Article
Multidisciplinary Sciences
Pollyanna Patriota, Serge Rezzi, Idris Guessous, Pedro Marques-Vidal
Summary: Several studies have shown an inverse association between serum levels of vitamin D and obesity. This study aimed to investigate the associations between vitamin D levels and various anthropometric markers and adipokines. The results revealed a negative correlation between vitamin D levels and most anthropometric markers, and a positive correlation with adiponectin levels in women. Total body fat was found to be the strongest marker associated with decreased vitamin D levels.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Charlotte Delrue, Reinhart Speeckaert, Joris R. R. Delanghe, Marijn M. M. Speeckaert
Summary: Vitamin D is an immune modulator that affects infection susceptibility. The relationship between vitamin D deficiency and mortality in sepsis patients remains unclear. Adequate vitamin D concentration may reduce mortality in sepsis patients with severe deficiency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Hyeri Seok, Jooyun Kim, Won Suk Choi, Dae Won Park
Summary: A prospective cohort study found that severe vitamin D deficiency significantly increased mortality in sepsis patients. Evaluating vitamin D levels in sepsis patients may become necessary in an aging society.
Review
Nutrition & Dietetics
Manuel Rupprecht, Stefan Wagenpfeil, Jakob Schoepe, Reinhold Vieth, Thomas Vogt, Joerg Reichrath
Summary: A meta-analysis was conducted to investigate the impact of oral vitamin D supplementation on serum 25-hydroxyvitamin D levels in healthy adults in Europe. The findings suggest that vitamin D supplementation can significantly increase serum 25(OH)D levels, with the effect influenced by dosage and baseline serum levels.
Article
Nutrition & Dietetics
Zaleha Md Isa, Nor Rumaizah Mohd Nordin, Muhammad Hilmi Mahmud, Syahirah Hashim
Summary: Vitamin D deficiency is prevalent worldwide, including in Malaysia, particularly among females, Indians, and those of Malay ethnicity. It can be managed through pharmacological or non-pharmacological approaches, and prevention methods include adequate intake, sun exposure, or supplementation. Special attention should be given to high-risk groups such as infants, obese patients, and the elderly.
Article
Nutrition & Dietetics
Jae-Hun Jung, Eun-Ah Kim, Sang-Yoon Lee, Jung-Eun Moon, Eun-Joo Lee, Sook-Hyun Park
Summary: This study aimed to investigate changes in vitamin D levels and factors associated with vitamin D deficiency (VDD) in Korean preterm infants during the first year of life. The study found a high incidence of VDD in these infants, with vitamin D levels at birth being the strongest predictor of VDD during follow-up. Vitamin D supplementation at 400 IU/day did not affect vitamin D levels during the first year of life. Further research is needed to determine the optimal vitamin D supplementation dose for Korean preterm infants.
Review
Nutrition & Dietetics
Andreea Bianca Stoica, Claudiu Marginean
Summary: This article reviews the impact of vitamin D deficiency on the health of infants, emphasizing its global significance and the need for further research and strategies. While conflicting results exist regarding the effects of vitamin D, it is clear that deficiency has significant implications, particularly for infants.
Article
Multidisciplinary Sciences
Sandra Alvear-Vega, Rodrigo Benavente-Contreras, Hector Vargas-Garrido
Summary: The social determinants associated with Serum 25-hydroxyvitamin D concentrations deficiency in older adults include gender, native origin, urban residence, sunlight exposure, and geographical latitude. Health promotion and prevention programs should be targeted towards older adults in urban areas, with a special focus on women, especially in the southernmost regions.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
John D. Sluyter, Yoshihiko Raita, Kohei Hasegawa, Ian R. Reid, Robert Scragg, Carlos A. Camargo
Summary: Using machine learning models to predict vitamin D deficiency showed higher accuracy in predicting 25(OH)D <25 nmol/L compared to traditional models, suggesting a potential role for machine learning models in participant selection for vitamin D supplement trials.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Jie Chen, Jiao Zhang, Jie Li, Ran Qin, Na Lu, David Goltzman, Dengshun Miao, Renlei Yang
Summary: Emerging observational data suggest that vitamin D deficiency is associated with knee osteoarthritis. However, the relationship between vitamin D level and osteoarthritis, as well as the role of vitamin D supplementation in prevention, are still controversial. This study found that 1,25(OH)2D3 deficiency accelerated the development of knee osteoarthritis in mice, while supplementation with 1,25(OH)2D3 rescued the phenotypes of osteoarthritis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Nutrition & Dietetics
Szymon Graczyk, Arkadiusz Grzeczka, Urszula Paslawska, Pawel Kordowitzki
Summary: Atrial fibrillation (AF) is a common and severe arrhythmia that can lead to ischemic stroke or heart failure. Vitamin D deficiency has been suggested as a critical factor in the development of AF, particularly after cardiac surgery. Supplementing with vitamin D has been found to reduce the risk of AF in both pre- and postoperative periods. The underlying mechanisms of how vitamin D affects the heart are not fully understood, but it is believed to act through multiple pathways. Despite the correlation between vitamin D deficiency and AF development, the topic is still widely debated and the results are subject to doubt.
