Article
Cardiac & Cardiovascular Systems
Erik S. G. Stroes, Harold E. Bays, Maciej Banach, Alberico L. Catapano, P. Barton Duell, Ulrich Laufs, G. B. John Mancini, Kausik K. Ray, William J. Sasiela, Yang Zhang, Antonio M. Gotto
Summary: This study demonstrates that bempedoic acid can reduce hsCRP levels in patients at risk of atherosclerotic cardiovascular disease. The changes in hsCRP and LDL-C are related, but the effect of bempedoic acid on hsCRP is independent of LDL-C lowering.
Article
Chemistry, Medicinal
Dong Yang, Guangfeng Niu, Jie Guo
Summary: The results of this study demonstrate that GTN has anti-inflammatory effects and can be used as an alternative agent for the management of arthritis.
PHARMACOGNOSY MAGAZINE
(2022)
Review
Medicine, General & Internal
Zheyu Zhang, Ruozheng Pi, Jieya Luo, Ji Liu, Aihua Zhang, Baofei Sun
Summary: This study found that levels of inflammatory cytokines were altered in individuals with arsenic exposure, indicating that arsenic exposure may trigger a cell-mediated inflammatory response. Therefore, regular examination of immune function, such as inflammatory cytokines, in individuals at risk of arsenic exposure is crucial for maintaining human health.
Article
Medicine, Research & Experimental
Mehrdad Zarei, Pooja Acharya, Ramaprasad Ravichandra Talahalli
Summary: The study showed that repeatedly using deep-fried oils may cause hepatic dysfunction, while adding ginger or turmeric during heating can prevent the hepatic inflammatory response.
Article
Food Science & Technology
Krittika Srisuksai, Kongphop Parunyakul, Pitchaya Santativongchai, Narumon Phaonakrop, Sittiruk Roytrakul, Phitsanu Tulayakul, Wirasak Fungfuang
Summary: Crocodile oil is rich in monounsaturated fatty acids and polyunsaturated fatty acids, which have antioxidant and cognitive effects. This study investigated the effect of crocodile oil on antioxidant activity and cognitive function in rats. The results showed that crocodile oil significantly decreased triglyceride levels and had stronger free radical scavenging ability compared to olive oil. It also improved memory function in rats without causing a decline in cognitive function. Therefore, crocodile oil can be considered as an alternative dietary oil with hypolipidemic and antioxidant effects.
Article
Nutrition & Dietetics
Maria Giovanna Cilberti, Antonella Santillo, Anna N. Polito, Giovanni Messina, Antonella Della Malva, Mariangela Caroprese, Agostino Sevi, Marzia Albenzio
Summary: The objective of this study was to evaluate the cytokine patterns in children with generalized epilepsy who were treated with different protein fractions from meat and fish sources. The results showed that TNF-alpha, IL-10, and IL-6 levels were not affected by the different protein fractions and sources, while IL-1 beta levels were significantly affected. Protein fractions from meat sources had higher levels of IL-1 beta compared to fish sources. Overall, the nutritional strategy based on protein from fish and meat sources may modulate the immunological cytokine pattern in infants with generalized epilepsy.
