Article
Medicine, General & Internal
Silva A. Arslanian, Tamara Hannon, Philip Zeitler, Lily C. Chao, Claudia Boucher-Berry, Margarita Barrientos-Perez, Elise Bismuth, Sergio Dib, Jang Ik Cho, David Cox
Summary: In this 26-week trial, researchers found that once-weekly treatment with dulaglutide has significant efficacy in improving glycemic control among youths with type 2 diabetes.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Silva A. Arslanian, Tamara Hannon, Philip Zeitler, Lily C. Chao, Claudia Boucher-Berry, Margarita Barrientos-Perez, Elise Bismuth, Sergio Dib, Jang Ik Cho, David Cox
Summary: The incidence of type 2 diabetes mellitus is increasing among youths. Treatment with dulaglutide at a once-weekly dose of 0.75 mg or 1.5 mg was superior to placebo in improving glycemic control through 26 weeks among youths with type 2 diabetes, without an effect on BMI.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Han-Chow E. Koh, Chao Cao, Bettina Mittendorfer
Summary: Plasma insulin clearance plays an important role in determining plasma insulin concentration and is closely related to excess adiposity, insulin sensitivity, and type 2 diabetes. The lower insulin clearance rate observed in people with obesity is not a compensatory response to insulin resistance, but directly linked to insulin sensitivity. Additionally, postprandial insulin clearance decreases due to increased delivery of insulin to tissues that clear insulin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Biochemistry & Molecular Biology
Roy W. Beck
Summary: Automated insulin delivery systems, used in type 1 diabetes, hold promise for patients with type 2 diabetes and are expected to have a significant impact on public health.
Review
Medicine, General & Internal
Ehtasham Ahmad, Soo Lim, Roberta Lamptey, David R. Webb, Melanie J. Davies
Summary: Type 2 diabetes accounts for nearly 90% of global diabetes cases, with an increasing number of affected individuals, particularly among young people. Early detection and proactive management are crucial for preventing complications and reducing mortality. Technology and precision medicine offer potential improvements to treatment outcomes but face significant barriers.
Article
Biochemistry & Molecular Biology
Yajun Wu, Yao Wang, Dongmin Liu
Summary: The prevalence of type 2 diabetes (T2D) is increasing worldwide. Genipin, a natural compound, can stimulate the secretion of glucagon-like peptide-1 (GLP-1) from intestinal L-cells. In mice, genipin administration can increase GLP-1 secretion and reverse hyperglycemia and insulin resistance caused by a high-fat diet (HFD). Genipin also improves lipid metabolism and reduces liver lipid accumulation in obese mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Jinni Meng, Yafei Zhu, Huixia Ma, Xiaobo Wang, Qipeng Zhao
Summary: Traditional Chinese medicine (TCM) has been shown to be effective and safe in treating diabetic cognitive dysfunction (DCD), mainly by improving insulin resistance, microvascular dysfunction, abnormal gut microbiota composition, and inflammation. More in vivo, in vitro, and clinical trials are needed to further understand the quality markers of TCM in DCD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Esben S. Lauritzen, Ulla Kampmann, Mette G. B. Pedersen, Lise-Lotte Christensen, Niels Jessen, Niels M-ller, Julie Stoy
Summary: The study investigated the metabolic effects of long-term melatonin treatment in patients with type 2 diabetes, revealing that melatonin treatment decreased insulin sensitivity and increased glucose-stimulated insulin secretion in male patients.
JOURNAL OF PINEAL RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Shengnan Shen, Qiwen Liao, Yin Kwan Wong, Xiao Chen, Chuanbin Yang, Chengchao Xu, Jichao Sun, Jigang Wang
Summary: In type 2 diabetes mellitus (T2DM) and its related disorders, inflammation and impaired insulin signaling play a significant role in the development of Alzheimer's disease (AD). This review highlights the therapeutic potential of melatonin, which has antioxidative and anti-inflammatory effects, in preventing the acceleration of AD in T2DM individuals.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Nutrition & Dietetics
Stephanie K. Nishi, Effie Viguiliouk, Cyril W. C. Kendall, David J. A. Jenkins, Frank B. Hu, John L. Sievenpiper, Alessandro Atzeni, Anoop Misra, Jordi Salas-Salvado
Summary: Diabetes is a global concern affecting a significant proportion of adults, and nut consumption has been associated with positive health outcomes. There is evidence suggesting that nut consumption may play a role in preventing and managing type 2 diabetes, although more research is needed to confirm these findings.
Review
Biochemistry & Molecular Biology
Lixiang Zhai, Jiayan Wu, Yan Y. Lam, Hiu Yee Kwan, Zhao-Xiang Bian, Hoi Leong Xavier Wong
Summary: Type 2 diabetes is a metabolic disorder characterized by insulin resistance and impaired insulin secretion leading to high blood sugar levels. Disturbances in gut microbiota play a significant role in the development of insulin resistance in T2D. Research on gut microbial metabolites and probiotics-based therapeutic strategies show promise in alleviating insulin resistance in T2D by modulating gut microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Sevgican Demir, Peter P. Nawroth, Stephan Herzig, Bilges Ekim Ustunel
Summary: Type 2 diabetes is a chronic metabolic disorder characterized by insulin resistance and high blood sugar levels, with complications affecting various organs. Effective therapies are lacking, and further research on novel treatment targets is needed to pave the way for potential prevention and treatment of this disease.
Review
Endocrinology & Metabolism
Zhang-Liu Jin, Wei Liu
Summary: The global incidence of type 2 diabetes is on the rise, and bariatric surgical procedures are effective in providing relief. The mechanisms of these surgeries involve increased satiety and alterations in gastrointestinal hormones. Understanding these mechanisms can aid in developing better non-surgical treatments for type 2 diabetes.
WORLD JOURNAL OF DIABETES
(2021)
Review
Endocrinology & Metabolism
Markku Laakso, Lilian Fernandes Silva
Summary: Statins are commonly used to prevent cardiovascular disease events, but they also increase the risk of type 2 diabetes. These two diseases share common genetic and environmental factors. Studies have confirmed the association between statin treatment and type 2 diabetes, and the purpose of this review is to summarize the important findings and describe the mechanisms behind the increased risk.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, Research & Experimental
Simeon I. Taylor, Zhinous Shahidzadeh Yazdi, Amber L. Beitelshees
Summary: Diabetes mellitus is a significant public health issue, with pharmacotherapy aiming to prevent complications. Clinical trials have shown that intensive glycemic control can slow the progression of complications, with some drugs also demonstrating cardiovascular benefits and slowed progression of diabetic kidney disease.
JOURNAL OF CLINICAL INVESTIGATION
(2021)