Article
Clinical Neurology
David J. Roh, Ifeyinwa S. Asonye, Fernanda Carvalho Poyraz, Jessica R. Magid-Bernstein, Evan F. Joiner, Radhika Avadhani, Issam Awad, Daniel F. Hanley, Wendy C. Ziai, Santosh B. Murthy
Summary: This study aimed to evaluate factors associated with intraventricular hemorrhage expansion and its impact on long-term outcomes. The authors found that acute hematoma characteristics, such as larger parenchymal volume, hematoma expansion, and thalamic intracerebral hemorrhage location, were associated with intraventricular hemorrhage expansion. Additionally, intraventricular hemorrhage expansion was associated with poor clinical outcomes. This study highlights the importance of optimizing hemostasis and preventing intraventricular hemorrhage expansion.
Article
Clinical Neurology
Fangke Xie, Qiang Tan, Anyong Yu, Peiwen Guo, Ling Wang, Zongwei Zeng, Liang Liang, Jishu Xian, Hua Feng, Zhi Chen
Summary: The presence of cfDNA in clots was observed shortly after intraventricular hemorrhage, and it was found to impair the fibrinolysis effects of tPA. Degradation of cfDNA by DNase1 enhanced fibrinolysis and improved functional outcomes, suggesting that targeting cfDNA degradation may be a promising approach to treat intraventricular hemorrhage.
JOURNAL OF NEUROSURGERY
(2021)
Article
Hematology
Ting Yang, Hongfei Jing, Yungang Cao, Xianda Lin, Jueyue Yan, Meijuan Xiao, Xiaoyan Huang, Zicheng Cheng, Zhao Han
Summary: The study found that patients with different subtypes of ICH after r-tPA treatment have different clinical outcomes. Specifically, the PH-2 subtype is significantly associated with early neurological deterioration and increased mortality at the third month.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2021)
Review
Clinical Neurology
Zelong Zheng, Qi Wang, Shujie Sun, Jinbiao Luo
Summary: Spontaneous intracerebral hemorrhage is one of the most devastating types of stroke, with high mortality and morbidity. The optimal management of this condition remains controversial, and conventional surgical interventions and medical management have shown limited benefit. However, minimally invasive surgery for intracerebral hemorrhage has shown promising results in early phase clinical trials.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Kazunori Toyoda, Manabu Inoue, Sohei Yoshimura, Hiroshi Yamagami, Makoto Sasaki, Mayumi Fukuda-Doi, Kazumi Kimura, Koko Asakura, Kaori Miwa, Takao Kanzawa, Masafumi Ihara, Rei Kondo, Masayuki Shiozawa, Masafumi Ohtaki, Kenji Kamiyama, Ryo Itabashi, Toru Iwama, Junya Aoki, Kazuo Minematsu, Haruko Yamamoto, Masatoshi Koga
Summary: This study focused on low-dose thrombolysis in patients with unknown onset stroke and found that patients with DWI-ASPECTS of 5 to 8 were more likely to have favorable outcomes after treatment.
Article
Pharmacology & Pharmacy
Yang Ye, Quan Li, Chun-Shui Pan, Li Yan, Kai Sun, Xiao-Yi Wang, Shu-Qi Yao, Jing-Yu Fan, Jing-Yan Han
Summary: The study demonstrated that QiShenYiQi (QSYQ) can attenuate tPA-induced brain edema and hemorrhage by protecting blood-brain barrier integrity, partly through restoration of energy metabolism, inflammation protection, and Src/Caveolin signaling activation. QSYQ was shown to be an effective adjunctive therapy to increase the safety of delayed tPA thrombolysis for ischemic stroke.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Johannes Kaesmacher, Thomas R. Meinel, Stefania Nannoni, Marta Olive-Gadea, Eike Piechowiak, Christian Maegerlein, Martina Goeldlin, Laurent Pierot, David J. Seiffge, Vitor Mendes Pereira, Mirjam R. Heldner, Lorenz Grunder, Vincent Costalat, Marcel Arnold, Tomas Dobrocky, Jan Gralla, Pasquale Mordasini, Urs Fischer
Summary: The extent of early ischemia may influence relative risks of sICH in IVT+MT versus direct MT patients, with an excess sICH risk in IVT+MT patients with low ASPECTS. If confirmed in post hoc analyses of randomized controlled trial data, IVT may be administered more carefully in patients with low ASPECTS eligible for and with direct access to MT.
