Article
Engineering, Biomedical
Hangkai Shen, Guy R. Fogel, Jia Zhu, Zhenhua Liao, Weiqiang Liu
Summary: LFPI reduced motion and intradiscal pressure at the transition segment under static loading, but induced higher motion and pressure at the adjacent segment. After surgery, vibration amplitudes of the L3-4 intradiscal pressure and L4-5 facet joint force decreased significantly. The DIAM system showed the most comparable biomechanics to the intact model and reduced dynamic responses under WBV.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2021)
Article
Chemistry, Multidisciplinary
Hung-Wen Wei, Shao-Ming Chuang, Chen-Sheng Chen
Summary: A new interspinous process device (NIPD) was developed to enhance spinal stability. The NIPD model showed a 23% decrease in ROM in extension, with minimal impact on disc stress and facet joint contact force.
APPLIED SCIENCES-BASEL
(2021)
Review
Orthopedics
Colleen Hood, Reza Zamani, Mohammad Akrami
Summary: This systematic review aimed to determine the prevalence, risk factors, and clinical and radiological impact of heterotopic ossification (HO) following lumbar total disc replacement (TDR). The review included 26 studies and estimated the pooled prevalence of HO to be between 13.2% and 15.3%. Age and follow-up time were identified as potential risk factors for HO. However, inconsistencies in the reporting of HO across the studies limited the ability to determine the impact of HO on clinical and radiological outcomes. The review recommends the development of guidelines to aid future researchers and reduce bias risks.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Clinical Neurology
Anna-Katharina Calek, Franziska Altorfer, Marie-Rosa Fasser, Jonas Widmer, Mazda Farshad
Summary: The purpose of this study is to develop and test a technique called synthetic vertebropexy that can be used after decompression surgery and compare it with the standard dorsal fusion procedure. The research found that both techniques have similar effects in reducing lumbar segmental motion, but differ in shear forces.
EUROPEAN SPINE JOURNAL
(2023)
Article
Multidisciplinary Sciences
Minhyeok Heo, Jihwan Yun, Hanjong Kim, Sang-Soo Lee, Seonghun Park
Summary: This study aimed to optimize a lumbar interspinous fixation device (LIFD) using a finite element model, allowing for minimally invasive surgery without compromising the normal behavior of the lumbar spine. The optimum number of spring turns and spring wire diameter were determined based on the dynamic range of motion (ROM) perspective. The optimized device was found to enhance stability and reduce the risk of degenerative diseases in adjacent lumbar segments.
Article
Computer Science, Interdisciplinary Applications
Wei Fan, Li-Xin Guo
Summary: The topping-off technique can reduce disc stress at the transition segment (L3-L4), while slightly increasing disc stress at its supra-adjacent segment (L2-L3). Bony fusion can decrease stress in L4 inferior endplate and rigid stabilizer, while having nearly no effect on stress in DIAM and L3-L4 disc.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2021)
Article
Engineering, Biomedical
Wei Fan, Chi Zhang, Dong-Xiang Zhang, Li-Xin Guo, Ming Zhang
Summary: This study aimed to compare the effects of two commonly used nonfusion posterior dynamic stabilization (NPDS) devices, PSDS and IPS, on the biomechanics of the implanted lumbar spine under static and vibration loadings. The results showed that the nonfusion models had higher range of motion (ROM) at L4-L5 level compared to the rigid fusion model, but lower ROM at adjacent levels. Additionally, there were biomechanical differences between the Bioflex and DIAM systems.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2022)
Article
Orthopedics
Kai-Yu Li, Hua-Lin Li, Lin-Jie Chen, Jian-Wei Xiang, Chen-Chao Li, Jun-Jie Weng, Nai-Feng Tian
Summary: This study aims to evaluate complications, clinical outcomes, and radiographic results following Coflex implantation. The majority of patients had improved clinical outcomes after surgery, but complications such as heterotopic ossification and Coflex loosening were observed in some cases.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Orthopedics
Yijian Zhang, Dongdong Lu, Wei Ji, Fan He, Angela Carley Chen, Huilin Yang, Xuesong Zhu
Summary: A Bayesian network meta-analysis of 10 randomized controlled trials revealed that non-fusion methods (decompression, interspinous process device) are effective options for treating lumbar spinal stenosis, with interspinous process device showing low complication rates but caution needed for its high reoperation rate.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2021)
Review
Clinical Neurology
Nicholas Hui, Kevin Phan, Mei-Yi Lee, Jack Kerferd, Telvinderjit Singh, Ralph J. Mobbs
Summary: This study demonstrated that cervical biomechanics significantly increased after CTDR, while there was no association with rates of HO and ROM-limiting HO. Single-level CTDR and duration of follow-up were associated with changes in cervical biomechanics.
GLOBAL SPINE JOURNAL
(2021)
Article
Clinical Neurology
Catharina D. Schenck, Sietse E. S. Terpstra, Wouter A. Moojen, Erik van Zwet, Wilco Peul, Mark P. Arts, Carmen L. A. Vleggeert-Lankamp
Summary: This study compared the long-term outcomes of decompressive surgery and IPD implantation in patients with intermittent neurogenic claudication due to lumbar spinal stenosis. The results showed that the success rates in terms of ZCQ score at 5-year follow-up were similar between the two groups, but the IPD group had a higher reoperation rate at 2 years after surgery. Additionally, the IPD group had a lower visual analog scale score for back pain during long-term follow-up.
JOURNAL OF NEUROSURGERY-SPINE
(2022)
Article
Orthopedics
Yoon Joo Cho, Jong-Beom Park, Dong-Gune Chang, Hong Jin Kim
Summary: This study aimed to investigate the 15-year survivorship and risk factors for reoperation of DIAM in surgery for 1-level lumbar disc herniation, finding that DIAM implantation significantly decreased reoperation rate for LDH. Therefore, DIAM implantation could be considered a useful intermediate step procedure for LDH surgery.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Orthopedics
Roland E. Willburger, Friederike Brinkhoff, Jan Nottenkamper, Jan Krapp, Stella Oberberg
Summary: The formation of HO is completed three years after THA, and after this point, HO will not further increase. If HO occurs or increases after more than three years postoperatively, other triggering causes should be considered.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Review
Cell Biology
Robert J. Pignolo, Maurizio Pacifici
Summary: Metabolic derivatives of vitamin A, known as retinoids, regulate tissue and organ functions prenatally and postnatally. Studies showed that chondrogenic cell differentiation and cartilage maturation require the absence of retinoid signaling and repression function by unliganded RARs. Synthetic retinoid agonists could be potential pharmacological agents to inhibit heterotopic ossification.
Review
Cell & Tissue Engineering
Lukasz Pulik, Bartosz Mierzejewski, Aleksandra Sibilska, Iwona Grabowska, Maria Anna Ciemerych, Pawel Legosz, Edyta Brzoska
Summary: Heterotopic ossification is the formation of bone in non-osseous tissues, and it can be caused by genetic or non-genetic factors. TGF beta 1, BMPs, activin A, and other factors are known to induce HO. Dysregulation of noncoding RNAs may also play a role in the development of HO.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell Biology
Libin Ni, Jian Xiao, Di Zhang, Zhenxuan Shao, Chongan Huang, Sheng Wang, Yaosen Wu, Naifeng Tian, Liaojun Sun, Aimin Wu, Yifei Zhou, Xiangyang Wang, Xiaolei Zhang
Summary: This study demonstrates the involvement of Irg-1 and itaconate in the recovery process of spinal cord injury (SCI). The overexpression of Irg-1 and treatment with itaconate show promising effects in suppressing inflammation and improving motor function recovery in SCI.
CELL DEATH & DISEASE
(2022)
Article
Orthopedics
Ben Wang, Jie Jin, Zhen-xuan Shao, Guang-yong Yang, Yan Lin, Hua-zi Xu, Cheng-long Xie, Jiao-xiang Chen, Xiao-lei Zhang, Zheng-hua Hong, Xiang-yang Wang
Summary: This study investigated a modified axial translaminar screw fixation for treating odontoid fractures, with accurate screw placement and simple operation being highlighted as key benefits. The surgical technique involved creating a small cortical window for visualized screw insertion, leading to successful outcomes and high patient satisfaction.
