Mechanistic and topological explanations in medicine: the case of medical genetics and network medicine
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Mechanistic and topological explanations in medicine: the case of medical genetics and network medicine
Authors
Keywords
Philosophy of science, Philosophy of medicine, Mechanistic explanation, Topological explanation, Network medicine, Genetic disease, Geneticization
Journal
SYNTHESE
Volume 195, Issue 1, Pages 147-173
Publisher
Springer Nature
Online
2015-12-29
DOI
10.1007/s11229-015-0983-y
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in asthma
- (2015) Amitabh Sharma et al. HUMAN MOLECULAR GENETICS
- Constraints on Localization and Decomposition as Explanatory Strategies in the Biological Sciences
- (2014) Michael Silberstein et al. PHILOSOPHY OF SCIENCE
- The Genetic Theory of Infectious Diseases: A Brief History and Selected Illustrations
- (2013) Jean-Laurent Casanova et al. Annual Review of Genomics and Human Genetics
- The search for organizing principles as a cure against reductionism in systems medicine
- (2013) Olaf Wolkenhauer et al. FEBS Journal
- Network-based Analysis of Genome Wide Association Data Provides Novel Candidate Genes for Lipid and Lipoprotein Traits
- (2013) Amitabh Sharma et al. MOLECULAR & CELLULAR PROTEOMICS
- The road from systems biology to systems medicine
- (2013) Olaf Wolkenhauer et al. PEDIATRIC RESEARCH
- Abstraction and the Organization of Mechanisms
- (2013) Arnon Levy et al. PHILOSOPHY OF SCIENCE
- Five Years of GWAS Discovery
- (2012) Peter M. Visscher et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Three kinds of new mechanism
- (2012) Arnon Levy BIOLOGY & PHILOSOPHY
- Exploring the human diseasome: the human disease network
- (2012) K.-I. Goh et al. Briefings in Functional Genomics
- Biological function through network topology: a survey of the human diseasome
- (2012) V. Janjic et al. Briefings in Functional Genomics
- Network Medicine Strikes a Blow against Breast Cancer
- (2012) Janine T. Erler et al. CELL
- The Emerging Paradigm of Network Medicine in the Study of Human Disease
- (2012) Stephen Y. Chan et al. CIRCULATION RESEARCH
- Luck or reason
- (2012) Albert-László Barabási NATURE
- Understanding pathology in the context of physiological mechanisms: the practicality of a broken-normal view
- (2011) Sara Moghaddam-Taaheri BIOLOGY & PHILOSOPHY
- Interactome Networks and Human Disease
- (2011) Marc Vidal et al. CELL
- The expanded human disease network combining protein–protein interaction information
- (2011) Xuehong Zhang et al. EUROPEAN JOURNAL OF HUMAN GENETICS
- The network takeover
- (2011) Albert-László Barabási Nature Physics
- From simple graphs to the connectome: Networks in neuroimaging
- (2011) Olaf Sporns NEUROIMAGE
- The Explanatory Force of Dynamical and Mathematical Models in Neuroscience: A Mechanistic Perspective*
- (2011) David Michael Kaplan et al. PHILOSOPHY OF SCIENCE
- Network medicine: a network-based approach to human disease
- (2010) Albert-László Barabási et al. NATURE REVIEWS GENETICS
- Topological explanations and robustness in biological sciences
- (2010) Philippe Huneman SYNTHESE
- Mechanisms, malfunctions and explanation in medicine
- (2009) Mauro Nervi BIOLOGY & PHILOSOPHY
- On the Explanatory Role of Mathematics in Empirical Science
- (2009) R. W. Batterman BRITISH JOURNAL FOR THE PHILOSOPHY OF SCIENCE
- Human genetics of infectious diseases: between proof of principle and paradigm
- (2009) Alexandre Alcaïs et al. JOURNAL OF CLINICAL INVESTIGATION
- Complex brain networks: graph theoretical analysis of structural and functional systems
- (2009) Ed Bullmore et al. NATURE REVIEWS NEUROSCIENCE
- Bridging the gap between systems biology and medicine
- (2009) Gilles Clermont et al. Genome Medicine
- Systems medicine: the future of medical genomics and healthcare
- (2009) Charles Auffray et al. Genome Medicine
- McKusick's Online Mendelian Inheritance in Man (OMIM(R))
- (2008) J. Amberger et al. NUCLEIC ACIDS RESEARCH
- The implications of human metabolic network topology for disease comorbidity
- (2008) D.- S. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started