Article
Cardiac & Cardiovascular Systems
Jessica Magid-Bernstein, Romuald Girard, Sean Polster, Abhinav Srinath, Sharbel Romanos, Issam A. Awad, Lauren H. Sansing
Summary: This review article provides an overview of the epidemiology, cause, mechanisms of injury, current treatment strategies, and future research directions of intracerebral hemorrhage (ICH). The incidence of hemorrhagic stroke has increased globally in the past 40 years, with changes in the cause over time due to improved hypertension management and increased use of anticoagulants. Preclinical and clinical trials have shed light on the underlying cause and mechanisms of injury from ICH, including the complex interaction between edema, inflammation, iron-induced injury, and oxidative stress. Although several trials have investigated the optimal medical and surgical management of ICH, there has been no clear improvement in survival and functional outcomes. Ongoing research into novel approaches for ICH management offers hope for reducing the devastating impact of this disease in the future.
CIRCULATION RESEARCH
(2022)
Article
Clinical Neurology
Kay-Cheong Teo, Sze-Man Fong, William C. Y. Leung, Ian Y. H. Leung, Yuen-Kwun Wong, Olivia M. Y. Choi, Ka-Keung Yam, Rachel C. N. Lo, Raymond T. F. Cheung, Shu-Leong Ho, Anderson C. O. Tsang, Gilberto K. K. Leung, Koon-Ho Chan, Kui-Kai Lau
Summary: This study aimed to determine the ideal hematoma volume cutoff for different intracerebral hemorrhage (ICH) locations in predicting ICH outcomes. The results showed that location-specific volume cutoff should be considered in patient selection for ICH trials, as the outcomes differed based on the size of the hematoma in different locations.
Article
Medicine, General & Internal
Ying Xian, Shuaiqi Zhang, Taku Inohara, Maria Grau-Sepulveda, Roland A. Matsouaka, Eric D. Peterson, Jonathan P. Piccini, Eric E. Smith, Kevin N. Sheth, Deepak L. Bhatt, Gregg C. Fonarow, Lee H. Schwamm
Summary: Patients with FXa inhibitor-associated ICH had a higher risk of mortality compared to those with warfarin-associated ICH but had better outcomes overall. Concomitant use of warfarin and antiplatelet therapy was associated with worse outcomes, while incremental risk was not significant in patients taking FXa inhibitors.
Article
Biochemistry & Molecular Biology
Ekaterina Vasilevskaya, Aleksandr Makarenko, Galina Tolmacheva, Irina Chernukha, Anastasiya Kibitkina, Liliya Fedulova
Summary: The study conducted a comprehensive short-term study on the development of cerebrovascular disorders in rats with an intracerebral hematoma model. The overall lethality of the model was 43.7% and it reflects the main diagnostic criteria for acute disorders of cerebral circulation.
Article
Biochemistry & Molecular Biology
Joana Maria Flaquer-Perez de Mendiola, Adria Arboix, Luis Garcia-Eroles, Maria Jose Sanchez-Lopez
Summary: This study investigates the effects of lobar and subcortical intracerebral hemorrhage (ICH) on the demographics, cerebrovascular risk factors, clinical characteristics, and early outcomes of patients. The results show that lobar ICH is independently associated with early seizures, chronic liver disease, hemianopia, headaches, alcohol abuse, hypertension, sensory deficit, and limb weakness. The in-hospital mortality is higher for lobar ICH compared to subcortical ICH. The study confirms that the site of bleeding in ICH patients significantly impacts their clinical profile, prognosis, and early mortality.
Article
Behavioral Sciences
Ling-Yi Liao, Pei-Dong Xu, Xiang-Qin Fang, Qing-Hua Wang, Yong Tao, Huan Cheng, Chang-Yue Gao
Summary: This study analyzed 304 patients with intracerebral hemorrhage and found that lower NIHSS scores, younger age, and drinking increased the risk of post-stroke spasticity, while smoking and hemorrhage in the thalamus reduced the risk.
