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Oncology
Yongguang Zhang, Danfeng Lin, Yongwei Zheng, Yuhong Chen, Mei Yu, Dongya Cui, Miaohui Huang, Xinlin Su, Yong Sun, Yabing Chen, Zhijian Qian, Karen-Sue Carlson, Renren Wen, Demin Wang
Summary: Deletion of miR-9-1 results in smaller size and postweaning lethality in mice, as well as lymphopenia and impaired osteoblastic bone formation.
Review
Cell Biology
Feng Li, Ying Ye, Xiaohua Lei, Wensheng Zhang
Summary: With the development of science and technology, mankind's exploration of outer space has increased tremendously. Settling in outer space or on other planets could help solve the Earth's resource crisis, but such settlement will first face the problem of reproduction. There are considerable differences between outer space and the Earth's environment, with the effects of gravity being one of the most significant. Studying the possible effects and underlying mechanisms of microgravity on embryonic stem cell (ESC) differentiation and embryonic development could help provide solutions to healthy living and reproduction in deep space. This article summarizes recent research progress on the effects of microgravity on ESCs and early embryonic development and proposes hypotheses regarding the potential mechanisms. In addition, we discuss the controversies and key questions in the field and indicate directions for future research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jaeeun Lim, Eiko Sakai, Fuminori Sakurai, Hiroyuki Mizuguchi
Summary: Research reveals that miR-27b plays an antagonistic role in the early differentiation of human-induced pluripotent stem cells (hiPS cells), impacting cell differentiation and gene expression by inhibiting the bone morphogenetic protein (BMP) signaling pathway.
SCIENTIFIC REPORTS
(2021)
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Cell Biology
Shiyang Chen, Yajuan Zheng, Xiaojuan Ran, Hui Du, Hua Feng, Lei Yang, Yating Wen, Changdong Lin, Shihui Wang, Mengwen Huang, Zhanjun Yan, Dianqing Wu, Hongyan Wang, Gaoxiang Ge, An Zeng, Yi Arial Zeng, Jianfeng Chen
Summary: T cell contact with intestinal stem cells and transient amplifying cells plays a crucial role in regulating ISC differentiation by influencing the Wnt and Notch signaling pathways through cell-cell signaling. This interaction is essential in maintaining intestinal homeostasis and highlighting the importance of immune cells in intestinal function.
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Reproductive Biology
Xianrong Xiong, Manzhen Yang, Zhuo Hai, Xixi Fei, Yanjin Zhu, Bangting Pan, Qinhui Yang, Yumian Xie, Yuying Cheng, Yan Xiong, Daoliang Lan, Wei Fu, Jian Li
Summary: Kdm2a deficiency affects early embryonic development and female fertility by altering the transcriptome profile and disrupting the PI3K/Akt signaling pathway.
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Medicine, General & Internal
Xiang Gao, Guanhao Hong, Weiqiang Zhan, Tianfeng Liu, Shouquan Yan, Mingzhu Deng, Chenlin Tu, Peng Li
Summary: This study found that DPA can promote the osteogenic differentiation of hBMSCs through the miR-9-5p/ERK/ALP signaling pathway. This provides a potential therapeutic strategy for patients with bone loss.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Lavanya Kalaimani, Bharanidharan Devarajan, Venkatesh Prajna Namperumalsamy, Muthukkaruppan Veerappan, Julie T. Daniels, Gowri Priya Chidambaranathan
Summary: This study reveals a regulatory role of hsa-miR-150-5p in maintaining corneal epithelial stem cells by inhibiting the activation of the Wnt signaling pathway.
