Article
Endocrinology & Metabolism
Sophie Buller, Sara Kohnke, Robert Hansford, Takahiro Shimizu, William D. Richardson, Clemence Blouet
Summary: This study reveals the plasticity of myelination in the adult median eminence (ME) and its regulation by nutritional signals. It shows that oligodendrocyte generation and myelin production are continuously occurring in the adult ME, but myelin amounts remain stable due to turnover. Furthermore, it demonstrates that the plasticity of ME myelination is influenced by diet and plays a role in energy balance regulation.
MOLECULAR METABOLISM
(2023)
Review
Endocrinology & Metabolism
Richard W. Clayton, Robin Lovell-Badge, Christophe Galichet
Summary: The median eminence acts as a vital interface between the hypothalamus and pituitary gland, and contains various non-neuronal cell types that may play a role in regulating neuroendocrine system function.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Reproductive Biology
Rodrigo A. Carrasco, Jaswant Singh, Marcelo H. Ratto, Gregg P. Adams
Summary: The study characterized the anatomical framework and sites of action of the NGF-mediated ovulation-inducing system in llamas. Both TrkA and P75 receptors were highly expressed in specific regions of the llama hypothalamus, with tanycytes playing a close role between GnRH and kisspeptin.
BIOLOGY OF REPRODUCTION
(2021)
Article
Endocrinology & Metabolism
Lisa L. Koorneef, Merel van der Meulen, Sander Kooijman, Elena Sanchez-Lopez, Jari F. Scheerstra, Maaike C. Voorhoeve, Ajith N. Nadamuni Ramesh, Patrick C. N. Rensen, Martin Giera, Jan Kroon, Onno C. Meijer
Summary: Add-on treatment with corticosterone can partially attenuate the metabolic effects of synthetic glucocorticoid dexamethasone, while exacerbating other effects.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Michelle Romijn, Luca J. L. van Tilburg, Jonneke J. Hollanders, Bibian van der Voorn, Paul de Goede, Koert M. Dolman, Annemieke C. Heijboer, Birit F. P. Broekman, Joost Rotteveel, Martijn J. J. Finken
Summary: The study compared the diurnal rhythmicity of breast milk glucocorticoids (GCs) between pregnant women seeking consultation for psychological distress and control mothers. Results showed no group differences in GC rhythms, but the total amount of milk cortisol was lower in the group with psychological distress. Further research is needed to investigate the impact of vertical transmission of breast milk GCs.
Article
Endocrinology & Metabolism
Eduard Murani, Nares Trakooljul, Frieder Hadlich, Siriluck Ponsuksili, Klaus Wimmers
Summary: The study reveals that glucocorticoid receptor (GR) signaling influences microglia in the hypothalamus and hippocampus, with differential transcriptional responses depending on sex and dosage. Dexamethasone induces a dysfunctional state of microglia in males, while priming microglia in females, which may predispose to different mental disorders.
NEUROENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Daiki Ueda, Naomi Yonemochi, Tomohiro Kamata, Masahiro Shibasaki, Junzo Kamei, John L. Waddington, Hiroko Ikeda
Summary: This study found that social novelty preference was impaired in diabetic mice, and NPY neurons may be activated in diabetic mice, impairing social novelty preference by promoting glutamatergic function through Y-2 receptors.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Andy Tran, Wenyuan He, Jim T. C. Chen, Leigh Wellhauser, Kathyrn E. Hopperton, Richard P. Bazinet, Denise D. Belsham
Summary: Consumption of a diet high in saturated fatty acids can lead to hypothalamic neuroinflammation, dysregulation of neuronal function, and induction of orexigenic neuropeptide Y (Npy). Intracellular metabolism of palmitate and metabolites like ceramide and phospholipids play a crucial role in mediating the effects of palmitate on Npy expression.
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Cell Biology
Yinqiong Huang, Xiahong Lin, Shu Lin
Summary: This research over the past decade has suggested that the pathogenic mechanisms of metabolic syndrome involve both peripheral tissues and central metabolic regulation imbalances. The hypothalamus, particularly the arcuate nucleus, is highlighted as the control center for metabolic homeostasis and energy balance, with Neuropeptide Y neurons playing a crucial role in integrating peripheral metabolic signals with the brain center. The manuscript aims to provide an overview of Neuropeptide Y's regulatory effects on metabolic syndrome and discuss clinical intervention strategies for neurometabolic diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Aakansha Sharma, Subhajit Das, Sayantan Sur, Jyoti Tiwari, Khushboo Chaturvedi, Neha Agarwal, Shalie Malik, Sangeeta Rani, Vinod Kumar
Summary: Through investigating the time course of photoperiodically driven transcriptional responses in physiologically contrasting seasonal life-history states in migratory blackheaded buntings, it was found that there were differences in gene expression between the photosensitive and photorefractory states. The results demonstrate the important role of hypothalamic molecular pathways in life-history-dependent activation.
