Review
Biochemical Research Methods
Amit Singh, Mansoor M. Amiji
Summary: Nanotechnology has greatly impacted the advancement in disease imaging, early detection, diagnosis, and prognosis. The unique properties of nanoparticles enable contrast enhancement for biomedical imaging and molecular level tissue-specific diagnosis. Small variations in nanoparticle size or composition can result in significant changes in their optical, magnetic, or electrical properties, allowing for unique possibilities of multiplexing.
CURRENT OPINION IN BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Yohana C. Toner, Adam A. Ghotbi, Sonum Naidu, Ken Sakurai, Mandy M. T. van Leent, Stefan Jordan, Farideh Ordikhani, Letizia Amadori, Alexandros Marios Sofias, Elizabeth L. Fisher, Alexander Maier, Nathaniel Sullivan, Jazz Munitz, Max L. Senders, Christian Mason, Thomas Reiner, Georgios Soultanidis, Jason M. Tarkin, James H. F. Rudd, Chiara Giannarelli, Jordi Ochando, Carlos Perez-Medina, Andreas Kjaer, Willem J. M. Mulder, Zahi A. Fayad, Claudia Calcagno
Summary: In recent years, there have been significant advancements in cardiovascular immuno-imaging using positron emission tomography (PET). Two approved PET tracers, FDG and DOTATATE, have shown great potential for inflammation imaging in cardiovascular patients. This study provides a detailed comparison of the effectiveness of DOTATATE-based radiotracers and FDG in mouse and rabbit models of cardiovascular inflammation, showing that DOTATATE may be a better option for assessing inflammation in cardiovascular disease.
SCIENTIFIC REPORTS
(2022)
Review
Cell Biology
Benjamin Bartlett, Herbert P. Ludewick, Silvia Lee, Shipra Verma, Roslyn J. Francis, Girish Dwivedi
Summary: This paper reviews the efficacy of different PET imaging radiotracers in characterizing and assessing the risk of vulnerable plaques in acute coronary syndrome. It also discusses the translational potential of novel radiotracers in animal studies and the challenges encountered in murine PET imaging.
Article
Biochemistry & Molecular Biology
Henry W. West, Charalambos Antoniades
Summary: Coronary artery disease remains a leading cause of morbidity and mortality globally, with a focus on understanding inflammatory mechanisms driving residual CAD risk. Advances in noninvasive detection of coronary artery inflammation and targeted therapies for inflammation have become critical issues in the field.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Health Care Sciences & Services
Simona Roxana Georgescu, Cristina Iulia Mitran, Madalina Irina Mitran, Clara Matei, Carolina Constantin, Monica Neagu, Mircea Tampa
Summary: Melanoma is an aggressive skin cancer with increasing incidence. Reliable biomarkers for diagnosis and prognosis are essential in clinical practice. This review discusses the latest studies on potential biomarkers in cutaneous melanoma.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Hematology
Bartolo Ferraro, Pierangela Giustetto, Olga Schengel, Ludwig T. Weckbach, Lars Maegdefessel, Oliver Soehnlein
Summary: This study aimed to establish a protocol for longitudinal monitoring of plaque composition in atherosclerosis, including lipid, collagen, macrophage burden, and endothelial permeability. The protocol was validated by correlating photoacoustic signals with histomorphometric and immunofluorescence analyses in albino Apoe(-/-) mice. The study demonstrates an innovative and non-invasive approach to assess arterial inflammation in mice.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Biotechnology & Applied Microbiology
Jiaying Zhang, Zefang Lin, Xiaojun Zhang, Rong Lin, Mengchao Cui, Weibing Miao, Shaobo Yao
Summary: The injection of Ga-68-DOTA-DiPSMA is safe and associated with low absorbed and effective doses. Ga-68-DOTA-DiPSMA demonstrates favorable kinetics and imaging characteristics, showing potential as an alternative for gallium-68-labeled PSMA clinical PET.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Greta Jarockyte, Marius Stasys, Vilius Poderys, Kornelija Buivydaite, Marijus Pleckaitis, Danute Bulotiene, Marija Matulionyte, Vitalijus Karabanovas, Ricardas Rotomskis
Summary: The study evaluated the biodistribution of biocompatible Tc-99m-BSA-Au NCs in animals, confirming their potential as photoluminescence-SPECT/CT agents and demonstrating their in vivo imaging capabilities.