Article
Nutrition & Dietetics
Rihwa Choi, Sung-Eun Cho, Sang Gon Lee, Eun Hee Lee
Summary: This retrospective study reviewed the prevalence of vitamin D deficiency in an adult Korean population between 2017 and 2021. The results show a decrease in the overall prevalence of vitamin D deficiency over time. Women were more likely to test their 25(OH)D level and had a higher prevalence of levels below 10 ng/mL compared to men, while their prevalence of levels below 30 ng/mL was lower than that of men. Younger patients had a higher prevalence of levels below 30 ng/mL compared to older patients.
Article
Biochemistry & Molecular Biology
Fabienne Jaun, Maria Boesing, Giorgia Luethi-Corridori, Kristin Abig, Nando Bloch, Stephanie Giezendanner, Victoria Grillmayr, Philippe Haas, Anne B. Leuppi-Taegtmeyer, Juergen Muser, Andrea Raess, Philipp Schuetz, Michael Brandle, Joerg D. Leuppi
Summary: The role of vitamin D in the COVID-19 pandemic has been controversial, and the effectiveness of vitamin D-3 supplementation in COVID-19 patients remains inconclusive. This study conducted a randomized, placebo-controlled double-blind trial on hospitalized COVID-19 patients to compare the effect of high-dose vitamin D-3 supplementation on length of hospital stay. The results showed that vitamin D-3 supplementation did not significantly shorten the hospital stay.
Article
Multidisciplinary Sciences
Maryam Vasheghani, Nasrin Jannati, Parvaneh Baghaei, Mitra Rezaei, Roqayeh Aliyari, Majid Marjani
Summary: Supplemental vitamin D may reduce the risk and mortality of viral pneumonia. Low levels of 25(OH)D were associated with severe disease, increased ICU admission, and mortality rate in hospitalized COVID-19 patients.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Souzana E. Xyda, Kalliopi Kotsa, Argyrios Doumas, Emmanouil Papanastasiou, Alexandros A. Garyfallos, George Samoutis
Summary: The prevalence of vitamin D deficiency is paradoxically high in both Mediterranean countries, Greece and Cyprus, despite ample sunlight in the region. Only the month and gender were significantly associated with vitamin D levels.
Article
Biochemistry & Molecular Biology
Guangrong Hu, Yonghan He, Yaozong Li, Xiao Hu, Sida Liu, Chang Liao, Rui Zhang, Xinyao Zhou, Hui Sun
Summary: The study investigated the effect of chronic hypoxia on TRPC6 in human podocytes. The results showed that chronic hypoxia significantly increased TRPC6 mRNA and protein expression levels, leading to an increase in intracellular Ca2+. Additionally, hypoxia induced cytoskeleton reorganization in podocytes, resulting in cell injury and dysfunction.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Yonghan He, Wen Li, Junling Zhang, Yang Yang, Yawei Qian, Daohong Zhou
Summary: The study shows that EF24 is a potent anti-MM agent, likely mediated by the suppression of UPR and the NF-kappa B pathway.
CURRENT CANCER DRUG TARGETS
(2021)
Article
Cell Biology
Mingxia Ge, Li Hu, Hongshun Ao, Meiting Zi, Qingpeng Kong, Yonghan He
Summary: Senescent cells (SCs) accumulate with age and contribute to age-related diseases. Clearing SCs can delay aging, treat age-related diseases, and extend healthspan. Targeting the proteins in the SC anti-apoptotic pathways with small molecules can selectively kill SCs, but current senolytics still have limitations in terms of safety, specificity, and broad-spectrum activity. New strategies such as PROTAC technology, CAR T cells, and ?-galactosidase-modified prodrugs have shown promising potential in clearing SCs.