SCIENTIFIC REPORTS
(2021)
Article
Genetics & Heredity
Kimberly W. Y. Mak, Wenyuan He, Neruja Loganathan, Denise D. Belsham
Summary: This study identified the first hypothalamic miRNA that directly targets the 3' UTR of mouse Npy, highlighting the involvement of miRNAs in the NPY system and providing an alternative target for control of NPY levels.
Article
Multidisciplinary Sciences
Lora L. Martucci, Jean-Marie Launay, Natsuko Kawakami, Cecile Sicard, Nathalie Desvignes, Mbarka Dakouane-Giudicelli, Barbara Spix, Maude Tetu, Franck -Olivier Gilmaire, Sloane Paulcan, Jacques Callebert, Cyrille Vaillend, Franz Bracher, Christian Grimm, Philippe Fossier, Sabine de la Porte, Hirotaka Sakamoto, John Morris, Antony Galione, Sylvie Granon, Jose-Manuel Cancela
Summary: Oxytocin is released in response to Ca2+ influx and release from intracellular stores, both critical for priming large dense-cored vesicles in hypothalamic neurons for exocytosis. This study shows that lysosomes surround dendritic vesicles and activation of endolysosomal two-pore channels (TPCs) provides the necessary Ca2+ signals to prime oxytocin release. TPC knockout mice and mice lacking TPC exhibit impaired oxytocin secretion and social behavior, which can be restored by direct administration of oxytocin.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Environmental Sciences
William A. Thompson, Mathilakath M. Vijayan
Summary: The ubiquitous use of antidepressants, such as venlafaxine, has led to increased concentrations of these pharmaceuticals in waterways, impacting neural development in zebrafish embryos. Early developmental exposure to venlafaxine disrupts the functioning of the hypothalamus-pituitary-interrenal axis in zebrafish, affecting cortisol levels and responses to stress across multiple generations. This study suggests that venlafaxine is an endocrine disruptor with potential long-term and generational consequences on stress axis activity.
ENVIRONMENTAL POLLUTION
(2021)
Article
Developmental Biology
Sharifuddin Rifat Ahmed, Elise Liu, Alissa Yip, Yuqi Lin, Evan Balaban, Maria Pompeiano
Summary: Mammalian TRPC5 channels are predominantly expressed in the brain, particularly in areas that play a role in neurotransmission. This study in chick embryos found a significant increase in TRPC5 expression in the brain between days 8 and 16 of incubation, suggesting a potential role in late embryonic brain development. The distribution and staining patterns of TRPC5 in the chick embryo brain provide new insights into its functions and possible contributions to brain development.
DEVELOPMENTAL NEUROBIOLOGY
(2022)
Article
Cell Biology
Emma K. McIlwraith, Calvin Lieu, Denise D. Belsham
Summary: BPA exposure in the hypothalamus leads to an increase in miR-708-5p, which controls neuropeptides directly linked to obesity. This endocrine disrupting chemical alters miRNA profiles, affecting energy balance and feeding behavior by modulating the expression of key genes involved in weight regulation.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Takahito Nasu, Mamoru Satoh, Tsuyoshi Hachiya, Yoichi Sutoh, Hideki Ohmomo, Sho Hitomi, Satoru Taguchi, Hiroto Kikuchi, Takamasa Kobayashi, Yuji Takahashi, Takuya Osaki, Yoshihiro Morino, Kenji Sobue, Atsushi Shimizu, Makoto Sasaki
Summary: This study identified a novel genetic variant, rs7798496, associated with elevated hs-cTnT levels and a high risk for cardiovascular disease in the general Japanese population through a GWAS. The presence of the rs7798496 T allele was strongly correlated with an increased risk for CVD, providing insights into potential genetic factors contributing to cardiovascular health risks.