Article
Immunology
Aaron M. Gusdon, Carol B. Thompson, Kendel Quirk, Yunis M. Mayasi, Radhika Avadhani, Issam A. Awad, Daniel F. Hanley, Wendy C. Ziai
Summary: The study found that in patients with ICH and IVH, treatment with alteplase compared to saline resulted in significantly enhanced inflammatory response in CSF leukocyte subtypes. Increased serum lymphocytes may be associated with better outcomes, while increased neutrophil-to-lymphocyte ratio (NLR) may be associated with worse outcomes.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Acoustics
Leela Goel, Huaiyu Wu, Bohua Zhang, Jinwook Kim, Paul A. Dayton, Zhen Xu, Xiaoning Jiang
Summary: The study evaluated the safety of a forward-viewing intravascular (FVI) transducer for sonothrombolysis, showing minimal risk in terms of tissue heating, vessel damage, and particle debris size. Further evaluation in animal models is warranted to explore its potential applications.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Claire S. Whyte, Hadj Ahmed. Mostefai, Kim M. Baeten, Andrew J. Lucking, David E. Newby, Nuala A. Booth, Nicola J. Mutch
Summary: The resolution of arterial thrombi relies on the endogenous fibrinolytic system. tPA primarily localizes to the thrombus head in a free and active form. Thrombi formed under high shear conditions are more resistant to fibrinolysis due to less tPA and increased PAI-1 concentrations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Audrey M. Thiebaut, Estelle R. Louet, Melina Ianszen, Marie-Julie Guichard, Daniel F. Hanley, Christophe Gaudin, Jerome Parcq
Summary: Intracerebral haemorrhage is a global medical need, affecting over 3 million people annually and resulting in the formation of a haematoma in the brain. Updated guidelines recognize the potential of minimally invasive approaches for haematoma evacuation, but current thrombolytic agents have limitations in terms of efficacy and safety. This study demonstrates that O2L-001, an extended-release formulation of the engineered recombinant tissue-type plasminogen activator (OptPA), offers improved efficacy and safety for haematoma evacuation.
Review
Biochemistry & Molecular Biology
Manuel Yepes, Yena Woo, Cynthia Martin-Jimenez
Summary: The neurovascular unit is a complex structure involving various cells and components that are essential for maintaining normal neuronal function. Plasminogen activators play a crucial role in regulating the function of the neurovascular unit, with dysfunction leading to neurodegenerative disorders. Research on the expression and function of tissue-type plasminogen activator and urokinase-type plasminogen activator in the neurovascular unit has provided valuable insights into neurovascular and neurodegenerative disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Stalik Dzhauari, Svetlana Litvinova, Anastasia Efimenko, Natalia Aleksandrushkina, Nataliya Basalova, Maxim Abakumov, Natalia Danilova, Pavel Malkov, Vadim Balabanyan, Tatiana Bezuglova, Viktor Balayants, Maxim Mnikhovich, Mikhail Gulyaev, Mariya Skryabina, Vladimir Popov, Dmitry Stambolsky, Tatiana Voronina, Vsevolod Tkachuk, Maxim Karagyaur
Summary: Brain-derived neurotrophic factor (BDNF) is a classic neuroprotective and pro-regenerative factor. Combining BDNF with urokinase-type plasminogen activator (uPA) provides effective neuroprotection and promotes neurological recovery after brain injury.
Article
Medicine, Research & Experimental
In-Hyoung Lee, Jong-Il Choi
Summary: This retrospective study compared outcomes of neuronavigation-assisted aspiration and thrombolysis in 102 patients with moderate-volume supratentorial spontaneous intracerebral hemorrhage using single and multiple catheter insertion. It found that single-catheter insertion shortened surgical time and reduced the incidence of catheter tract hemorrhage compared to multi-catheter insertion.
MEDICAL SCIENCE MONITOR
(2021)
Article
Multidisciplinary Sciences
Bohua Zhang, Huaiyu Wu, Howuk Kim, Phoebe J. Welch, Ashley Cornett, Greyson Stocker, Raul G. Nogueira, Jinwook Kim, Gabe Owens, Paul A. Dayton, Zhen Xu, Chengzhi Shi, Xiaoning Jiang
Summary: This research demonstrates a new vortex ultrasound technique for endovascular sonothrombolysis, which has the potential to significantly improve the treatment of cerebral venous sinus thrombosis. The study shows that the new technique increases the lytic rate by at least 64.3% compared to conventional ultrasound treatment. In vitro experiments also achieved complete recanalization of a completely occluded model within 8 minutes, with a record-high lytic rate. This vortex ultrasound thrombolysis technique presents a new life-saving tool for severe CVST cases.
