Dissecting the chemical interactions and substrate structural signatures governing RNA polymerase II trigger loop closure by synthetic nucleic acid analogues

A Chemical Perspective on Transcriptional Fidelity: Dominant Contributions of Sugar Integrity Revealed by Unlocked Nucleic Acids

(2013) Liang Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Understanding the Molecular Basis of RNA Polymerase II Transcription

(2013) Su Zhang et al.   ISRAEL JOURNAL OF CHEMISTRY

Chemical fidelity of an RNA polymerase ribozyme

(2013) James Attwater et al.   Chemical Science

Basic mechanism of transcription by RNA polymerase II

(2012) Vladimir Svetlov et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

RNA polymerase II transcription: Structure and mechanism

(2012) Xin Liu et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A Movie of RNA Polymerase II Transcription

(2012) Alan C.M. Cheung et al.   CELL

The Emerging World of Synthetic Genetics

(2012) John C. Chaput et al.   CHEMISTRY & BIOLOGY

Dissecting Chemical Interactions Governing RNA Polymerase II Transcriptional Fidelity

(2012) Matthew W. Kellinger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The sweet allure of XNA

(2012) Fintan R Steele et al.   NATURE BIOTECHNOLOGY

5-formylcytosine and 5-carboxylcytosine reduce the rate and substrate specificity of RNA polymerase II transcription

(2012) Matthew W Kellinger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Trigger loop dynamics mediate the balance between the transcriptional fidelity and speed of RNA polymerase II

(2012) M. H. Larson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic Genetic Polymers Capable of Heredity and Evolution

(2012) V. B. Pinheiro et al.   SCIENCE

Thermodynamic and biological evaluation of a thrombin binding aptamer modified with several unlocked nucleic acid (UNA) monomers and a 2′-C-piperazino-UNA monomer

(2011) Troels B. Jensen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Chemistry of nucleic acids: impacts in multiple fields

(2011) Omid Khakshoor et al.   CHEMICAL COMMUNICATIONS

Locked vs. unlocked nucleic acids (LNA vs. UNA): contrasting structures work towards common therapeutic goals

(2011) Meghan A. Campbell et al.   CHEMICAL SOCIETY REVIEWS

Dynamics of Pyrophosphate Ion Release and Its Coupled Trigger Loop Motion from Closed to Open State in RNA Polymerase II

(2011) Lin-Tai Da et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

RNA Polymerase II with Open and Closed Trigger Loops: Active Site Dynamics and Nucleic Acid Translocation

(2010) Michael Feig et al.   BIOPHYSICAL JOURNAL

Stepwise mechanism for transcription fidelity

(2010) Yulia Yuzenkova et al.   BMC BIOLOGY

Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo

(2010) Maria B. Laursen et al.   Molecular BioSystems

The crystal structure of an ‘All Locked’ nucleic acid duplex

(2010) André Eichert et al.   NUCLEIC ACIDS RESEARCH

Thermodynamics of RNA duplexes modified with unlocked nucleic acid nucleotides

(2010) Anna Pasternak et al.   NUCLEIC ACIDS RESEARCH

RNA polymerase II trigger loop residues stabilize and position the incoming nucleotide triphosphate in transcription

(2010) X. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UNA (unlocked nucleic acid): A flexible RNA mimic that allows engineering of nucleic acid duplex stability

(2009) Niels Langkjær et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A movie of the RNA polymerase nucleotide addition cycle

(2009) Florian Brueckner et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Nonpolar Nucleoside Mimics as Active Substrates for Human Thymidine Kinases

(2009) Sarah K. Jarchow-Choy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Role of the RNA polymerase trigger loop in catalysis and pausing

(2009) Jinwei Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Basis of Transcription: Backtracked RNA Polymerase II at 3.4 Angstrom Resolution

(2009) D. Wang et al.   SCIENCE

Transient Reversal of RNA Polymerase II Active Site Closing Controls Fidelity of Transcription Elongation

(2008) Maria L. Kireeva et al.   MOLECULAR CELL

The RNA Polymerase II Trigger Loop Functions in Substrate Selection and Is Directly Targeted by α-Amanitin

(2008) Craig D. Kaplan et al.   MOLECULAR CELL

Structural basis of transcription inhibition by α-amanitin and implications for RNA polymerase II translocation

(2008) Florian Brueckner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY