α-Synuclein Protects Neurons from Apoptosis Downstream of Free-Radical Production Through Modulation of the MAPK Signalling Pathway

Molecular targets of oxidative stress

(2011) Simon V. Avery   BIOCHEMICAL JOURNAL

Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson’s disease model

(2011) Won-Seok Choi et al.   JOURNAL OF CELL BIOLOGY

Overexpression of α-Synuclein Down-Regulates BDNF Expression

(2010) Yuhe Yuan et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The Genetics of Parkinson Disease

(2010) Lynn M. Bekris et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

α-Synuclein at the Synaptic Gate

(2010) D. James Surmeier   NEURON

Reduced expression of peroxisome-proliferator activated receptor gamma coactivator-1α enhances α-synuclein oligomerization and down regulates AKT/GSK3β signaling pathway in human neuronal cells that inducibly express α-synuclein

(2010) Abdul Shukkur Ebrahim et al.   NEUROSCIENCE LETTERS

Neuroprotective Upregulation of Endogenous Alpha-Synuclein Precedes Ubiquitination in Cultured Dopaminergic Neurons

(2010) R. E. J. Musgrove et al.   NEUROTOXICITY RESEARCH

Human brain cortex: mitochondrial oxidative damage and adaptive response in Parkinson disease and in dementia with Lewy bodies

(2009) Ana Navarro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Peroxidase Mechanism of Lipid-dependent Cross-linking of Synuclein with Cytochromec

(2009) Hülya Bayır et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipidomic profiling in mouse brain reveals differences between ages and genders, with smaller changes associated with α-synuclein genotype

(2009) Irit Rappley et al.   JOURNAL OF NEUROCHEMISTRY

The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7,in vitro

(2009) Christian Johannes Gloeckner et al.   JOURNAL OF NEUROCHEMISTRY

Contribution of a mitochondrial pathway to excitotoxic neuronal necrosis

(2009) Dae-Won Seo et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Mitochondrial association of alpha-synuclein causes oxidative stress

(2008) M. S. Parihar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The effect of α-synuclein knockdown on MPP+ toxicity in models of human neurons

(2008) Timothy M. Fountaine et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

(2008) Latha Devi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Controlling the mass action of α-synuclein in Parkinson’s disease

(2008) Changyoun Kim et al.   JOURNAL OF NEUROCHEMISTRY

Complex I deficiency in Parkinson's disease frontal cortex

(2007) W. Davis Parker et al.   BRAIN RESEARCH