ORTHOPAEDIC SURGERY
(2022)
Correction
Medicine, General & Internal
Gang Zheng, Yu Zhan, Haoli Wang, Zucheng Luo, Fanghong Zheng, Yifei Zhou, Yaosen Wu, Sheng Wang, Yan Wu, Guangheng Xiang, Cong Xu, Huazi Xu, Naifeng Tian, Xiaolei Zhang
Article
Cell Biology
Chenglong Xie, Yifeng Shi, Zuoxi Chen, Xin Zhou, Peng Luo, Chenxuan Hong, Naifeng Tian, Yaosen Wu, Yifei Zhou, Yan Lin, Haicheng Dou, Aimin Wu, Qishan Huang, Xiaolei Zhang, Xiangyang Wang
Summary: This study explored the effects of apigenin on intervertebral disc degeneration (IVDD) and found that it has a protective role in NP cells. It was found that apigenin can inhibit apoptosis, senescence, and ECM degradation, and also restore the blockage of autophagic flux. Mechanistically, apigenin promotes the nuclear translocation of TFEB via the AMPK/mTOR signaling pathway to alleviate autophagy dysfunction.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Libin Ni, Zhen Lin, Sunli Hu, Yifeng Shi, Zhichen Jiang, Jiayi Zhao, Yifei Zhou, Yaosen Wu, Naifeng Tian, Liaojun Sun, Aimin Wu, Zongyou Pan, Xiaolei Zhang, Xiangyang Wang
Summary: This study found that exogenous supplementation of itaconate inhibits inflammation and senescence of chondrocytes through the Nrf2/STING/NF-kappa B axis, reducing the progression of osteoarthritis. Itaconate also regulates the polarization of macrophages, reducing apoptosis of chondrocytes. In vivo, intra-articular injection of itaconate reduces cartilage degradation and synovial membrane inflammation in a mouse model of osteoarthritis.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Engineering, Environmental
Zengjie Zhang, Xiaolei Zhang, Chenggui Wang, Wangsiyuan Teng, Hongyuan Xing, Fangqian Wang, Eloy Yinwang, Hangxiang Sun, Yan Wu, Chengcheng Yu, Xupeng Chai, Zhiyong Qian, Xiaohua Yu, Zhaoming Ye, Xiangyang Wang
Summary: Persistent inflammation during the secondary injury of spinal cord injury is identified as the main cause of poor regenerative capability of spinal cord. Extracellular vesicles derived from M2 microglia have shown therapeutic potential for inflammation alleviation and neural regeneration. However, their applications in spinal cord injury treatment are limited due to issues such as poor accumulation, short retention, and lack of controlled release. Therefore, a novel thermosensitive hydrogel system was developed to deliver M2 derived extracellular vesicles for spinal cord injury treatment. The hydrogel enabled effective retention and controlled release of the vesicles, resulting in improved motor nerve functional recovery. Mechanistic study revealed that the sustained release of the vesicles attenuated local inflammation and inhibited neuron apoptosis, thus protecting the spinal cord. This approach provides a microenvironment-responsive and noninvasive method to improve spinal cord injury therapy through both anti-inflammatory and neural protective mechanisms.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Plant Sciences
Yifeng Shi, Jiaoxiang Chen, Sunlong Li, Yuhao Wu, Caiyu Yu, LiBin Ni, Jian Xiao, Zhenxuan Shao, Huanqing Zhu, Jianshun Wang, Xiangyang Wang, Xiaolei Zhang
Summary: Tangeretin, a natural flavonoid with anti-inflammatory properties, has been found to inhibit inflammation and extracellular matrix (ECM) degradation, effectively preventing the progression of osteoarthritis (OA). These effects are mediated through the Nrf2/NF-kappa B and MAPK/NF-kappa B pathways.