Review
Clinical Neurology
Luca Saba, Valentina Nardi, Riccardo Cau, Ajay Gupta, Hooman Kamel, Jasjit S. Suri, Antonella Balestrieri, Terenzio Congiu, Anthony P. H. Butler, Steven Gieseg, Daniela Fanni, Giulia Cerrone, Roberto Sanfilippo, Josep Puig, Qi Yang, Lorenzo Mannelli, Gavino Faa, Giuseppe Lanzino
Summary: This review summarizes the current understanding of carotid plaque calcification and the role of calcium in atherosclerotic carotid disease. The analysis includes laboratory studies, histopathologic studies, and imaging findings, aiming to understand the clinical implications of carotid artery calcifications, such as their association with plaque stability and stroke risk. Further investigations with modern imaging techniques are expected to enhance our understanding of carotid artery calcification and its relationship with stroke risk.
Article
Radiology, Nuclear Medicine & Medical Imaging
Philip Z. Mannes, Sina Tavakoli
Summary: In recent years, there has been an increasing recognition of the importance of immunometabolism in atherogenesis, particularly in understanding the role of immune cell activation and intracellular metabolism. Metabolic imaging, particularly with F-18-FDG, holds promise in providing valuable clinical insights for risk assessment and treatment monitoring in atherosclerosis patients.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Elaina Kelland, Manisha S. S. Patil, Sanjay Patel, Sian P. Cartland, Mary M. M. Kavurma
Summary: TNF-related apoptosis-inducing ligand (TRAIL) was originally discovered for its ability to kill cancer cells, but recent evidence suggests its pleiotropic functions in the cardiovascular system. Circulating TRAIL concentrations have potential as prognostic and/or diagnostic factors for cardiovascular diseases (CVD). Pre-clinical studies show therapeutic capacity for TRAIL signals in atherosclerotic disease and diseases of the myocardium. This review highlights the prognostic, diagnostic, and therapeutic potential of TRAIL signals in CVDs, including the impact of diabetes mellitus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Xiude Fan, Rebecca L. McCullough, Emily Huang, Annette Bellar, Adam Kim, Kyle L. Poulsen, Craig J. McClain, Mack Mitchell, Arthur J. McCullough, Svetlana Radaeva, Bruce Barton, Gyongyi Szabo, Srinivasan Dasarathy, Daniel M. Rotroff, Laura E. Nagy
Summary: This study found that acute alcohol-associated hepatitis (AH) is associated with a significant disruption of the complement system, with changes in complement proteins indicating disease severity and predicting mortality. Specifically, low levels of CFI and sC5b9 were associated with increased 90-day mortality in AH patients. Inclusion of complement markers, especially CFI and sC5b9, could enhance diagnostic and prognostic accuracy for AH patients.
Article
Chemistry, Multidisciplinary
Shumei Huang, Zejun Li, Wenhui You, Guansheng Zheng, Huatang Zhang, Yin Jiang, Hongyan Sun
Summary: This study explored a novel fluorescein-based H2S donor, FL-H2S, as an anti-inflammatory agent. The results showed that FL-H2S efficiently released H2S, had good biocompatibility, and enabled real-time intracellular H2S release and imaging. In vivo experiments using a rat model confirmed the anti-inflammatory effects of FL-H2S, and the anti-inflammatory mechanism was elucidated through ELISA and WB analysis.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Anna Szyszkowska, Sylwia Baranska, Robert Sawicki, Ewa Tarasiuk, Marlena Dubatowka, Marcin Kondraciuk, Emilia Sawicka-Smiarowska, Malgorzata Knapp, Jerzy Glowinski, Karol Kaminski, Anna Lisowska
Summary: The aim of this study was to evaluate the importance of insulin-like growth-factor-binding protein 7 (IGFBP-7) as a marker for symptomatic peripheral artery disease (PAD). The results showed that patients with PAD had significantly higher levels of IGFBP-7 compared to the control group, regardless of the location of the disease. In addition, patients with higher IGFBP-7 concentrations were more likely to experience death or major adverse cardiovascular events during the follow-up period.
Article
Immunology
Yajuan Fu, Lingbo Xu, Hui Zhang, Ning Ding, Juan Zhang, Shengchao Ma, Anning Yang, Yinjv Hao, Yujing Gao, Yideng Jiang
Summary: This study identified the common differentially expressed genes associated with atherosclerosis and type 2 diabetes mellitus, and validated CD4 and PLEK as key genes in these two diseases. This finding may contribute to the development of diagnosis and therapeutic strategies.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hui Liu, Hongjun Jin, Junbin Han, Xuyi Yue, Hao Yang, Mohamed A. Zayed, Robert J. Gropler, Zhude Tu
MOLECULAR IMAGING AND BIOLOGY
(2018)
Article
Chemistry, Organic
Xuyi Yue, Hongjun Jin, Hui Liu, Zonghua Luo, Xiang Zhang, Kota Kaneshige, Hubert P. Flores, Joel S. Perlmutter, Stanley M. Parsons, Zhude Tu
ORGANIC & BIOMOLECULAR CHEMISTRY
(2017)
Article
Chemistry, Medicinal
Zonghua Luo, Xuyi Yue, Hao Yang, Hui Liu, Robyn S. Klein, Zhude Tu
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2018)
Article
Chemistry, Medicinal
Zonghua Luo, Adam J. Rosenberg, Hui Liu, Junbin Han, Zhude Tu
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Pharmacology & Pharmacy
Hongjun Jin, Junbin Han, Derek Resing, Hui Liu, Xuyi Yue, Rebecca L. Miller, Kathleen M. Schoch, Timothy M. Miller, Joel S. Perlmutter, Terrance M. Egan, Zhude Tu
EUROPEAN JOURNAL OF PHARMACOLOGY
(2018)
Article
Radiology, Nuclear Medicine & Medical Imaging
Adam J. Rosenberg, Michael L. Nickels, Michael L. Schulte, H. Charles Manning
NUCLEAR MEDICINE AND BIOLOGY
(2018)
Review
Biochemical Research Methods
Renata Mikolajczak, Nicholas P. van der Meulen, Suzanne E. Lapi
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
C. Shaun Loveless, Lauren L. Radford, Samuel J. Ferran, Stacy L. Queern, Matthew R. Shepherd, Suzanne E. Lapi
Article
Biochemistry & Molecular Biology
Clayton A. Whitmore, Mariam I. Boules, William J. Behof, Justin R. Haynes, Dmitry Koktysh, Adam J. Rosenberg, Mohammed N. Tantawy, Wellington Pham
Summary: This study reports the design and synthesis of a novel [C-11]promethazine PET radioligand for future in vivo studies, with high radiochemical purity and molar activity. The specificity of the probe was demonstrated through autoradiography using human hippocampal tissues.
Article
Multidisciplinary Sciences
William J. Behof, Clayton A. Whitmore, Justin R. Haynes, Adam J. Rosenberg, Mohammed N. Tantawy, Todd E. Peterson, Fiona E. Harrison, Robert B. Beelman, Wellington Pham
Summary: This study successfully demonstrated the biodistribution of ERGO in vivo using a [C-11]ERGO PET radioligand, showing significant accumulation in the brain, eyes, and small intestine of the mice. The radioligand also remained strong in the brain 30 minutes post-injection, marking the first preclinical demonstration of ERGO's biodistribution in a highly sensitive and non-invasive manner.
SCIENTIFIC REPORTS
(2021)
Article
Biochemical Research Methods
Adam J. Rosenberg, Yiu-Yin Cheung, Fei Liu, Todd E. Peterson, James Silverman, Ciaran M. Considine, Daniel O. Claassen
Summary: In this study, a fully automated synthesis procedure for [F-18]MH.MZ radiotracer was developed using commercially available materials. The synthesis time was 100 min with a radiochemical yield of 7 +/- 0.9% (n = 3), and the radiochemical purity and molar activity met the relevant release criteria.
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
(2022)
Article
Chemistry, Medicinal
Clayton A. Whitmore, Justin R. Haynes, William J. Behof, Adam J. Rosenberg, Mohammed N. Tantawy, Brian C. Hachey, Brian E. Wadzinski, Benjamin W. Spiller, Todd E. Peterson, Krista C. Paffenroth, Fiona E. Harrison, Robert B. Beelman, Printha Wijesinghe, Joanne A. Matsubara, Wellington Pham
Summary: The study assessed the effects of ERGO consumption on the progression of Alzheimer's disease in young 5XFAD mice. The results showed that ERGO could reduce amyloid plaques, oxidative stress, and restore glucose metabolism. The study also highlights the importance of imaging technology in evaluating treatment response.
Article
Chemistry, Medicinal
Adam J. Rosenberg, Yiu-Yin Cheung, Fei Liu, Carina Sollert, Todd E. Peterson, Jonathan A. Kropski
Summary: The study presents a developed method to utilize liquid-target cyclotron-produced gallium-68 to prepare [Ga-68]Ga-FAPI-46. A fully-automated manufacturing process was developed, which successfully produced sufficient activity levels of [Ga-68]Ga-FAPI-46 for clinical research doses. The final product met all release criteria and the process consistently provided high radiochemical yield.
EJNMMI RADIOPHARMACY AND CHEMISTRY
(2023)
Article
Chemistry, Organic
Zonghua Luo, Junbin Han, Hui Liu, Adam J. Rosenberg, Delphine L. Chen, Robert J. Gropler, Joel S. Perlmutter, Zhude Tu
ORGANIC & BIOMOLECULAR CHEMISTRY
(2018)