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Atsushi Hozawa, Kozo Tanno, Naoki Nakaya, Tomohiro Nakamura, Naho Tsuchiya, Takumi Hirata, Akira Narita, Mana Kogure, Kotaro Nochioka, Ryohei Sasaki, Nobuyuki Takanashi, Kotaro Otsuka, Kiyomi Sakata, Shinichi Kuriyama, Masahiro Kikuya, Osamu Tanabe, Junichi Sugawara, Kichiya Suzuki, Yoichi Suzuki, Eiichi N. Kodama, Nobuo Fuse, Hideyasu Kiyomoto, Hiroaki Tomita, Akira Uruno, Yohei Hamanaka, Hirohito Metoki, Mami Ishikuro, Taku Obara, Tomoko Kobayashi, Kazuyuki Kitatani, Takako Takai-Igarashi, Soichi Ogishima, Mamoru Satoh, Hideki Ohmomo, Akito Tsuboi, Shinichi Egawa, Tadashi Ishii, Kiyoshi Ito, Sadayoshi Ito, Yasuyuki Taki, Naoko Minegishi, Naoto Ishii, Masao Nagasaki, Kazuhiko Igarashi, Seizo Koshiba, Ritsuko Shimizu, Gen Tamiya, Keiko Nakayama, Hozumi Motohashi, Jun Yasuda, Atsushi Shimizu, Tsuyoshi Hachiya, Yuh Shiwa, Teiji Tominaga, Hiroshi Tanaka, Kotaro Oyama, Ryoichi Tanaka, Hiroshi Kawame, Akimune Fukushima, Yasushi Ishigaki, Tomoharu Tokutomi, Noriko Osumi, Tadao Kobayashi, Fuji Nagami, Hiroaki Hashizume, Tomohiko Arai, Yoshio Kawaguchi, Shinichi Higuchi, Masaki Sakaida, Ryujin Endo, Satoshi Nishizuka, Ichiro Tsuji, Jiro Hitomi, Motoyuki Nakamura, Kuniaki Ogasawara, Nobuo Yaegashi, Kengo Kinoshita, Shigeo Kure, Akio Sakai, Seiichiro Kobayashi, Kenji Sobue, Makoto Sasaki, Masayuki Yamamoto
Summary: The study established a community-based cohort to assess the long-term impact of the Great East Japan Earthquake on disaster victims and gene-environment interactions on major disease incidence. Results showed that 70% of participants joined at health check-up sites, Type 1 survey participants were more likely to have psychological distress, women were more likely to have psychological distress than men, and coastal residents had higher levels of psychological distress compared to inland residents.
JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Pathology
Hideki Ohmomo, Shohei Komaki, Kanako Ono, Yoichi Sutoh, Tsuyoshi Hachiya, Eri Arai, Hiroyuki Fujimoto, Teruhiko Yoshida, Yae Kanai, Makoto Sasaki, Atsushi Shimizu
Summary: FFPE-derived DNA showed significant differences in fragment size, library construction, and mapping ratio compared to FF-derived DNA, indicating technical improvements are necessary for using archived FFPE resources.
PATHOLOGY INTERNATIONAL
(2021)
Article
Environmental Sciences
Yuka Kotozaki, Mamoru Satoh, Kozo Tanno, Hideki Ohmomo, Ryo Otomo, Fumitaka Tanaka, Takahito Nasu, Satoru Taguchi, Hiroto Kikuchi, Takamasa Kobayashi, Atsushi Shimizu, Kiyomi Sakata, Jiro Hitomi, Kenji Sobue, Makoto Sasaki
Summary: The study investigated the association between xanthine oxidoreductase (XOR) activity and cardiovascular disease (CVD) risk in a general Japanese population. Results showed that high XOR activity was independently associated with increased risk for CVD and may serve as an indicator for cardiovascular risk in the population.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Oncology
Hideki Ohmomo, Sei Harada, Shohei Komaki, Kanako Ono, Yoichi Sutoh, Ryo Otomo, So Umekage, Tsuyoshi Hachiya, Kota Katanoda, Toru Takebayashi, Atsushi Shimizu
Summary: The study found differences in DNA methylation and transcriptome profiles between heated tobacco product (HTP) users and smokers, although to a lesser extent than smokers. However, the long-term molecular genetic effects of HTP use remain unknown and further long-term studies are needed.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Endocrinology & Metabolism
Yoichi Sutoh, Shohei Komaki, Taiki Yamaji, Shiori Suzuki, Ryoko Katagiri, Norie Sawada, Kanako Ono, Hideki Ohmomo, Tsuyoshi Hachiya, Yayoi Otsuka-Yamasaki, Akira Takashima, So Umekage, Motoki Iwasaki, Atsushi Shimizu
Summary: The study identified significant associations between MICA and MICB gene expression levels with various health risks, and confirmed the causal effect of MICA expression on Graves' disease. These findings highlight the immunoregulatory role of MICA expression in peripheral blood mononuclear cells and suggest the importance of further functional assays in inflammatory diseases.
Article
Oncology
Shohei Komaki, Hideki Ohmomo, Tsuyoshi Hachiya, Yoichi Sutoh, Kanako Ono, Ryohei Furukawa, So Umekage, Yayoi Otsuka-Yamasaki, Kozo Tanno, Makoto Sasaki, Atsushi Shimizu
Summary: The majority of CpGs were longitudinally stable over three months, with stable CpGs enriched in metabolism-related genes. Dynamic CpGs were more likely to be EWAS markers of various traits, particularly immune- and inflammatory-related traits.