Review
Biotechnology & Applied Microbiology
Yuhao Wu, Shiwei Shen, Yifeng Shi, Naifeng Tian, Yifei Zhou, Xiaolei Zhang
Summary: In this article, the involvement of senescence in intervertebral disc degeneration (IVDD) is reviewed, and the potential of senolytics in eliminating senescent disc cells and alleviating IVDD is discussed. A table listing potential drugs for IVDD therapy is also provided.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Rheumatology
Shiyao Liao, Qiangqiang Zheng, Haotian Shen, Guang Yang, Yuzi Xu, Xiaolei Zhang, Hongwei Ouyang, Zongyou Pan
Summary: HECTD1 plays a crucial role in the pathogenesis of osteoarthritis by regulating chondrocyte autophagy through ubiquitinating and targeting Rubicon for proteasomal degradation. This finding reveals the importance of HECTD1 in the development of osteoarthritis.
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Orthopedics
S. Li, X. Pan, Y. Wu, Y. Tu, W. Hong, J. Ren, J. Miao, T. Wang, W. Xia, J. Lu, J. Chen, X. Hu, Y. Lin, X. Zhang, X. Wang
Summary: In this study, the protective effect of Interleukin-37 (IL-37) on intervertebral disc degeneration (IDD) was evaluated. IL-37 was found to decrease during the IDD process and the experimental results showed that IL-37 can suppress the SASP factors level and senescence phenotype in IL-1b treated cells. Animal experiments also demonstrated that IL-37 can alleviate IDD progression in a puncture-induced rat model. Mechanistic studies revealed that IL-37 inhibits IDD progression by downregulating the activation of the NF-kB pathway through the activation of IL-1R8.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Orthopedics
Weiyi Xia, Jian Xiao, ChengLin Tong, Jiajie Lu, Yurong Tu, Sunlong Li, Libing Ni, Yifeng Shi, Peng Luo, Xiaolei Zhang, Xiangyang Wang
Summary: The effects of Orientin on murine chondrocytes treated with IL-1 beta were evaluated in vitro, and the healing effect of Orientin was assessed in a standard OA model in mice. Results showed that Orientin suppressed pro-inflammatory mediators and cartilage degradation, and downregulated activation of NF-kappa B by activating Nrf2/HO-1 axis and SIRT6 signaling pathway, suggesting its potential as a treatment for OA.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Chemistry, Medicinal
Cheng Teng, Jingtao Wu, Zhao Zhang, Jinquan Wang, Ye Yang, Chengji Dong, Long Wu, Zhen Lin, Yuezheng Hu, Jing Wang, Xiaolei Zhang, Zhongke Lin
Summary: This study investigated the effect of fucoxanthin (FX) on oxidative stress-induced nucleus pulposus (NP) cell apoptosis and its molecular mechanism. The results showed that FX could reduce apoptosis and extracellular matrix degradation by regulating the Sirt1 and PERK-eIF2 alpha-ATF4-CHOP signaling pathways. In vivo experiments demonstrated that FX improved intervertebral disc degeneration (IDD). These findings suggest that FX may be a potential drug for the treatment of IDD.
PHYTOTHERAPY RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Yu Chen, Chenyu Wu, Xiaoying Zhao, Hongye Tan, Chenchao Li, Yuxin Deng, Ximiao Chen, Yaosen Wu, Naifeng Tian, Xiaolei Zhang, Yifei Zhou, Liaojun Sun
Summary: This study found that the drug 20-Deoxyingenol (20-DOI) can enhance the autophagy-lysosomal pathway in nucleus pulposus cells by activating transcription factor EB (TFEB), thereby suppressing cell senescence and impeding the progression of IVDD.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wenxian Zhou, Yifeng Shi, Hui Wang, Linjie Chen, Caiyu Yu, Xufei Zhang, Lei Yang, Xiaolei Zhang, Aimin Wu
Summary: A study has found that physical exercise promotes the expression of a protein called irisin, which protects against intervertebral disc degeneration. This discovery suggests that increasing the activity of irisin through either exercise or drugs could help alleviate back pain and slow down the progression of the disease.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Geriatrics & Gerontology
Sunlong Li, Chongan Huang, Jian Xiao, Yuhao Wu, Zengjie Zhang, Yifei Zhou, Naifeng Tian, Yaosen Wu, Xiangyang Wang, Xiaolei Zhang
Summary: This review summarizes the changes in plasma cytokine levels in diabetic patients and discusses the potential role of elevated cytokines in diabetes-induced IVDD.