Article
Cell & Tissue Engineering
Wu Yang, Weiwen Zhu, Yunfei Yang, Minkang Guo, Husun Qian, Weiqian Jiang, Yu Chen, Chengjie Lian, Zijie Xu, Haobo Bai, Tingmei Chen, Jian Zhang
Summary: The study revealed that exosomes and miRNA from necrotic bone tissues of NONFH patients are involved in the pathogenesis of NONFH by inhibiting osteogenesis and angiogenesis. MiR-100-5p in NONFH exosomes targets BMPR2 and suppresses the BMPR2/SMAD1/5/9 signaling pathway, leading to NONFH-like damage. Silencing miR-100-5p expression rescues the reduction in osteogenesis and angiogenesis by activating the BMPR2/SMAD1/5/9 signaling pathway.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Thulaj Meharwade, Loick Joumier, Maxime Parisotto, Vivian Huynh, Edroaldo Lummertz da Rocha, Mohan Malleshaiah
Summary: Embryonic stem cells can simulate multiple states resembling different stages of early embryogenesis, and bone morphogenetic protein (BMP) signaling can induce the totipotent state. Cross-activated pathways can constrain the role of BMP, but by inhibiting these pathways, we can enhance the proportion of totipotent cells.
Article
Multidisciplinary Sciences
Lavanya Kalaimani, Bharanidharan Devarajan, Venkatesh Prajna Namperumalsamy, Muthukkaruppan Veerappan, Julie T. Daniels, Gowri Priya Chidambaranathan
Summary: This study aimed to investigate the regulatory role of hsa-miR-143-3p in corneal epithelial stem cells (CESCs). The researchers found that high expression of hsa-miR-143-3p increased colony forming potential and inhibited the expression of differentiation marker Cx43. Additionally, hsa-miR-143-3p was found to downregulate target genes involved in the Wnt-beta-catenin and MAPK signaling pathways, indicating its importance in maintaining the stemness of CESCs.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Yuchong Zhao, Yun Wang, Wei Chen, Shuya Bai, Wang Peng, Mengli Zheng, Yilei Yang, Bin Cheng, Zhou Luan
Summary: In pancreatic cancer, eIF4A1 downregulates E-cadherin expression through the c-MYC/miR-9 axis, promoting EMT and metastasis. Intervention on eIF4A1 and c-MYC can reduce the EMT and metastasis capabilities of pancreatic cancer cells.
CANCER CELL INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Joachim Hanna, Flavio Beke, Louise M. O'Brien, Chrysa Kapeni, Hung-Chang Chen, Valentina Carbonaro, Alexander B. Kim, Kamal Kishore, Timon E. Adolph, Mikkel-Ole Skjoedt, Karsten Skjoedt, Marc de la Roche, Maike de la Roche
Summary: The study implicates Hedgehog signaling in Th17 polarization and intestinal immunopathology, suggesting the potential therapeutic use of Hedgehog inhibitors in the treatment of inflammatory bowel disease.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Ming Lyu, Xu Wang, Xiangyu Meng, Hongrun Qian, Qian Li, Baoxia Ma, Zhiying Zhang, Kun Xu
Summary: This study reveals the role of chi-miR-487b-3p in regulating skeletal muscle development in goats. It inhibits myoblast proliferation and differentiation by targeting IRS1 and activating the PI3K/Akt signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Zhongrui Wang, Xiqian Zhou, Xiaochong Deng, Danrong Ye, Diya Liu, Baian Zhou, Wenfang Zheng, Xuehui Wang, Yuying Wang, Oyungerel Borkhuu, Lin Fang
Summary: Breast cancer is the most common cancer type in women worldwide. This study demonstrates that miR-186-5p inhibits proliferation and induces apoptosis in breast cancer cells by targeting ANXA9. These findings provide a potential therapeutic target for breast cancer.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Zhousheng Yang, Tianyu Li, Chunyan Wang, Mingyu Meng, Shenglan Tan, Lei Chen
Summary: Dihydromyricetin (DMY), a natural flavonoid compound extracted from Ampelopsis grossedentata, has been identified as a potential therapeutic chemical for treating atherosclerosis. This study investigates the mechanism by which DMY suppresses M1 macrophage polarization in atherosclerosis. The results showed that DMY treatment significantly reduced M1 macrophage markers and p65-positive macrophage numbers in the vessel wall of Apoe-deficient (Apoe(-/-)) mice.
MEDIATORS OF INFLAMMATION
(2023)