BRAIN AND BEHAVIOR
(2023)
Article
Clinical Neurology
Edith H. Svensson, Martin Soderholm
Summary: Higher baseline FGF23 levels were significantly associated with incident intracerebral hemorrhage (ICH), particularly in lobar and non-lobar ICH. FGF23 was also significantly associated with fatal ICH, ICH with large volume, and ICH with poor functional outcome. Further studies are needed to determine if this association is causal.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Clinical Neurology
Turner S. Baker, John Durbin, Zachary Troiani, Luis Ascanio-Cortez, Rebecca Baron, Anthony Costa, Fred Rincon, Frederick Colbourne, Patrick Lyden, Stephan A. Mayer, Christopher P. Kellner
Summary: Therapeutic hypothermia has shown significant benefits in improving long-term outcomes in intracerebral hemorrhage in preclinical studies, but clinical studies have not yet confirmed these findings. More randomized controlled studies are needed to determine the true effectiveness of therapeutic hypothermia in this condition.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Clinical Neurology
Ashkan Shoamanesh, Magdy Selim
Summary: Hyperlipidemia is common in patients with intracerebral hemorrhage (ICH), but the benefits and harms of lipid-lowering treatments in this patient population are still unclear. There is currently no consensus on the optimal management strategy for hyperlipidemia after ICH, and more research is needed to guide treatment.
Article
Clinical Neurology
Linxin Li, Santosh B. Murthy
Summary: This article reviews the cardiovascular complications after ICH, including ischemic and hemorrhagic events, and highlights potential secondary stroke and venous thrombotic prevention strategies. The article also discusses the epidemiology and risk factors associated with these complications and their impact on ICH outcomes.
Article
Chemistry, Analytical
Junjie Zhang, Xianwei Su, Ao Qi, Lulu Liu, Lijian Zhang, Yu Zhong, Simin Xu, Ximei Liu, Juan Hu, Yusen Chen, Chun-yang Zhang, Chun Cai
Summary: The study developed a targeted metabolomic method to identify potential biomarkers for differentiating healthy individuals, AIS patients, and ICH patients, with 20-OH-LTB4 and CYP4F2 identified as potential biomarkers for ICH diagnosis and risk assessment. The method may provide a powerful platform for ICH diagnosis, prevention, and treatment assessment.
Review
Endocrinology & Metabolism
Zexu Wang, Jie Wang, Jiayan Wang, Yinghua Liao, Xin Hu, Manni Wang
Summary: This study summarized the relationship between obesity and mortality after intracerebral hemorrhage (ICH). The findings suggest that obesity may be associated with lower mortality in ICH, reflecting the obesity paradox in this disease.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Alastair J. S. Webb, David J. Werring
Summary: Despite advances in stroke management, hypertension remains a major risk factor for cerebrovascular disease. Blood pressure control is important, but doesn't fully prevent vascular cognitive impairment. The relationship between hypertension and cerebral blood flow control is not well understood. Increased blood pressure variability and changes in arterial stiffness may contribute to the risk of stroke. Targeting cerebral pulsatility and vascular reactivity in early clinical trials shows promise. The role of cerebral autoregulation as a modifiable risk factor is still uncertain. Understanding the pathophysiology of hypertension-related cerebrovascular disease may help prevent chronic cerebrovascular disease, acute events, and vascular cognitive impairment.
Article
Clinical Neurology
Laurent Derex, Sylvain Rheims, Laure Peter-Derex
Summary: Seizures are common after intracerebral hemorrhage and can have negative effects on outcomes, but the debate on whether treatment or prevention is beneficial continues. Further research on seizures and their management is needed to determine the best approach for improving clinical outcomes.
JOURNAL OF NEUROLOGY
(2021)
Review
Clinical Neurology
Lingling Qiu, Fangwang Fu, Wenyuan Zhang, Jinfeng He, Zhenxiang Zhan, Zicheng Cheng
Summary: This meta-analysis aimed to investigate the prevalence rate, risk factors, and clinical outcomes of remote intracerebral hemorrhage (rICH) after intravenous thrombolysis in acute ischemic stroke. The pooled prevalence of rICH was 3.2%, and patients with rICH were older, more likely to be female, and had a higher proportion of prior stroke, chronic heart failure, and cardioembolism. Small vessel disease markers were strongly associated with rICH. The presence of rICH decreased the likelihood of favorable outcomes and increased the risk of mortality.
JOURNAL OF NEUROLOGY
(2023)
