Article
Clinical Neurology
Anna M. Pietroboni, Annalisa Colombi, Tiziana Carandini, Luca Sacchi, Chiara Fenoglio, Giorgio Marotta, Andrea Arighi, Milena A. De Riz, Giorgio G. Fumagalli, Massimo Castellani, Marco Bozzali, Elio Scarpini, Daniela Galimberti
Summary: This study evaluates the use of amy-PET in patients with Alzheimer's disease and non-AD dementia. The results suggest that amy-PET is useful for assessing microstructural white matter injury in non-AD dementia, but may not be suitable for evaluating white matter damage in AD patients due to amyloid accumulation.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Neurosciences
Lauren Edwards, Kelsey R. Thomas, Alexandra J. Weigand, Emily C. Edmonds, Alexandra L. Clark, Kayla S. Walker, Einat K. Brenner, Daniel A. Nation, Pauline Maillard, Mark W. Bondi, Katherine J. Bangen
Summary: This study found that white matter hyperintensity (WMH) volume can moderate the association between AD biomarkers and cognition, with a quadratic effect between WMH and A beta on memory; however, there was no interaction between linear or quadratic effects of WMH and A beta on executive function; additionally, there was no interaction between WMH volume and tau-PET on cognitive measures.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Endocrinology & Metabolism
Julie Ottoy, Miracle Ozzoude, Katherine Zukotynski, Min Su Kang, Sabrina Adamo, Christopher Scott, Joel Ramirez, Walter Swardfager, Benjamin Lam, Aparna Bhan, Parisa Mojiri, Alex Kiss, Stephen Strother, Christian Bocti, Michael Borrie, Howard Chertkow, Richard Frayne, Robin Hsiung, Robert Laforce, Michael D. Noseworthy, Frank S. Prato, Demetrios J. Sahlas, Eric E. Smith, Phillip H. Kuo, Jordan A. Chad, Ofer Pasternak, Vesna Sossi, Alexander Thiel, Jean-Paul Soucy, Jean-Claude Tardif, Sandra E. Black, Maged Goubran
Summary: This study investigated the relationship between A beta-PET signal in white matter (WM) regions and diffusion MRI-based microstructural alterations. The results showed that decreased A beta-PET signal in WMH regions was closely associated with higher free water and higher WMH volume, while increased A beta-PET signal in normal-appearing WM was closely associated with higher cortical A beta and lower free water-adjusted FA. Furthermore, cognitive impairment was more closely related to higher free water than to either free water-adjusted FA or WM PET.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Keenan A. Walker, Noah Silverstein, Yun Zhou, Timothy M. Hughes, Clifford R. Jack, David S. Knopman, A. Richey Sharrett, Dean F. Wong, Thomas H. Mosley, Rebecca F. Gottesman
Summary: White matter hyperintensity volume is modestly positively associated with elevated amyloid in older adults without dementia, with a stronger association observed among Black participants. However, there was no association between white matter microstructure and elevated amyloid. These findings need to be further validated in larger, multiethnic cohorts.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Clinical Neurology
Clifford R. Jack Jr, Heather J. Wiste, Alicia Algeciras-Schimnich, Dan J. Figdore, Christopher G. Schwarz, Val J. Lowe, Vijay K. Ramanan, Prashanthi Vemuri, Michelle M. Mielke, David S. Knopman, Jonathan Graff-Radford, Bradley F. Boeve, Kejal Kantarci, Petrice M. Cogswell, Matthew L. Senjem, Jeffrey L. Gunter, Terry M. Therneau, Ronald C. Petersen
Summary: Staging the severity of Alzheimer's disease pathology is important for therapeutic trials and clinical prognosis. Biomarkers such as amyloid and tau PET can be used for disease staging, but plasma biomarkers would be more practical.
