Development of Novel Pharmacotherapeutics for Tobacco Dependence: Progress and Future Directions

Bupropion Binds to Two Sites in the Torpedo Nicotinic Acetylcholine Receptor Transmembrane Domain: A Photoaffinity Labeling Study with the Bupropion Analogue [125I]-SADU-3-72

(2012) Akash Pandhare et al.   BIOCHEMISTRY

AT-1001: A High Affinity and Selective α3β4 Nicotinic Acetylcholine Receptor Antagonist Blocks Nicotine Self-Administration in Rats

(2012) Lawrence Toll et al.   NEUROPSYCHOPHARMACOLOGY

Activation of Nuclear PPARγ Receptors by the Antidiabetic Agent Pioglitazone Suppresses Alcohol Drinking and Relapse to Alcohol Seeking

(2011) Serena Stopponi et al.   BIOLOGICAL PSYCHIATRY

The selective anandamide transport inhibitor VDM11 attenuates reinstatement of nicotine seeking behaviour, but does not affect nicotine intake

(2011) Islam Gamaleddin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Both GABAB receptor activation and blockade exacerbated anhedonic aspects of nicotine withdrawal in rats

(2011) Styliani Vlachou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Habenular α5 nicotinic receptor subunit signalling controls nicotine intake

(2011) Christie D. Fowler et al.   NATURE

Lateral habenula neurons signal errors in the prediction of reward information

(2011) Ethan S Bromberg-Martin et al.   NATURE NEUROSCIENCE

Habenula “Cholinergic” Neurons Corelease Glutamate and Acetylcholine and Activate Postsynaptic Neurons via Distinct Transmission Modes

(2011) Jing Ren et al.   NEURON

The 5-HT2C Receptor Agonist Lorcaserin Reduces Nicotine Self-Administration, Discrimination and Reinstatement: Relationship to Feeding Behavior and Impulse Control

(2011) Guy A Higgins et al.   NEUROPSYCHOPHARMACOLOGY

Alpha7 Nicotinic Acetylcholine Receptors Modulate Motivation to Self-Administer Nicotine: Implications for Smoking and Schizophrenia

(2011) Darlene H Brunzell et al.   NEUROPSYCHOPHARMACOLOGY

Varenicline Dose Dependently Enhances Responding for Nonpharmacological Reinforcers and Attenuates the Reinforcement-Enhancing Effects of Nicotine

(2011) M. E. Levin et al.   NICOTINE & TOBACCO RESEARCH

Adherence to Varenicline in the COMPASS Smoking Cessation Intervention Trial

(2011) S. L. Catz et al.   NICOTINE & TOBACCO RESEARCH

Blockade of CRF1 receptors in the central nucleus of the amygdala attenuates the dysphoria associated with nicotine withdrawal in rats

(2011) Adrie W. Bruijnzeel et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Protein kinase C epsilon modulates nicotine consumption and dopamine reward signals in the nucleus accumbens

(2011) A. M. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct contributions of nicotinic acetylcholine receptor subunit  4 and subunit  6 to the reinforcing effects of nicotine

(2011) R. Exley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alpha7-nicotinic receptors modulate nicotine-induced reinforcement and extracellular dopamine outflow in the mesolimbic system in mice

(2011) Morgane Besson et al.   PSYCHOPHARMACOLOGY

Granular Insular Cortex Inactivation as a Novel Therapeutic Strategy for Nicotine Addiction

(2010) Benoit Forget et al.   BIOLOGICAL PSYCHIATRY

Association of polymorphisms of the serotonergic system with smoking initiation in Caucasians

(2010) Maria Iordanidou et al.   DRUG AND ALCOHOL DEPENDENCE

Adverse Effects and Tolerability of Medications for the Treatment of Tobacco Use and Dependence

(2010) J. Taylor Hays et al.   DRUGS

Pharmacokinetics, Safety, and Tolerability Following Multiple Oral Doses of Varenicline Under Various Titration Schedules in Elderly Nonsmokers

(2010) Qinying Zhao et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Argonaute 2 in dopamine 2 receptor–expressing neurons regulates cocaine addiction

(2010) Anne Schaefer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Association between neuropeptide Y receptor 2 polymorphism and the smoking behavior of elderly Japanese

(2010) Naomi Sato et al.   JOURNAL OF HUMAN GENETICS

Histone deacetylase inhibition decreases preference without affecting aversion for nicotine

(2010) Veronica Pastor et al.   JOURNAL OF NEUROCHEMISTRY

Nicotinic Acetylcholine Receptors in the Mesolimbic Pathway: Primary Role of Ventral Tegmental Area  6 2* Receptors in Mediating Systemic Nicotine Effects on Dopamine Release, Locomotion, and Reinforcement

(2010) C. Gotti et al.   JOURNAL OF NEUROSCIENCE

Hypocretins Regulate the Anxiogenic-Like Effects of Nicotine and Induce Reinstatement of Nicotine-Seeking Behavior

