The RIG-I ATPase core has evolved a functional requirement for allosteric stabilization by the Pincer domain

Incoming RNA Virus Nucleocapsids Containing a 5′-Triphosphorylated Genome Activate RIG-I and Antiviral Signaling

(2013) Michaela Weber et al.   Cell Host & Microbe

Targeting the viral Achilles’ heel: recognition of 5′-triphosphate RNA in innate anti-viral defence

(2013) Jan Rehwinkel et al.   CURRENT OPINION IN MICROBIOLOGY

Parts, assembly and operation of the RIG-I family of motors

(2013) David C Rawling et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

ATPase-driven oligomerization of RIG-I on RNA allows optimal activation of type-I interferon

(2013) Jenish R Patel et al.   EMBO REPORTS

RNA sensing: the more RIG-I the merrier?

(2013) Jan Rehwinkel   EMBO REPORTS

Defining the functional determinants for RNA surveillance by RIG-I

(2013) Andrew Kohlway et al.   EMBO REPORTS

Master sensors of pathogenic RNA – RIG-I like receptors

(2013) Martin Schlee   IMMUNOBIOLOGY

RIG-I-Like Receptors Evolved Adaptively in Mammals, with Parallel Evolution at LGP2 and RIG-I

(2013) Rachele Cagliani et al.   JOURNAL OF MOLECULAR BIOLOGY

RIG-I Forms Signaling-Competent Filaments in an ATP-Dependent, Ubiquitin-Independent Manner

(2013) Alys Peisley et al.   MOLECULAR CELL

Conformational rearrangements of RIG-I receptor on formation of a multiprotein:dsRNA assembly

(2013) Simone A. Beckham et al.   NUCLEIC ACIDS RESEARCH

Positive Evolutionary Selection On the RIG-I-Like Receptor Genes in Mammals

(2013) Ana Lemos de Matos et al.   PLoS One

Quantitative full time course analysis of nonlinear enzyme cycling kinetics

(2013) Wenxiang Cao et al.   Scientific Reports

Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5

(2012) Bin Wu et al.   CELL

RIG-I detects infection with liveListeriaby sensing secreted bacterial nucleic acids

(2012) Zeinab Abdullah et al.   EMBO JOURNAL

Ubiquitin-Induced Oligomerization of the RNA Sensors RIG-I and MDA5 Activates Antiviral Innate Immune Response

(2012) Xiaomo Jiang et al.   IMMUNITY

The Thermodynamic Basis for Viral RNA Detection by the RIG-I Innate Immune Sensor

(2012) Adriana Vela et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Duplex RNA activated ATPases (DRAs)

(2012) Dahai Luo et al.   RNA Biology

A structure-based model of RIG-I activation

(2012) D. Kolakofsky et al.   RNA

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor RIG-I

(2012) Dahai Luo et al.   STRUCTURE

Structural and biochemical studies of RIG-I antiviral signaling

(2012) Miao Feng et al.   Protein & Cell

55 Amino acid linker between helicase and carboxyl terminal domains of RIG-I functions as a critical repression domain and determines inter-domain conformation

(2011) Maiko Kageyama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural Basis for the Activation of Innate Immune Pattern-Recognition Receptor RIG-I by Viral RNA

(2011) Eva Kowalinski et al.   CELL

Structural Insights into RNA Recognition by RIG-I

(2011) Dahai Luo et al.   CELL

The RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signalling

(2011) Filiz Civril et al.   EMBO REPORTS

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

The PYHIN protein family as mediators of host defenses

(2011) Stefan A. Schattgen et al.   IMMUNOLOGICAL REVIEWS

RIG-I-like receptors: cytoplasmic sensors for non-self RNA

(2011) Hiroki Kato et al.   IMMUNOLOGICAL REVIEWS

Molecular Mechanism of Signal Perception and Integration by the Innate Immune Sensor Retinoic Acid-inducible Gene-I (RIG-I)

(2011) Marco Binder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of RNA recognition and activation by innate immune receptor RIG-I

(2011) Fuguo Jiang et al.   NATURE

RIG-I like receptors and their signaling crosstalk in the regulation of antiviral immunity

(2011) Hilario J Ramos et al.   Current Opinion in Virology

Reconstitution of the RIG-I Pathway Reveals a Signaling Role of Unanchored Polyubiquitin Chains in Innate Immunity

(2010) Wenwen Zeng et al.   CELL

Dali server: conservation mapping in 3D

(2010) Liisa Holm et al.   NUCLEIC ACIDS RESEARCH

Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing

(2010) A. Baum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structural Basis of 5′ Triphosphate Double-Stranded RNA Recognition by RIG-I C-Terminal Domain

(2010) Cheng Lu et al.   STRUCTURE

Recognition of 5′ Triphosphate by RIG-I Helicase Requires Short Blunt Double-Stranded RNA as Contained in Panhandle of Negative-Strand Virus

(2009) Martin Schlee et al.   IMMUNITY

Regulation of Signal Transduction by Enzymatically Inactive Antiviral RNA Helicase Proteins MDA5, RIG-I, and LGP2

(2009) Darja Bamming et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Motif III in Superfamily 2 “Helicases” Helps Convert the Binding Energy of ATP into a High-Affinity RNA Binding Site in the Yeast DEAD-Box Protein Ded1

(2009) Josette Banroques et al.   JOURNAL OF MOLECULAR BIOLOGY

Cytosolic Viral Sensor RIG-I Is a 5'-Triphosphate-Dependent Translocase on Double-Stranded RNA

(2009) S. Myong et al.   SCIENCE

Translocation and Unwinding Mechanisms of RNA and DNA Helicases

(2008) Anna Marie Pyle   Annual Review of Biophysics

NOD-Like Receptors: Role in Innate Immunity and Inflammatory Disease

(2008) Grace Chen et al.   Annual Review of Pathology-Mechanisms of Disease

Agonist and Antagonist Recognition by RIG-I, a Cytoplasmic Innate Immunity Receptor

(2008) C. T. Ranjith-Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Essential Role of the N-terminal Domain in the Regulation of RIG-I ATPase Activity

(2008) Peter Gee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

(2008) Hiroki Kato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Analysis of the Isolated SecA DEAD Motor Suggests a Mechanism for Chemical–Mechanical Coupling

(2008) Stanley Nithianantham et al.   JOURNAL OF MOLECULAR BIOLOGY

The C-Terminal Regulatory Domain Is the RNA 5′-Triphosphate Sensor of RIG-I

(2008) Sheng Cui et al.   MOLECULAR CELL