Article
Clinical Neurology
Jay Shah, Fei Gao, Baoxin Li, Valentina Ghisays, Ji Luo, Yinghua Chen, Wendy Lee, Yuxiang Zhou, Tammie L. S. Benzinger, Eric M. Reiman, Kewei Chen, Yi Su, Teresa Wu
Summary: A Residual Inception Encoder-Decoder Neural Network model was developed and validated to harmonize amyloid PET imaging data from different tracers, resulting in significantly stronger correlations between global amyloid burden indices and voxel-wise measurements in both training and testing cohorts. Further investigation is ongoing to improve the model and apply it to additional tracers.
ALZHEIMERS & DEMENTIA
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiaxuan Peng, Wei Wang, Qiaowei Song, Jie Hou, Hui Jin, Xue Qin, Zhongyu Yuan, Yuguo Wei, Zhenyu Shu
Summary: This study built a model using white-matter radiomics features on PET and machine learning methods to predict progression from MCI to AD. The clinical dementia rating (CDR) scores, Alzheimer's disease assessment scale (ADAS) scores, and psychoradiomics signature (PS) were found to independently predict MCI progression to AD. An integrated model combining multimodal data and machine learning successfully identified MCI patients at a high risk of progression to AD.
ACADEMIC RADIOLOGY
(2023)
Article
Neuroimaging
Austin M. Bazydlo, Matthew D. Zammit, Minjie Wu, Patrick J. Lao, Douglas C. Dean, Sterling C. Johnson, Dana L. Tudorascu, Ann Cohen, Karly A. Cody, Beau Ances, Charles M. Laymon, William E. Klunk, Shahid Zaman, Benjamin L. Handen, Sigan L. Hartley, Andrew L. Alexander, Bradley T. Christian
Summary: The study focused on the correlation between white matter microstructure and amyloid load in adults with DS at risk for developing AD. Results indicated widespread age-by-amyloid interaction, with negative association of FA and positive association of MD with amyloid. These findings align with white matter microstructural changes observed in late onset AD in non-DS populations.
NEUROIMAGE-CLINICAL
(2022)
Review
Medicine, General & Internal
Miriam Conte, Maria Silvia De Feo, Marko Magdi Abdou Sidrak, Ferdinando Corica, Joana Gorica, Giorgia Maria Granese, Luca Filippi, Giuseppe De Vincentis, Viviana Frantellizzi
Summary: This article provides a systematic review of current and novel PET tracers for tauopathies. The results indicate that PET imaging can serve as a valuable tool for diagnosis, although further research on promising ligands is needed for differential diagnosis.
Article
Neurosciences
Thalia T. Dimopoulos, Stephen L. P. Lippi, Jorge Fernandez Davila, Rachel E. Barkey, Erin N. Doherty, Jane M. Flinn
Summary: This study assessed the effects of white button mushroom supplementation on spatial memory and plaque formation in mice with A beta mutations. The results showed that mice on the WBM diet had improved spatial memory and fewer amyloid plaques.
Article
Biochemistry & Molecular Biology
Santiago Ramirez, Suelyn Koerich, Natalia Astudillo, Nicole De Gregorio, Rabab Al-Lahham, Tyler Allison, Natalia Pessoa Rocha, Fei Wang, Claudio Soto
Summary: This study aimed to evaluate the effect of removing Aβ from blood plasma on the accumulation of amyloid plaques in the brain. The results showed a reduction in Aβ levels in the plasma and insoluble brain fractions, as well as a decrease in amyloid plaque burden and changes in plaque size distribution in the cortex and hippocampus. These findings support the importance of targeting Aβ in the periphery and suggest plasma exchange as a potential non-pharmacological strategy for slowing down AD pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
K. P. Ng, J. Y. Shen, H. J. Chiew, A. S. L. Ng, N. Kandiah, P. Rosa-Neto, S. Gauthier
Summary: The AT(N) framework classifies individuals in the Alzheimer's disease (AD) continuum by combining cognitive stage with biomarkers of amyloid-beta (Aβ), tau (T), and neurodegeneration (N). This study examines the association between white matter hyperintensities (WMH) and AD pathophysiology (Aβ and tau). The evidence supporting the association between WMH and Aβ is conflicting, highlighting the need for further research to understand the relationship between WMH and AT(N) biomarkers.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Sarah K. Royse, Davneet S. Minhas, Brian J. Lopresti, Alice Murphy, Tyler Ward, Robert A. Koeppe, Santiago Bullich, Susan DeSanti, William J. Jagust, Susan M. Landau
Summary: This study addressed challenges in multisite studies using multiple beta-amyloid radiotracers by deriving standardized Centiloid transformations and internally consistent positivity thresholds for [F-18]florbetaben (FBB) and [F-18]florbetapir (FBP) PET data. The findings demonstrate the feasibility of harmonized PET acquisition and analysis and the internal consistency of positivity thresholds in standardized units, contributing to improved replicability in research and clinical trials.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Review
Clinical Neurology
Lizhen Cheng, Wei Li, Yixin Chen, Yijia Lin, Beiyun Wang, Qihao Guo, Ya Miao
Summary: Plasma A beta 42 values and plasma A beta 42/A beta 40 ratio could serve as independent biomarkers for predicting A beta-PET status, while plasma A beta 40 values may not distinguish between PET (+) and PET (-) individuals.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Clinical Neurology
Antoine Garnier-Crussard, Francois Cotton, Pierre Krolak-Salmon, Gael Chetelat
Summary: White matter hyperintensities (WMH) are vascular lesions frequently seen in older adults, but recent evidence suggests that non-vascular mechanisms, particularly in Alzheimer's disease (AD), may also contribute to WMH. This alternative hypothesis is supported by arguments from neuropathology, neuroimaging, fluid biomarkers, and genetics. The underlying mechanisms of AD-related WMH, such as neurodegeneration or neuroinflammation, are discussed, as well as the implications for AD diagnosis and management. Testing this hypothesis and addressing remaining challenges can improve personalized care for patients.
ALZHEIMERS & DEMENTIA
(2023)
Article
Chemistry, Medicinal
Melissa Egbertson, Georgia B. McGaughey, Steven M. Pitzenberger, Shaun R. Stauffer, Craig A. Coburn, Shawn J. Stachel, Wenjin Yang, James C. Barrow, Lou Anne Neilson, Melody McWherter, Debra Perlow, Bruce Fahr, Sanjeev Munshi, Timothy J. Allison, Katharine Holloway, Harold G. Selnick, ZhiQiang Yang, John Swestock, Adam J. Simon, Sethu Sankaranarayanan, Dennis Colussi, Katherine Tugusheva, Ming-Tain Lai, Beth Pietrak, Shari Haugabook, Lixia Jin, I-W. Chen, Marie Holahan, Maria Stranieri-Michener, Jacquelynn J. Cook, Joseph Vacca, Samuel L. Graham
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2015)
Meeting Abstract