MECHANISMS OF AGEING AND DEVELOPMENT
(2021)
Review
Cell Biology
Li Hu, Huiqin Li, Meiting Zi, Wen Li, Jing Liu, Yang Yang, Daohong Zhou, Qing-Peng Kong, Yunxia Zhang, Yonghan He
Summary: Cellular senescence is an irreversible process of cell growth arrest caused by various stresses, and elimination of senescent cells may have significant implications for delaying aging and treating age-related diseases. However, senescent cells exhibit resistance to apoptosis, highlighting the importance of studying the underlying mechanisms of apoptotic resistance for the development of targeted therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Genetics & Heredity
Ming-Xia Ge, Jian-Jun Jiang, Li-Qin Yang, Xing-Li Yang, Yong-Han He, Gong-Hua Li, Qing-Peng Kong
Summary: Deep RNA sequencing of blood samples from long-lived families revealed that circRNA expression in long-lived elderly individuals does not follow an age-accumulating pattern. Weighted co-expression network analysis identified circRNA modules associated with healthy aging pathways.
Article
Multidisciplinary Sciences
Fu-Hui Xiao, Qin Yu, Zhi-Li Deng, Ke Yang, Yunshuang Ye, Ming-Xia Ge, Dongjing Yan, Hao-Tian Wang, Xiao-Qiong Chen, Li-Qin Yang, Bin-Yu Yang, Rong Lin, Wen Zhang, Xing-Li Yang, Lei Dong, Yonghan He, Jumin Zhou, Wang-Wei Cai, Ji Li, Qing-Peng Kong
Summary: Through transcriptome analysis of long-lived individuals, it was found that the ribosome pathway is significantly down-regulated, likely controlled by the transcription factor ETS1, which can regulate the expression of ribosomal protein genes to reduce cellular senescence.
Article
Biology
Xin Zhang, Huiqin Li, Xiupeng Lv, Li Hu, Wen Li, Meiting Zi, Yonghan He
Summary: Immunotherapy has significantly impacted tumor treatment, but clinical outcomes are variable. This review discusses the resistance mechanisms of tumors to immune checkpoint inhibitors and explores the effects of diets on tumor immunotherapy.
Article
Cell Biology
Li Hu, Chanjuan Dong, Zhe Wang, Shengyuan He, Yiwen Yang, Meiting Zi, Huiqin Li, Yanghuan Zhang, Chuanjie Chen, Runzi Zheng, Shuting Jia, Jing Liu, Xuan Zhang, Yonghan He
Summary: We developed a near-infrared fluorescent probe, XZ1208, that can be cleaved rapidly by beta-galactosidase and generates a strong fluorescence signal in senescent cells. XZ1208 showed high specificity and sensitivity in labeling senescent cells in various models. It achieved long-term duration in labeling senescence without causing significant toxicities.
Editorial Material
Multidisciplinary Sciences
Fu-Hui Xiao, Hao-Tian Wang, Xiao-Qiong Chen, Ming-Xia Ge, Dongjing Yan, Xing-Li Yang, Li-Qin Yang, Rong Lin, Rong-Hui Guo, Wen Zhang, Nelson Leung-Sang Tang, Yonghan He, Jumin Zhou, Wang-Wei Cai, Qing-Peng Kong
NATIONAL SCIENCE REVIEW
(2023)
Review
Oncology
Jiahua Liu, Runzi Zheng, Yanghuan Zhang, Shuting Jia, Yonghan He, Jing Liu
Summary: This review provides an overview of the molecular mechanisms, microenvironmental factors, and therapeutic strategies of skin aging and melanoma, and discusses potential common targets between melanoma and cell senescence.
Meeting Abstract
Oncology
Yang Yang, Natacha Jn-Simon, Wanyi Hu, Peiyi Zhang, Guangrong Zheng, Liya Pi, Yonghan He, Daohong Zhou
Article
Geriatrics & Gerontology
Yaqun Huang, Ming-Xia Ge, Yu-Hong Li, Jing-Lin Li, Qin Yu, Fu-Hui Xiao, Hong-Shun Ao, Li-Qin Yang, Ji Li, Yonghan He, Qing-Peng Kong
Summary: This study found that long-lived individuals have lower inflammation levels and higher expression of ATF7. Loss of ATF7 leads to cellular senescence, while its overexpression delays senescence progress and secretion of senescence-associated secretory phenotype. These findings suggest that ATF7 is a longevity-promoting factor that lowers cellular senescence and inflammation in long-lived individuals.
Article
Geriatrics & Gerontology
Yaqun Huang, Ming-Xia Ge, Yu-Hong Li, Jing-Lin Li, Qin Yu, Fu-Hui Xiao, Hong-Shun Ao, Li-Qin Yang, Ji Li, Yonghan He, Qing-Peng Kong
Summary: This study found that long-lived individuals have lower inflammation levels and up-regulation of ATF7. Overexpression of ATF7 can delay cellular senescence and inhibit inflammation, thus promoting longevity.