(2010) A. Plaza-Zabala et al.   JOURNAL OF NEUROSCIENCE

Effects of Hydroxymetabolites of Bupropion on Nicotine Dependence Behavior in Mice

(2010) M. I. Damaj et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Striatal microRNA controls cocaine intake through CREB signalling

(2010) Jonathan A. Hollander et al.   NATURE

Sequence variants at CHRNB3–CHRNA6 and CYP2A6 affect smoking behavior

(2010) Thorgeir E Thorgeirsson et al.   NATURE GENETICS

Chipping away at the genetics of smoking behavior

(2010) Christopher I Amos et al.   NATURE GENETICS

Genome-wide meta-analyses identify multiple loci associated with smoking behavior

(2010)   NATURE GENETICS

MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212

(2010) Heh-In Im et al.   NATURE NEUROSCIENCE

Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens

(2010) Quincey LaPlant et al.   NATURE NEUROSCIENCE

The habenula: from stress evasion to value-based decision-making

(2010) Okihide Hikosaka   NATURE REVIEWS NEUROSCIENCE

A neurotensin analog, NT69L, attenuates intravenous nicotine self-administration in rats

(2010) Mona Boules et al.   NEUROPEPTIDES

Association study of a functional catechol-o-methyltransferase polymorphism and smoking in healthy Caucasian subjects

(2010) Gordana Nedic et al.   NEUROSCIENCE LETTERS

Tobacco dependence, the insular cortex and the hypocretin connection

(2010) Paul J. Kenny   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Activation of the opioid μ1, but not δ or κ, receptors is required for nicotine reinforcement in a rat model of drug self-administration

(2010) Xiu Liu et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Alteration of intravenous nicotine self-administration by opioid receptor agonist and antagonists in rats

(2010) Naila Ismayilova et al.   PSYCHOPHARMACOLOGY

Varenicline blocks nicotine intake in rats with extended access to nicotine self-administration

(2010) Olivier George et al.   PSYCHOPHARMACOLOGY

Essential Role of the Histone Methyltransferase G9a in Cocaine-Induced Plasticity

(2010) I. Maze et al.   SCIENCE

Genome-wide Association Study of Smoking Initiation and Current Smoking

(2009) Jacqueline M. Vink et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2 ) with nicotine addiction

(2009) A. Mobascher et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes

(2009) Nancy L. Saccone et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Stimulation of dopamine release by nicotinic acetylcholine receptor ligands in rat brain slices correlates with the profile of high, but not low, sensitivity α4β2 subunit combination

(2009) David J. Anderson et al.   BIOCHEMICAL PHARMACOLOGY

Nicotinic receptor-based therapeutics and candidates for smoking cessation

(2009) Linda P. Dwoskin et al.   BIOCHEMICAL PHARMACOLOGY

The CHRNA5-CHRNA3-CHRNB4 Nicotinic Receptor Subunit Gene Cluster Affects Risk for Nicotine Dependence in African-Americans and in European-Americans

(2009) N. L. Saccone et al.   CANCER RESEARCH

Role of 5p15.33 (TERT-CLPTM1L), 6p21.33 and 15q25.1 (CHRNA5-CHRNA3) variation and lung cancer risk in never-smokers

(2009) Y. Wang et al.   CARCINOGENESIS

Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5

(2009) Jen C. Wang et al.   HUMAN MOLECULAR GENETICS

Sazetidine-A, a Selective  4 2 Nicotinic Receptor Desensitizing Agent and Partial Agonist, Reduces Nicotine Self-Administration in Rats

(2009) E. D. Levin et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The Rostromedial Tegmental Nucleus (RMTg), a GABAergic Afferent to Midbrain Dopamine Neurons, Encodes Aversive Stimuli and Inhibits Motor Responses

(2009) Thomas C. Jhou et al.   NEURON

Genome-wide Analysis of Chromatin Regulation by Cocaine Reveals a Role for Sirtuins

(2009) William Renthal et al.   NEURON

Effect of the α4β2∗ nicotinic acetylcholine receptor partial agonist varenicline on dopamine release in β2 knock-out mice with selective re-expression of the β2 subunit in the ventral tegmental area

(2009) Christelle Reperant et al.   NEUROPHARMACOLOGY

α-Conotoxin MII-Sensitive Nicotinic Acetylcholine Receptors in the Nucleus Accumbens Shell Regulate Progressive Ratio Responding Maintained by Nicotine

(2009) Darlene H Brunzell et al.   NEUROPSYCHOPHARMACOLOGY

Association and Interaction Analyses of GABBR1 and GABBR2 with Nicotine Dependence in European- and African-American Populations

(2009) Ming D. Li et al.   PLoS One

Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with ‘pleasurable buzz’ during early experimentation with smoking

(2008) Richard Sherva et al.   ADDICTION

Variants in Nicotinic Receptors and Risk for Nicotine Dependence

(2008) Laura Jean Bierut et al.   AMERICAN JOURNAL OF PSYCHIATRY

Pharmacology of Nicotine: Addiction, Smoking-Induced Disease, and Therapeutics

(2008) Neal L. Benowitz   Annual Review of Pharmacology and Toxicology

Nicotinic α7- or β2-containing receptor knockout: Effects on radial-arm maze learning and long-term nicotine consumption in mice

(2008) Edward D. Levin et al.   BEHAVIOURAL BRAIN RESEARCH

A Risk Allele for Nicotine Dependence in CHRNA5 Is a Protective Allele for Cocaine Dependence

(2008) Richard A. Grucza et al.   BIOLOGICAL PSYCHIATRY

Gene-Gene Interactions Among CHRNA4, CHRNB2, BDNF, and NTRK2 in Nicotine Dependence

(2008) Ming D. Li et al.   BIOLOGICAL PSYCHIATRY

The CHRNA5/A3/B4 Gene Cluster Variability as an Important Determinant of Early Alcohol and Tobacco Initiation in Young Adults

(2008) Isabel R. Schlaepfer et al.   BIOLOGICAL PSYCHIATRY

The Role of Cystine-Glutamate Exchange in Nicotine Dependence in Rats and Humans

(2008) Lori A. Knackstedt et al.   BIOLOGICAL PSYCHIATRY

Nicotinic Receptor Gene Variants Influence Susceptibility to Heavy Smoking

(2008) V. L. Stevens et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Smokers with the CHRNA Lung Cancer-Associated Variants Are Exposed to Higher Levels of Nicotine Equivalents and a Carcinogenic Tobacco-Specific Nitrosamine

(2008) L. Le Marchand et al.   CANCER RESEARCH

The serotonin 2A receptor gene in alcohol dependence and tobacco smoking

(2008) Evelise Regina Polina et al.   DRUG AND ALCOHOL DEPENDENCE

Influence of Neuronal Nicotinic Receptors over Nicotine Addiction and Withdrawal

(2008) Mariella De Biasi et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Significant association of the neurexin-1 gene (NRXN1) with nicotine dependence in European- and African-American smokers

(2008) J. Nussbaum et al.   HUMAN MOLECULAR GENETICS

Cocaine-like neurochemical effects of antihistaminic medications

(2008) Gianluigi Tanda et al.   JOURNAL OF NEUROCHEMISTRY

Crucial Role of  4 and  6 Nicotinic Acetylcholine Receptor Subunits from Ventral Tegmental Area in Systemic Nicotine Self-Administration

(2008) S. Pons et al.   JOURNAL OF NEUROSCIENCE

Positive Modulation of GABAB Receptors Decreased Nicotine Self-Administration and Counteracted Nicotine-Induced Enhancement of Brain Reward Function in Rats

(2008) N. E. Paterson et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Roles of Accessory Subunits in  4 2* Nicotinic Receptors

(2008) A. Kuryatov et al.   MOLECULAR PHARMACOLOGY

α-5/α-3 nicotinic receptor subunit alleles increase risk for heavy smoking

(2008) W Berrettini et al.   MOLECULAR PSYCHIATRY

A variant associated with nicotine dependence, lung cancer and peripheral arterial disease

(2008) Thorgeir E. Thorgeirsson et al.   NATURE

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

(2008) Rayjean J. Hung et al.   NATURE

Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1

(2008) Christopher I Amos et al.   NATURE GENETICS

Representation of negative motivational value in the primate lateral habenula

(2008) Masayuki Matsumoto et al.   NATURE NEUROSCIENCE

Decoding the Epigenetic Language of Neuronal Plasticity

(2008) Emiliana Borrelli et al.   NEURON

Genetic Association of the CHRNA6 and CHRNB3 Genes with Tobacco Dependence in a Nationally Representative Sample

(2008) Nicole R Hoft et al.   NEUROPSYCHOPHARMACOLOGY

NMDA Receptors Regulate Nicotine-Enhanced Brain Reward Function and Intravenous Nicotine Self-Administration: Role of the Ventral Tegmental Area and Central Nucleus of the Amygdala

(2008) Paul J Kenny et al.   NEUROPSYCHOPHARMACOLOGY

Insular hypocretin transmission regulates nicotine reward

(2008) J. A. Hollander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Varenicline versus transdermal nicotine patch for smoking cessation: results from a randomised open-label trial

(2008) H-J Aubin et al.   THORAX

Epigenetic mechanisms in drug addiction

(2008) William Renthal et al.   TRENDS IN MOLECULAR MEDICINE

A Candidate Gene Approach Identifies the CHRNA5-A3-B4 Region as a Risk Factor for Age-Dependent Nicotine Addiction

(2008) Robert B. Weiss et al.   PLoS Genetics