Oncology
Steven J. Isakoff, Johanna C. Bendell, Andres Cervantes, Jean-Charles Soria, L. R. Molife, Sandra M. Sanabria-Bohorquez, Elizabeth A. Punnoose, Shidong Jia, Premal Patel, Cristina Saura
Article
Oncology
Dejan Juric, Rodrigo Dienstmann, Andres Cervantes, Manuel Hidalgo, Wells Messersmith, George R. Blumenschein, Josep Tabernero, Desamparados Roda, Antonio Calles, Antonio Jimeno, Xiaodong Wang, Sandra Sanabria Bohorquez, Cecilia Leddy, Catherine Littman, Amy V. Kapp, David S. Shames, Elicia Penuel, Lukas C. Amler, Andrea Pirzkall, Jose Baselga
CLINICAL CANCER RESEARCH
(2015)
Article
Chemistry, Medicinal
William D. Shipe, Steven S. Sharik, James C. Barrow, Georgia B. McGaughey, Cory R. Theberge, Jason M. Uslaner, Youwei Yan, John J. Renger, Sean M. Smith, Paul J. Coleman, Christopher D. Cox
JOURNAL OF MEDICINAL CHEMISTRY
(2015)
Article
Oncology
Thomas Bengtsson, Sandra M. Sanabria-Bohorquez, Timothy J. McCarthy, David S. Binns, Rodney J. Hicks, Alex J. de Crespigny
Meeting Abstract
Oncology
A. Varga, J. C. Soria, A. Hollebecque, P. LoRusso, U. Vaishampayan, K. Okrah, S. M. A. Huang, E. Murray, S. Sanabria-Bohorquez, M. Tagen, H. Dokainish, L. Mueller, H. Burris
EUROPEAN JOURNAL OF CANCER
(2016)
Article
Oncology
Cristina Saura, Desamparados Roda, Susana Rosello, Mafalda Oliveira, Teresa Macarulla, Jose Alejandro Perez-Fidalgo, Rafael Morales-Barrera, Juan Manuel Sanchis-Garcia, Luna Musib, Nageshwar Budha, Jin Zhu, Michelle Nannini, Wai Y. Chan, Sandra M. Sanabria Bohorquez, Raymond D. Meng, Kui Lin, Yibing Yan, Premal Patel, Jose Baselga, Josep Tabernero, Andres Cervantes
Article
Oncology
Dejan Juric, Ian Krop, Ramesh K. Ramanathan, Timothy R. Wilson, Joseph A. Ware, Sandra M. Sanabria Bohorquez, Heidi M. Savage, Deepak Sampath, Laurent Salphati, Ray S. Lin, Huan Jin, Hema Parmar, Jerry Y. Hsu, Daniel D. Von Hoff, Jose Baselga
Editorial Material
Chemistry, Medicinal
James C. Barrow
ACS MEDICINAL CHEMISTRY LETTERS
(2019)
Article
Chemistry, Medicinal
Michael M. Wormald, Glen Ernst, Huijun Wei, James C. Barrow
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2019)
Article
Pharmacology & Pharmacy
Yupin Su, Michael DePasquale, Gangling Liao, Ingrid Buchler, Gongliang Zhang, Spencer Byers, Gregory V. Carr, James Barrow, Huijun Wei
Summary: Selective inhibition of MBCOMT has shown promise in blocking dopamine metabolism, potentially improving cognitive deficits in disorders such as schizophrenia, ADHD, and traumatic brain injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Editorial Material
Chemistry, Medicinal
Craig W. Lindsley, James Barrow, Kelly Chibale, Maria Laura Bolognesi, Stuart Conway, William Denny, Ke Ding, Stefan Laufer, Luhua Lai, Hong Liu, Nouri Neamati, Takayoshi Suzuki, Nicholas Meanwell, Wendy Young
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Editorial Material
Chemistry, Medicinal
James C. Barrow, Craig W. Lindsey
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Sandip Mukherjee, Molee Chakraborty, Jake Haubner, Glen Ernst, Michael DePasquale, Danielle Carpenter, James C. Barrow, Anutosh Chakraborty
Summary: Obesity and nonalcoholic fatty liver disease (NAFLD) are global health concerns. LI-2242, an inhibitor of the inositol pyrophosphate pathway, shows potential therapeutic effects in obesity and NAFLD by reducing body weight, improving glycemic parameters, and ameliorating hepatic steatosis. LI-2242 also enhances mitochondrial oxygen consumption rate and insulin signaling in adipocytes and hepatocytes in vitro.
Meeting Abstract
Oncology
Frederike Bensch, Elly van der Veen, Annelies Jorritsma, Marjolijn Lub-de Hooge, Ronald Boellaard, Sjoukje Oosting, Carolien Schroder, Jeroen Hiltermann, Anthonie van der Wekken, Harry Groen, Bernard Fine, Nathan McKnight, Sandra Sanabria Bohorquez, Simon Williams, Luisa Veronese, Christoph Mancao, Adrienne H. Brouwers, Elisabeth de Vries