RAG2 mutants alter DSB repair pathway choice in vivo and illuminate the nature of ‘alternative NHEJ’

RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia

(2014) Elli Papaemmanuil et al.   NATURE GENETICS

Modernizing the Nonhomologous End-Joining Repertoire: Alternative and Classical NHEJ Share the Stage

(2013) Ludovic Deriano et al.   Annual Review of Genetics

Alternative End-Joining and Classical Nonhomologous End-Joining Pathways Repair Different Types of Double-Strand Breaks during Class-Switch Recombination

(2013) E. M. Cortizas et al.   JOURNAL OF IMMUNOLOGY

DNA double-strand-break complexity levels and their possible contributions to the probability for error-prone processing and repair pathway choice

(2013) A. Schipler et al.   NUCLEIC ACIDS RESEARCH

RAG2’s Acidic Hinge Restricts Repair-Pathway Choice and Promotes Genomic Stability

(2013) Marc A. Coussens et al.   Cell Reports

Regulation of PI-3-Kinase and Akt Signaling in T Lymphocytes and Other Cells by TNFR Family Molecules

(2013) Takanori So et al.   Frontiers in Immunology

Terminal deoxynucleotidyl transferase requires KU80 and XRCC4 to promote N-addition at non-V(D)J chromosomal breaks in non-lymphoid cells

(2012) Imenne Boubakour-Azzouz et al.   NUCLEIC ACIDS RESEARCH

A Streamlined Method for Detecting Structural Variants in Cancer Genomes by Short Read Paired-End Sequencing

(2012) Martina Mijušković et al.   PLoS One

Structural mutations in cancer: mechanistic and functional insights

(2012) Koichiro Inaki et al.   TRENDS IN GENETICS

V(D)J Recombination: Mechanisms of Initiation

(2011) David G. Schatz et al.   Annual Review of Genetics

Coupling of V(D)J Recombination to the Cell Cycle Suppresses Genomic Instability and Lymphoid Tumorigenesis

(2011) Li Zhang et al.   IMMUNITY

Selection of Individual VH Genes Occurs at the Pro-B to Pre-B Cell Transition

(2011) W. Meng et al.   JOURNAL OF IMMUNOLOGY

Targeting Abnormal DNA Repair in Therapy-Resistant Breast Cancers

(2011) L. A. Tobin et al.   MOLECULAR CANCER RESEARCH

DNA Ligase III Promotes Alternative Nonhomologous End-Joining during Chromosomal Translocation Formation

(2011) Deniz Simsek et al.   PLoS Genetics

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

The expression of TRMT2A, a novel cell cycle regulated protein, identifies a subset of breast cancer patients with HER2 over-expression that are at an increased risk of recurrence

(2010) David G Hicks et al.   BMC CANCER

Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4

(2010) Cristian Boboila et al.   JOURNAL OF EXPERIMENTAL MEDICINE

H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes

(2010) Beth A. Helmink et al.   NATURE

An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway

(2010) Yu Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies

(2010) Wael Y. Mansour et al.   NUCLEIC ACIDS RESEARCH

The roles of the RAG1 and RAG2 “non-core” regions in V(D)J recombination and lymphocyte development

(2009) Jessica M. Jones et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Papillary and muscle invasive bladder tumors with distinct genomic stability profiles have different DNA repair fidelity and KU DNA-binding activities

(2008) Johanne Bentley et al.   GENES CHROMOSOMES & CANCER

Distinct roles of XRCC4 and Ku80 in non-homologous end-joining of endonuclease- and ionizing radiation-induced DNA double-strand breaks

(2008) Leonie Schulte-Uentrop et al.   NUCLEIC ACIDS RESEARCH

RAG2's non-core domain contributes to the ordered regulation of V(D)J recombination

(2008) John D. Curry et al.   NUCLEIC ACIDS RESEARCH