Article
Food Science & Technology
Shing-Hwa Liu, Yu-Ching Chen, Huei-Ping Tzeng, Meng-Tsan Chiang
Summary: Supplementation of omega-3 fatty acids-enriched fish oil has shown positive effects in preventing obesity and preserving muscle mass in rats fed a high-fat diet. The study found that fish oil supplementation can inhibit the expression of ubiquitin ligases and promote muscle growth. Additionally, fish oil effectively reversed inflammatory responses in muscles and improved the balance between protein synthesis and degradation by activating key signaling pathways.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Public, Environmental & Occupational Health
Hend Alqaderi, Fahad Hegazi, Fahd Al-Mulla, Chung-Jung Chiu, Alpdogan Kantarci, Ebaa Al-Ozairi, Mohamed Abu-Farha, Saadoun Bin-Hasan, Aishah Alsumait, Jehad Abubaker, Sriraman Devarajan, J. Max Goodson, Hatice Hasturk, Mary Tavares
Summary: This study evaluated the relationship between specific salivary biomarkers, obesity, and intermediate hyperglycemia in children. Longitudinal analyses showed that higher salivary CRP and insulin levels were predictive of hyperglycemia and obesity.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Health Care Sciences & Services
Aleksandra Makarewicz, Malgorzata Jamka, Jakub Geltz, Angelika Smidowicz, Marta Kokot, Nina Kaczmarek, Edyta Madry, Jaroslaw Walkowiak
Summary: This meta-analysis compared the effects of endurance, strength, and combined training on inflammatory markers and adipokine concentrations in overweight and obese adults. The findings suggest that endurance training is more effective than strength training in reducing CRP, IL-6, and visfatin concentrations, while combined training is more beneficial in reducing TNF-alpha levels. There were no differences between the effects of different types of training on adiponectin and leptin concentrations. Further studies are needed to determine the optimal training for adiponectin and leptin concentrations in this population.
Article
Biochemistry & Molecular Biology
Arik Sheinenzon, Mona Shehadeh, Regina Michelis, Ety Shaoul, Ohad Ronen
Summary: This study examined the correlation between albumin levels and inflammatory indices in hospitalized patients, showing negative correlations between albumin and CRP/white blood cell levels and positive correlations with platelets/hemoglobin levels. The strongest negative correlation between albumin and CRP was found in the Internal Medicine departments. Linear regression analysis revealed a minor effect of CRP on albumin levels, particularly at very high CRP levels. Further exploration of the mechanisms underlying this negative correlation is needed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Environmental Sciences
Alaa El-Din H. Sayed, Hamdy A. M. Soliman, Shaimaa K. Idriss, Sary Kh. Abdel-Ghaffar, Asmaa A. A. Hussein
Summary: This study aimed to evaluate the catfish's response to exposure to monoaromatic petroleum hydrocarbons (benzene, toluene, and xylene) and its recovery after exposure. Oxidative stress, histopathological changes, and immunological changes were used as biomarkers. The results showed that benzene and xylene exposure significantly increased cortisol, lipid peroxidation, and cytokines (IL-1 beta, IL-6) levels compared to control. Fishes exposed to benzene exhibited a significant decrease in superoxide dismutase (SOD), total antioxidant capacity (TAC), and acetylcholinstease (Ach) levels. Histopathological signs in the liver, kidney, and spleen were observed after exposure, but most of these lesions improved or disappeared after the recovery period. Monocyclic aromatic hydrocarbons (BTX) are hazardous to fish, and their toxicity levels were benzene > xylene > toluene even after the recovery period.
WATER AIR AND SOIL POLLUTION
(2023)
Article
Fisheries
Amro M. Soliman, Daniel R. Barreda
Summary: Acute inflammation plays a crucial role in the immune responses of fish, protecting the host from infection and promoting tissue repair. Inflammatory signals and mediators drive leukocyte recruitment, antimicrobial mechanisms, and resolution of inflammation. Understanding the kinetics and unique characteristics of fish inflammation is important for studying fish diseases and potential treatments.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2023)
Article
Nursing
Rebecca Hoban, Hadar Nir, Emily Somerset, Jordan Lewis, Sharon Unger, Deborah L. O'Connor
Summary: This study investigated the cytokines and inflammatory markers in the breastmilk of parents of very preterm infants, as well as their correlations with infant's stool calprotectin. The results showed detectable inflammatory markers in the breastmilk, some of which changed over time, but no correlation was found with infant's stool calprotectin.
JOURNAL OF HUMAN LACTATION
(2023)
Article
Neurosciences
Victoria T. Ethridge, Nathan M. Gargas, Martha J. Sonner, Raquel J. Moore, Shannon H. Romer, Candice Hatcher-Solis, Joyce G. Rohan
Summary: Transcranial direct current stimulation (tDCS) enhances synaptic plasticity and reduces inflammatory cytokine levels in rodent models, supporting its therapeutic potential for neurological disorders.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Maryam Pourhassan, Nina Babel, Lars Sieske, Timm Henning Westhoff, Rainer Wirth
Summary: This study found that certain cytokines, particularly IL-18, were associated with poor appetite in acutely ill older hospitalized patients, indicating that they may be considered as potential targets for the prevention and treatment of malnutrition.
Article
Food Science & Technology
Engeda Dessalegn, Geremew Bultosa, GulelatDesse Haki, F. Chen, H. P. Vasantha Rupasinghe
Summary: This study found that the aqueous methanol extract of Ethiopian cardamom seeds has higher antioxidant activity and anti-cancer effect. In vitro, the aqueous methanol extract showed stronger anti-proliferative effect on HepG2 cells.
INTERNATIONAL JOURNAL OF FOOD PROPERTIES
(2022)
Article
Biochemistry & Molecular Biology
Wasitha P. D. W. Thilakarathna, H. P. Vasantha Rupasinghe
Summary: Conventional extraction methods of proanthocyanidins using toxic organic solvents raise concerns. A new method using food-grade ethanol was developed for grape seeds and grape seed powder, optimizing extraction conditions for maximum yield of PAC.
Article
Nutrition & Dietetics
Niluni M. Wijesundara, Song F. Lee, Ross Davidson, Zhenyu Cheng, H. P. Vasantha Rupasinghe
Summary: The study found that carvacrol has anti-inflammatory properties and may be used to manage the pain associated with streptococcal pharyngitis.
Article
Chemistry, Multidisciplinary
Khushwant S. Bhullar, Manal A. Nael, Khaled M. Elokely, Jeremie A. Doiron, Luc M. LeBlanc, Gregoire Lassalle-Claux, Mohamed Salla, Fahad S. Aldawsari, Mohamed Touaibia, H. P. Vasantha Rupasinghe
Summary: Due to their robust antioxidant properties, phenolic acids and their analogs have been extensively studied for their ability to activate cellular antioxidant pathways. This study investigated the effects of modifications to the chemical structure of these phenolic acids on their antioxidant and cytoprotective activities. The ketone analog of caffeic acid phenethyl ester (CAPE) was identified as a unique antioxidant molecule with the function of ERK-mediated Nrf2 activation.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Flavia A. R. dos Santos, Jadriane A. Xavier, Felipe C. da Silva, J. P. Jose Merlin, Marilia O. F. Goulart, H. P. Vasantha Rupasinghe
Summary: The study found that the ethanolic extract of seeds of Brazilian Passiflora edulis fruits (PESE) and piceatannol (PIC) have potential in anti-diabetic, anti-glycation, and antioxidant activities, warranting further investigation.
Article
Cell Biology
Madumani Amararathna, David W. Hoskin, H. P. Vasantha Rupasinghe
Summary: Anthocyanins are effective compounds for treating various human diseases, but their therapeutic efficacy can be reduced due to degradation. This study developed a direct delivery system of anthocyanins into pulmonary tissues using encapsulated nanocarriers, which increased the stability and therapeutic efficacy of the anthocyanins.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Pharmacology & Pharmacy
Niluni M. Wijesundara, Song F. Lee, Zhenyu Cheng, Ross Davidson, David N. Langelaan, H. P. Vasantha Rupasinghe
Summary: This study investigated the bactericidal mechanism of carvacrol on Streptococcus pyogenes. It was found that carvacrol primarily killed the bacteria by disrupting membrane integrity and increasing permeability. Carvacrol also showed affinity with specific membrane phospholipids. This research provides insight for the development of natural health products for managing streptococcal pharyngitis or other therapeutic applications.