Article
Geriatrics & Gerontology
Johannes Boltze, Jaroslaw A. Aronowski, Jerome Badaut, Marion S. Buckwalter, Mateo Caleo, Michael Chopp, Kunjan R. Dave, Nadine Didwischus, Rick M. Dijkhuizen, Thorsten R. Doeppner, Jens P. Dreier, Karim Fouad, Mathias Gelderblom, Karen Gertz, Dominika Golubczyk, Barbara A. Gregson, Edith Hamel, Daniel F. Hanley, Wolfgang Haertig, Friedhelm C. Hummel, Maulana Ikhsan, Miroslaw Janowski, Jukka Jolkkonen, Saravanan S. Karuppagounder, Richard F. Keep, Inga K. Koerte, Zaal Kokaia, Peiying Li, Fudong Liu, Ignacio Lizasoain, Peter Ludewig, Gerlinde A. S. Metz, Axel Montagne, Andre Obenaus, Alex Palumbo, Monica Pearl, Miguel Perez-Pinzon, Anna M. Planas, Nikolaus Plesnila, Ami P. Raval, Maria A. Rueger, Lauren H. Sansing, Farida Sohrabji, Charlotte J. Stagg, R. Anne Stetler, Ann M. Stowe, Dandan Sun, Akihiko Taguchi, Mickael Tanter, Sabine U. Vay, Raghu Vemuganti, Denis Vivien, Piotr Walczak, Jian Wang, Ye Xiong, Marietta Zille
Summary: The past decade has witnessed significant advancements in both diagnosis and treatment of cerebrovascular diseases, with the introduction of thrombectomy in ischemic stroke and the identification of new therapeutic targets based on deeper understanding of pathomechanisms. Additionally, translational aspects are increasingly recognized in basic science studies, enhancing their predictive value for clinical application.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Immunology
Michael H. Askenase, Brittany A. Goods, Hannah E. Beatty, Arthur F. Steinschneider, Sofia E. Velazquez, Artem Osherov, Margaret J. Landreneau, Shaina L. Carroll, Tho B. Tran, Victor S. Avram, Riley S. Drake, G. James Gatter, Jordan A. Massey, Saravanan S. Karuppagounder, Rajiv R. Ratan, Charles C. Matouk, Kevin N. Sheth, Wendy C. Ziai, Adrian R. Parry-Jones, Issam A. Awad, Mario Zuccarello, Richard E. Thompson, Jesse Dawson, Daniel F. Hanley, J. Christopher Love, Alex K. Shalek, Lauren H. Sansing
Summary: By analyzing longitudinal transcriptional profiles in the hematomas of patients with ICH, it was found that the myeloid response to ICH displays a conserved progression from proinflammatory to proresolution states over time. These findings provide insights into the time course of immune responses in the human brain after injury and identify transcriptional programs associated with neurological recovery.
SCIENCE IMMUNOLOGY
(2021)
Article
Clinical Neurology
Carlos S. Kase, Daniel F. Hanley
NEUROLOGIC CLINICS
(2021)
Article
Medicine, Research & Experimental
Brittany A. Goods, Michael H. Askenase, Erica Markarian, Hannah E. Beatty, Riley S. Drake, Ira Fleming, Jonathan H. DeLong, Naomi H. Philip, Charles C. Matouk, Issam A. Awad, Mario Zuccarello, Daniel F. Hanley, J. Christopher Love, Alex K. Shalek, Lauren H. Sansing
Summary: This study focused on intracerebral hemorrhage (ICH) in a patient, revealing the importance of inflammation in brain tissue injury and demonstrating dynamic changes in leukocyte responses over time using single-cell RNA-Seq. The findings suggest that sensitive methods such as scRNA-Seq could provide greater understanding of complex intracerebral events.
Article
Immunology
Aaron M. Gusdon, Carol B. Thompson, Kendel Quirk, Yunis M. Mayasi, Radhika Avadhani, Issam A. Awad, Daniel F. Hanley, Wendy C. Ziai
Summary: The study found that in patients with ICH and IVH, treatment with alteplase compared to saline resulted in significantly enhanced inflammatory response in CSF leukocyte subtypes. Increased serum lymphocytes may be associated with better outcomes, while increased neutrophil-to-lymphocyte ratio (NLR) may be associated with worse outcomes.