CLINICAL EPIGENETICS
(2021)
Article
Sport Sciences
Yuichiro Nishida, Megumi Hara, Hideki Ohmomo, Kanako Ono, Atsushi Shimizu, Mikako Horita, Chisato Shimanoe, Naoto Taguchi, Yasuki Higaki, Keitaro Tanaka
Summary: This study found that higher accelerometer-assessed total PA was associated with increased DNA methylation levels at the cg07030336 (VTI1A/ZDHHC6) site in the general population in Japan. In addition, a divergent relationship was found between methylation levels at the cg07030336 site and several inflammatory biomarkers.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Oncology
Shohei Komaki, Hideki Ohmomo, Tsuyoshi Hachiya, Yoichi Sutoh, Kanako Ono, Ryohei Furukawa, So Umekage, Yayoi Otsuka-Yamasaki, Shiori Minabe, Akira Takashima, Kozo Tanno, Makoto Sasaki, Atsushi Shimizu
Summary: This study analyzed the fluctuations of epigenetic age in samples from two Japanese men and found that there were considerable fluctuations in epigenetic age over a 3-month period, and these fluctuations were not suppressed by correcting for cell-type composition.
CLINICAL EPIGENETICS
(2022)
Article
Physiology
Satoru Taguchi, Takahito Nasu, Mamoru Satoh, Yuka Kotozaki, Kozo Tanno, Fumitaka Tanaka, Koichi Asahi, Hideki Ohmomo, Hiroto Kikuchi, Takamasa Kobayashi, Yoshihiro Morino, Atsushi Shimizu, Kenji Sobue, Makoto Sasaki
Summary: This study investigated the association between XOR activity and renal function in a general Japanese population. The results showed that high XOR activity was associated with the severity of chronic kidney disease (CKD).
KIDNEY & BLOOD PRESSURE RESEARCH
(2022)
Article
Multidisciplinary Sciences
Y-h. Taguchi, Shohei Komaki, Yoichi Sutoh, Hideki Ohmomo, Yayoi Otsuka-Yamasaki, Atsushi Shimizu
Summary: This study integrated gene expression, DNA methylation, and genomic variants using a kernel tensor decomposition-based method. The selected genes and genomic variants were found to be significantly associated with transcription factors enriched in KEGG pathway terms and intra-related regulatory network.
Article
Geriatrics & Gerontology
Shohei Komaki, Masatoshi Nagata, Eri Arai, Ryo Otomo, Kanako Ono, Yukiko Abe, Hideki Ohmomo, So Umekage, Natsuko Shinozaki, Tsuyoshi Hachiya, Yoichi Sutoh, Yayoi Otsuka-Yamasaki, Yasumichi Arai, Nobuyoshi Hirose, Akio Yoneyama, Hideyuki Okano, Makoto Sasaki, Yae Kanai, Atsushi Shimizu
Summary: This study explored the epigenetic signatures of exceptional healthy longevity and found that it depends not only on maintaining young epigenetic states but also on advanced states of specific epigenetic regions.
LANCET HEALTHY LONGEVITY
(2023)
Article
Public, Environmental & Occupational Health
Sei Harada, Hideki Ohmomo, Minako Matsumoto, Mizuki Sata, Miho Iida, Aya Hirata, Naoko Miyagawa, Kazuyo Kuwabara, Suzuka Kato, Ryota Toki, Shun Edagawa, Daisuke Sugiyama, Asako Sato, Akiyoshi Hirayama, Masahiro Sugimoto, Tomoyoshi Soga, Masaru Tomita, Atsushi Shimizu, Tomonori Okamura, Toru Takebayashi
Summary: This study found that both smoking and HTP use are associated with plasma metabolites, particularly with the glutamate pathway. Smoking is more similar to HTP use in terms of metabolite profiles compared to never smoking. Smoking and HTP use may contribute to the development of cardiovascular disease through the modulation of glutamate metabolism.
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Peripheral Vascular Disease
Harutomo Numazaki, Takahito Nasu, Mamoru Satoh, Yuka Kotozaki, Kozo Tanno, Koichi Asahi, Hideki Ohmomo, Atsushi Shimizu, Shinichi Omama, Yoshihiro Morino, Kenji Sobue, Makoto Sasaki
Summary: This study found an association between vascular endothelial dysfunction and stroke incidence in the general Japanese population, indicating that a low FMD value may indicate future stroke risk.
INTERNATIONAL JOURNAL OF CARDIOLOGY CARDIOVASCULAR RISK AND PREVENTION
(2023)
Article
Cardiac & Cardiovascular Systems
Hiroto Kikuchi, Takahito Nasu, Mamoru Satoh, Yuka Kotozaki, Kozo Tanno, Koichi Asahi, Hideki Ohmomo, Takamasa Kobayashi, Satoru Taguchi, Yoshihiro Morino, Atsushi Shimizu, Kenji Sobue, Makoto Sasaki
Summary: This study found that decreased TP1NP levels may indicate future CAD risk and atherosclerosis progression in the general Japanese population.
IJC HEART & VASCULATURE
(2022)
