Review
Radiology, Nuclear Medicine & Medical Imaging
Mitchell A. Klenner, Giancarlo Pascali, Benjamin H. Fraser, Tamim A. Darwish
Summary: Deuterium labelling of pharmaceuticals is a useful strategy for altering pharmacokinetic properties, especially in improving metabolic resistance. However, when applied to radiopharmaceuticals for PET imaging experiments, it is crucial to consider the formation of radiometabolites and use deuterium labelling to minimize their impact. Various categories of deuterated radiopharmaceuticals are explored for investigating different activities and diseases, with deuteration strategies leading to a kinetic isotope effect for reducing metabolism rates. Evaluation of synthetic approaches and clinical implications highlight the potential for introducing deuterated radiopharmaceuticals into routine practice.
NUCLEAR MEDICINE AND BIOLOGY
(2021)
Article
Chemistry, Medicinal
Falguni Basuli, Tim E. Phelps, Xiang Zhang, Carolyn C. Woodroofe, Jyoti Roy, Peter L. Choyke, Rolf E. Swenson, Elaine M. Jagoda
Summary: The high expression of PSMA in prostate cancers has led to the development of a PSMA-targeted PET imaging agent called [F-18]DCFPyL, which has good binding affinity to tumors and kidneys. A new oxime radiotracer, [F-18]2a, was found to have comparable tumor targeting to [F-18]DCFPyL but with lower uptake in the kidneys.
Article
Chemistry, Multidisciplinary
Jin Young Chai, Hyojin Cha, Sung-Sik Lee, Young-Ho Oh, Sungyul Lee, Dae Yoon Chi
Summary: The synthesis of fluorine-18 labeled fluoroform with high molar activity is essential for the development of fluorine-18 labeled aryl-CF3 radiopharmaceuticals for PET imaging. The study proposed a strategy for synthesizing fluoroform and elucidated the mechanism of the fluorination reaction, showing the superiority of the S(N)2 pathway. The research demonstrated the potential for preparing fluorine-18 labeled fluoroform with high molar activity through experimental and theoretical studies.
Article
Chemistry, Physical
Lulu Pei, Weiqi Chen, Pengfei Ju, Hong Zhou, Zhou Xu, Li Ji, Tianbao Ma, Hongxuan Li, Xiaohong Liu, Huidi Zhou, Jianmin Chen
Summary: The vacuum tribological behaviors of a-C:H film are regulated by interfacial activity, with strong activity leading to carbon transfer and wear while weak activity leads to beneficial carbon structures. The catalytic nature of gold induces perfect graphene nanoscrolls at the sliding interface, achieving long vacuum wear life. This study provides new insights for extending the life of carbon films in vacuum.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Medicinal
Benoit Laleu, Yuichiro Akao, Atsuko Ochida, Sandra Duffy, Leonardo Lucantoni, David M. Shackleford, Gong Chen, Kasiram Katneni, Francis C. K. Chiu, Karen L. White, Xue Chen, Angelika Sturm, Koen J. Dechering, Benigno Crespo, Laura M. Sanz, Binglin Wang, Sergio Wittlin, Susan A. Charman, Vicky M. Avery, Nobuo Cho, Masahiro Kamaura
Summary: A novel antimalarial scaffold was discovered through a phenotypic high-throughput screen, with a potent inhibitor 19f identified as 95-fold more potent than the original hit compound. Profiling of 19f showed a fast in vitro killing profile, and its in vivo activity in a murine model of human malaria was dose-dependent, providing a concomitant benefit.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Mitchell A. Klenner, Giancarlo Pascali, Massimiliano Massi, Benjamin H. Fraser
Summary: PET-fluorescence imaging is an emerging field that combines positron emission tomography and fluorescence imaging techniques, utilizing probes containing fluorophores and radioisotopes to provide complementary information. Different fluorine-18 labelled PET-fluorescence probes have been classified into four groups based on the implemented fluorophore, with a systematic comparison of their properties to aid future endeavors in PET-fluorescence chemistry.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Shivashankar Khanapur, Kenneth Lye, Dipendu Mandal, Xin Jie Wee, Edward G. Robins, Rowan D. Young
Summary: We present a general method for labeling both CF3 and CF2H groups in various chemical settings. The method provides good radiochemical yields and molar activities, and is applicable to biologically relevant compounds. The use of target compounds as starting materials and the simplicity of the method make it attractive for drug and radiotracer development.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Xiang Zhang, Falguni Basuli, Zhen-Dan Shi, Swati Shah, Jianfeng Shi, Amelia Mitchell, Jianhao Lai, Zeping Wang, Dima A. Hammoud, Rolf E. Swenson
Summary: In this study, a series of fluorine-18-labeled L-rhamnose derivatives were developed as potential PET tracers for various fungal and bacterial strains. The tracer showed good stability and renal clearance in mice, with minimal tissue and skeletal uptake and a low background signal in healthy mice.
Article
Chemistry, Medicinal
Malvika Sardana, Louise Breuil, Sebastien Goutal, Maud Goislard, Mikhail Kondrashov, Etienne Marchal, Florent L. Besson, Christophe Dugave, Gail Wrigley, Anna C. Jonson, Bertrand Kuhnast, Magnus Schou, Nicolas Tournier, Charles S. Elmore, Fabien Caille
Summary: A spirocyclic hypervalent iodine precursor was synthesized for the isotopic labeling of Crizotinib, and PET imaging demonstrated the feasibility of [F-18](R)-Crizotinib for in vivo imaging. The study suggests that this method can be used for further research on enhancing the brain penetration of Crizotinib.
Article
Neurosciences
Raphael Sura Daveau, Ian Law, Otto Molby Henriksen, Steen Gregers Hasselbalch, Ulrik Bjorn Andersen, Lasse Anderberg, Liselotte Hojgaard, Flemming Littrup Andersen, Claes Nohr Ladefoged
Summary: The study demonstrates that using activity reduction and AI-assisted denoising in PET scans can successfully reduce image noise, improve visual quality, and maintain stability of clinical metrics.
Article
Chemistry, Multidisciplinary
Jay S. Wright, Richard Ma, E. William Webb, Wade P. Winton, Jenelle Stauff, Kevin Cheng, Allen F. Brooks, Melanie S. Sanford, Peter J. H. Scott
Summary: This report presents the development of a Zn(OTf)(2)-mediated method for converting alpha-tertiary haloamides to the corresponding alpha-tertiary fluoroamides. Under optimized conditions, high radiochemical conversion can be achieved. This method has been successfully applied to prepare various model radiofluorides.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Anna Pees, Maria J. W. D. Vosjan, Neil Vasdev, Albert D. Windhorst, Danielle J. Vugts
Summary: This article describes the first synthesis and application of fluorine-18 labelled Ruppert-Prakash reagent [F-18]Me3SiCF3, which was used to successfully prepare F-18-trifluoromethylated compounds by reacting with benzaldehydes, acetophenones and benzophenones.
CHEMICAL COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Zhengyuan Zhou, Michael R. Zalutsky, Satish K. Chitneni
Summary: The study investigated the feasibility of using F-18-labeled RG7388 as a PET tracer for imaging MDM2 expression in tumors. Fluorinated analogues of RG7388 were synthesized and their inhibitory potency against MDM2 was determined. F-18-labeled RG7388 showed good uptake and specificity in cell lines and in vivo mouse models, suggesting its potential for PET imaging of MDM2.
MOLECULAR PHARMACEUTICS
(2021)
Article
Chemistry, Physical
Weiwei Xie, Jianhao Huang, Liting Huang, Shipeng Geng, Shuqin Song, Panagiotis Tsiakaras, Yi Wang
Summary: In this study, fluorine-doped cobalt molybdate nanosheet arrays were synthesized on graphite felt to enhance the kinetics of the oxygen evolution reaction. The F-CoMoO4 electrocatalyst showed improved OER performance due to the induction of oxygen vacancies and optimization of the electronic configuration of CoMoO4. The DFT results revealed that the change in Mo 4d state led to a decrease in band-gap and an increase in electrical conductivity, thereby optimizing the intrinsic activity of CoMoO4. The synthesis strategy employed in this work may offer insights for enhancing the electrical conductivity of other transition metal oxides.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2022)
Article
Chemistry, Physical
Miguel Diaz-Sanchez, Isabel Hernandez-Benitez, Diana Diaz-Garcia, Sanjiv Prashar, Santiago Gomez-Ruiz
Summary: In recent years, titanium dioxide has shown high photocatalytic effectiveness in various decontamination processes. This study found that modifying titanium dioxide with carbon species with high surface porosity can enhance its adsorption capacity and activation potential. The addition of different types of carbon materials enables efficient degradation of organic pollutants and catalytic reactions.