Article
Biochemistry & Molecular Biology
Ming-Xia Ge, Qin Yu, Gong-Hua Li, Li-Qin Yang, Yonghan He, Ji Li, Qing-Peng Kong
Summary: This study profiles the transcriptome dynamics of human dermal fibroblast cells during the progression from proliferation to senescence. Four trajectories of gene expression changes were identified as senescence progresses. Some genes showed continuous up-regulation or down-regulation, while others remained stable until entering the senescent state. These findings provide new insights into the dynamic regulatory mechanism of cellular senescence.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Cell Biology
Liyun Guo, Yajuan Chen, Huiqin Li, Fanqian Yin, Mingxia Ge, Li Hu, Meiting Zi, Zhenghong Qin, Yonghan He
Summary: This study found that telomere length shortens with age in humans, with females maintaining their telomeres better than males. There is a strong association of telomere length between mothers and their offspring, but not between fathers and their offspring. Telomere length is inversely associated with visceral fat index in females and positively associated with apolipoprotein A levels. Impairment of lipid metabolism may contribute to telomere length shortening in the Chinese population.
Article
Nutrition & Dietetics
Sarah Maria Barneze Costa, Raghavendra Lakshmana Shetty Hallur, David Rafael Abreu Reyes Postdoc, Juliana Ferreira Floriano Postdoc, Maria Antonieta de Barros Leite Carvalhaes, Helio Rubens de Carvalho Nunes, Luis Sobrevia, Paola Valero, Angelica Mercia Pascon Barbosa, Marilza Cunha Vieira Rudge
Summary: This study aimed to assess maternal dietary intake patterns, anthropometric measures, and biochemical markers in women with gestational diabetes mellitus and pregnancy-specific urinary incontinence. The results showed that pregnant women in the gestational diabetes mellitus pregnancy-specific urinary incontinence group had higher body mass index, arm circumference, and triceps skinfold than the other groups, indicating an obesogenic maternal environment. Significant differences in dietary food intake were also observed. The study emphasizes the need for a comprehensive strategy for pregnant women with gestational diabetes mellitus and pregnancy-specific urinary incontinence to address obesity and micronutrient deficiencies.
Article
Nutrition & Dietetics
Aikaterina Vasileiou, Dominique Searle, Sofus C. Larsen, Faidon Magkos, Graham Horgan, R. James Stubbs, Ines Santos, Antonio L. Palmeira, Berit L. Heitmann
Summary: The study compared self-reported total energy intake with total energy expenditure estimated from Fitbit Charge 2 algorithms. The results showed that self-reported energy intake was generally lower than energy expenditure, and the degree of underestimation varied among different populations.
Article
Nutrition & Dietetics
Ziya Erokay Metin, Ozge Mengi Celik, Nevra Koc
Summary: This study demonstrates a significant relationship between climate change awareness and sustainable and healthy eating behaviors as well as adherence to the Mediterranean diet.
Article
Nutrition & Dietetics
Carolline Santos Miranda, Flavia Maria Silva-Veiga, Daiana Araujo Santana-Oliveira, Isabela Macedo Lopes Vasques-Monteiro, Julio Beltrame Daleprane, Vanessa Souza-Mello
Summary: This study investigates the role of peroxisome proliferator-activated receptor (PPAR) activation on thermogenic pathways and mitochondrial metabolism in mouse adipose tissue. The results show that activation of PPARa and dual PPARa/y can reduce body mass, mitigate insulin resistance, and induce browning in white adipose tissue. Preserved mitochondrial metabolism emerges as a potential target for obesity treatment using PPAR agonists, with possible clinical applications.
Article
Nutrition & Dietetics
Qi Ren, Hao-Fan Wu, Ding-Ye Yu, Feng-Min Zhang, Zi-Le Shen, Guo-Wei Huang, Feng Lin, Wei-Zhe Chen, Zhen Yu
Summary: The study aimed to develop a nomogram incorporating preoperative factors for predicting low skeletal muscle mass index and low skeletal muscle radiodensity. The models were calibrated and assessed for their predictive ability using training and validation cohorts, and the clinical usefulness was evaluated using decision curve analysis.
Article
Nutrition & Dietetics
Ruben Castillo-Ortega, Juan Vega-Vargas, Samuel Duran-Aguero
Summary: This study found that during the COVID-19 pandemic, patients with type 1 diabetes experienced decreased adherence to diabetes care, leading to an increase in HbA1c levels, BMI, impaired linear growth, and more hospitalizations. The shift to telemedicine as the main healthcare service also had significant effects on diabetes management.
Article
Nutrition & Dietetics
Yi-Hsiu Chen, Jung-An Lin, Jiun-Rong Chen, Ya-Ling Chen, Suh-Ching Yang
Summary: Regular nutrition consultations have been shown to have significant effects on reducing cardiovascular disease risk factors, especially for individuals with obesity.
Article
Nutrition & Dietetics
Jacinta Winderlich, Bridget Little, Felix Oberender, Tessa Bollard, Tamara Farrell, Samantha Jenkins, Emma Landorf, Andrea McCall, Jessica Menzies, Katie O. ' Brien, Carla Rowe, Kirsten Sim, Melanie van der Wilk, Jemma Woodgate, Eldho Paul, Andrew A. Udy, Emma J. Ridley
Summary: The study aims to describe nutrition provision in Australian and New Zealand pediatric intensive care units, assess the adequacy of enteral nutrition, and evaluate the methods for estimating energy and protein requirements.
Article
Nutrition & Dietetics
Xi Zhang, Jia-Xin Huang, Meng Tang, Qi Zhang, Li Deng, Chun-Hua Song, Wei Li, Han-Ping Shi, Ming-Hua Cong
Summary: The study found that the modified Controlling Nutritional Status system, which includes C-reactive protein as an inflammatory parameter, is more accurate than the traditional system in predicting the survival of patients with cancer cachexia. High Controlling Nutritional Status and modified Controlling Nutritional Status are both independent risk factors for survival and have a negative impact on survival in patients with advanced-stage cancers, such as esophagogastric and colorectal cancer.
Article
Nutrition & Dietetics
Karolien Dams, Gregory R. A. De Meyer, Rita Jacobs, Tom Schepens, Stany Perkisas, Greta Moorkens, Philippe Jorens
Summary: The study aimed to investigate the development of muscle atrophy in COVID-19 intensive care unit patients and its relationship with hospital outcomes. The results showed that the difference in muscle thickness was linked to the outcome, with the best survival observed in the group with stable muscle thickness.
Article
Nutrition & Dietetics
Bruna Clemente Cota, Mariana de Santis Filgueiras, Patricia Feliciano Pereira, Leidjaira Lopes Juvanhol, Juliana Farias de Novaes
Summary: This study found that higher consumption of ultra-processed food (UPF) and a diet consisting of high proinflammatory foods were associated with the normal-weight obesity (NWO) phenotype in children.
Article
Nutrition & Dietetics
Victor Nogueira da Cruz Silveira, Cleber Lopes Campelo, Antonio Luis Rodrigues da Costa, Patricia Maria Abreu Machado, Ana Karina Teixeira da Cunha Franca, Alcione Miranda dos Santos
Summary: This psychometric study proposed a scale for estimating the consumption of ultra processed foods using item response theory. The study used data from a representative sample of 2515 adolescents aged 18 and 19 from Brazilian Birth Cohorts Consortium. The findings demonstrated that the proposed scale can accurately estimate the consumption of ultra processed foods and is correlated with latent traits related to food consumption.
Article
Nutrition & Dietetics
Dehao Yang, Jiaqi Huang, Jingyu Hu, Minyue Zhang, Haobo Xie, Yilin Chen, Yining Jin, Zerui Jiang, Yanchu Wang, Jinrong Zhu, Xin Lu, Siqi Chen, Yiyun Weng, Guangyong Chen
Summary: This study investigates the association between malnutrition and 6-month outcomes in acute ischemic stroke patients with or without intravenous thrombolysis. The results show a significant association between malnutrition and poor functional outcome.
Article
Nutrition & Dietetics
Ainoa Cristina de Oliveira Candido, Felipe Silva Neves, Vanessa Sequeira Fontes, Adriana Soares Torres Melo, Eliane Rodrigues de Faria, Michele Pereira Netto, Renata Maria Souza Oliveira, George Luiz Lins Machado-Coelho, Ana Paula Carlos Candido
Summary: This study investigated the frequency of breakfast consumption and its associations with the consumption of food at different degrees of industrial processing and with overweight indicators in Brazilian adolescents. The results showed that 20% of adolescents skipped breakfast and 46% of their caloric intake came from ultra-processed foods. Skipping breakfast was associated with increased consumption of ultra-processed foods, higher BMI-for-age, and higher body fat percentage.