JOURNAL OF NEUROINFLAMMATION
(2021)
Editorial Material
Neurosciences
Lourdes R. Carhuapoma, Avni Kapadia, Henry A. Glick, Daniel F. Hanley
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2021)
Article
Neurosciences
Ali Mansour, Andrea Loggini, Faten El Ammar, Ronald Alvarado-Dyer, Sean Polster, Agnieszka Stadnik, Paramita Das, Peter C. Warnke, Bakhtiar Yamini, Christos Lazaridis, Christopher Kramer, W. Andrew Mould, Meghan Hildreth, Matthew Sharrock, Daniel F. Hanley, Fernando D. Goldenberg, Issam A. Awad
Summary: This study aimed to enhance procedure deployment rates and technical performance with minimally invasive surgery and thrombolysis for intracerebral hemorrhage (ICH) evacuation (MISTIE) in post-trial clinical practice. Results showed that AI-based measurements had excellent correlation with manual segmentation, and higher technical success rates were achieved in post-trial clinical practice compared to the MISTIE III trial.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2021)
Correction
Immunology
Wei Zhu, Yufeng Gao, Jieru Wan, Xi Lan, Xiaoning Han, Shanshan Zhu, Weidong Zang, Xuemei Chen, Wendy Ziai, Daniel F. Hanley, Scott J. Russo, Ricardo E. Jorge, Jian Wang
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Clinical Neurology
David J. Roh, Ifeyinwa S. Asonye, Fernanda Carvalho Poyraz, Jessica R. Magid-Bernstein, Evan F. Joiner, Radhika Avadhani, Issam Awad, Daniel F. Hanley, Wendy C. Ziai, Santosh B. Murthy
Summary: This study aimed to evaluate factors associated with intraventricular hemorrhage expansion and its impact on long-term outcomes. The authors found that acute hematoma characteristics, such as larger parenchymal volume, hematoma expansion, and thalamic intracerebral hemorrhage location, were associated with intraventricular hemorrhage expansion. Additionally, intraventricular hemorrhage expansion was associated with poor clinical outcomes. This study highlights the importance of optimizing hemostasis and preventing intraventricular hemorrhage expansion.
Review
Clinical Neurology
Adnan Qureshi, Abdullah Lodhi, Iqra N. Akhtar, Xiaoyu Ma, Danish Kherani, Chun Shing Kwok, Daniel E. Ford, Daniel F. Hanley, Ameer E. Hassan, Thanh N. Nguyen, Alejandro M. Spiotta, Syed F. Zaidi
Summary: This systematic review found conflicting evidence on the benefit of intra-arterial thrombolysis (IAT) in patients with acute stroke undergoing mechanical thrombectomy (MT). Statistical analysis showed no significant difference in functional independence, mortality, or angiographic recanalization between IAT and MT alone. Furthermore, the study design and quality had a significant impact on the association between IAT and functional independence at 90 days.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Editorial Material
Critical Care Medicine
Lourdes R. Carhuapoma, Radhika Avadhani, Daniel F. Hanley
NEUROCRITICAL CARE
(2023)
Article
Clinical Neurology
Abdulaziz T. Bako, Thomas Potter, Alan P. Pan, Jonika Tannous, Gavin Britz, Wendy C. Ziai, Issam Awad, Daniel Hanley, Farhaan S. Vahidy
Summary: The study examined the relationship between corticostriatal A beta-amyloid deposition and cognitive dysfunction in patients with Parkinson disease at risk for dementia. PET imaging and neuropsychological assessments were conducted on 40 PD patients, revealing a significant correlation between cortical PiB binding and global cognitive function.
Letter
Clinical Neurology
Vishank A. Shah, Lourdes Carhuapoma, Daniel F. Hanley, Wendy C. Ziai
Article
Medicine, Research & Experimental
Daniel F. F. Hanley Jr, Gordon R. Bernard, Consuelo H. Wilkins, Harry P. Selker, Jamie P. Dwyer, J. Michael Dean, Daniel Kelly Benjamin Jr, Sarah E. Dunsmore, Salina P. Waddy, Kenneth L. L. Wiley Jr, Marisha E. Palm, W. Andrew Mould, Daniel F. Ford, Jeri S. Burr, Jacqueline Huvane, Karen Lane, Lori Poole, Terri L. Edwards, Nan Kennedy, Leslie R. Boone, Jasmine Bell, Emily Serdoz, Loretta M. Byrne, Paul A. Harris
Summary: New technologies and disruptions caused by COVID-19 have led to the expansion of decentralized clinical trials, which hold promise for increasing efficiency and reducing barriers. The Trial Innovation Network has provided recommendations for decentralized approaches and has consulted on numerous research proposals. While some elements of decentralized trials have worked well, others require further refinement and assessment. Efforts are needed to build trust and ensure access to remote technology for inclusive participation in decentralized clinical trials.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Review
Medicine, Research & Experimental
Michael E. Singer, Dallas C. Hack, Daniel F. Hanley
Summary: This article explores the integration of the long development path of medical devices with the necessity for diagnostic capabilities for mild traumatic brain injury (mTBI/concussion), demonstrating the effective role of public-private partnerships (PPPs). Through PPP collaborations, multiple FDA clearances and product introductions have been achieved, meeting urgent military and public needs.
JOURNAL OF CLINICAL AND TRANSLATIONAL SCIENCE
(2022)
