Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potency

Title
Methyl-substitution of an iminohydantoin spiropiperidine β-secretase (BACE-1) inhibitor has a profound effect on its potency
Authors
Keywords
Amyloid, Beta secretase, Spiropiperidine, Magic methyl effect
Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 25, Issue 21, Pages 4812-4819
Publisher
Elsevier BV
Online
2015-07-03
DOI
10.1016/j.bmcl.2015.06.082

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