nutrition, nutrients, and associated health benefits, leading to the formation of a nutrition industry centered around natural foods and FFIs.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Zainab Khudhair, Rafid Alhallaf, Ramon M. Eichenberger, Matt Field, Lutz Krause, Javier Sotillo, Alex Loukas
Summary: The gastrointestinal helminth Nippostrongylus brasiliensis has therapeutic potential for treating metabolic syndrome and type 2 diabetes (T2D) by modulating the immune response and gut microbiota composition.
Article
Multidisciplinary Sciences
Starin McKeen, Nicole C. Roy, Jane Adair Mullaney, Hannah Eriksen, Amy Lovell, Martin Kussman, Wayne Young, Karl Fraser, Clare R. Wall, Warren C. McNabb
Summary: This study characterized the changes in the gut microbiome composition, metagenomic functional capacity, and associated metabolites during the introduction of solid foods in infants. The results showed that the microbiome composition diversified during the first year of life, while the functional capacity of the gut microbiome remained stable. The introduction of solid foods resulted in significant changes in the relative abundance of sequences assigned to KEGG pathways and taxonomic assignments, as well as stronger correlations with metabolites compared to continued diet diversification. This study provides insights into the trends in microbiome composition and functional capacity during the complementary feeding period and identifies potential metabolite targets for future investigations.
Review
Nutrition & Dietetics
Silvia Berciano, Juliana Figueiredo, Tristin D. Brisbois, Susan Alford, Katie Koecher, Sara Eckhouse, Roberto Ciati, Martin Kussmann, Jose M. Ordovas, Katie Stebbins, Jeffrey B. Blumberg
Summary: Precision Nutrition (PN) is an individualized approach to nutritional recommendations based on various factors. It recognizes that healthful diets can differ between individuals and that health and dietary responses change over time. Despite concerns about the scientific support for current products and services, PN shows promise in improving healthspan and reducing healthcare costs. Advancing PN will require investment in multidisciplinary collaborations, engagement of healthcare professionals and payers, and system-wide collaboration to advocate for evidence-based PN and regulatory support.
FRONTIERS IN NUTRITION
(2022)
Editorial Material
Nutrition & Dietetics
Martin Kussmann
Review
Nutrition & Dietetics
Eva Kiesswetter, Julia Stadelmaier, Maria Petropoulou, Jakub Morze, Kathrin Grummich, Isabelle Roux, Roberta Lay, Lisa Himmelsbach, Martin Kussmann, Christine Roeger, Malte Rubach, Hans Hauner, Lukas Schwingshackl
Summary: The health effects of dairy products on cardiometabolic markers remain debated. A systematic review and network meta-analysis found that high-dairy intake had no detrimental effects on anthropometric outcomes, blood lipids, and blood pressure. Low-fat and full-fat dairy improved blood pressure but may impair glycemic control. Yogurt showed beneficial effects on waist circumference, triglycerides, and high-density lipoprotein cholesterol.
ADVANCES IN NUTRITION
(2023)
Article
Physics, Atomic, Molecular & Chemical
Martin Kussmann
Summary: Mass spectrometry (MS) has become the most informative and versatile analytical technology in molecular and structural biology. It enables the discovery, identification, and characterization of biomolecules and facilitates the understanding of their interactions and effects. MS has also played a crucial role in the field of molecular nutrition, providing comprehensive and rapid identification and characterization of nutrients and bioactives. Furthermore, it has the potential to contribute to personalized and systems nutrition, leading to science-based recommendations and actions for public and personal health.
EUROPEAN JOURNAL OF MASS SPECTROMETRY
(2023)
Review
Nutrition & Dietetics
Martin Kussmann
Summary: Nature's bioactive substances offer potential solutions to human, animal, and environmental health issues. However, the utilization of bioactive peptides and natural bioactives has been underdeveloped. The future lies in employing systems-level and artificial intelligence approaches to better understand their functions and accelerate the development and implementation of solutions.
Article
Medicine, Research & Experimental
Amy L. Lovell, Hannah Eriksen, Starin McKeen, Jane Mullaney, Wayne Young, Karl Fraser, Eric Altermann, Olivier Gasser, Martin Kussmann, Nicole C. Roy, Warren C. McNabb, Clare R. Wall
Summary: This 6-month prospective non-randomised feasibility study conducted in Auckland, New Zealand, aimed to investigate the feasibility and acceptability of a food intervention for infants before introducing complementary foods. The study found that recruiting infants before introducing complementary foods is feasible and the food-based intervention received acceptable adherence. These results will inform a full-scale randomized controlled trial with adjustments to the collection of biological samples to examine the effect of a prebiotic food on the prevalence of respiratory tract infections during infancy.
PILOT AND FEASIBILITY STUDIES
(2022)