Review
Food Science & Technology
Nilushni Sivapragasam, Nilanivetha Neelakandan, H. P. Vasantha Rupasinghe
Summary: Fermented food has gained popularity as a value-added category, and blueberries are considered superfoods. However, the bioavailability of bioactives in blueberries is low. This review focuses on the fermentation processes of blueberry, and how it enhances the bioavailability of nutrients and bioactive compounds, leading to potential health benefits when consumed as fermented blueberry products.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Oladapo F. Fagbohun, Caroline R. Gillies, Kieran P. J. Murphy, H. P. Vasantha Rupasinghe
Summary: Cancer is a global issue with millions of new cases and deaths each year. Diet and nutrients have a significant impact on cancer risk, and recent advancements in research have focused on the effects of dietary components on cancer prevention through nutrigenomics. This review highlights the importance and benefits of nutrigenomics in developing approaches for cancer prevention and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Tharindu L. Suraweera, J. P. Jose Merlin, Graham Dellaire, Zhaolin Xu, H. P. Vasantha Rupasinghe
Summary: Cancer is a leading cause of death globally, but current treatments like chemotherapy and radiation therapy have significant side effects. Therefore, the prevention of cancer through dietary modifications has gained interest. This study examined the potential of selected flavonoids in reducing reactive oxygen species (ROS) and DNA damage induced by carcinogens through the activation of the Nrf2/ARE pathway. The results showed that genistein and PCB2 could effectively reduce ROS and DNA damage, and further research is needed to understand the role of dietary flavonoids in regulating the Nrf2/ARE pathway in carcinogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Oladapo F. Fagbohun, Jitcy S. Joseph, Olumayowa V. Oriyomi, H. P. Vasantha Rupasinghe
Summary: Frondosides are the major saponins of the North Atlantic sea cucumber. They possess amphiphilic characteristics and have been widely studied for their potential therapeutic activities. Recent studies have shown that frondoside-containing extracts from C. frondosa exhibit various biological activities, but the exact mechanism(s) of action are not clearly understood. This review discusses the different frondosides of C. frondosa, their potential therapeutic activities, and recent advances in extraction techniques.
Review
Chemistry, Analytical
Shahida Anusha Siddiqui, Ali Ali Redha, Molla Salauddin, Iskandar Azmy Harahap, H. P. Vasantha Rupasinghe
Summary: Replacing conventional solvents with deep eutectic solvents (DES) has shown promising effects on the extraction yield of (poly)phenols. Combining DES with ultrasound-assisted extraction (UAE) can further enhance the extraction efficiency. Factors such as DES composition, solvent-to-sample ratio, and UAE parameters need to be considered for optimizing the extraction process.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2023)
Article
Food Science & Technology
Quinn Cavanagh, Marianne Su-Ling Brooks, H. P. Vasantha Rupasinghe
Summary: Spent coffee grounds (SCG) are a by-product of instant coffee and coffee beverage brewing, and they have the potential to be transformed into new food ingredients with various nutritional and functional benefits through innovative processing technologies. SCG contain a rich composition of nutrients and bioactive compounds, and they can be used in sustainable food production.
Article
Biodiversity Conservation
Cindy H. J. Yu, Zoe Migicovsky, Jun Song, H. P. Vasantha Rupasinghe
Summary: This study screened apple cultivars from Canada's Apple Biodiversity Collection to identify high (poly)phenol-containing specialty apples with antidiabetic properties, providing new insights into the prevention and management of Type 2 diabetes.
PLANTS PEOPLE PLANET
(2023)
Review
Toxicology
Purvi Trivedi, Amna Abbas, Christian Lehmann, H. P. Vasantha Rupasinghe
Summary: COVID-19, caused by SARS-CoV-2, is a highly contagious disease that has become a global pandemic. It is characterized by respiratory symptoms and inflammatory injury due to excessive cytokine release. Precautionary measures such as vaccination, social distancing, mask usage, hygiene, and a healthy diet can help attenuate organ damage from COVID-19 infection.
JOURNAL OF XENOBIOTICS
(2022)