CATALYSIS COMMUNICATIONS
(2022)
Article
Chemistry, Analytical
Tara Mastren, Aranh Pen, Shaun Loveless, Bernadette V. Marquez, Elizabeth Bollinger, Boone Marois, Nicholas Hubley, Kyle Brown, David J. Morrissey, Graham F. Peaslee, Suzanne E. Lapi
ANALYTICAL CHEMISTRY
(2015)
Article
Chemistry, Inorganic & Nuclear
A. Lake Wooten, Benjamin C. Lewis, Suzanne E. Lapi
APPLIED RADIATION AND ISOTOPES
(2015)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Bernadette V. Marquez, Suzanne E. Lapi
JOURNAL OF NUCLEAR MEDICINE
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nilantha Bandara, Alex Zheleznyak, Kaavya Cherukuri, David A. Griffith, Chris Limberakis, David A. Tess, Chen Jianqing, Rikki Waterhouse, Suzanne E. Lapi
MOLECULAR IMAGING AND BIOLOGY
(2016)
Article
Biochemical Research Methods
Tara Mastren, Bernadette V. Marquez, Deborah E. Sultan, Elizabeth Bollinger, Paul Eisenbeis, Tom Voller, Suzanne E. Lapi
Article
Biochemistry & Molecular Biology
Matthew D. Graaf, Bernadette V. Marquez, Nai-Hua Yeh, Suzanne E. Lapi, Kevin D. Moeller
ACS CHEMICAL BIOLOGY
(2016)
Article
Chemistry, Inorganic & Nuclear
A. Lake Wooten, Benjamin C. Lewis, Daniel J. Szatkowski, Deborah H. Sultan, Kinda I. Abdin, Thomas F. Voller, Yongjian Liu, Suzanne E. Lapi
APPLIED RADIATION AND ISOTOPES
(2016)
Article
Cardiac & Cardiovascular Systems
Hongjun Jin, Hao Yang, Hui Liu, Yunxiao Zhang, Xiang Zhang, Adam J. Rosenberg, Yongjian Liu, Suzanne E. Lapi, Zhude Tu
JOURNAL OF NUCLEAR CARDIOLOGY
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Brian D. Wright, Joseph Whittenberg, Amit Desai, Christina DiFelice, Paul J. A. Kenis, Suzanne E. Lapi, David E. Reichert
JOURNAL OF NUCLEAR MEDICINE
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xingyu Nie, Richard Laforest, Andrew Elvington, Gwendalyn J. Randolph, Jie Zheng, Tom Voller, Dana R. Abendschein, Suzanne E. Lapi, Pamela K. Woodard
JOURNAL OF NUCLEAR MEDICINE
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Richard Laforest, Suzanne E. Lapi, Reiko Oyama, Ron Bose, Adel Tabchy, Bernadette V. Marquez-Nostra, Jennifer Burkemper, Brian D. Wright, Jennifer Frye, Sarah Frye, Barry A. Siegel, Farrokh Dehdashti
MOLECULAR IMAGING AND BIOLOGY
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xingyu Nie, Gwendalyn J. Randolph, Andrew Elvington, Nilantha Bandara, Alexander Zheleznyak, Robert J. Gropler, Pamela K. Woodard, Suzanne E. Lapi
NUCLEAR MEDICINE AND BIOLOGY
(2016)
Article
Engineering, Environmental
Jennifer L. Burkemper, Tolulope A. Aweda, Adam J. Rosenberg, David M. Lunderberg, Graham F. Peaslee, Suzanne E. Lapi
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2017)
Review
Biochemical Research Methods
Renata Mikolajczak, Nicholas P. van der Meulen, Suzanne E. Lapi
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
C. Shaun Loveless, Lauren L. Radford, Samuel J. Ferran, Stacy L. Queern, Matthew R. Shepherd, Suzanne E. Lapi
